MX2015012877A - Metodos para la sintesis de esfingomielinas y dihidroesfingomielinas. - Google Patents

Metodos para la sintesis de esfingomielinas y dihidroesfingomielinas.

Info

Publication number
MX2015012877A
MX2015012877A MX2015012877A MX2015012877A MX2015012877A MX 2015012877 A MX2015012877 A MX 2015012877A MX 2015012877 A MX2015012877 A MX 2015012877A MX 2015012877 A MX2015012877 A MX 2015012877A MX 2015012877 A MX2015012877 A MX 2015012877A
Authority
MX
Mexico
Prior art keywords
synthesis
includes methods
present
drone
dihydrosphingomyelins
Prior art date
Application number
MX2015012877A
Other languages
English (en)
Inventor
Andreas Peer
Daniela Carmen Oniciu
Stefan Heckhoff
Benoit Oswald
Peter Rebmann
Miguel Gonzalez
Patrik Sauter
Original Assignee
Cerenis Therapeutics Holding Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerenis Therapeutics Holding Sa filed Critical Cerenis Therapeutics Holding Sa
Publication of MX2015012877A publication Critical patent/MX2015012877A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/141—Esters of phosphorous acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/24—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and acyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención incluye métodos para la síntesis de esfingomielinas y dihidroesfingomielinas. La presente invención también incluye métodos para la síntesis de esfingosinas y dihidroesfingosinas. La presente invención además incluye métodos para la síntesis de ceramidas y dihidroceramidas.
MX2015012877A 2013-03-15 2014-03-14 Metodos para la sintesis de esfingomielinas y dihidroesfingomielinas. MX2015012877A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361801641P 2013-03-15 2013-03-15
EP13306056 2013-07-23
PCT/IB2014/000494 WO2014140787A2 (en) 2013-03-15 2014-03-14 Methods for the synthesis of sphingomyelins and dihydrosphingomyelins

Publications (1)

Publication Number Publication Date
MX2015012877A true MX2015012877A (es) 2016-02-03

Family

ID=51538203

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012877A MX2015012877A (es) 2013-03-15 2014-03-14 Metodos para la sintesis de esfingomielinas y dihidroesfingomielinas.

Country Status (15)

Country Link
US (3) US20140316154A1 (es)
EP (3) EP2970344A2 (es)
JP (2) JP6438417B2 (es)
KR (1) KR20150132188A (es)
CN (1) CN105051051B (es)
AU (2) AU2014229638B2 (es)
BR (1) BR112015023558A2 (es)
CA (1) CA2900902C (es)
DK (1) DK3363805T3 (es)
HK (2) HK1212705A1 (es)
MX (1) MX2015012877A (es)
PH (1) PH12015501835A1 (es)
SG (2) SG11201506456VA (es)
WO (1) WO2014140787A2 (es)
ZA (1) ZA201505860B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE033661T2 (en) 2009-02-16 2017-12-28 Cerenis Therapeutics Holding Sa Apolipoprotein A-1 mimetics
SI2629776T1 (sl) 2010-10-18 2017-12-29 Cerenis Therapeutics Holding Sa Spojine, sestavki in postopki, uporabni za mobilizacijo holesterola
US9708354B2 (en) 2013-03-15 2017-07-18 Cerenis Therapeutics Holding Sa Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
MX2015012877A (es) * 2013-03-15 2016-02-03 Cerenis Therapeutics Holding Sa Metodos para la sintesis de esfingomielinas y dihidroesfingomielinas.
TW201919686A (zh) 2017-08-10 2019-06-01 法商塞勒尼斯醫療控股公司 脫輔基子(apomers)
ES2984285T3 (es) 2017-08-10 2024-10-29 Abionyx Pharma Sa Cargómeros
JPWO2019189133A1 (ja) * 2018-03-27 2021-03-18 日油株式会社 スフィンゴミエリン誘導脂質およびその製造方法
JP7303618B2 (ja) * 2018-10-05 2023-07-05 日本精化株式会社 スフィンゴリン脂質前駆体及びその製造方法、並びに、スフィンゴリン脂質の製造方法
MX2022012906A (es) 2020-04-16 2023-03-14 Abionyx Pharma Sa Terapia con cer-001 para tratar enfermedad renal.
IL297336A (en) 2020-04-16 2022-12-01 Abionyx Pharma Sa Methods for the treatment of serious conditions by lipid binding complexes of basic proteins
WO2021209808A1 (en) 2020-04-16 2021-10-21 Abionyx Pharma Sa Cer-001 therapy for treating kidney disease
JP2023543498A (ja) 2020-10-01 2023-10-16 アビオニクス ファーマ エスエー 脂質結合タンパク質ベースの複合体を使用した、眼疾患を治療するための方法
IL307670A (en) 2021-04-15 2023-12-01 Abionyx Pharma Sa Use of lipid-binding protein-based complexes in organ preservation solutions
AU2023250345A1 (en) 2022-04-06 2024-11-14 Abionyx Pharma Sa Methods for treating eye diseases using lipid binding protein-based complexes
WO2023194798A1 (en) 2022-04-06 2023-10-12 Abionyx Pharma Sa Methods for treating leukocytosis, endothelial dysfunction and carditis using lipid binding protein-based complexes
WO2023237927A2 (en) 2022-06-10 2023-12-14 Abionyx Pharma Sa Methods for treating hyperinflammatory conditions using lipid binding protein -based complexes
WO2023237935A2 (en) 2022-06-10 2023-12-14 Abionyx Pharma Sa Methods for treating acute conditions using lipid binding protein-based complexes
WO2024003612A2 (en) 2022-06-28 2024-01-04 Abionyx Pharma Sa Compounds and processes for the synthesis of sphingomyelins
WO2024150064A1 (en) 2023-01-13 2024-07-18 Abionyx Pharma Sa Lipid binding protein molecule therapy

