MX387128B - Métodos para la síntesis de esfingomielinas y dihidroesfingomielinas. - Google Patents

Métodos para la síntesis de esfingomielinas y dihidroesfingomielinas.

Info

Publication number
MX387128B
MX387128B MX2015012877A MX2015012877A MX387128B MX 387128 B MX387128 B MX 387128B MX 2015012877 A MX2015012877 A MX 2015012877A MX 2015012877 A MX2015012877 A MX 2015012877A MX 387128 B MX387128 B MX 387128B
Authority
MX
Mexico
Prior art keywords
synthesis
sphingomyelins
methods
dihydroesphingomyelins
present
Prior art date
Application number
MX2015012877A
Other languages
English (en)
Other versions
MX2015012877A (es
Inventor
Andreas Peer
Benoit Oswald
Daniela Carmen Oniciu
Miguel Gonzalez
Patrik Sauter
Peter Rebmann
Stefan Heckhoff
Original Assignee
Cerenis Therapeutics Holding Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerenis Therapeutics Holding Sa filed Critical Cerenis Therapeutics Holding Sa
Publication of MX2015012877A publication Critical patent/MX2015012877A/es
Publication of MX387128B publication Critical patent/MX387128B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/141—Esters of phosphorous acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/24—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and acyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención incluye métodos para la síntesis de esfingomielinas y dihidroesfingomielinas. La presente invención también incluye métodos para la síntesis de esfingosinas y dihidroesfingosinas. La presente invención además incluye métodos para la síntesis de ceramidas y dihidroceramidas.
MX2015012877A 2013-03-15 2014-03-14 Métodos para la síntesis de esfingomielinas y dihidroesfingomielinas. MX387128B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361801641P 2013-03-15 2013-03-15
EP13306056 2013-07-23
PCT/IB2014/000494 WO2014140787A2 (en) 2013-03-15 2014-03-14 Methods for the synthesis of sphingomyelins and dihydrosphingomyelins

Publications (2)

Publication Number Publication Date
MX2015012877A MX2015012877A (es) 2016-02-03
MX387128B true MX387128B (es) 2025-03-19

Family

ID=51538203

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012877A MX387128B (es) 2013-03-15 2014-03-14 Métodos para la síntesis de esfingomielinas y dihidroesfingomielinas.

Country Status (16)

Country Link
US (3) US20140316154A1 (es)
EP (3) EP2970344A2 (es)
JP (2) JP6438417B2 (es)
KR (1) KR20150132188A (es)
CN (1) CN105051051B (es)
AU (2) AU2014229638B2 (es)
BR (1) BR112015023558A2 (es)
CA (1) CA2900902C (es)
DK (1) DK3363805T3 (es)
ES (1) ES3017659T3 (es)
HK (1) HK1214266A1 (es)
MX (1) MX387128B (es)
PH (1) PH12015501835B1 (es)
SG (2) SG11201506456VA (es)
WO (1) WO2014140787A2 (es)
ZA (1) ZA201505860B (es)

