CN102631470A - Ejiao Guiqi granules and manufacturing method thereof - Google Patents
Ejiao Guiqi granules and manufacturing method thereof Download PDFInfo
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- CN102631470A CN102631470A CN2012101363592A CN201210136359A CN102631470A CN 102631470 A CN102631470 A CN 102631470A CN 2012101363592 A CN2012101363592 A CN 2012101363592A CN 201210136359 A CN201210136359 A CN 201210136359A CN 102631470 A CN102631470 A CN 102631470A
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- corii asini
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Abstract
The invention relates to Ejiao Guiqi Granules and a manufacturing method of thereof. The Ejiao Guiqi granules belong to health foods and have the function of improving alimentary anemia. The Ejiao Guiqi granules comprise the following active ingredients by weight: 30-80 parts of donkey-hide gelatin; 20-50 parts of codonopsis pilosula; 10-40 parts of padix rehmanniae preparata; 20-40 parts wolfberry fruit; 20-40 parts of rhizoma atractylodis macrocephalae; 1-4 parts of vitamin C; 0.5-2 parts of ferrous lactate; and 750-1000 parts of white sugar. The Ejiao Guiqi granules are manufactured through the processes such as melting the donkey-hide gelatin by heat, boiling codonopsis pilosula, padix rehmanniae preparata, wolfberry fruit and hizome atractylodis macrocephalae with water for extraction, performing vacuum concentration, ethanol precipitation and ethanol recovery, mixing, granulating, drying, grading, packing and the like. The Ejiao Guiqi granules have the characteristics of scientific formulation, reasonable process and the like. Through human body tests, the Ejiao Guiqi granules are proven to have functions of improving alimentary anemia and promoting health, have no adverse effect on health, and are safe and reliable to eat.
Description
Technical field
The present invention relates to a kind of Colla Corii Asini and return the method for stilbene granule and preparation thereof.
Background technology
Long-term anemia is prone to cause weakness, tired, sleepy, is because of due to the muscle anoxia; Skin, mucosal pallor, the influence of the distribution of conjunctiva and capillary of skin and the easypro factors such as state that contract.Color that it is generally acknowledged tarsal conjunctiva, hand size thenar and nail matrix is reliable; Cardiopalmus is one of the most outstanding symptom, and tachycardia is arranged, and can hear soft systolic murmur at the apex of the heart or pulmonary area, is called anemic murmur, and serious anemia can be heard diastolic murmur.Serious anemia or original coronary heart disease can cause angina pectoris, cardiac dilatation, heart failure; Respiratory system, out of breath or dyspnea mostly is because due to respiratory center hypoxia or the hypercapnia.
According to World Health Organization's statistics, the whole world has 3,000,000,000 people to suffer from anemia in various degree approximately, and cause that because of suffering from anemia the dead number of all kinds of diseases is up to ten million every year.The population probability of middle national trouble anemia is higher than western countries, and in the crowd who suffers from anemia, the women is apparently higher than the male, and old man and child are higher than the young and the middle aged.In recent years, because of the nutritional disorder that factors such as the change of diet style, fat-reducing cause, formed the crowd of another type of anemia.Therefore the health food market demand of improving nutritional anemia is huge.
Having the nutritional anemia of improvement health care foods in the market many is main with capsule, oral liquid formulation, but its accumulating and take equal inconvenience, and prescription is complicated, and production cost is high.
Summary of the invention
Technical problem to be solved by this invention is the weak point that overcomes the existing health food of enriching blood; Providing a kind of is primary raw material with Colla Corii Asini, Radix Codonopsis, Radix Rehmanniae Preparata, Fructus Lycii and the Rhizoma Atractylodis Macrocephalae, adds an amount of trace elements iron and ascorbic Colla Corii Asini is returned stilbene granule and production method thereof.
Colla Corii Asini of the present invention is returned the stilbene granule, and its contained active component is made up of the following weight proportion raw material: Colla Corii Asini 30-80; Radix Codonopsis 20-50; Radix Rehmanniae Preparata 10-40; Fructus Lycii 20-40; Rhizoma Atractylodis Macrocephalae 20-40; Vitamin C 1-4; Ferrous lactate 0.5-2; White sugar 750-1000.
