CN105105148A - Method for producing gelatina nigra preparation for improving nutritional anemia - Google Patents
Method for producing gelatina nigra preparation for improving nutritional anemia Download PDFInfo
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- CN105105148A CN105105148A CN201510610557.1A CN201510610557A CN105105148A CN 105105148 A CN105105148 A CN 105105148A CN 201510610557 A CN201510610557 A CN 201510610557A CN 105105148 A CN105105148 A CN 105105148A
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- hide gelatin
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- 208000036654 deficiency anemia Diseases 0.000 title abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000000843 powder Substances 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 16
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 14
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a method for producing gelatina nigra preparation for improving nutritional anemia. The preparation is characterized in that the active ingredients contained in the preparation include the following raw materials in parts by weight: 95-98 parts of gelatina nigra composite powder, 0.5-3 parts of ferrous fumarate, 0-2 parts of silicon dioxide and 0-2 parts of magnesium stearate, wherein the gelatina nigra composite powder is prepared by concentrating and drying a mixture of angelicae sinensis extract and molten gelatina nigra; the angelicae sinensis extract includes the following raw materials: 30-60 parts of angelicae sinensis, 20-40 parts of processed astragalus membranaceus with honey and 10-30 parts of Chinese jujube. The production method includes the following processing steps: melting the gelatina nigra, pretreating the medicinal materials, extracting, performing ethanol precipitation, recycling ethyl alcohol, mixing, pelletizing and packaging. According to the invention, the adopted raw material components are scientific in compatibility; the modern food and medicine processing technology is adopted, and the adopted capsules have the advantages of being stable in quality, high in bioavailability, good in effect and quick to take effect; experiments show that the gelatina nigra preparation has the health care function of improving nutritional anemia.
Description
Technical field
The invention belongs to technical field of health care food, particularly a kind of ass hide gelatin preparation production method improving alimentary anemia.
Background technology
According to World Health Organization's statistics, the whole world about has 3,000,000,000 people to suffer from anaemia in various degree, causes that the number of various diseases and death is up to ten million every year because suffering from anaemia.The population probability of middle national trouble anaemia is higher than western countries, and in the crowd suffering from anaemia, women is apparently higher than the male sex, and old man and children, higher than the young and the middle aged, according to the statistics of Beijing in 2000, suffer from the women of alimentary anemia up to 47%.In recent years, the trophic disturbance caused because of the factor such as change, fat-reducing of diet style, defines the crowd of another class anaemia.Therefore the health food market demand improving alimentary anemia is huge.
Alimentary anemia morbidity is comparatively slow, and majority is potentiality, but this trend continues, not only affects daily life, can occur complicated ischemic clinical symptoms time serious.At present, nutritional health food market being improved alimentary anemia is not a lot, and there is the deficiency of two aspects: one is that effect is obvious not, two be take effect slower.Customer satisfaction is not high.For this problem, be badly in need of providing a kind of health food improving alimentary anemia, to solve in the past, like product effect not obviously, take effect slower problem, and exploitation has the capsule manufacture method of effective, instant effect of righting reinforcing, nourishing qi and blood, nourshing Yin and drynsessmoistening prescription, prevention anaemia.
Summary of the invention
Technical problem to be solved by this invention overcomes the existing weak point improving alimentary anemia health food, providing one with donkey-hide gelatin, the Radix Astragali, when being classified as primary raw material, adding appropriate trace elements iron and ascorbic ass hide gelatin preparation production method.
For achieving the above object, the present invention adopts following technical scheme:
Improve an ass hide gelatin preparation production method for alimentary anemia, it is characterized in that contained active component is made up of the raw material of following weight proportioning: donkey-hide gelatin composite powder 95-98, ferrous fumarate 0.5-3, silica 0-2, dolomol 0-2.
