CN105707883B - Crow pheasant composition and the preparation method and application thereof - Google Patents
Crow pheasant composition and the preparation method and application thereof Download PDFInfo
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- CN105707883B CN105707883B CN201511027129.2A CN201511027129A CN105707883B CN 105707883 B CN105707883 B CN 105707883B CN 201511027129 A CN201511027129 A CN 201511027129A CN 105707883 B CN105707883 B CN 105707883B
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of crow pheasant composition and the preparation method and application thereof, which is mainly made of the following raw material by weight：12 parts of 60 70 parts of crow pheasant extract, 68 parts of duck blood powder, 45 parts of yam flour, 23 parts of haricot bean powder, 12 parts of peach kernel powder, first 68 parts of digested tankage, 35 parts of medlar powder, 35 parts of licorice powder, 35 parts of Flos Rosae Rugosas pollen and honey；The preparation method is that by first digested tankage, medlar powder, licorice powder and the alcohol extracting of Flos Rosae Rugosas pollen elder generation, water carries again, and remaining material tanning will be added after being mixed with crow pheasant extract by extracting solution twice, and the crow pheasant composition is made.The crow pheasant composition of the present invention effect that has many advantages, such as to enrich blood is good, without any side effects；The property of active ingredient, can be such that the active ingredient in each raw material leaches completely, and then the drug effect of crow pheasant composition is enable to give full play in the abundant each raw material of consideration of preparation method of the present invention.
Description
Technical field
The present invention relates to field of health care products.It is more particularly related to a kind of crow pheasant composition and its preparation side
Method and application.
Background technology
Crow pheasant also known as coucal (Centropus sinensis) belong to Cuculiformes Cuculidae crow cuckoo category.Crow pheasant
It is distributed in China Zhejiang, Fujian, Guangxi, Guangdong, South of Guizhou, Western Yunnan to southern Xishuangbanna, Hainan and Sichuan.
According to records, crow pheasant removes the dry entirety of internal organ or Xian Ti gynaecology is used for menstruation regulating, enriches blood, and bruise, rheumatism are controlled in external application.During reputation is full
Outer gynaecology's good medicine hair chicken wine is exactly to dry all or fresh body as main ingredient using what crow pheasant removed internal organs, is incorporated Radix Codonopsis, Rhizoma Chuanxiong, dragon
Made of the multi-flavors medicinal material such as bone, root of Dahurain angelica impregnates, there is the effect of promoting blood circulation and removing blood stasis, menstruation regulating promoting lactation, relaxing tendons and activating collaterals.Due to hair chicken wine with
Wine is carrier, and for the crowd for not liking to drink or discomfort is drunk, popularization and application are restricted.
Invention content
It is an object of the invention to solve at least the above, and provide the advantages of at least will be described later.
It is a still further object of the present invention to provide a kind of crow pheasant compositions and the preparation method and application thereof.The composition master
Will using crow pheasant extract as raw material, be aided with the integration of drinking and medicinal herbs food such as duck blood powder, yam flour, haricot bean powder and peach kernel powder prepare and
At, so that the advantage between each ingredient is combined, significant effect of enriching blood, and without any side effects, wide application of the crowd.
In order to realize these purposes and other advantages according to the present invention, provide a kind of crow pheasant composition, mainly by
The following raw material by weight is made：60-70 parts of crow pheasant extract, 6-8 parts of duck blood powder, 4-5 parts of yam flour, haricot bean powder 2-
3 parts, 1-2 parts of peach kernel powder, first 6-8 parts of digested tankage, 3-5 parts of medlar powder, 3-5 parts of licorice powder, 3-5 parts of Flos Rosae Rugosas pollen and honey 1-2
Part, wherein
The crow pheasant extract is after slaughtering unhairing by crow pheasant, go internal organ, drying and crushing, and gained crow pheasant is thick
Powder uses volume fraction for 75% ethyl alcohol, ultrasonic wave-immersion combined techniques extraction, filtering, and gained filtrate decompression is concentrated and is made
, a concentration of 0.8g crude drugs/ml of the crow pheasant extract；
Ultrasonic wave of the present invention-immersion combined techniques extraction refers to that crow pheasant coarse powder is placed in the second that volume fraction is 75%
In alcohol under certain temperature soak extraction, in soaking process, certain time is ultrasonically treated to soak using ultrasonic wave daily, with
Improve the recovery rate of crow pheasant.
The duck blood powder is that the water of its 5-8 times of weight amount is added into fresh duck blood, is spray-dried again after homogeneous obtained；
The yam flour, haricot bean powder and peach kernel powder are crushed respectively by Chinese yam, hyacinth bean and peach kernel after cleaning, drying
It is made to 80-100 mesh；
The member digested tankage, medlar powder, licorice powder and Flos Rosae Rugosas pollen, are respectively by meat, the fruit of Chinese wolfberry, Radix Glycyrrhizae and rose
Hua Jing cleans, dry after, be crushed to 30-50 mesh and be made.
