CN105031407A - Traditional Chinese medicine formula for treating rheumatism and rheumatoid, preparation method and application of traditional Chinese medicine formula - Google Patents
Traditional Chinese medicine formula for treating rheumatism and rheumatoid, preparation method and application of traditional Chinese medicine formula Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine formula for treating rheumatism and rheumatoid. The traditional Chinese medicine is characterized by being mainly prepared from the following raw materials in parts by weight: 100-700 parts of pismire powder, 100-380 parts of American ginseng, 200-1,000 parts of astragalus membranaceus and 200-1,000 parts of semen coicis. The traditional Chinese medicine formula has the beneficial effects that the traditional Chinese medicine is accurate in curative effect and not easy to recur; the wide patients with rheumatism and rheumatoid are prevented from being tortured by the diseases; and the living quality is greatly improved.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to one and treat rheumatism, rheumatoid Chinese medicine formula, its preparation method and application.
Background technology
Rheumatic and rheumatoid diseases belongs to the category of China's Chinese medicine arthromyodynia, its cardinal symptom be place's pain such as muscle, joint, muscles and bones, miserable, weigh, numb, joint stuffiness, or arthroncus, it is one of persistent ailment of serious harm human health, sickness rate rises year by year in recent years, and disability rate also rises year by year.The common medicine of rheumatic and rheumatoid diseases is non-steroid antiinflammatory drug and hormone therapy, and side effect is very big, and patient is difficult to tolerance.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides one and treating rheumatism, rheumatoid Chinese medicine formula, its preparation method and application.
The technical solution adopted in the present invention is: one treats rheumatism, rheumatoid Chinese medicine formula, and the raw material mainly comprising following mass parts is made: Formica fusca powder 100-700 part, Radix Panacis Quinquefolii 100-380 part, Radix Astragali 200-1000 part, Semen Coicis 200-1000 part.
Preferably, the raw material that described Chinese medicine formula mainly comprises following mass parts is made: Formica fusca powder 300-500 part, Radix Panacis Quinquefolii 200-280 part, Radix Astragali 500-700 part, Semen Coicis 500-700 part.
Preferably, the raw material that described Chinese medicine formula mainly comprises following mass parts is made: Formica fusca powder 100-700 part, Radix Panacis Quinquefolii 100-380 part, Radix Astragali 200-1000 part, Semen Coicis 200-1000 part, Rhizoma Polygonati 200-1000 part, Radix Paeoniae Alba 100-700 part, wrinkled papaya 200-1000 part, Radix Salviae Miltiorrhizae 50-550 part, Fructus Lycii 400-1200 part, Rhizoma Dioscoreae 400-1200 part, Cortex Cinnamomi 200-1000 part, Fructus Jujubae 200-1000 part.
Preferably, the raw material that described Chinese medicine formula mainly comprises following mass parts is made: Formica fusca powder 300-500 part, Radix Panacis Quinquefolii 200-280 part, Radix Astragali 500-700 part, Semen Coicis 500-700 part, Rhizoma Polygonati 500-700 part, Radix Paeoniae Alba 300-500 part, wrinkled papaya 500-700 part, Radix Salviae Miltiorrhizae 200-400 part, Fructus Lycii 700-900 part, Rhizoma Dioscoreae 700-900 part, Cortex Cinnamomi 500-700 part, Fructus Jujubae 500-700 part.
Preferably, described Chinese medicine formula also comprises the adjuvant of following mass parts: potassium sorbate 4-8 part, aspartame 2-4 part, purified water 3000-4000 part.In the present invention, potassium sorbate is as antiseptic; Aspartame is as sweeting agent; Purified water is as solvent, all the routine selections in industry, certainly, the present invention is not limited to above selection, anyly can play same or similar effect and the additive meeting relevant regulations all can use, as the selection of additive, belong to prior art, art technology people can obtain easily, just repeats no more at this.
In order to explain the present invention better, below the raw material in the present invention and compatibility relationship are further elaborated.