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146810A3 (de) 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
US5220043A (en) * 1991-03-21 1993-06-15 Ohio University Synthesis of D-erythro-sphingomyelins
RU2160093C2 (ru) 1993-11-16 2000-12-10 Скайефарма Инк. Везикулы с регулируемым высвобождением активных ингредиентов
US5766627A (en) 1993-11-16 1998-06-16 Depotech Multivescular liposomes with controlled release of encapsulated biologically active substances
CA2320117A1 (en) * 1998-02-12 1999-08-19 Emory University Sphingolipid derivatives and their methods of use
JP2004002215A (ja) * 2002-05-23 2004-01-08 National Institute Of Advanced Industrial & Technology スフィンゴ脂質誘導体の製造方法
JP2007517860A (ja) 2004-01-15 2007-07-05 バイオラブ・リミテッド スフィンゴミエリン、その中間体及びその調製方法
EP1750673B1 (en) 2004-05-17 2009-12-02 Tekmira Pharmaceuticals Corporation Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof
ATE417607T1 (de) 2004-06-29 2009-01-15 Jado Technologies Gmbh Sphingolipide gegen krankhafte prozesse in lipid rafts
JP4825947B2 (ja) 2004-08-04 2011-11-30 学校法人関西学院 不飽和アミノジオール類の製造方法
JP2006045113A (ja) 2004-08-04 2006-02-16 Kemikurea:Kk リン酸エステル類
US8206750B2 (en) 2005-03-24 2012-06-26 Cerenis Therapeutics Holding S.A. Charged lipoprotein complexes and their uses
US7470664B2 (en) 2005-07-20 2008-12-30 Merck & Co., Inc. HCV NS3 protease inhibitors
JP2007204384A (ja) 2006-01-31 2007-08-16 Kemikurea:Kk 光学活性リン酸誘導体およびこれを用いた光学活性スフィンゴシン１−リン酸誘導体の製造方法
WO2008096880A1 (ja) * 2007-02-09 2008-08-14 Gifu University スフィンゴ糖脂質の合成法
ATE526313T1 (de) 2007-03-09 2011-10-15 Otsuka Chemical Co Ltd Sphingosinverbindung, verfahren zu deren herstellung und sphingomyelinaseinhibitor
AU2009302042A1 (en) 2008-10-07 2010-04-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Liposomal systems comprising sphingomyelin
HUE041797T2 (hu) 2011-02-07 2019-05-28 Cerenis Therapeutics Holding Sa Lipoprotein-komplexek és elõállításuk és alkalmazásuk
FR3000959B1 (fr) * 2013-01-14 2015-08-21 Holis Technologies Nouveaux intermediaires de synthese permettant d'acceder avec de bons rendements a des derives de sphingosines, ceramides et sphingomyelines
MX2015012877A (es) 2013-03-15 2016-02-03 Cerenis Therapeutics Holding Sa Metodos para la sintesis de esfingomielinas y dihidroesfingomielinas.
US9708354B2 (en) 2013-03-15 2017-07-18 Cerenis Therapeutics Holding Sa Methods for the synthesis of sphingomyelins and dihydrosphingomyelins