Preferably, the crow pheasant composition, is mainly made of the following raw material by weight：Crow pheasant extracts
It is 65 parts of object, 7 parts of duck blood powder, 4.5 parts of yam flour, 2.5 parts of haricot bean powder, 1.5 parts of peach kernel powder, first 7 parts of digested tankage, 4 parts of medlar powder, sweet
1.5 parts of 4 parts of grass meal, 4 parts of Flos Rosae Rugosas pollen and honey.
A kind of preparation method of crow pheasant composition, includes the following steps：
Step 1：Crow pheasant is slaughtered into unhairing, internal organ, drying is removed, and be crushed into coarse powder, weighs the coarse powder simultaneously
The volume fraction that its 8 times of weight amount is added is the ethyl alcohol of 75-90%, is continuously extracted 5 days, is carried using ultrasonic wave-immersion combined techniques
It filters after the completion of taking, obtains the first filtrate and the first filter residue, then 6 times of weight amounts of the coarse powder are added into first filter residue
Volume fraction is the ethyl alcohol of 60-75%, continues continuous extraction 5 days using ultrasonic wave-immersion combined techniques, is filtered after the completion of extraction,
The second filtrate and the second filter residue are obtained, the first filtrate and the second filtrate are merged and is concentrated under reduced pressure, crow pheasant extract is obtained, it is described
A concentration of 0.8g crude drugs/ml of crow pheasant extract；
Step 2: first digested tankage of above-mentioned parts by weight, medlar powder, licorice powder and Flos Rosae Rugosas pollen are mixed, through 10 times of weight
The alcohol reflux that the volume fraction of amount is 50-60% extracts, and filtering obtains third filtrate and third filter residue；
Step 3: by water refluxing extraction of the third filter residue through 15-20 times of weight amounts, filtering obtains the 4th filtrate and the
Four filter residues；
Step 4: weighing the crow pheasant extract of above-mentioned parts by weight, and itself and the third filtrate and the 4th are filtered
Liquid merges, and duck blood powder, yam flour, haricot bean powder and the peach kernel powder of above-mentioned parts by weight is added, after mixing, by gained mixture big fire
After boiled, slightly boiling is kept to continue to boil 5-6h, until its liquid specific gravity reaches 1.25-1.3g/cm3, cease fire, object to be mixed is cooled to
At 60 DEG C or less, it is added the honey of above-mentioned parts by weight, to get the crow pheasant composition after mixing.
Preferably, the preparation method of the crow pheasant composition, in the step 1, the ultrasonic wave-immersion knot
Legal extraction conditions are 70-80 DEG C of Extracting temperature, ultrasonic time 2-3h/ days, ultrasonic power 400-450w.
Preferably, the preparation method of the crow pheasant composition, in the step 2, refluxing extraction is specially to flow back
Extraction 1-2 times, each 1-1.5h, refluxing extraction temperature are 50-55 DEG C.
Preferably, the preparation method of the crow pheasant composition, in the step 3, refluxing extraction is specially to flow back
Extraction 1-2 times, each 1.5-2h, refluxing extraction temperature are 65-70 DEG C.
Preferably, the preparation method of the crow pheasant composition further includes being added into the crow pheasant composition
Suitable pharmaceutically acceptable auxiliary material, is prepared into crow pheasant oral preparation.
The crow pheasant oral preparation includes capsule, tablet, granule, oral solution, pill or slow release long-acting agent.
A kind of application of crow pheasant composition, the crow pheasant composition is for enriching blood.
The present invention includes at least following advantageous effect：
The crow pheasant composition of the present invention, using crow pheasant extract as major ingredient, with duck blood powder, yam flour, haricot bean powder, peach kernel
Powder, first digested tankage, medlar powder, licorice powder, Flos Rosae Rugosas pollen and honey are auxiliary material, wherein there is crow pheasant nourishing yin and supplementing blood, wind-dispelling to remove
It is wet and other effects；Duck blood, which has, prevents hypoferric anemia, hemostasis blood coagulation and other effects, and various trace elements can be provided for human body, are removed
The damage of dust and poisonous metal particle to human body in human body；Chinese yam have tonifying middle-Jiao and Qi, quench one's thirst promote the production of body fluid, beauty treatment and raising are exempted from
Epidemic disease power and other effects；Hyacinth bean has warming spleen and stomach, only quenches one's thirst, anti-anti-cancer and cancer-preventing and improves immunity and other effects；There is peach kernel promoting blood circulation to dispel
The stasis of blood relaxes bowel and other effects；Meat have nourish help, fill blood, benefiting intellegence and calming heart, tranquilizing the mind the effect of；The fruit of Chinese wolfberry has
Liver-kidney tonifying, anti-aging and promotion hematopoiesis function and other effects；Radix Glycyrrhizae have invigorate the spleen and benefit qi, be clearing heat and detoxicating, the work(such as coordinating the drug actions of a prescription
Effect；Rose has regulating the flow of vital energy Xie Yu, promoting blood circulation scattered silt and menstruction regulating and pain relieving and other effects；Honey has that tonifying middle-Jiao and Qi, the work(such as relax bowel
It imitates, each raw material mutually cooperates in formula, and advantage combines, significant effect of enriching blood, and each raw material is the food of food or integration of drinking and medicinal herbs
Object, it is without any side effects.