Formica fusca powder, Formica fusca powder refers to Polyhachis vicina Roger (PolyrhachisvicinaRoger) as raw material dries the powder ground to form, the abundant formic acid to rheumatism, rheumatoid factor is had in Polyhachis vicina Roger body, it can penetrate seven, joint aspect, reduce the activity of virus, the traditional Chinese medical science is thought, Polyhachis vicina Roger is a kind of tonic medicine of gentleness, has effect of strengthening the body resistance, life lengthening, kidney invigorating and YANG supporting, strong muscles and bones, eliminating blood stasis and smoothing collaterals.
Radix Panacis Quinquefolii, Classification system Panaxquinquefolius, another name Radix Panacis Quinquefolii, Radix Panacis Quinquefolii, Western Radix Ginseng, the traditional Chinese medical science is thought, Radix Panacis Quinquefolii has YIN nourishing and QI supplementing, effect that the mind calming and mentality promoting, clearing away heat and promoting production of body fluid, pathogenic fire reducing are relieved summer heat.Radix Panacis Quinquefolii has the double effects of QI invigorating and pathogenic fire reducing simultaneously, thus mend and not dry be the special feature of Radix Panacis Quinquefolii.
The Radix Astragali, Classification system Astragalusmembranaceus (Fisch.) Bunge, the Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and can the process of delaying cell aging.
Semen Coicis is the kernel of grass Semen Coicis Coixlacryma-jobiL.var.meyuan (Romen.) Stapf, another name Semen Coicis, NLIUGU, Semen Coicis.The traditional Chinese medical science is thought, Semen Coicis has spleen invigorating eliminating dampness by diuresis, effect of eliminating impediment antidiarrheal.Be usually used in the diseases such as edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen.
Rhizoma Polygonati, Classification system Polygonatumsibiricum is HUANGJING ZANYU CAPSULE, rhizome horizontal walk, cylindric, tuberosity expands.Impeller is raw, stockless.General spring, season in autumn two gather, good with quality of gathering autumn, cultivate 3 ~ 4 year autumn overground part withered after gather, take rhizome, removing aerial parts and fibrous root, washes away earth, to put in food steamer steaming to when presenting glossy, taking-up is dried or is dried, or after putting and boiling in water, pulls out and dry or dry.The traditional Chinese medical science is thought, Rhizoma Polygonati sweet in the mouth is put down, and has effect of boosting qi and nourishing yin, tonifying speen and tonifying kidney.Be usually used in weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat such as to be quenched one's thirst the disease.
The Radix Paeoniae Alba, Classification system Cynanchumotophyllum is the hematonic in Chinese medicine.Bitter in the mouth, acid; Cold nature; Return liver, spleen channel.The traditional Chinese medical science is thought, the Radix Paeoniae Alba have enrich blood, effect of yin fluid astringing easing the affected liver, relieving spasm to stop pain.
Wrinkled papaya, Latin literary fame: Chaenomelesspeciosa (Sweet) Nakai, fruit containing malic acid, tartaric acid, citric acid and vitamin C etc., is used as medicine after drying, has and drives phoenix, relaxing muscles and tendons, active, analgesia, detumescence, pleasant effect.For arranging myenteron spasm, stomachache of vomiting and diarrhoea, rheumatic arthritis, soreness of waist and knee joint.
Radix Salviae Miltiorrhizae, Chinese medicine name.For the dry root welding technology of labiate Radix Salviae Miltiorrhizae SalviamiltiorrhizaBge..The traditional Chinese medical science is thought, Radix Salviae Miltiorrhizae has effect of blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, the relieving restlessness that clears away heart-fire, removing heat from blood eliminating carbuncle.Gather for obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, abdominal mass abdominal mass, the disease such as pyretic arthralgia pain, dysphoria and insomnia, menoxenia, dysmenorrhea amenorrhea and skin infection swell and ache.
Fructus Lycii, Latin literary fame: FRUCTUSLYCII is the mature fruit of matrimony vine of solanaceae plant.Pluck when summer, autumn fruit maturation, removing fruit stem, put after shady and cool place dries in the air and corrugate to peel, then be exposed to the sun stiff to crust, sarcocarp is soft and get final product.The traditional Chinese medical science is thought, Fructus Lycii has effect of the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough, for hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst and the disease such as seminal emission.