Described donkey-hide gelatin composite powder mixes with the donkey-hide gelatin of molten with angelica extract, and make through concentrate drying, its weight proportion is: the donkey-hide gelatin 50-70 of molten, angelica extract 30-50;
The raw material composition of described angelica extract: Radix Angelicae Sinensis 30-60, preparing astragalus membranaceus 20-40, date 10-30;
Ass hide gelatin preparation production method of the present invention, comprises following processing step:
(1) donkey-hide gelatin molten: add in jacketed pan by the donkey-hide gelatin of formula ratio, adds the purified water of 1.8-2.2 times of weight, stirs and be heated to donkey-hide gelatin all to dissolve, then boiling sterilization 30 minutes, lets cool for subsequent use;
(2) medicinal material pre-treatment: by formula ratio without going mouldy, the Radix Angelicae Sinensis of free from insect pests, preparing astragalus membranaceus, date clean up with water respectively;
(3) extract: Radix Angelicae Sinensis step (2) obtained, preparing astragalus membranaceus, date drop in multi-function extractor, extracting in water 2 times adds the water of 7-9 times amount for the first time, and after heating boils 1.5-2.5 hour, extract 100 order silks filter; Second time adds the water of 5-7 times of weight, and after heating boils 1.5-2 hour, extract 100 order silks filter; Merge secondary raffinate for subsequent use, it is abandoned by the dregs of a decoction;
(4) Vacuum Concentration: the extract that step (3) obtains is placed in vacuum concentrator and concentrates, temperature controls below 85 DEG C, and vacuum is 0.04-0.06Mpa, and being concentrated into relative density is 1.08-1.10, obtains concentrate, cooling is stand-by;
(5) alcohol precipitation: the concentrate that step (4) obtains is carried out alcohol precipitation, the edible ethanol adding 95% is 50%-55% to alcohol content, stirs, and leaves standstill 24 hours, gets supernatant 120 order silks and filter to obtain alcoholic solution, stand-by;
(6) ethanol is reclaimed: joined by above-mentioned alcoholic solution in alcohol distillation column and carry out recovery ethanol extremely without alcohol taste;
(7) dry powder process: above-mentioned alcohol precipitation extract is mixed with the donkey-hide gelatin of molten, then concentrate drying makes 80-100 object donkey-hide gelatin composite powder to moisture 3-7%;
(8) mix: the donkey-hide gelatin composite powder that the ferrous fumarate of formula ratio, silica, dolomol and step (7) obtain is joined in mixer, stir 10-15 minute, mix, to mixture uniform color;
(9) granulate packaging: the mixed material that step (8) obtains is joined in granulator and granulates, packaging capsule preparations of the present invention.
In prescription of the present invention, the taste of various raw material, property, effect are: donkey-hide gelatin: sweet, flat.Return lung, liver, kidney channel, effect is tonified the blood and arrest bleeding, nourshing Yin and drynsessmoistening prescription;
The sweet slightly warm in nature of Radix Astragali taste.Return lung, spleen, liver, kidney channel.Polishing is shown admittedly, holder sore myogenic.Cure mainly the empty spontaneous perspiration of body, rush down for a long time, prolapse of the anus, the prolapse of uterus, chronic nephritis, body is impractical swollen, chronic ulcer, open sore part disunion of a specified duration; Preparing astragalus membranaceus has tonifying Qi, nourishes blood, effect in benefit, is applicable to the diseases such as internal injury overstrain, splenasthenic diarrhea, the deficiency of vital energy, the deficiency of blood, laboured breathing;
Radix Angelicae Sinensis taste is sweet and weigh, therefore specially can enrich blood, and its gas is light and pungent, therefore again can promoting circulation of blood, and bowl spares has, and have benefit in row, be the key medicine in blood, it can be enriched blood, and can invigorate blood circulation again, both can stimulate the menstrual flow, again can be active.All menoxenias, dysmenorrhoea, deficiency of blood amenorrhoea, sallow complexion, weak anaemia, uterine hemorrhage, postpartum blood stasis, example, through the common disease of women such as (during menstrual onset, occurring that mouth and nose are bled), can use angelica for treating;
The vitamin content of date is very high, there is the good reputation of " natural complex ball ", there is nourishment for vitality, enrich blood, effect such as qi-restoratives benefit gas, nourishing blood and tranquilization, strengthening the spleen and stomach etc., be the good health nutrient of the patient such as weakness of the spleen and the stomach, insufficiency of vital energy and blood, lassitude, insomnia;
Compatibility ferrous fumarate supplements as source of iron, improves hypoferric anemia, because it is ferrous, can better be absorbed by the body.
Make a general survey of above-mentioned whole formula, each taste compatibility complements each other, and brings out the best in each other, and plays the effect of righting reinforcing, nourishing qi and blood, activating blood circulation, prevention anaemia altogether, has advantage that is effective, instant effect.
The invention has the beneficial effects as follows:
1, the raw material components compatibility science adopted, each component complements one another, brings out the best in each other, and the results showed, has the health-care efficacy improving alimentary anemia.
2, the capsule adopted has steady quality, bioavilability advantages of higher, compares with pill with tablet, and hard shell capsules in the gastrointestinal tract disintegration is very fast, effective fast, good absorbing, bioavilability are high, and can moistureproof, lucifuge, stable in properties, be convenient to preserve, extend release of active agent.