Crow pheasant extract in the present invention is that crow pheasant is placed in ethanol solution, using ultrasonic wave-immersion combined techniques
Continuous extraction, extraction filter and concentrate filtrate decompression and be made after the completion, and compared with traditional hair chicken wine, extraction time is short, extraction
Rate is high, and the activity of active ingredient is kept in extract, and content is high.
The preparation method of the crow pheasant composition of the present invention has fully considered the property of the active ingredient in each raw material, will be first
Water carries again for digested tankage, medlar powder, licorice powder and the alcohol extracting of Flos Rosae Rugosas pollen elder generation, and will be after extracting solution is mixed with crow pheasant extract twice
Remaining material tanning is added, so that the active ingredient in each raw material is leached completely, and then enable the drug effect of crow pheasant composition
It gives full play to.
Part is illustrated to embody by further advantage, target and the feature of the present invention by following, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Description of the drawings
Fig. 1 is influence of the crow pheasant composition of the present invention to hydracetin-induced anemia mice model immune organ；
Fig. 2 is influence of the crow pheasant composition of the present invention to hydracetin-induced anemia mice model erythrocyte membrane ATPase vigor；
Wherein, compared with normal group##P<0.01；Compared with model group*P<0.05,**P<0.01。
Specific implementation mode
With reference to embodiment, the present invention is described in further detail, to enable those skilled in the art with reference to specification
Word can be implemented according to this.
It should be noted that experimental method described in following embodiments is unless otherwise specified conventional method, it is described
Reagent and material commercially obtain unless otherwise specified.
Embodiment 1：
A kind of crow pheasant composition, is mainly made of the following raw material by weight：60 parts of crow pheasant extract, duck blood
6 parts of powder, 4 parts of yam flour, 2 parts of haricot bean powder, 1 part of peach kernel powder, first 6 parts of digested tankage, 3 parts of medlar powder, 3 parts of licorice powder, Flos Rosae Rugosas pollen 3
1 part of part and honey, wherein
The crow pheasant extract is after slaughtering unhairing by crow pheasant, go internal organ, drying and crushing, and gained crow pheasant is thick
Powder uses volume fraction for 75% ethyl alcohol, ultrasonic wave-immersion combined techniques extraction, filtering, and gained filtrate decompression is concentrated and is made
, a concentration of 0.8g crude drugs/ml of the crow pheasant extract；
The duck blood powder is that the water of its 5 times of weight amount is added into fresh duck blood, is spray-dried again after homogeneous obtained；
The yam flour, haricot bean powder and peach kernel powder are crushed respectively by Chinese yam, hyacinth bean and peach kernel after cleaning, drying
It is made to 80 mesh；
The member digested tankage, medlar powder, licorice powder and Flos Rosae Rugosas pollen, are respectively by meat, the fruit of Chinese wolfberry, Radix Glycyrrhizae and rose
Hua Jing cleans, dry after, be crushed to 30 mesh and be made.
A kind of preparation method of crow pheasant composition, includes the following steps：
Step 1：Crow pheasant is slaughtered into unhairing, internal organ, drying is removed, and be crushed into coarse powder, weighs the coarse powder simultaneously
The ethyl alcohol that the volume fraction of its 8 times of weight amount is 75% is added, is continuously extracted 5 days, has been extracted using ultrasonic wave-immersion combined techniques
At rear filtering, the first filtrate and the first filter residue are obtained, then the body of 6 times of weight amounts of the coarse powder is added into first filter residue
The ethyl alcohol that fraction is 60% continues continuous extraction 5 days using ultrasonic wave-immersion combined techniques, is filtered after the completion of extraction, obtain second
Filtrate and the second filter residue merge the first filtrate and the second filtrate and are concentrated under reduced pressure, obtain crow pheasant extract, the crow pheasant
A concentration of 0.8g crude drugs/ml of extract；
Step 2: first digested tankage of above-mentioned parts by weight, medlar powder, licorice powder and Flos Rosae Rugosas pollen are mixed, through 10 times of weight
The alcohol reflux that the volume fraction of amount is 50% extracts, and filtering obtains third filtrate and third filter residue；
Step 3: by water refluxing extraction of the third filter residue through 15 times of weight amounts, filtering obtains the 4th filtrate and the 4th filter
Slag；
Step 4: weighing the crow pheasant extract of above-mentioned parts by weight, and itself and the third filtrate and the 4th are filtered
Liquid merges, and duck blood powder, yam flour, haricot bean powder and the peach kernel powder of above-mentioned parts by weight is added, after mixing, by gained mixture big fire
After boiled, slightly boiling is kept to continue to boil 5h, until its liquid specific gravity reaches 1.25g/cm3, cease fire, object to be mixed be cooled to 60 DEG C with
When lower, it is added the honey of above-mentioned parts by weight, to get the crow pheasant composition after mixing.
