CN104146201A - Total nutrient formulation food for patients with rheumatoid arthritis - Google Patents
Total nutrient formulation food for patients with rheumatoid arthritis Download PDFInfo
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- CN104146201A CN104146201A CN201410405558.8A CN201410405558A CN104146201A CN 104146201 A CN104146201 A CN 104146201A CN 201410405558 A CN201410405558 A CN 201410405558A CN 104146201 A CN104146201 A CN 104146201A
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- food
- rheumatoid arthritis
- vitamin
- nutrient formulation
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/21—Streptococcus, lactococcus
- A23V2400/249—Thermophilus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
Abstract
The invention provides a total nutrient formulation food, a specific total nutrient formulation food or a non-total nutrient formulation food for patients with rheumatoid arthritis. The formulation is developed by meeting the requirements of 'general rules of special metical-use formulation food', considering the physical characteristics of the patients with rheumatoid arthritis, combining research results of advanced physiology, medicine, nutriology and clinical application of Harvard University recently and according to the essence theory of traditional Chinese medicine of combining elimination and tonification and balancing nutrition (simultaneously conditioning liver, spleen and kidney is a main principle). The total nutrient formulation food is prepared by mixing multiple medicine and food purpose traditional Chinese medicine extract essences, a plurality of probiotics and short peptides as main materials, as well as prebiotics, carbohydrates, amino acids, multiple vitamins and mineral substances as auxiliary materials. The total nutrient formulation food can be used as a single nutrition source to meet the nutrition requirements of the patients with rheumatoid arthritis, and has the efficacies of nourishing blood and tendons, eliminating numbness and relieving pain, dispelling wind, eliminating dampness, warming channel, expelling cold, strengthening spleen and kidney, relieving swelling and pain and boosting immunity.
Description
Technical field
The invention belongs to integration of drinking and medicinal herbs class formula and food technology field, specifically the Traditional Chinese Medicine marrow of " medicine among integration of drinking and medicinal herbs " is theoretical and " multiple probio " combines, and adds to take the full nutrient formulation food of rheumatoid arthritis, specific full nutrient formulation food or the non-full nutrient formulation food that small peptide, prebiotics, amino acid, carbohydrate, B B-complex, composite mineral matter make as auxiliary material.
Background technology
Rheumatoid arthritis (English: Rheumatoid arthritis, be called for short RA), it is a kind of long-term chronic inflammation that is caused immune system attack joint by autoimmunity obstacle, this inflammation can cause dysarthrasis until maimed, and can lose because of joint pain and wearing and tearing the mobility of part, this illness also can affect other abarticular tissues methodically, comprise skin, blood vessel, heart, lung and muscle etc., rheumatoid arthritis (Rheumatoid arthritis, RA) be a kind of general autoimmunity disease that chronic aggressivity arthritis is feature of take, the lesion characteristic of rheumatoid arthritis is synovitis, and the articular cartilage causing thus and destruction of bone, finally cause joint deformity, if without regular treatment, approximately 75% patient occurred maimed in 3 years, the pathogenic factor of rheumatoid arthritis is still not clear, it is generally acknowledged and heredity, environment, the factors such as infection are closely related: 1, inherent cause, risk ill in 1 grade of relatives of rheumatoid arthritis patients is high 1.5 times compared with general population, twin studies result shows, in the various factors relevant to rheumatoid arthritis, inherent cause accounts for 50% ~ 60%, comprise HLA-DR to the rheumatoid arthritis relevant tumor susceptibility gene of falling ill, PADI4 and PTPN22 etc., 2, infective agent, some virus and bacterium infect may be as initiation factor, start the individuality generation immune response of carrying tumor susceptibility gene, and then cause the morbidity of rheumatoid arthritis, comprise Epstein-Barr virus to the rheumatoid arthritis relevant pathogen of falling ill, assays for parvovirus B 19, influenza virus and Much's bacillus etc., 3, sex hormone, rheumatoid arthritis incidence of disease men and women's ratio is 1: 2~4, indicative hormone may participate in morbidity, in addition, Female Patients with Rheumatoid Arthritis state of an illness within period of pregnancy can alleviate, divide the easily recurrence of 1 ~ 3 month puerperium, prompting progesterone level declines or female-progestational hormone is lacked of proper care may be relevant with the morbidity of rheumatoid arthritis, 4, other factors, smoking, cold, injuring the factors such as direct stimulation outward may be relevant with the generation of rheumatoid arthritis, " integration of drinking and medicinal herbs " is to one of contribution of mankind's most worthy among Chinese original medical science, the traditional Chinese medical science always emphasize " medication not as dietotherapy ", dietotherapy become modern pursue recover one's original simplicity, the optimal selection of health diet, allow people dispel slight illness in the process of enjoying cuisines, avoided having an injection, taking medicine, even the hardship of operation.
For food of special nutrients, in developed countries such as the U.S., European Union, there are corresponding regulation and Application and Development; And wholefood is clearly stipulated in China GB29922-2013 < < special medicine purposes formula food general rule > > food security national standard: the full nutrient formulation food of 2.1.1: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need; 2.1.2 specific full nutrient formulation food: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need under specified disease or medical condition.
Traditional Chinese medical science traditional medicine is thought: " spleen (being digestive system) is the foundation of acquired constitution ", stomach health is healthy basis, and 99% of human nutrition need to lean on intestinal absorption, and in intestines, disease is also the source of ten thousand diseases; But along with the age is larger, profitable strain in enteron aisle (probio) ratio reduces gradually; As Bifidobacterium Bifidum accounts for 98% period infant, during to the middle age, be down to and only account for 5% in 10%, 65 years old later; People is older, and probio is fewer, and function of intestinal canal also declines thereupon gradually, more and more studies show that, normal flora has many irreplaceable effects in human body digestion, immunity and the aspect such as disease-resistant; The generation development of change and various diseases, particularly intestines problem that gut flora forms is closely related, and finds from existing clinical research: probio can play regulating intestinal canal flora, controls intestinal inflammatory effect, is a kind of control method of intervening safely and effectively.