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US8378068B2 (en) 2009-02-16 2013-02-19 Cerenis Therapeutics Holding Sa Apolipoprotein A-I mimics
SG10201708237SA (en) 2010-10-18 2017-11-29 Cerenis Therapeutics Holding Sa Compounds, compositions and methods useful for cholesterol mobilisation
US9708354B2 (en) 2013-03-15 2017-07-18 Cerenis Therapeutics Holding Sa Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
MX387128B (es) 2013-03-15 2025-03-19 Cerenis Therapeutics Holding Sa Métodos para la síntesis de esfingomielinas y dihidroesfingomielinas.
US20190046608A1 (en) 2017-08-10 2019-02-14 Cerenis Therapeutics Holding Sa Apomers
US20190048049A1 (en) 2017-08-10 2019-02-14 Cerenis Therapeutics Holding Sa Cargomers
EP3778611B1 (en) * 2018-03-27 2022-10-12 NOF Corporation Sphingomyelin-derived lipid and method for producing same
JP7303618B2 (ja) * 2018-10-05 2023-07-05 日本精化株式会社 スフィンゴリン脂質前駆体及びその製造方法、並びに、スフィンゴリン脂質の製造方法
US20240033322A1 (en) 2020-04-16 2024-02-01 Abionyx Pharma Sa Methods for treating acute conditions using lipid binding protein-based complexes
EP4135838A1 (en) 2020-04-16 2023-02-22 Abionyx Pharma SA Cer-001 therapy for treating kidney disease
WO2021209808A1 (en) 2020-04-16 2021-10-21 Abionyx Pharma Sa Cer-001 therapy for treating kidney disease
MX2023003877A (es) 2020-10-01 2023-04-18 Abionyx Pharma Sa Composiciones que comprenden complejos basados en proteina de union a lipidos para usarse en el tratamiento de enfermedades oculares.
AU2022258815A1 (en) 2021-04-15 2023-10-19 Abionyx Pharma Sa Use of lipid binding protein-based complexes in organ preservation solutions
WO2023194798A1 (en) 2022-04-06 2023-10-12 Abionyx Pharma Sa Methods for treating leukocytosis, endothelial dysfunction and carditis using lipid binding protein-based complexes
EP4504150A1 (en) 2022-04-06 2025-02-12 Abionyx Pharma SA Methods for treating eye diseases using lipid binding protein-based complexes
US20250360184A1 (en) 2022-06-10 2025-11-27 Abionyx Pharma Sa Methods for treating acute conditions using lipid binding protein-based complexes
WO2023237927A2 (en) 2022-06-10 2023-12-14 Abionyx Pharma Sa Methods for treating hyperinflammatory conditions using lipid binding protein -based complexes
CA3260759A1 (en) 2022-06-28 2024-01-04 Abionyx Pharma Sa SPHINGOMYELIN COMPOUNDS AND SYNTHETIC PROCESSES
IL322074A (en) 2023-01-13 2025-09-01 Abionyx Pharma Sa Treatment using a lipid-binding protein molecule
WO2025093929A1 (en) 2023-10-31 2025-05-08 Abionyx Pharma Sa Lipid binding protein molecule therapy

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AU765809B2 (en) * 1998-02-12 2003-10-02 Emory University Sphingolipid derivatives and their methods of use
JP2004002215A (ja) * 2002-05-23 2004-01-08 National Institute Of Advanced Industrial & Technology スフィンゴ脂質誘導体の製造方法
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MX387128B (es) * 2013-03-15 2025-03-19 Cerenis Therapeutics Holding Sa Métodos para la síntesis de esfingomielinas y dihidroesfingomielinas.

Also Published As

Publication number Publication date
CN105051051A (zh) 2015-11-11
EP3363805B1 (en) 2020-12-16
WO2014140787A2 (en) 2014-09-18
US20160075634A1 (en) 2016-03-17
AU2018267598A1 (en) 2018-12-06
EP2970344A2 (en) 2016-01-20
SG10201804887YA (en) 2018-07-30
PH12015501835A1 (en) 2015-11-09
WO2014140787A3 (en) 2015-03-26
PH12015501835B1 (en) 2015-11-09
HK1214266A1 (zh) 2016-07-22
AU2014229638B2 (en) 2018-09-06
ZA201505860B (en) 2017-11-29
CA2900902A1 (en) 2014-09-18
HK1212705A1 (zh) 2016-06-17
DK3363805T3 (da) 2021-03-08
AU2014229638A1 (en) 2015-08-20
BR112015023558A2 (pt) 2017-07-18
MX2015012877A (es) 2016-02-03
JP2016511281A (ja) 2016-04-14
KR20150132188A (ko) 2015-11-25
CA2900902C (en) 2022-08-02
ES3017659T3 (en) 2025-05-13
SG11201506456VA (en) 2015-09-29
CN105051051B (zh) 2021-07-16
US9643915B2 (en) 2017-05-09
EP3842443B1 (en) 2025-02-19
US20140316154A1 (en) 2014-10-23
US20170204122A1 (en) 2017-07-20
EP3842443C0 (en) 2025-02-19
EP3363805A1 (en) 2018-08-22
EP3842443A1 (en) 2021-06-30
JP2018168171A (ja) 2018-11-01
JP6438417B2 (ja) 2018-12-12

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