The preparation method of the crow pheasant composition, in the step 1, the extraction of the ultrasonic wave-immersion combined techniques
Condition is 70 DEG C of Extracting temperature, ultrasonic time 3h/ days, ultrasonic power 400w.
The preparation method of the crow pheasant composition, in the step 2, refluxing extraction is specially refluxing extraction 1 time,
Each 1h, refluxing extraction temperature are 55 DEG C.
The preparation method of the crow pheasant composition, in the step 3, refluxing extraction is specially refluxing extraction 1 time,
Each 1.5h, refluxing extraction temperature are 70 DEG C.
The preparation method of the crow pheasant composition further includes adding suitable medicine into the crow pheasant composition
Acceptable auxiliary material on, is prepared into crow pheasant oral preparation.
A kind of application of crow pheasant composition, the crow pheasant composition is for enriching blood.
Embodiment 2：
A kind of crow pheasant composition, is mainly made of the following raw material by weight：65 parts of crow pheasant extract, duck blood
7 parts of powder, 4.5 parts of yam flour, 2.5 parts of haricot bean powder, 1.5 parts of peach kernel powder, first 7 parts of digested tankage, 4 parts of medlar powder, 4 parts of licorice powder, rose
1.5 parts of 4 parts of rare pollen and honey, wherein
The crow pheasant extract is after slaughtering unhairing by crow pheasant, go internal organ, drying and crushing, and gained crow pheasant is thick
Powder uses volume fraction for 75% ethyl alcohol, ultrasonic wave-immersion combined techniques extraction, filtering, and gained filtrate decompression is concentrated and is made
, a concentration of 0.8g crude drugs/ml of the crow pheasant extract；
The duck blood powder is that the water of its 6 times of weight amount is added into fresh duck blood, is spray-dried again after homogeneous obtained；
The yam flour, haricot bean powder and peach kernel powder are crushed respectively by Chinese yam, hyacinth bean and peach kernel after cleaning, drying
It is made to 90 mesh；
The member digested tankage, medlar powder, licorice powder and Flos Rosae Rugosas pollen, are respectively by meat, the fruit of Chinese wolfberry, Radix Glycyrrhizae and rose
Hua Jing cleans, dry after, be crushed to 40 mesh and be made.
A kind of preparation method of crow pheasant composition, includes the following steps：
Step 1：Crow pheasant is slaughtered into unhairing, internal organ, drying is removed, and be crushed into coarse powder, weighs the coarse powder simultaneously
The ethyl alcohol that the volume fraction of its 8 times of weight amount is 85% is added, is continuously extracted 5 days, has been extracted using ultrasonic wave-immersion combined techniques
At rear filtering, the first filtrate and the first filter residue are obtained, then the volume of 6 times of weight amounts of the coarse powder is added into first filter residue
The ethyl alcohol that score is 70% continues continuous extraction 5 days using ultrasonic wave-immersion combined techniques, is filtered after the completion of extraction, obtain the second filter
Liquid and the second filter residue merge the first filtrate and the second filtrate and are concentrated under reduced pressure, obtain crow pheasant extract, the crow pheasant carries
Take a concentration of 0.8g crude drugs/ml of object；
Step 2: first digested tankage of above-mentioned parts by weight, medlar powder, licorice powder and Flos Rosae Rugosas pollen are mixed, through 10 times of weight
The alcohol reflux that the volume fraction of amount is 55% extracts, and filtering obtains third filtrate and third filter residue；
Step 3: by water refluxing extraction of the third filter residue through 18 times of weight amounts, filtering obtains the 4th filtrate and the 4th filter
Slag；
Step 4: weighing the crow pheasant extract of above-mentioned parts by weight, and itself and the third filtrate and the 4th are filtered
Liquid merges, and duck blood powder, yam flour, haricot bean powder and the peach kernel powder of above-mentioned parts by weight is added, after mixing, by gained mixture big fire
After boiled, slightly boiling is kept to continue to boil 5.5h, until its liquid specific gravity reaches 1.28g/cm3, cease fire, object to be mixed is cooled to 60 DEG C
When following, it is added the honey of above-mentioned parts by weight, to get the crow pheasant composition after mixing.
The preparation method of the crow pheasant composition, in the step 1, the extraction of the ultrasonic wave-immersion combined techniques
Condition is 75 DEG C of Extracting temperature, ultrasonic time 2.5h/ days, ultrasonic power 420w.
The preparation method of the crow pheasant composition, in the step 2, refluxing extraction is specially refluxing extraction 2 times,
Each 1.2h, refluxing extraction temperature are 53 DEG C.
The preparation method of the crow pheasant composition, in the step 3, refluxing extraction is specially refluxing extraction 2 times,
Each 1.7h, refluxing extraction temperature are 68 DEG C.
The preparation method of the crow pheasant composition further includes adding suitable medicine into the crow pheasant composition
Acceptable auxiliary material on, is prepared into crow pheasant oral preparation.
A kind of application of crow pheasant composition, the crow pheasant composition is for enriching blood.