Colla Corii Asini of the present invention is returned the particulate production method of stilbene, comprises following processing step:
(1) Colla Corii Asini molten: the Colla Corii Asini of formula ratio is added in the jacketed pan, add the purified water of 1.8-2.2 times of weight, stir and be heated to Colla Corii Asini and all dissolve, boiling sterilization is 30 minutes again, puts cold standby;
(2) medical material pre-treatment: with the nothing of formula ratio go mouldy, the Radix Codonopsis of free from insect pests, Radix Rehmanniae Preparata, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae respectively water clean up;
(3) extract: Radix Codonopsis, Radix Rehmanniae Preparata, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae that step (2) is obtained drop in the multi-function extractor, extracting in water 2 times, and add the water of 9-11 times of weight the first time, and after heated and boiled 1.8-2.5 hour, extracting solution filters with 120 order silks; Add for the second time the water of 7-9 times of weight, after heated and boiled 1.5-2 hour, extracting solution filters with 120 order silks; It is subsequent use to merge secondary raffinate, and medicinal residues are abandoned it;
(4) vacuum concentration: the extracting solution that step (3) is obtained places vacuum concentrator to concentrate, and temperature is controlled at below 85 ℃, and vacuum is 0.04-0.06Mpa, and being concentrated into relative density is 1.08-1.10, gets concentrated solution, and cooling is for use;
(5) precipitate with ethanol: the concentrated solution that step (4) is obtained carries out precipitate with ethanol, adds 95% edible ethanol and is 50%-55% to containing the alcohol amount, stirs, and leaves standstill 24 hours, gets supernatant and crosses with 120 order silks and filter alcoholic solution, and is for use;
(6) reclaim ethanol: will above-mentioned alcoholic solution join and reclaim ethanol in the alcohol distillation column to there not being the alcohol flavor, the relative density of concentrated solution is 1.20-1.25, gets the precipitate with ethanol concentrated solution;
(7) white sugar is pulverized: with the white sugar of formula ratio, pulverize with multifunctional crusher 80 eye mesh screens;
(8) mix: white sugar, the step (1) that ferrous lactate, vitamin C, the step (7) of formula ratio obtained obtains the precipitate with ethanol concentrated solution that Colla Corii Asini (melted) and step (6) obtain and joins in the mixer; Stirred 10-15 minute; Mix homogeneously, even to the mixture color and luster;
(9) granulate: the mixed material that step (8) is obtained joins in the granulator, granulates with 14 eye mesh screens;
(10) airpillow-dry: the granule that step (9) is obtained joins in the boiling-bed drying, 70-80 ℃ airpillow-dry 25-35 minute, moisture Control is below 5%;
(11) granulate: the dry good granule that step (10) is obtained joins in the pelletizing machine, with 14 eye mesh screen granulate, pack and get final product.
In prescription of the present invention, the flavor of various raw materials, property, effect are: Colla Corii Asini: sweet, flat.Return lung, liver, kidney channel.The effect tonifying blood and arresting bleeding is nourshing Yin and drynsessmoistening prescription.Radix Codonopsis: nature and flavor are sweet, and are flat, have invigorating middle warmer, QI invigorating, promote the production of body fluid, nourish blood, spleen invigorating, abirritative effect, are suitable for diseases such as dried weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea.Radix Rehmanniae Preparata: sweet, tepor; Return liver, kidney channel; The effect nourishing YIN and supplementing blood, beneficial essence is filled out marrow.Fructus Lycii: flat, return liver, kidney channel.Fructus Lycii has invigorating the liver and kidney, beneficial vital essence, longue meat, improves complexion, makes eye bright and calm the nerves, dispel the wind and control the effect of void, life lengthening, hard muscles and bones.The Rhizoma Atractylodis Macrocephalae: bitter, sweet, warm, return spleen, stomach warp.The effect invigorating the spleen and benefiting QI, the dampness diuretic.Vitamin C: effect promotes the absorption of ferrum.Ferrous lactate: effect is replenished ferrum.
Colla Corii Asini is many to be made up of ossein and partial hydrolysate thereof, contains total nitrogen and is about 16%, is mainly protein.The aminoacid that hydrolysis generates has lysine, arginine, histidine etc., has good blood tonification effect; Colla Corii Asini and Radix Codonopsis, Fructus Lycii, Radix Rehmanniae Preparata share, and the effect of then enriching blood is more lived (selecting from " science of prescription ").Ferrum is the synthetic requisite material of haemachrome of erythrocyte; Absorb intravital ferrum and combine to form haemachrome with protoporphyrin, haemachrome combines with globin to form hemoglobin again, and then the sophisticated erythrocyte of bud into; And vitamin C can promote folic acid to become tetrahydrofolic acid; It is synthetic to help nucleic acid, promotes the erythrocyte growth, can make Fe
3+Be reduced into Fe
2+Thereby, be prone to be absorbed by the body.