Rhizoma Dioscoreae, Latin literary fame: CommonYamRhizome, medicinal source is Dioscoreaceae plant Rhizoma Dioscoreae dry rhizome.The traditional Chinese medical science is thought, Rhizoma Dioscoreae has and nourishes strong, aid digestion, hold back sweating due to debility, effect of antidiarrheal, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes are quenched one's thirst, oliguria frequently, seminal emission, women's leukorrhagia and dyspeptic chronic enteritis.
Cortex Cinnamomi, Classification system: CinnamomumcassiaPresl is the dry bark of canella Cortex Cinnamomi.The traditional Chinese medical science is thought, Cortex Cinnamomi has effect of complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Cure mainly decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache had loose bowels, the more floating and heat in the upper and cold in the lower of colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, empty sun.
Fructus Jujubae, Classification system: jujube is the dry mature fruit of Rhamnaceae jujube Fructus Jujubae ZiziphusjujubaMill.var.inermis (Bunge) Rehd..Gather during fruit maturation in autumn, dry and get final product.The traditional Chinese medical science is thought, Fructus Jujubae has effect of invigorating the spleen and replenishing QI and tranquilizing by nourishing the heart.For diarrhea due to hypofunction of the spleen, cardiopalmus, insomnia and night sweat.
The effect of Raw of the present invention is: present invention uses Formica fusca powder, utilizes formic acid abundant in Formica fusca powder as to rheumatism, rheumatoid factor, is aided with the YIN nourishing and QI supplementing of Radix Panacis Quinquefolii, effect that the mind calming and mentality promoting, clearing away heat and promoting production of body fluid, pathogenic fire reducing are relieved summer heat; With the improvement blood supply of cardiac muscle of the Radix Astragali, improve immunologic function; Add the spleen invigorating eliminating dampness by diuresis of Semen Coicis, effect of eliminating impediment antidiarrheal, produce excellent treatment rheumatism, rheumatoid compound recipe effect.
Meanwhile, effect of Rhizoma Polygonati boosting qi and nourishing yin, tonifying speen and tonifying kidney is aided with; The Radix Paeoniae Alba is enriched blood, effect of yin fluid astringing easing the affected liver; Wrinkled papaya drives effect of phoenix, relaxing muscles and tendons; Effect of Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle; Effect of Fructus Lycii the kidney invigorating and essence nourishing, Rhizoma Dioscoreae nourishes strong, to hold back sweating due to debility effect; Effect of Cortex Cinnamomi complement sun, removing accumulated cold.After effect of Fructus Jujubae invigorating the spleen and replenishing QI, tranquilizing by nourishing the heart, further enhancing the drug effect of Chinese medicine formula in the present invention, serve better therapeutic effect.
Potassium sorbate, formal name used at school 2,4-potassium hexadiene is colourless to the crystallization of white flakes shape or crystalline powder, odorless or slightly stink.Belong to acid antiseptic, the main antiseptic being used as food and medicine.
Aspartame, also known as aspartame, is a kind of artificial sweetener of non-carbohydrate class.Aspartame is a kind of natural function oligosaccharide, and unlikely dental caries, sweet taste are pure, hygroscopicity is low, without stickiness, can not cause the obvious rising of blood glucose, is applicable to patients with diabetes mellitus, is usually used in the sweeting agent of food, medicine.
Purified water, is the water of the hyoscine that drinking water obtains through the way of distillation, ion exchange, hyperfiltration or other suitable methods, not containing any additive, is commonly used for the solvent of medicine.
Present invention also offers a kind of preparation method of above-mentioned Chinese medicine formula, comprise the following steps:
(1) extract: after described Formica fusca powder being added soak with ethanol, cross leaching filtrate, obtain Formica fusca powder alcoholic solution, described Formica fusca powder alcoholic solution evaporating solvent is obtained concentrated solution I, again surplus stock is added purified water to decoct, cross leaching filtrate and evaporating solvent obtains raw material dissolution fluid, then add people's ethanol to described raw material dissolution fluid, after leaving standstill, cross leaching filtrate, obtain ethanol extract, described ethanol extract evaporating solvent is obtained concentrated solution II;
(2) prepare: by described concentrated solution I and concentrated solution II mix homogeneously, obtain original liquid; After described potassium sorbate and aspartame being dissolved by a part of purified water, add in described original liquid, then join in described original liquid by remaining purified water, stir after leaving standstill and cross leaching filtrate, get product medicinal liquid.