Embodiment 3：
A kind of crow pheasant composition, is mainly made of the following raw material by weight：70 parts of crow pheasant extract, duck blood
8 parts of powder, 5 parts of yam flour, 3 parts of haricot bean powder, 2 parts of peach kernel powder, first 8 parts of digested tankage, 5 parts of medlar powder, 5 parts of licorice powder, Flos Rosae Rugosas pollen 5
2 parts of part and honey, wherein
The crow pheasant extract is after slaughtering unhairing by crow pheasant, go internal organ, drying and crushing, and gained crow pheasant is thick
Powder uses volume fraction for 75% ethyl alcohol, ultrasonic wave-immersion combined techniques extraction, filtering, and gained filtrate decompression is concentrated and is made
, a concentration of 0.8g crude drugs/ml of the crow pheasant extract；
The duck blood powder is that the water of its 8 times of weight amount is added into fresh duck blood, is spray-dried again after homogeneous obtained；
The yam flour, haricot bean powder and peach kernel powder are crushed respectively by Chinese yam, hyacinth bean and peach kernel after cleaning, drying
It is made to 100 mesh；
The member digested tankage, medlar powder, licorice powder and Flos Rosae Rugosas pollen, are respectively by meat, the fruit of Chinese wolfberry, Radix Glycyrrhizae and rose
Hua Jing cleans, dry after, be crushed to 50 mesh and be made.
A kind of preparation method of crow pheasant composition, includes the following steps：
Step 1：Crow pheasant is slaughtered into unhairing, internal organ, drying is removed, and be crushed into coarse powder, weighs the coarse powder simultaneously
The ethyl alcohol that the volume fraction of its 8 times of weight amount is 90% is added, is continuously extracted 5 days, has been extracted using ultrasonic wave-immersion combined techniques
At rear filtering, the first filtrate and the first filter residue are obtained, then the volume of 6 times of weight amounts of the coarse powder is added into first filter residue
The ethyl alcohol that score is 75% continues continuous extraction 5 days using ultrasonic wave-immersion combined techniques, is filtered after the completion of extraction, obtain the second filter
Liquid and the second filter residue merge the first filtrate and the second filtrate and are concentrated under reduced pressure, obtain crow pheasant extract, the crow pheasant carries
Take a concentration of 0.8g crude drugs/ml of object；
Step 2: first digested tankage of above-mentioned parts by weight, medlar powder, licorice powder and Flos Rosae Rugosas pollen are mixed, through 10 times of weight
The alcohol reflux that the volume fraction of amount is 60% extracts, and filtering obtains third filtrate and third filter residue；
Step 3: by water refluxing extraction of the third filter residue through 20 times of weight amounts, filtering obtains the 4th filtrate and the 4th filter
Slag；
Step 4: weighing the crow pheasant extract of above-mentioned parts by weight, and itself and the third filtrate and the 4th are filtered
Liquid merges, and duck blood powder, yam flour, haricot bean powder and the peach kernel powder of above-mentioned parts by weight is added, after mixing, by gained mixture big fire
After boiled, slightly boiling is kept to continue to boil 6h, until its liquid specific gravity reaches 1.3g/cm3, cease fire, object to be mixed be cooled to 60 DEG C with
When lower, it is added the honey of above-mentioned parts by weight, to get the crow pheasant composition after mixing.
The preparation method of the crow pheasant composition, in the step 1, the extraction of the ultrasonic wave-immersion combined techniques
Condition is 80 DEG C of Extracting temperature, ultrasonic time 2h/ days, ultrasonic power 450w.
The preparation method of the crow pheasant composition, in the step 2, refluxing extraction is specially refluxing extraction 2 times,
Each 1.5h, refluxing extraction temperature are 50 DEG C.
The preparation method of the crow pheasant composition, in the step 3, refluxing extraction is specially refluxing extraction 2 times,
Each 2h, refluxing extraction temperature are 65 DEG C.
The preparation method of the crow pheasant composition further includes adding suitable medicine into the crow pheasant composition
Acceptable auxiliary material on, is prepared into crow pheasant oral preparation.
A kind of application of crow pheasant composition, the crow pheasant composition is for enriching blood.
Embodiment 4：
A kind of crow pheasant composition, is mainly made of the following raw material by weight：68 parts of crow pheasant extract, duck blood
7 parts of powder, 5 parts of yam flour, 2.5 parts of haricot bean powder, 1.5 parts of peach kernel powder, first 7 parts of digested tankage, 4 parts of medlar powder, 4 parts of licorice powder, rose
2 parts of 4 parts of pollen and honey, wherein
The crow pheasant extract is after slaughtering unhairing by crow pheasant, go internal organ, drying and crushing, and gained crow pheasant is thick
Powder uses volume fraction for 75% ethyl alcohol, ultrasonic wave-immersion combined techniques extraction, filtering, and gained filtrate decompression is concentrated and is made
, a concentration of 0.8g crude drugs/ml of the crow pheasant extract；
The duck blood powder is that the water of its 8 times of weight amount is added into fresh duck blood, is spray-dried again after homogeneous obtained；
The yam flour, haricot bean powder and peach kernel powder are crushed respectively by Chinese yam, hyacinth bean and peach kernel after cleaning, drying
It is made to 100 mesh；
The member digested tankage, medlar powder, licorice powder and Flos Rosae Rugosas pollen, are respectively by meat, the fruit of Chinese wolfberry, Radix Glycyrrhizae and rose
Hua Jing cleans, dry after, be crushed to 50 mesh and be made.