In sum, more than all medicines be monarch with the Colla Corii Asini nourishing blood, Radix Codonopsis is invigorated blood circulation and is minister, is aided with the Radix Rehmanniae Preparata YIN nourishing, Fructus Lycii, Rhizoma Atractylodis Macrocephalae QI invigorating, the ferrous lactate iron supplement, vitamin C promotes absorbing of ferrum, thereby reaches the purpose of improving nutritional anemia.Have characteristics such as scientific formulation, technology be reasonable.Through human feeding trial, have the health care that improves nutritional anemia, and health is had no adverse effects, edible safety, reliable.
The specific embodiment
Colla Corii Asini is returned the stilbene granule, is made up of the following weight proportion raw material: Colla Corii Asini 70; Radix Codonopsis 40; Radix Rehmanniae Preparata 30; Fructus Lycii 30; The Rhizoma Atractylodis Macrocephalae 30; Vitamin C 3; Ferrous lactate 1.1; White sugar 900.
Its preparation method comprises following processing step:
(1) Colla Corii Asini molten: the Colla Corii Asini of formula ratio is added in the jacketed pan, add the purified water of 1.8-2.2 times of weight, stir and be heated to Colla Corii Asini and all dissolve, boiling sterilization is 30 minutes again, puts cold standby;
(2) medical material pre-treatment: with the nothing of formula ratio go mouldy, the Radix Codonopsis of free from insect pests, Radix Rehmanniae Preparata, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae respectively water clean up;
(3) extract: Radix Codonopsis, Radix Rehmanniae Preparata, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae that step (2) is obtained drop in the multi-function extractor, extracting in water 2 times, and add the water of 9-11 times of weight the first time, and after heated and boiled 1.8-2.5 hour, extracting solution filters with 120 order silks; Add for the second time the water of 7-9 times of weight, after heated and boiled 1.5-2 hour, extracting solution filters with 120 order silks; It is subsequent use to merge secondary raffinate, and medicinal residues are abandoned it;
(4) vacuum concentration: the extracting solution that step (3) is obtained places vacuum concentrator to concentrate, and temperature is controlled at below 85 ℃, and vacuum is 0.04-0.06Mpa, and being concentrated into relative density is 1.08-1.10, gets concentrated solution, and cooling is for use;
(5) precipitate with ethanol: the concentrated solution that step (4) is obtained carries out precipitate with ethanol, adds 95% edible ethanol and is 50%-55% to containing the alcohol amount, stirs, and leaves standstill 24 hours, gets supernatant and crosses with 120 order silks and filter alcoholic solution, and is for use;
(6) reclaim ethanol: will above-mentioned alcoholic solution join and reclaim ethanol in the alcohol distillation column to there not being the alcohol flavor, the relative density of concentrated solution is 1.20-1.25, gets the precipitate with ethanol concentrated solution;
(7) white sugar is pulverized: with the white sugar of formula ratio, pulverize with multifunctional crusher 80 eye mesh screens;
(8) mix: white sugar, the step (1) that ferrous lactate, vitamin C, the step (7) of formula ratio obtained obtains the precipitate with ethanol concentrated solution that Colla Corii Asini (melted) and step (6) obtain and joins in the mixer; Stirred 10-15 minute; Mix homogeneously, even to the mixture color and luster;
(9) granulate: the mixed material that step (8) is obtained joins in the granulator, granulates with 14 eye mesh screens;
(10) airpillow-dry: the granule that step (9) is obtained joins in the boiling-bed drying, 70-80 ℃ airpillow-dry 25-35 minute, moisture Control is below 5%;
(11) granulate: the dry good granule that step (10) is obtained joins in the pelletizing machine, with 14 eye mesh screen granulate, pack and get final product.
Claims (3)
1. one kind has the Colla Corii Asini that improves the nutritional anemia function and returns the stilbene granule, and it is characterized in that: its contained active component is made up of the following weight proportion raw material: Colla Corii Asini 30-80; Radix Codonopsis 20-50; Radix Rehmanniae Preparata 10-40; Fructus Lycii 20-40; Rhizoma Atractylodis Macrocephalae 20-40; Vitamin C l-4; Ferrous lactate 0.5-2; White sugar 750-1000.
2. have the Colla Corii Asini that improves the nutritional anemia function and return the stilbene granule according to claim l is described, it is characterized in that: its contained active component is made up of the following weight proportion raw material: Colla Corii Asini 70; Radix Codonopsis 40; Radix Rehmanniae Preparata 30; Fructus Lycii 30; The Rhizoma Atractylodis Macrocephalae 30; Vitamin C 3; Ferrous lactate 1.1; White sugar 900.