Preferably, after step (2) preparation, (3) sterilization filling is also comprised: by described finished product medicinal liquid sterilizing 20-40 minute at the temperature of 100-110 DEG C, be cooled to room temperature, fill, pack after lamp inspection.Directly can encapsulate after sterilization filling, preserve, and put on market.
Preferably, step (1) extract in service property (quality) mark be 70% ethanol described Formica fusca powder is soaked, the quality of ethanol be the 6-10 of described Formica fusca powder quality doubly, soak time is 90-150 hour; The ethanol being 70% by Formica fusca powder filtering residue service property (quality) mark after crossing leaching filtrate carries out reflux, extract, and the quality of ethanol is 6-10 times of described Formica fusca powder filtering residue quality, and reflux, extract, temperature is 70-78 DEG C, and reflux extracting time is 1-3 hour; Formica fusca powder alcoholic solution is obtained after the extracting solution mix homogeneously that the filtrate obtained after immersion and reflux, extract, are obtained; Described concentrated solution I is 1.04-1.06 the relative density of 50 DEG C; Surplus stock is added purified water when decocting, carry out at twice, the quality adding purified water is for the first time 6-10 times of surplus stock quality, and decocting time is 1-3 hour, the quality adding purified water is for the second time 4-8 times of surplus stock quality, and decocting time is 1-3 hour; After the filtrate mixing obtained twice, evaporating solvent obtains raw material dissolution fluid, described raw material dissolution fluid is 1.12-1.18 the relative density of 60 DEG C, again described raw material dissolution fluid is added people's ethanol, obtain the system that ethanol mass fraction is 50-70%, leave standstill after 18-30 hour, cross leaching filtrate, obtain ethanol extract, described ethanol extract evaporating solvent is obtained concentrated solution II.Adopt above-mentioned parameter, what the active component in raw material can be proposed is more thorough, the selection of chemical reagent, temperature, time and solvent evaporation amount, be inventor under the prerequisite carefully analyzing physical property, take into account the optimal choice that product quality and production cost are made.Wherein the contrast object of relative density is purified water.
It should be noted that, because the ethanol that mass fraction is 70% is selected as conventional a kind of concentration, should as limitation of the invention, those skilled in the art reach same effect easily via using the ethanol of variable concentrations, just repeat no more at this.
Preferably, in step (2) preparation, mixing time is 20-40 minute, and time of repose is 18-30 hour.Under this mixing time and time of repose, can ensure fully dissolve and leave standstill complete, ensure the quality of finished product medicinal liquid.
The invention also discloses the application of above-mentioned Chinese medicine formula in preparation treatment rheumatism, antirheumatic, described medicine is medically acceptable any preparation.
Beneficial effect of the present invention is:
1, the invention provides one and treat rheumatism, rheumatoid Chinese medicine formula, determined curative effect and not easily recurring, make vast rheumatism, rheumatoid patient decocting from disease, substantially increase quality of life.
2, the invention provides one and treat rheumatism, rheumatoid Chinese medicine formula, compare with traditional non-steroid antiinflammatory drug with hormonal medicaments, curative effect is obvious and side effect is little, and patient is more acceptant.
Detailed description of the invention
Embodiment 1
The invention provides one and treat rheumatism, rheumatoid Chinese medicine formula, the raw material mainly comprising following quality is made: Formica fusca powder 100g, Radix Panacis Quinquefolii 100g, Radix Astragali 200g, Semen Coicis 200g.
Embodiment 2
The invention provides one and treat rheumatism, rheumatoid Chinese medicine formula, the raw material mainly comprising following quality is made: Formica fusca powder 700g, Radix Panacis Quinquefolii 380g, Radix Astragali 1000g, Semen Coicis 1000g.