3, the present invention adopts with natural component raw material, adopt modern food medicine process technology, optimize the nutritional health function of each component raw material, improve edible safety, utilize capsule formulation feature simultaneously, make a kind of have improve alimentary anemia, be easy to absorption of human body, edible and easy to carry capsule preparations.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
Gather and select donkey-hide gelatin raw material, the donkey-hide gelatin of formula ratio is added in jacketed pan, add the purified water of 2 times of weight, stir and be heated to donkey-hide gelatin and all dissolve, then boiling sterilization 30 minutes, let cool for subsequent use;
Gather and select Radix Angelicae Sinensis, preparing astragalus membranaceus, date raw material, by formula ratio without going mouldy, the preparing astragalus membranaceus of free from insect pests, Radix Angelicae Sinensis, date clean up with water respectively, drop in multi-function extractor by cleaned Radix Angelicae Sinensis, preparing astragalus membranaceus, date, extracting in water 2 times, adds the water of 7 amounts for the first time, and after heating boils 2 hours, extract 100 order silks filter, second time adds the water of 7 times of weight, and after heating boils 1.5 hours, extract 100 order silks filter, merge secondary raffinate for subsequent use, it is abandoned by the dregs of a decoction, again the extract of filtration is placed in vacuum concentrator to concentrate, temperature controls below 85 DEG C, vacuum is 0.06Mpa, being concentrated into relative density is 1.08-1.10, obtain concentrate, alcohol precipitation is carried out again by cooling the concentrate obtained, edible ethanol to the alcohol content adding 95% is 55%, stir, leave standstill 24 hours, get supernatant 120 order silks and filter to obtain alcoholic solution, again the alcoholic solution of filtration is joined in alcohol distillation column and carry out recovery ethanol extremely without alcohol taste, above-mentioned alcohol precipitation extract is mixed in proportion with the donkey-hide gelatin of molten, then concentrate drying makes 80 order pulvis to moisture 5%, obtained donkey-hide gelatin composite powder 98 kilograms, for subsequent use,
Gather and select the ferrous fumarate 1 kilogram of formula ratio, silica 0.5 kilogram, dolomol 0.5 kilogram, and donkey-hide gelatin composite powder 98 kilograms, join in mixer, stir 10 minutes, mix, to mixture uniform color; The mixed material obtained is joined in granulator and granulates, packaging capsule preparations of the present invention.
Embodiment 2:
Gather and select donkey-hide gelatin raw material, the donkey-hide gelatin of formula ratio is added in jacketed pan, add the purified water of 1.8 times of weight, stir and be heated to donkey-hide gelatin and all dissolve, then boiling sterilization 30 minutes, let cool for subsequent use;
Gather and select Radix Angelicae Sinensis, preparing astragalus membranaceus, date raw material, by formula ratio without going mouldy, the preparing astragalus membranaceus of free from insect pests, Radix Angelicae Sinensis, date clean up with water respectively, drop in multi-function extractor by cleaned Radix Angelicae Sinensis, preparing astragalus membranaceus, date, extracting in water 2 times, adds the water of 9 amounts for the first time, and after heating boils 2 hours, extract 100 order silks filter, second time adds the water of 5 times of weight, and after heating boils 1.5 hours, extract 100 order silks filter, merge secondary raffinate for subsequent use, it is abandoned by the dregs of a decoction, again the extract that filtration obtains is placed in vacuum concentrator to concentrate, temperature controls below 85 DEG C, vacuum is 0.05Mpa, being concentrated into relative density is 1.10, obtain concentrate, alcohol precipitation is carried out again by cooling the concentrate obtained, edible ethanol to the alcohol content adding 95% is 55%, stir, leave standstill 24 hours, get supernatant 120 order silks and filter to obtain alcoholic solution, again the alcoholic solution of filtration is joined in alcohol distillation column and carry out recovery ethanol extremely without alcohol taste, above-mentioned alcohol precipitation extract is mixed in proportion with the donkey-hide gelatin of molten, then concentrate drying makes 100 order pulvis to moisture 5%, obtained donkey-hide gelatin composite powder 49 kilograms, for subsequent use,
Gather and select the ferrous fumarate 0.5 kilogram of formula ratio, silica 0.3 kilogram, dolomol 0.2 kilogram, and donkey-hide gelatin composite powder 49 kilograms, join in mixer, stir 15 minutes, mix, to mixture uniform color; The mixed material obtained is joined in granulator and granulates, packaging capsule preparations of the present invention.