Also Published As

Publication number Publication date
HK1212705A1 (zh) 2016-06-17
CN105051051A (zh) 2015-11-11
WO2014140787A2 (en) 2014-09-18
AU2018267598A1 (en) 2018-12-06
AU2014229638A1 (en) 2015-08-20
BR112015023558A2 (pt) 2017-07-18
JP2016511281A (ja) 2016-04-14
JP6438417B2 (ja) 2018-12-12
US20170204122A1 (en) 2017-07-20
DK3363805T3 (da) 2021-03-08
SG11201506456VA (en) 2015-09-29
US9643915B2 (en) 2017-05-09
EP2970344A2 (en) 2016-01-20
CN105051051B (zh) 2021-07-16
SG10201804887YA (en) 2018-07-30
HK1214266A1 (zh) 2016-07-22
EP3363805A1 (en) 2018-08-22
EP3842443A1 (en) 2021-06-30
CA2900902C (en) 2022-08-02
PH12015501835B1 (en) 2015-11-09
US20140316154A1 (en) 2014-10-23
EP3363805B1 (en) 2020-12-16
PH12015501835A1 (en) 2015-11-09
KR20150132188A (ko) 2015-11-25
WO2014140787A3 (en) 2015-03-26
AU2014229638B2 (en) 2018-09-06
CA2900902A1 (en) 2014-09-18
ZA201505860B (en) 2017-11-29
JP2018168171A (ja) 2018-11-01
US20160075634A1 (en) 2016-03-17

Similar Documents

Publication Publication Date Title
MX2015012877A (es) Metodos para la sintesis de esfingomielinas y dihidroesfingomielinas.
WO2014080389A3 (en) Autonomous ground station interfacing aerial delivery
Aad et al. Measurement of the top quark charge in pp collisions at $\sqrt {s}= 7$ TeV with the ATLAS detector
Aad et al. Search for WZ resonances in the fully leptonic channel using pp collisions at s= 8 TeV with the ATLAS detector
Aad et al. Search for heavy long-lived charged particles with the ATLAS detector in pp collisions at s= 7 TeV
EP2974958A3 (en) Post-type apparatus for containing and charging unmanned vertical take-off and landing aircraft and method of containing and charging unmanned vertical take-off and landing aircraft using the same
GB201908936D0 (en) Method and apparatus for facilitating the operation of an on-site energy storage system to co-optimize battery dispatch
WO2014074739A3 (en) Efficient modeling system
WO2014074684A3 (en) Automated sample processing system
MX2019005418A (es) Sistemas y metodos para distribucion de productos por medio de vehiculos terrestres autonomos para areas restringidas designadas por consumidores.
MX2017000274A (es) Estacion de seleccion con almacen automatizado.
MY164928A (en) Luggage processing station
MX2016003655A (es) Optimizacion de secuencia de entrega de uno a muchos.
GB2499898A (en) Attenuating internal multiples from seismic data
WO2011156023A3 (en) Enhanced payments for shipping
CL2015000575A1 (es) Método para proporcionar información relacionada con el uso de un sistema de transporte público (pts), que comprende recibir datos relacionados con el pts en respuesta a un primer usuario mediante un primer dispositivo de comunicación en tanto que el primer usuario utiliza el pts, y proporcionar datos, en un segundo dispositivo de comunicación, relacionados con el pts a un segundo usuario en respuesta a los datos recibidos; sistema; producto de programa informático.
WO2014067530A3 (en) Method of distributing airport baggage
WO2012127210A3 (en) Gravity gradiometer survey techniques
MX349521B (es) Sistema y metodo para llenar y dispensar órdenes.
GB201105730D0 (en) Method apparatus and computer program product for compressing data
GB2568185A (en) Apparatus and method for providing item interaction with a virtual store
MX2017006057A (es) Sistema y método de entrega mejorados.
MX2016010672A (es) Metodo y sistema de transacciones electronicas mediante un accesorio portatil.
ATLAS Collaboration atlas. publications@ cern. ch et al. Search for lepton flavour violation in the eμ continuum with the ATLAS detector in s=7~TeV pp collisions at the LHC
WO2015073210A3 (en) Interactive experimentation