Embodiment 3
The invention provides one and treat rheumatism, rheumatoid Chinese medicine formula, the raw material mainly comprising following quality is made: Formica fusca powder 400g, Radix Panacis Quinquefolii 240g, Radix Astragali 600g, Semen Coicis 600g.
Embodiment 4
The invention provides one and treat rheumatism, rheumatoid Chinese medicine formula, the raw material mainly comprising following quality is made: Formica fusca powder 300g, Radix Panacis Quinquefolii 200g, Radix Astragali 500g, Semen Coicis 500g.
Embodiment 5
The invention provides one and treat rheumatism, rheumatoid Chinese medicine formula, the raw material mainly comprising following quality is made: Formica fusca powder 500g, Radix Panacis Quinquefolii 280g, Radix Astragali 700g, Semen Coicis 700g.
Embodiment 6
The invention provides one and treat rheumatism, rheumatoid Chinese medicine formula, the raw material mainly comprising following quality is made: Formica fusca powder 100g, Radix Panacis Quinquefolii 100g, Radix Astragali 200g, Semen Coicis 200g, Rhizoma Polygonati 200g, Radix Paeoniae Alba 100g, wrinkled papaya 200g, Radix Salviae Miltiorrhizae 50g, Fructus Lycii 400g, Rhizoma Dioscoreae 400g, Cortex Cinnamomi 200g, Fructus Jujubae 200g.
Embodiment 7
The invention provides one and treat rheumatism, rheumatoid Chinese medicine formula, the raw material mainly comprising following quality is made: Formica fusca powder 700g, Radix Panacis Quinquefolii 380g, Radix Astragali 1000g, Semen Coicis 1000g, Rhizoma Polygonati 1000g, Radix Paeoniae Alba 700g, wrinkled papaya 1000g, Radix Salviae Miltiorrhizae 550g, Fructus Lycii 1200g, Rhizoma Dioscoreae 1200g, Cortex Cinnamomi 1000g, Fructus Jujubae 1000g.
Embodiment 8
The invention provides one and treat rheumatism, rheumatoid Chinese medicine formula, the raw material mainly comprising following quality is made: Formica fusca powder 400g, Radix Panacis Quinquefolii 240g, Radix Astragali 600g, Semen Coicis 600g, Rhizoma Polygonati 600g, Radix Paeoniae Alba 400g, wrinkled papaya 600g, Radix Salviae Miltiorrhizae 300g, Fructus Lycii 800g, Rhizoma Dioscoreae 800g, Cortex Cinnamomi 600g, Fructus Jujubae 600g.
Embodiment 9
The invention provides one and treat rheumatism, rheumatoid Chinese medicine formula, the raw material mainly comprising following quality is made: Formica fusca powder 300g, Radix Panacis Quinquefolii 200g, Radix Astragali 500g, Semen Coicis 500g, Rhizoma Polygonati 500g, Radix Paeoniae Alba 300g, wrinkled papaya 500g, Radix Salviae Miltiorrhizae 200g, Fructus Lycii 700g, Rhizoma Dioscoreae 700g, Cortex Cinnamomi 500g, Fructus Jujubae 500g.
Embodiment 10
The invention provides one and treat rheumatism, rheumatoid Chinese medicine formula, the raw material mainly comprising following quality is made: Formica fusca powder 500g, Radix Panacis Quinquefolii 280g, Radix Astragali 700g, Semen Coicis 700g, Rhizoma Polygonati 700g, Radix Paeoniae Alba 500g, wrinkled papaya 700g, Radix Salviae Miltiorrhizae 400g, Fructus Lycii 900g, Rhizoma Dioscoreae 900g, Cortex Cinnamomi 700g, Fructus Jujubae 700g.