Embodiment 3
The present invention sets forth the beneficial effect of described product by experiment further, and test carries out according to improving the evaluation test method of alimentary anemia function in " health food inspection and assessment technical specification ".
The alimentary anemia function animal experiment that improves provided by the invention is reported as follows:
1, materials and methods
1,1 sample: provided by the present inventor.Human oral's recommended amounts is every day 2 times, each 3, and adult's body weight is by 60kg double calculation, and amounting to dosage is 0.042g/kg/bw.
1,2 animals used as test and environment: male SD rat 56 of weaning at the beginning of SPF level only develops good fortune district Dong Chuan Animal Science service department by Changsha to be provided, animal used as test production licence number SCXK(Hunan) 2009-0012. experimental situation is barrier environment.Experimental session experimental situation temperature 22.C ~ 24. humidity 50% ~ 56%.Animal used as test occupancy permit number is SYXK(Hunan) No. 2010-0011.
1,3 low iron feeds: green permanent spring nutritional health food technological development Co., Ltd provides by Beijing.
1,4 dosage select congenial group to give mode with tested material: feed to the low iron feed of rat and deionized water from on-test, adopt Rotating Stainless Steel Cage tool and food tank, avoid iron pollution in experimentation.Start selected part rat weekly from the 3rd week and adopt tail hematometry hemoglobin (Hb), until when most rat Hb is lower than 100g/L, adopt body weight and the content of hemoglobin of the whole rat of tail hematometry, choose the rat 40 of Hb<100g/l only as test model animal, according to Anemia in Rats Hb level and body weight, it is divided into 0.21g/kg.bw, 0.42g/kg/bw, 1.26/kg.bw tri-test group (being equivalent to the 5.10.30 of human body RD doubly) and low iron control group at random, often organize 10, single cage is raised.
Basic, normal, high dosage component other sample thief 4.20g, 8.40g, 25.20g add deionized water to 200mL, and contrast gives equal-volume solvent, gavage amount 1.0ml/100kg.bw.Each group is continued to give low iron feed and deionized water, continuous 30 days.
1.5 key instrument
1.5.1722S spectrophotometer.
1.5.2RF-540 fluophotometer.
1.6 experimental techniques:
The detection (HemoCue) of 16.1 hemoglobins: measure rat hemoglobin content modeling latter stage and recovery test end.Get tail blood 10 μ L and add 2.5mL containing in the reagent of the potassium ferricyanide, mixing, places 15 minutes; Select 0.5 centimetre of optical path cuvette, under 540nm wavelength, with reagent zeroing, all samples pipe density is multiplied by 736, is HC (g/L).
1.6.2 the detection of Erythrocyte chemokine recepter: during off-test, gets tail blood 20 μ L, after anticoagulant heparin agent process, adopts sepectrophotofluorometer method to measure Erythrocyte chemokine recepter.
1.7 experiment material are according to system degree: with Excel, Spss software expert statistical analysis.
2 results
2.1 donkey-hide gelatin capsules of the present invention are on the impact of rat body weight
From table 1, each dosage group is tested just, test mid-term, test last rat body weight and the growth of experimental session rat body weight is compared with control group, no significant difference (p>0.05)
Table 1 sample is on the impact of rat body weight
2.2 donkey-hide gelatin capsules of the present invention are on the impact of rat hemoglobin
The content of hemoglobin no significant difference of each group rat before test.After experiment, each dosage group hemoglobin compares with control group rising, high dose group with compare difference and have conspicuousness (p<0.55) (see table 2).Elevation amplitude average out to 10.53g/l before and after three dosage group hemoglobins
Table 2 sample is on the impact of rat hemoglobin
2.3 donkey-hide gelatin capsule of the present invention is on the impact of protoporphyrin free in Rat Erythrocytes.
From table 3, the Erythrocyte chemokine recepter of each dosage group rat compares with control group reduction trend, high dose group with compare difference and have conspicuousness (p<0.05)
Table 3 sample is on the impact of protoporphyrin free in Rat Erythrocytes
3 brief summaries
Under this laboratory condition; after per os gives the donkey-hide gelatin capsule of the present invention of Anemia model rat 0.21g/kg.bw, 0.42g/kg.bw, 1.26g/kg.bw dosage, 1.26g/kg.bw dosage group rat hemoglobin and low iron control group comparing difference have conspicuousness (p<0.05); Three dosage group rat hemoglobin elevation amplitude on average reach more than 10g/L; 1.26g/kg.bw dosage group Erythrocyte chemokine recepter has conspicuousness (p<0.05) than difference with comparing.Point out this sample to have and improve animal nutritional anaemia function.