A kind of preparation method of crow pheasant composition, includes the following steps：
Step 1：Crow pheasant is slaughtered into unhairing, internal organ, drying is removed, and be crushed into coarse powder, weighs the coarse powder simultaneously
The ethyl alcohol that the volume fraction of its 8 times of weight amount is 75% is added, is continuously extracted 5 days, has been extracted using ultrasonic wave-immersion combined techniques
At rear filtering, the first filtrate and the first filter residue are obtained, then the volume of 6 times of weight amounts of the coarse powder is added into first filter residue
The ethyl alcohol that score is 75% continues continuous extraction 5 days using ultrasonic wave-immersion combined techniques, is filtered after the completion of extraction, obtain the second filter
Liquid and the second filter residue merge the first filtrate and the second filtrate and are concentrated under reduced pressure, obtain crow pheasant extract, the crow pheasant carries
Take a concentration of 0.8g crude drugs/ml of object；
Step 2: first digested tankage of above-mentioned parts by weight, medlar powder, licorice powder and Flos Rosae Rugosas pollen are mixed, through 10 times of weight
The alcohol reflux that the volume fraction of amount is 60% extracts, and filtering obtains third filtrate and third filter residue；
Step 3: by water refluxing extraction of the third filter residue through 20 times of weight amounts, filtering obtains the 4th filtrate and the 4th filter
Slag；
Step 4: weighing the crow pheasant extract of above-mentioned parts by weight, and itself and the third filtrate and the 4th are filtered
Liquid merges, and duck blood powder, yam flour, haricot bean powder and the peach kernel powder of above-mentioned parts by weight is added, after mixing, by gained mixture big fire
After boiled, slightly boiling is kept to continue to boil 6h, until its liquid specific gravity reaches 1.3g/cm3, cease fire, object to be mixed be cooled to 60 DEG C with
When lower, it is added the honey of above-mentioned parts by weight, to get the crow pheasant composition after mixing.
The preparation method of the crow pheasant composition, in the step 1, the extraction of the ultrasonic wave-immersion combined techniques
Condition is 75 DEG C of Extracting temperature, ultrasonic time 3h/ days, ultrasonic power 450w.
The preparation method of the crow pheasant composition, in the step 2, refluxing extraction is specially refluxing extraction 2 times,
Each 1.5h, refluxing extraction temperature are 55 DEG C.
The preparation method of the crow pheasant composition, in the step 3, refluxing extraction is specially refluxing extraction 2 times,
Each 2h, refluxing extraction temperature are 70 DEG C.
Embodiment 5：Crow pheasant composition functional authorization is tested
1 material
1.1 SPF grades of animal female KM mouse, 18~22g of weight are provided by Guangxi Medical University's Experimental Animal Center,
Quality certification number SCXK (osmanthus) 2014-0002.
1.2 medicinal material crow pheasant compositions.
1.3 drugs and reagent acetylphenylhydrazine (APH, Shanghai one chemical reagent work of purple, lot number：ZY150623), injection ring phosphinylidyne
Amine (CTX, Shanxi Powerdone Pharmaceutical Co., Ltd., lot number：04131209), (Shandong Donga donkey-hide gelatin share has complex prescription glue mucilage
Limit company, Chinese medicines quasi-word：Z20083345), physiological saline (Guangdong Litai Pharmacy stock Co., Ltd, lot number：15051434),
(Bioengineering Research Institute, lot number are built up in Nanjing to ATP enzyme kit：20151010).
1.4 instrument Sysmex-2000 Automatic Blood Cell Analyzers (Japan), Multiskan Go all-wave length microplate reader
(Thermo Scientific companies, Finland), EL204 electronic balances (plum Teller-support benefit Instrument Ltd.).
2 methods
The extraction of 2.1 medicinal materials prepares crow pheasant composition according to the step of embodiment of the present invention 4.
2.2 hydracetin-induced anemia mice models structure uses acetylphenylhydrazine (APH) and cyclophosphamide (CTX) A compound method of establishing model, mouse
APH normal saline solutions being subcutaneously injected within the 2nd, 5 day in experiment, dosage is followed successively by 20,40mgkg-1, from the 6th day, daily abdomen
Chamber injects CTX40mgkg-1, continuous 4d.
