CN105051046A - β-氨基羰基类化合物、其制备方法、药物组合物及其用途 - Google Patents

β-氨基羰基类化合物、其制备方法、药物组合物及其用途 Download PDF

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CN105051046A
CN105051046A CN201480016980.2A CN201480016980A CN105051046A CN 105051046 A CN105051046 A CN 105051046A CN 201480016980 A CN201480016980 A CN 201480016980A CN 105051046 A CN105051046 A CN 105051046A
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heteroaryls
base
circle heterocycles
unit
aryl
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CN105051046B (zh
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朱维良
沈敬山
王贺瑶
蒋涛
周雨人
陈筑熙
蒋翔锐
孙鹏
张强
王震
张容霞
李剑峰
索瑾
徐志建
李波
刘颖涛
蒋华良
陈凯先
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NANJING PAILEXING MEDICAL TECHNOLOGY CO LTD
Shanghai Institute of Materia Medica of CAS
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NANJING PAILEXING MEDICAL TECHNOLOGY CO LTD
Shanghai Institute of Materia Medica of CAS
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Abstract

本发明属于药物化学领域。具体而言，本发明涉及一种如下通式I所示的新的β-氨基羰基类化合物或其互变异构体、对映体、消旋体或其药学上可接受的盐，其制备方法，药物组合物及其作为二肽基肽酶IV(DPP-4)抑制剂的用途。该类化合物或其药物组合物作为DPP-4抑制剂可用于治疗II型糖尿病、高血糖症、肥胖症或胰岛素抵抗症。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
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CN104059068B (zh) * 2013-03-20 2017-02-08 中国科学院上海药物研究所 β‑氨基羰基类化合物、其制备方法、药物组合物及其用途
CN104876851A (zh) * 2015-05-15 2015-09-02 南京大学 一类含吲哚-3羧酸骨架的哌嗪类衍生物的制备方法及在抗癌药物中的应用
CN106810537B (zh) * 2015-11-27 2019-05-07 中国科学院大连化学物理研究所 一种适用于水油两相体系手性催化剂及其制备和应用
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KR102638151B1 (ko) * 2017-05-17 2024-02-16 데날리 테라퓨틱스 인크. 키나아제 억제제 및 이의 용도
WO2019201291A1 (zh) * 2018-04-20 2019-10-24 中国科学院上海药物研究所 组蛋白乙酰转移酶(hat)抑制剂及其用途
CN112961113A (zh) * 2020-04-14 2021-06-15 北京新康哌森医药科技有限公司 一种盐酸氨溴索杂质的制备方法
JP7466664B2 (ja) 2020-07-31 2024-04-12 深▲川▼市橄欖生物医薬科技有限公司 ピラジン化合物およびその調製方法と使用

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0585999A (ja) * 1991-09-27 1993-04-06 Suntory Ltd ２−インダニルグリシン及びその関連化合物
WO1998035939A1 (fr) * 1997-02-18 1998-08-20 Sanwa Kagaku Kenkyusho Co., Ltd. Derives de diamide malonique et utilisation de ces derniers
WO1999033798A1 (fr) * 1997-12-25 1999-07-08 Yamanouchi Pharmaceutical Co., Ltd. Derives heterocycliques azotes
CN1427826A (zh) * 2000-03-10 2003-07-02 布里斯托尔-迈尔斯斯奎布公司 基于环丙基稠合的吡咯烷二肽基肽酶iv抑制剂、它们的制备方法及用途
WO2004089362A1 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S 2-cyanopyrroles and their analogues as ddp-iv inhibitors
WO2006097175A1 (en) * 2005-03-18 2006-09-21 Santhera Pharmaceuticals (Schweiz) Ag Dpp-iv inhibitors
CN1870990A (zh) * 2003-11-04 2006-11-29 默克公司 作为糖尿病治疗或预防用二肽基肽酶iv抑制剂的稠合苯基丙氨酸衍生物
WO2007053819A2 (en) * 2005-10-31 2007-05-10 Bristol-Myers Squibb Company Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase iv and methods
CN104059068A (zh) * 2013-03-20 2014-09-24 中国科学院上海药物研究所 β-氨基羰基类化合物、其制备方法、药物组合物及其用途

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0585999A (ja) * 1991-09-27 1993-04-06 Suntory Ltd ２−インダニルグリシン及びその関連化合物
WO1998035939A1 (fr) * 1997-02-18 1998-08-20 Sanwa Kagaku Kenkyusho Co., Ltd. Derives de diamide malonique et utilisation de ces derniers
WO1999033798A1 (fr) * 1997-12-25 1999-07-08 Yamanouchi Pharmaceutical Co., Ltd. Derives heterocycliques azotes
CN1427826A (zh) * 2000-03-10 2003-07-02 布里斯托尔-迈尔斯斯奎布公司 基于环丙基稠合的吡咯烷二肽基肽酶iv抑制剂、它们的制备方法及用途
WO2004089362A1 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S 2-cyanopyrroles and their analogues as ddp-iv inhibitors
CN1870990A (zh) * 2003-11-04 2006-11-29 默克公司 作为糖尿病治疗或预防用二肽基肽酶iv抑制剂的稠合苯基丙氨酸衍生物
WO2006097175A1 (en) * 2005-03-18 2006-09-21 Santhera Pharmaceuticals (Schweiz) Ag Dpp-iv inhibitors
WO2007053819A2 (en) * 2005-10-31 2007-05-10 Bristol-Myers Squibb Company Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase iv and methods
CN104059068A (zh) * 2013-03-20 2014-09-24 中国科学院上海药物研究所 β-氨基羰基类化合物、其制备方法、药物组合物及其用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
COLUMBUS,OHIO, US REGISTRY[ONLINE]: ""STN检索报告"", 《STN REGISTRY》 *
WILSON BAKER ET AL.: ""Attempts to prepare New Aromatic Systems. Part I. cycloPentindene. Phenylcyclopentanecarboxylic Acids,and Derived Ketones."", 《JOURNAL OF THE CHEMICAL SOCIETY（RESUMED）》 *

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