CN105051051B - 用于合成神经鞘磷脂和二氢神经鞘磷脂的方法 - Google Patents

用于合成神经鞘磷脂和二氢神经鞘磷脂的方法 Download PDF

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CN105051051B
CN105051051B CN201480015700.6A CN201480015700A CN105051051B CN 105051051 B CN105051051 B CN 105051051B CN 201480015700 A CN201480015700 A CN 201480015700A CN 105051051 B CN105051051 B CN 105051051B
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erythro
palmitoyl
benzoyl
compound
acid
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CN105051051A (zh
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D·C·奥尼丘
S·海克霍夫
B·奥斯瓦尔德
P·瑞伯曼恩
A·皮尔
M·冈赞勒兹
P·萦特
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Saris Treatment Holdings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
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    • C07F9/141—Esters of phosphorous acids
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    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
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    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
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    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/24—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and acyclic
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    • C07C231/00—Preparation of carboxylic acid amides
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    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
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    • C07F9/08—Esters of oxyacids of phosphorus
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN201480015700.6A 2013-03-15 2014-03-14 用于合成神经鞘磷脂和二氢神经鞘磷脂的方法 Active CN105051051B (zh)

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US201361801641P 2013-03-15 2013-03-15
US61/801,641 2013-03-15
EP13306056 2013-07-23
EP13306056.6 2013-07-23
PCT/IB2014/000494 WO2014140787A2 (en) 2013-03-15 2014-03-14 Methods for the synthesis of sphingomyelins and dihydrosphingomyelins

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EP2396017B1 (en) 2009-02-16 2015-07-01 Cerenis Therapeutics Holding SA Apolipoprotein a-i mimics
ES2646835T3 (es) 2010-10-18 2017-12-18 Cerenis Therapeutics Holding Sa Compuestos, composiciones y procedimientos útiles para la movilización del colesterol
US9708354B2 (en) 2013-03-15 2017-07-18 Cerenis Therapeutics Holding Sa Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
US20140316154A1 (en) * 2013-03-15 2014-10-23 Cerenis Therapeutics Holding Sa Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
TW201919686A (zh) 2017-08-10 2019-06-01 法商塞勒尼斯醫療控股公司 脫輔基子(apomers)
ES2984285T3 (es) 2017-08-10 2024-10-29 Abionyx Pharma Sa Cargómeros
JPWO2019189133A1 (ja) * 2018-03-27 2021-03-18 日油株式会社 スフィンゴミエリン誘導脂質およびその製造方法
JP7303618B2 (ja) * 2018-10-05 2023-07-05 日本精化株式会社 スフィンゴリン脂質前駆体及びその製造方法、並びに、スフィンゴリン脂質の製造方法
WO2021209808A1 (en) 2020-04-16 2021-10-21 Abionyx Pharma Sa Cer-001 therapy for treating kidney disease
US11752163B2 (en) 2020-04-16 2023-09-12 Abionyx Pharma Sa CER-001 therapy for treating kidney disease
US20240033322A1 (en) 2020-04-16 2024-02-01 Abionyx Pharma Sa Methods for treating acute conditions using lipid binding protein-based complexes
EP4221686A2 (en) 2020-10-01 2023-08-09 Abionyx Pharma SA Compositions comprising lipid binding protein-based complexes for use for treating eye diseases
WO2022219413A1 (en) 2021-04-15 2022-10-20 Abionyx Pharma Sa Use of lipid binding protein-based complexes in organ preservation solutions
AU2023251245A1 (en) 2022-04-06 2024-11-14 Abionyx Pharma Sa Methods for treating leukocytosis, endothelial dysfunction and carditis using lipid binding protein-based complexes
JP2025511845A (ja) 2022-04-06 2025-04-16 アビオニクス ファーマ エスエー 脂質結合タンパク質ベースの複合体を使用した、眼疾患を治療するための方法
JP2025519606A (ja) 2022-06-10 2025-06-26 アビオニクス ファーマ エスエー 脂質結合タンパク質に基づく複合体を使用して急性状態を処置するための方法
IL317448A (en) 2022-06-10 2025-02-01 Abionyx Pharma Sa Methods for treating hyperinflammatory conditions using complexes based on lipid-binding proteins
JP2025521721A (ja) 2022-06-28 2025-07-10 アビオニクス ファーマ エスエー スフィンゴミエリンの合成のための化合物およびプロセス
JP2026504047A (ja) 2023-01-13 2026-02-03 アビオニクス ファーマ エスエー 脂質結合タンパク質分子療法
WO2025093929A1 (en) 2023-10-31 2025-05-08 Abionyx Pharma Sa Lipid binding protein molecule therapy

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PH12015501835B1 (en) 2015-11-09
DK3363805T3 (da) 2021-03-08
AU2014229638A1 (en) 2015-08-20
BR112015023558A2 (pt) 2017-07-18
JP2018168171A (ja) 2018-11-01
SG10201804887YA (en) 2018-07-30
EP3842443C0 (en) 2025-02-19
HK1212705A1 (zh) 2016-06-17
WO2014140787A2 (en) 2014-09-18
US20160075634A1 (en) 2016-03-17
CA2900902A1 (en) 2014-09-18
US20170204122A1 (en) 2017-07-20
SG11201506456VA (en) 2015-09-29
WO2014140787A3 (en) 2015-03-26
US9643915B2 (en) 2017-05-09
MX2015012877A (es) 2016-02-03
US20140316154A1 (en) 2014-10-23
CA2900902C (en) 2022-08-02
ES3017659T3 (en) 2025-05-13
KR20150132188A (ko) 2015-11-25
EP3842443B1 (en) 2025-02-19
JP6438417B2 (ja) 2018-12-12
PH12015501835A1 (en) 2015-11-09
AU2018267598A1 (en) 2018-12-06
EP2970344A2 (en) 2016-01-20
EP3363805B1 (en) 2020-12-16
ZA201505860B (en) 2017-11-29
CN105051051A (zh) 2015-11-11
EP3363805A1 (en) 2018-08-22
EP3842443A1 (en) 2021-06-30
MX387128B (es) 2025-03-19
JP2016511281A (ja) 2016-04-14
HK1214266A1 (zh) 2016-07-22
AU2014229638B2 (en) 2018-09-06

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