Embodiment 11
Present invention also offers a kind of method preparing above-mentioned Chinese medicine formula, comprise the following steps:
(1) extract: the ethanol being 70% by described Formica fusca powder service property (quality) mark soaks described Formica fusca powder, and the quality of ethanol is 6 times of described Formica fusca powder quality, and soak time is 90 hours; The ethanol being 70% by Formica fusca powder filtering residue service property (quality) mark after crossing leaching filtrate carries out reflux, extract, and the quality of ethanol is 6 times of described Formica fusca powder filtering residue quality, and reflux, extract, temperature is 70 DEG C, and reflux extracting time is 1 hour; Formica fusca powder alcoholic solution is obtained after the extracting solution mix homogeneously that the filtrate obtained after immersion and reflux, extract, are obtained; Described Formica fusca powder alcoholic solution evaporating solvent is obtained concentrated solution I, described concentrated solution I is 1.04 the relative density of 50 DEG C, again surplus stock is added purified water to decoct, surplus stock is added purified water when decocting, carry out at twice, the quality adding purified water is for the first time 6 times of surplus stock quality, and decocting time is 1 hour, the quality adding purified water is for the second time 4 times of surplus stock quality, and decocting time is 1 hour; After the filtrate mixing obtained twice, evaporating solvent obtains raw material dissolution fluid, described raw material dissolution fluid is 1.12 the relative density of 60 DEG C, obtain the system that ethanol mass fraction is 50%, leave standstill after 18 hours, cross leaching filtrate, obtain ethanol extract, described ethanol extract evaporating solvent is obtained concentrated solution II;
(2) prepare: by described concentrated solution I and concentrated solution II mix homogeneously, obtain original liquid; After described potassium sorbate and aspartame being dissolved by a part of purified water, add in described original liquid, then join in described original liquid by remaining purified water, stir 20 minutes, leave standstill after 18 hours and cross leaching filtrate, get product medicinal liquid.
(3) sterilization filling: by the sterilizing 20 minutes at the temperature of 100 DEG C of described finished product medicinal liquid, be cooled to room temperature, fill, pack after lamp inspection.
Embodiment 12
Present invention also offers a kind of method preparing above-mentioned Chinese medicine formula, comprise the following steps:
(1) extract: the ethanol being 70% by described Formica fusca powder service property (quality) mark soaks described Formica fusca powder, and the quality of ethanol is 10 times of described Formica fusca powder quality, and soak time is 150 hours; The ethanol being 70% by Formica fusca powder filtering residue service property (quality) mark after crossing leaching filtrate carries out reflux, extract, and the quality of ethanol is 10 times of described Formica fusca powder filtering residue quality, and reflux, extract, temperature is 78 DEG C, and reflux extracting time is 3 hours; Formica fusca powder alcoholic solution is obtained after the extracting solution mix homogeneously that the filtrate obtained after immersion and reflux, extract, are obtained; Described Formica fusca powder alcoholic solution evaporating solvent is obtained concentrated solution I, described concentrated solution I is 1.06 the relative density of 50 DEG C, again surplus stock is added purified water to decoct, surplus stock is added purified water when decocting, carry out at twice, the quality adding purified water is for the first time 10 times of surplus stock quality, and decocting time is 3 hours, the quality adding purified water is for the second time 8 times of surplus stock quality, and decocting time is 3 hours; After the filtrate mixing obtained twice, evaporating solvent obtains raw material dissolution fluid, described raw material dissolution fluid is 1.18 the relative density of 60 DEG C, obtain the system that ethanol mass fraction is 70%, leave standstill after 30 hours, cross leaching filtrate, obtain ethanol extract, described ethanol extract evaporating solvent is obtained concentrated solution II;
(2) prepare: by described concentrated solution I and concentrated solution II mix homogeneously, obtain original liquid; After described potassium sorbate and aspartame being dissolved by a part of purified water, add in described original liquid, then join in described original liquid by remaining purified water, stir 40 minutes, leave standstill after 30 hours and cross leaching filtrate, get product medicinal liquid.
(3) sterilization filling: by the sterilizing 40 minutes at the temperature of 110 DEG C of described finished product medicinal liquid, be cooled to room temperature, fill, pack after lamp inspection.