3. produce claim l or 2 and describedly have the Colla Corii Asini that improves the nutritional anemia function and return the particulate method of stilbene for one kind, comprise following processing step:
(1) Colla Corii Asini molten: the Colla Corii Asini of formula ratio is added in the jacketed pan, add the purified water of 1.8-2.2 times of weight, stir and be heated to Colla Corii Asini and all dissolve, boiling sterilization is 30 minutes again, puts cold standby;
(2) medical material pre-treatment: with the nothing of formula ratio go mouldy, the Radix Codonopsis of free from insect pests, Radix Rehmanniae Preparata, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae respectively water clean up;
(3) extract: Radix Codonopsis, Radix Rehmanniae Preparata, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae that step (2) is obtained drop in the multi-function extractor, extracting in water 2 times, and add the water of 9-11 times of weight the first time, and after heated and boiled 1.8-2.5 hour, extracting solution filters with 120 order silks; Add for the second time the water of 7-9 times of weight, after heated and boiled 1.5-2 hour, extracting solution filters with 120 order silks; It is subsequent use to merge secondary raffinate, and medicinal residues are abandoned it;
(4) vacuum concentration: the extracting solution that step (3) is obtained places vacuum concentrator to concentrate, and temperature is controlled at below 85 ℃, and vacuum is 0.04-0.06Mpa, and being concentrated into relative density is 1.08-1.10, gets concentrated solution, and cooling is for use;
(5) precipitate with ethanol: the concentrated solution that step (4) is obtained carries out precipitate with ethanol, adds 95% edible ethanol and is 50%-55% to containing the alcohol amount, stirs, and leaves standstill 24 hours, gets supernatant and crosses with 120 order silks and filter alcoholic solution, and is for use;
(6) reclaim ethanol: will above-mentioned alcoholic solution join and reclaim ethanol in the alcohol distillation column to there not being the alcohol flavor, the relative density of concentrated solution is 1.20-1.25, gets the precipitate with ethanol concentrated solution;
(7) white sugar is pulverized: with the white sugar of formula ratio, pulverize with multifunctional crusher 80 eye mesh screens;
(8) mix: white sugar, the step (1) that ferrous lactate, vitamin C, the step (7) of formula ratio obtained obtains the precipitate with ethanol concentrated solution that Colla Corii Asini (melted) and step (6) obtain and joins in the mixer; Stirred 10-15 minute; Mix homogeneously, even to the mixture color and luster;
(9) granulate: the mixed material that step (8) is obtained joins in the granulator, granulates with 14 eye mesh screens;
(10) airpillow-dry: the granule that step (9) is obtained joins in the boiling-bed drying, 70-80 ℃ airpillow-dry 25-35 minute, moisture Control is below 5%;
(11) granulate: the dry good granule that step (10) is obtained joins in the pelletizing machine, with 14 eye mesh screen granulate, pack and get final product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103211093A (en) * | 2013-03-27 | 2013-07-24 | 广州绿州生物技术有限公司 | Chinese herbal medicine growth promotion feed additive for livestock and preparation method of feed additive |
| CN105105148A (en) * | 2015-09-23 | 2015-12-02 | 威海紫光金奥力生物技术有限公司 | Method for producing gelatina nigra preparation for improving nutritional anemia |
| CN105343156A (en) * | 2015-12-01 | 2016-02-24 | 江苏晨牌药业集团股份有限公司 | Angelica sinensis and radix astragali particles and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342267A (en) * | 2008-08-20 | 2009-01-14 | 李少平 | Donkey-hide gelatin angelica polymorpha & hoantchy particle and method of preparing the same |
-
2012
- 2012-05-05 CN CN2012101363592A patent/CN102631470A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342267A (en) * | 2008-08-20 | 2009-01-14 | 李少平 | Donkey-hide gelatin angelica polymorpha & hoantchy particle and method of preparing the same |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103211093A (en) * | 2013-03-27 | 2013-07-24 | 广州绿州生物技术有限公司 | Chinese herbal medicine growth promotion feed additive for livestock and preparation method of feed additive |
| CN105105148A (en) * | 2015-09-23 | 2015-12-02 | 威海紫光金奥力生物技术有限公司 | Method for producing gelatina nigra preparation for improving nutritional anemia |
| CN105343156A (en) * | 2015-12-01 | 2016-02-24 | 江苏晨牌药业集团股份有限公司 | Angelica sinensis and radix astragali particles and preparation method thereof |
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Application publication date: 20120815 |