Claims (4)
1. improve an ass hide gelatin preparation production method for alimentary anemia, it is characterized in that contained active component is made up of the raw material of following weight proportioning: donkey-hide gelatin composite powder 95-98, ferrous fumarate 0.5-3, silica 0-2, dolomol 0-2.
2. a kind of ass hide gelatin preparation production method improving alimentary anemia according to claim 1, it is characterized in that described donkey-hide gelatin composite powder mixes with the donkey-hide gelatin of molten with angelica extract, make through concentrate drying, its weight proportion is: the donkey-hide gelatin 50-70 of molten, angelica extract 30-50.
3. a kind of ass hide gelatin preparation production method improving alimentary anemia according to claim 1, is characterized in that the raw material of described angelica extract consists of: Radix Angelicae Sinensis 30-60, preparing astragalus membranaceus 20-40, date 10-30.
4. a kind of ass hide gelatin preparation production method improving alimentary anemia according to claim 1, is characterized in that described ass hide gelatin preparation production method, comprises following processing step:
(1) donkey-hide gelatin molten: add in jacketed pan by the donkey-hide gelatin of formula ratio, adds the purified water of 1.8-2.2 times of weight, stirs and be heated to donkey-hide gelatin all to dissolve, then boiling sterilization 30 minutes, lets cool for subsequent use;
(2) medicinal material pre-treatment: by formula ratio without going mouldy, the Radix Angelicae Sinensis of free from insect pests, preparing astragalus membranaceus, date clean up with water respectively;
(3) extract: Radix Angelicae Sinensis step (2) obtained, preparing astragalus membranaceus, date drop in multi-function extractor, extracting in water 2 times adds the water of 7-9 times amount for the first time, and after heating boils 1.5-2.5 hour, extract 100 order silks filter; Second time adds the water of 5-7 times of weight, and after heating boils 1.5-2 hour, extract 100 order silks filter; Merge secondary raffinate for subsequent use, it is abandoned by the dregs of a decoction;
(4) Vacuum Concentration: the extract that step (3) obtains is placed in vacuum concentrator and concentrates, temperature controls below 85 DEG C, and vacuum is 0.04-0.06Mpa, and being concentrated into relative density is 1.08-1.10, obtains concentrate, cooling is stand-by;
(5) alcohol precipitation: the concentrate that step (4) obtains is carried out alcohol precipitation, the edible ethanol adding 95% is 50%-55% to alcohol content, stirs, and leaves standstill 24 hours, gets supernatant 120 order silks and filter to obtain alcoholic solution, stand-by;
(6) ethanol is reclaimed: joined by above-mentioned alcoholic solution in alcohol distillation column and carry out recovery ethanol extremely without alcohol taste;
(7) dry powder process: above-mentioned alcohol precipitation extract is mixed with the donkey-hide gelatin of molten, then concentrate drying makes 80-100 object donkey-hide gelatin composite powder to moisture 3-7%;
(8) mix: the donkey-hide gelatin composite powder that the ferrous fumarate of formula ratio, silica, dolomol and step (7) obtain is joined in mixer, stir 10-15 minute, mix, to mixture uniform color;
(9) granulate packaging: the mixed material that step (8) obtains is joined in granulator and granulates, packaging capsule preparations of the present invention.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114129647A (en) * | 2021-12-08 | 2022-03-04 | 江西广恩和药业股份有限公司 | Oral liquid and preparation method thereof |
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| CN101850002A (en) * | 2009-10-16 | 2010-10-06 | 北京同仁堂健康药业股份有限公司 | Composition with function of improving nutritional anemia |
| CN102631470A (en) * | 2012-05-05 | 2012-08-15 | 钱家美 | Ejiao Guiqi granules and manufacturing method thereof |
| CN104825681A (en) * | 2015-05-23 | 2015-08-12 | 周末 | Traditional Chinese medicine composition for improving alimentary anemia |
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| CN101342267A (en) * | 2008-08-20 | 2009-01-14 | 李少平 | Donkey-hide gelatin angelica polymorpha & hoantchy particle and method of preparing the same |
| CN101850002A (en) * | 2009-10-16 | 2010-10-06 | 北京同仁堂健康药业股份有限公司 | Composition with function of improving nutritional anemia |
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| CN114129647B (en) * | 2021-12-08 | 2022-11-25 | 江西广恩和药业股份有限公司 | Oral liquid and preparation method thereof |
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