Embodiment 13
Present invention also offers a kind of method preparing above-mentioned Chinese medicine formula, comprise the following steps:
(1) extract: the ethanol being 70% by described Formica fusca powder service property (quality) mark soaks described Formica fusca powder, and the quality of ethanol is 8 times of described Formica fusca powder quality, and soak time is 120 hours; The ethanol being 70% by Formica fusca powder filtering residue service property (quality) mark after crossing leaching filtrate carries out reflux, extract, and the quality of ethanol is 8 times of described Formica fusca powder filtering residue quality, and reflux, extract, temperature is 74 DEG C, and reflux extracting time is 2 hours; Formica fusca powder alcoholic solution is obtained after the extracting solution mix homogeneously that the filtrate obtained after immersion and reflux, extract, are obtained; Described Formica fusca powder alcoholic solution evaporating solvent is obtained concentrated solution I, described concentrated solution I is 1.05 the relative density of 50 DEG C, again surplus stock is added purified water to decoct, surplus stock is added purified water when decocting, carry out at twice, the quality adding purified water is for the first time 8 times of surplus stock quality, and decocting time is 2 hours, the quality adding purified water is for the second time 6 times of surplus stock quality, and decocting time is 2 hours; After the filtrate mixing obtained twice, evaporating solvent obtains raw material dissolution fluid, described raw material dissolution fluid is 1.15 the relative density of 60 DEG C, obtain the system that ethanol mass fraction is 60%, leave standstill after 24 hours, cross leaching filtrate, obtain ethanol extract, described ethanol extract evaporating solvent is obtained concentrated solution II;
(2) prepare: by described concentrated solution I and concentrated solution II mix homogeneously, obtain original liquid; After described potassium sorbate and aspartame being dissolved by a part of purified water, add in described original liquid, then join in described original liquid by remaining purified water, stir 30 minutes, leave standstill after 24 hours and cross leaching filtrate, get product medicinal liquid.
(3) sterilization filling: by the sterilizing 30 minutes at the temperature of 105 DEG C of described finished product medicinal liquid, be cooled to room temperature, fill, pack after lamp inspection.
Embodiment 14
The present embodiment is the clinical trial to the Chinese medicine formula in the present invention
(1), testing crew physical data
Select various rheumatism, rheumatoid patient 400 example made a definite diagnosis through hospital, wherein: male 200 example, women 200 example; 21 ~ 65 years old age, 46 years old mean age.In 400 routine patients, rheumatoid arthritis patients is 299 people; Whole body rheumatic arthritis patient is 68 people; Depositing the damage of old property is 33 people.
(2), testing crew diagnosis basis
With " Chinese medical disease Standardization of diagnosis and curative effect (ZY/T001.1-94) " for standard, with data such as clinical manifestation, hospital diagnosis conclusion, B ultrasonic reports for foundation, carry out reference, get rid of Other diseases.
(3), test method
Adopt the formula in embodiment 8, the finished product that the method in embodiment 13 is obtained, the dose wherein in embodiment 8 is 1000 parts, daily three parts, morning, noon and afternoon each portion.Take 180 days continuously, if period fully recovers, withdrawal.
(4), result of the test and conclusion
The cure rate for the treatment of rheumatism provided by the invention, rheumatoid Chinese medicine formula treatment calculus is 89.5%, and total effective rate is 99.0%, illustrates that Chinese medicine formula of the present invention all has definite curative effect to treatment rheumatism, rheumatoid.
The present invention is not limited to above-mentioned preferred forms; anyone can draw other various forms of products under enlightenment of the present invention; no matter but any change is done in its shape or structure; every have identical with the application or akin technical scheme, all drops within protection scope of the present invention.
Claims (10)
1. treat rheumatism, a rheumatoid Chinese medicine formula, it is characterized in that, the raw material mainly comprising following mass parts is made: Formica fusca powder 100-700 part, Radix Panacis Quinquefolii 100-380 part, Radix Astragali 200-1000 part, Semen Coicis 200-1000 part.
2. Chinese medicine formula according to claim 1, is characterized in that, the raw material mainly comprising following mass parts is made: Formica fusca powder 300-500 part, Radix Panacis Quinquefolii 200-280 part, Radix Astragali 500-700 part, Semen Coicis 500-700 part.