2.3 groupings and administration cleaning grade experiment female mice (20 ± 2g) 60, are randomly divided into 6 groups, i.e., normal group, mould
Type group, crow pheasant composition low dose group, crow pheasant composition middle dose group, crow pheasant composition high dose group and compound ass-hide gelatin
Slurry group (positive), every group 10.By a group sub-cage rearing, universal feed is fed, free water, natural lighting, 20~30 DEG C of temperature,
Environment is adapted to be tested after 5 days.According to grouping situation, to normal group, model group every intragastric administration on mice 0.1mL/10g steaming daily
Distilled water 1 time；The daily every intragastric administration on mice 0.025mL/10g crow pheasants composition of low dose group and 0.075mL/10g distilled water 1
It is secondary；Middle dose group every intragastric administration on mice 0.05mL/10g crow pheasants composition and 0.05mL/10g distilled water 1 time daily；High dose
The daily every intragastric administration on mice 0.1mL/10g crow pheasants composition of group 1 time；0.1mL/ is administered in every intragastric administration on mice to positive group daily
10g complex prescription glue mucilages 1 time.In experiment, the 1st day starts, and 9d is administered in continuous gavage.
The measurement each group of 2.4 periphery blood routines is taken a blood sample in 1.5h eyeground veins clump after the last administration respectively as 1.5mL
EP is managed in (anticoagulant heparin), conventional using Automatic Blood Cell Analyzer detection periphery, include mainly white blood cell count(WBC) (WBC),
Red blood cell count(RBC) (RBC), content of hemoglobin (HGB), red blood cell overstock (HCT) 4 indexs.Peripheral hemogram can directly react
Blood is full of virtual state.
Thymus gland, the spleen of all mouse are taken out in the measurement dissection of 2.5 Immune Organs Indexes, with one thousandth electronic balance
It weighs, calculates Thymus and Spleen index, thymus index=thymic weight (mg)/mice weights (g), spleen as follows
Index=spleen (mg)/mice weights (g).Thymus gland and spleen are all important immune organ, and spleen also has certain hematopoiesis
Function, thus immune and hematopoiesis function height can be reflected by the variation of immune organ weight indirectly.
The measurement of 2.6 RBC ATPase Activities：20 μ L of whole blood in 2.4 EP pipes are taken, the distilled water of 24 times of amounts is added, are mixed
Even, be vortexed concussion 1min, stands 15min, then the concussion 1min that is vortexed, then stands 15min, makes its abundant haemolysis, until solution is saturating
It is bright.Hemolysate is taken to measure erythrocyte membrane Na+- K+-ATP enzymes and Ca2+-Mg2+-ATP enzyme activity according to ATP enzyme kit specification
Property.Erythrocyte membrane ATPase is a kind of important enzyme, is maintaining red cell morphology, structure and Function important function.
2.7 statistical analysis experimental datas are analyzed using SPSS17.0, and experimental result is indicated using x ± s, between group
Compare, P for statistical analysis using ANOVA<0.05 indicates statistically significant.
3 results
The variation of 3.1 peripheral hemograms causes the leucocyte, red thin of model group mouse using APH and CTX joint molding methods
Born of the same parents, hemoglobin, red blood cell is overstock significantly reduces, and the fall of wherein leucocyte is maximum.It handles by administration, respectively gives
Each index of medicine group has different degrees of raising.The white blood cell count(WBC) and red blood cell count(RBC) of each administration group be respectively 1.92~
2.77×109A/L, 7.08~7.76 × 1012The overstocked value of a/L, content of hemoglobin and red blood cell respectively 110.9~
123.7g·L-1, 38.97~42.58,4 indexs be above model group.In each administration group, crow pheasant composition middle dosage
Leucocyte, hemoglobin and the red blood cell of group, high dose group and positive group, which are overstock, significantly increases (P<0.01) it is shown in Table 1.
1 crow pheasant composition of table to deficiency of blood mouse peripheral blood influence (N=10)
Note：Compared with normal group##P<0.01；Compared with model group*P<0.05,**P<0.01。
Normally group and each administration group thymus index are above model group for the variation of 3.2 immune organs, and index and spleen index is below
Model group, wherein middle dose group, high dose group and positive group thymus index significantly increase (p<0.01), middle dose group, high dose
Group and positive group index and spleen index significantly reduce (P<0.01), see Fig. 1.
3.3 erythrocyte membrane Na+-K+ATP enzyme and Ca2+-Mg2+The measurement of atpase activity
Compared with normal group, model group erythrocyte membrane Na+-K+ATP enzyme and Ca2+-Mg2+ATP enzyme vigor significantly reduces
(P<0.01)；Compared with model group, in each administration group, middle dose group, high dose group and positive group erythrocyte membrane Na+-K+-ATP
Enzyme activity and Ca2+-Mg2+ATP enzyme vigor significantly increases (P<0.01), see Fig. 2.
4 conclusions
3 side of model group peripheral hemogram, immune organ and erythrocyte membrane ATPase vigor is can be seen that from table 1, Fig. 1 and Fig. 2
Face index and normal group relatively there were significant differences (P<0.01), illustrate that hydracetin-induced anemia mice model replicates successfully.
It can also be seen that compared with model group from table 1, Fig. 1 and Fig. 2, each administration group periphery blood targets (WBC, RBC,
HGB, HCT), thymus index, erythrocyte membrane ATPase (Na+-K+-ATP enzymes, Ca2+-Mg2+-ATP enzymes) be above model group, spleen
Dirty index is below model group；Periphery blood targets (WBC, HGB, HCT), thymus index, the spleen of middle dose group and high dose group
Dirty index and erythrocyte membrane ATPase vigor are suitable with positive group.