3. Chinese medicine formula according to claim 1, it is characterized in that, also comprise the raw material of following mass parts: Rhizoma Polygonati 200-1000 part, Radix Paeoniae Alba 100-700 part, wrinkled papaya 200-1000 part, Radix Salviae Miltiorrhizae 50-550 part, Fructus Lycii 400-1200 part, Rhizoma Dioscoreae 400-1200 part, Cortex Cinnamomi 200-1000 part, Fructus Jujubae 200-1000 part.
4. Chinese medicine formula according to claim 3, it is characterized in that, the raw material mainly comprising following mass parts is made: Formica fusca powder 300-500 part, Radix Panacis Quinquefolii 200-280 part, Radix Astragali 500-700 part, Semen Coicis 500-700 part, Rhizoma Polygonati 500-700 part, Radix Paeoniae Alba 300-500 part, wrinkled papaya 500-700 part, Radix Salviae Miltiorrhizae 200-400 part, Fructus Lycii 700-900 part, Rhizoma Dioscoreae 700-900 part, Cortex Cinnamomi 500-700 part, Fructus Jujubae 500-700 part.
5., according to the arbitrary described Chinese medicine formula of claim 1-4, it is characterized in that, also comprise the adjuvant of following mass parts: potassium sorbate 4-8 part, aspartame 2-4 part, purified water 3000-4000 part.
6. a preparation method for Chinese medicine formula according to claim 5, is characterized in that, comprises the following steps:
(1) extract: after described Formica fusca powder being added soak with ethanol, cross leaching filtrate, obtain Formica fusca powder alcoholic solution, described Formica fusca powder alcoholic solution evaporating solvent is obtained concentrated solution I, again surplus stock is added purified water to decoct, cross leaching filtrate and evaporating solvent obtains raw material dissolution fluid, then add people's ethanol to described raw material dissolution fluid, after leaving standstill, cross leaching filtrate, obtain ethanol extract, described ethanol extract evaporating solvent is obtained concentrated solution II;
(2) prepare: by described concentrated solution I and concentrated solution II mix homogeneously, obtain original liquid; After described potassium sorbate and aspartame being dissolved by a part of purified water, add in described original liquid, then join in described original liquid by remaining purified water, stir after leaving standstill and cross leaching filtrate, get product medicinal liquid.
7. preparation method according to claim 6, it is characterized in that, after step (2) preparation, also comprise (3) sterilization filling: by described finished product medicinal liquid sterilizing 20-40 minute at the temperature of 100-110 DEG C, be cooled to room temperature, fill, packs after lamp inspection.
8. preparation method according to claim 6, it is characterized in that, step (1) extract in service property (quality) mark be 70% ethanol described Formica fusca powder is soaked, the quality of ethanol be the 6-10 of described Formica fusca powder quality doubly, soak time is 90-150 hour; The ethanol being 70% by Formica fusca powder filtering residue service property (quality) mark after crossing leaching filtrate carries out reflux, extract, and the quality of ethanol is 6-10 times of described Formica fusca powder filtering residue quality, and reflux, extract, temperature is 70-78 DEG C, and reflux extracting time is 1-3 hour; Formica fusca powder alcoholic solution is obtained after the extracting solution mix homogeneously that the filtrate obtained after immersion and reflux, extract, are obtained; The relative density of described concentrated solution I is 1.04-1.06; Surplus stock is added purified water when decocting, carry out at twice, the quality adding purified water is for the first time 6-10 times of surplus stock quality, and decocting time is 1-3 hour, the quality adding purified water is for the second time 4-8 times of surplus stock quality, and decocting time is 1-3 hour; After the filtrate mixing obtained twice, evaporating solvent obtains raw material dissolution fluid, the relative density of described raw material dissolution fluid is 1.12-1.18, again described raw material dissolution fluid is added people's ethanol, obtain the system that ethanol mass fraction is 50-70%, leave standstill after 18-30 hour, cross leaching filtrate, obtain ethanol extract, described ethanol extract evaporating solvent is obtained concentrated solution II.
9. preparation method according to claim 6, is characterized in that, in step (2) preparation, mixing time is 20-40 minute, and time of repose is 18-30 hour.
10. the application of the arbitrary described Chinese medicine formula of claim 1-4 in preparation treatment rheumatism, antirheumatic, described medicine is medically acceptable any preparation.
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