To sum up, illustrate that crow pheasant composition has blood nourishing function.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details.
Claims (5)
1. a kind of preparation method of crow pheasant composition, which is characterized in that include the following steps：
Step 1：Crow pheasant is slaughtered into unhairing, removes internal organ, drying, and be crushed into coarse powder, weigh the coarse powder and be added
The volume fraction of its 8 times of weight amount is the ethyl alcohol of 75-90%, is continuously extracted 5 days, has been extracted using ultrasonic wave-immersion combined techniques
At rear filtering, the first filtrate and the first filter residue are obtained, then the volume of 6 times of weight amounts of the coarse powder is added into first filter residue
Score is the ethyl alcohol of 60-75%, continues continuous extraction 5 days using ultrasonic wave-immersion combined techniques, is filtered after the completion of extraction, obtains the
Two filtrates and the second filter residue merge the first filtrate and the second filtrate and are concentrated under reduced pressure, obtain crow pheasant extract, the red hair
A concentration of 0.8g crude drugs/ml of chicken extract；
Step 2: by first digested tankage of 6-8 parts by weight, the medlar powder of 3-5 parts by weight, the licorice powder of 3-5 parts by weight and 3-5 weight
The Flos Rosae Rugosas pollen mixing of part, the alcohol reflux that the volume fraction through 10 times of weight amounts is 50-60% extract, and filtering obtains third and filters
Liquid and third filter residue；
Step 3: by water refluxing extraction of the third filter residue through 15-20 times of weight amounts, filtering obtains the 4th filtrate and the 4th filter
Slag；
Step 4: weighing the crow pheasant extract of 60-70 parts by weight, and itself and the third filtrate and the 4th filtrate are closed
And add the duck blood powder of 6-8 parts by weight, the yam flour of 4-5 parts by weight, the haricot bean powder of 2-3 parts by weight and 1-2 parts by weight peach
Benevolence powder, after mixing, by gained mixture big fire it is boiled after, keep slightly boiling continue boil 5-6h, until its liquid specific gravity reach 1.25-
1.3g/cm3, cease fire, when object to be mixed is cooled to 60 DEG C or less, the honey of addition 1-2 parts by weight, to get described red after mixing
Hair chicken composition；
Wherein, the duck blood powder is that the water of its 5-8 times of weight amount is added into fresh duck blood, is spray-dried again after homogeneous obtained；
The yam flour, haricot bean powder and peach kernel powder are crushed to respectively by Chinese yam, hyacinth bean and peach kernel after cleaning, drying
80-100 mesh is made；
The member digested tankage, medlar powder, licorice powder and Flos Rosae Rugosas pollen are respectively to pass through meat, the fruit of Chinese wolfberry, Radix Glycyrrhizae and rose
After cleaning, drying, it is crushed to 30-50 mesh and is made.
2. the preparation method of crow pheasant composition as described in claim 1, which is characterized in that described super in the step 1
The extraction conditions of sound wave-immersion combined techniques are 70-80 DEG C of Extracting temperature, ultrasonic time 2-3h/ days, ultrasonic power 400-450w.
3. the preparation method of crow pheasant composition as described in claim 1, which is characterized in that in the step 2, reflux carries
It is 50-55 DEG C to take specially refluxing extraction 1-2 times, each 1-1.5h, refluxing extraction temperature.
4. the preparation method of crow pheasant composition as described in claim 1, which is characterized in that in the step 3, reflux carries
It is 65-70 DEG C to take specially refluxing extraction 1-2 times, each 1.5-2h, refluxing extraction temperature.
5. the preparation method of crow pheasant composition as described in claim 1, which is characterized in that further include, to the crow pheasant
Suitable pharmaceutically acceptable auxiliary material is added in composition, is prepared into crow pheasant oral preparation.
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| CN103892002A (en) * | 2014-04-03 | 2014-07-02 | 安徽源和堂药业股份有限公司 | Ginseng and Chinese wolfberry tea capable of benefiting vital energy and replenishing blood |
| CN104784413A (en) * | 2015-03-19 | 2015-07-22 | 宁波高新区苗姑养生科技有限公司 | Nutrition powder having effects of promoting qi to activate blood and used for regulating irregular female menstruation |
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| CN103892002A (en) * | 2014-04-03 | 2014-07-02 | 安徽源和堂药业股份有限公司 | Ginseng and Chinese wolfberry tea capable of benefiting vital energy and replenishing blood |
| CN104784413A (en) * | 2015-03-19 | 2015-07-22 | 宁波高新区苗姑养生科技有限公司 | Nutrition powder having effects of promoting qi to activate blood and used for regulating irregular female menstruation |
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| Title |
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| 褐翅鸦鹃高效液相色谱指纹图谱初步研究;徐永莉等;《湖北农业科学》;20150228;第54卷(第4期);第960页左栏第1段，961页左栏第3段 * |
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