The relation of rheumatoid arthritis and gut flora: the experiment of this respect was once done by Third Military Medical University, it collects the early stage RA patient's (RA group) of 30 example and 21 routine health volunteer (control group) fecal samples, cultivates and measures gut flora count level, extract fecal sample genomic DNA, pcr amplification bacterium V6-V8 district 16SrDNA, product is separated through denaturing gradient gel electrophoresis, obtain gut flora DGGE collection of illustrative plates, analyze enteric bacteria richness, Shannon-Wiener index, uniformity index, by the non-weighting class method of average, image is carried out to similitude cluster analysis, and draw cluster arborescence, research RA Intestinal Mucosal Injury in Patients Undergoing flora structure and health volunteer's difference, result Bifidobacterium content: RA group is (6.21 ± 1.48) CFU/ml, significantly lower than control group (8.55 ± 0.90) CFU/ml(P < 0.01), the content of bacteroides fragilis: RA group is (6.54 ± 1.28) CFU/ml, significantly lower than control group (8.73 ± 0.90) CFU/ml(P < 0.01), lactobacillus, clostridium, enterobacteria, enterococcus quantity variance not statistically significant (P > 0.05), gut flora DGGE collection of illustrative plates shows: with control group [richness: (22.8 ± 3.12), Shannon-Wiener index: (2.98 ± 0.26), the uniformity: (0.96 ± 0.05)] compare, RA organizes richness [(16.0 ± 1.05), P < 0.01], Shannon-Wiener index [(2.48 ± 0.14), P < 0.01] and the uniformity [(0.90 ± 0.05), P < 0.01] significantly reduce, the kind (richness) that shows respectively RA Intestinal Mucosal Injury in Patients Undergoing bacterium, flora complex structure degree, the relative density of bacterium (uniformity) significantly reduces, in DGGE collection of illustrative plates lower zone RA Intestinal Mucosal Injury in Patients Undergoing flora band quantity, reduce, disappear obviously, the cluster analysis of collection of illustrative plates similitude shows: it is two classes that 20 routine samples gather, in one class sample, comprise 10 routine patients and 1 routine Healthy People, in two class samples, comprise 9 routine Healthy Peoples, show that RA Intestinal Mucosal Injury in Patients Undergoing flora has higher similitude, RA and Healthy People gut flora similitude are low, there is flora imbalance in the early stage RA Intestinal Mucosal Injury in Patients Undergoing of conclusion, there were significant differences for enteric bacteria quantity and structure and Healthy People, its the change of divergence may be one of pathogenic factors of rheumatoid arthritis.
Though directly probiotic oral has certain effect, but because probio one cannot field planting in enteron aisle, and stop, occupy-place are seldom, easily run off, and withdraw rear harmful bacteria and easily recur, and associated patient needs long-term taking, and treatment cycle is long, often uses rear recurrence rate very high, for shortening the treatment cycle of associated patient, recurrence rate after minimizing drug withdrawal, this team is by studying the key technology of probio field planting mechanism in enteron aisle over nearly 3 year, make great efforts to seek to improve " medicine among integration of drinking and medicinal herbs " compound of probio field planting in enteron aisle, consider several key elements of probio field planting in enteron aisle: the existence of prebiotics can be played field planting effect, the enteron aisle adhesive capacity of the reduction of enteron aisle pH environment and raising probiotic cell etc., based on above-mentioned key element, suitable food materials screen from tens of kinds " medicines among integration of drinking and medicinal herbs " in this seminar, found first interpolation Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, the extract of the traditional Chinese medicine ingredients of the integration of drinking and medicinal herbs such as Gorgon fruit and jerusalem artichoke and stachyose, yeast, after Glu etc., external source probio is had to very strong field planting effect, for the prescription of probio in enteral microecological formulation selects to provide experimental basis.
Favourable is in the market primary raw material in order to eat source property small peptide, add the mushroom of medicine-food two-purpose, dried orange peel, matrimony vine, Chinese yam, Poria cocos, the extract of sealwort etc., B B-complex and mineral matter form compound prescription, utilize in addition the product that probio is primary raw material, but also do not find the constitutive character in conjunction with rheumatoid arthritis patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility is with the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, amino acid, multivitamin, several mineral materials is the full nutrient formulation food that auxiliary material is made, specific full nutrient formulation food or similar products.
goal of the invention
The object of the invention is inheriting on the theoretical treatment method of traditional Chinese medical science marrow, the initiative extract by the probio of multiple raising rheumatoid arthritis patients immunity and " medicine among integration of drinking and medicinal herbs " compound combines, interpolation is with small peptide, amino acid, carbohydrate, multivitamin, several mineral materials is auxiliary material, not only can supplement the rheumatoid arthritis patients institute essential nutrients of hypoimmunity, improve body nutrition condition, can also and utilize the function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function, probio can play regulating intestinal canal flora, toxic and side effect is little, safe and effective, and the full nutrient formulation food that the acceptable applicable rheumatoid arthritis patients of people is edible, specific full nutrient formulation food or non-full nutrient formulation food.
summary of the invention:
This R&D team is according to the requirement of < < special medicine purposes formula food general rule > >, in conjunction with the constitutive character of rheumatoid arthritis patients, the advanced physiology of comprehensive nowadays American Harvard University, medicine, the achievement in research such as nutrition and clinical practice, according to " the middle residence that disappears is mended ", theoretical (the liver of marrow of the Traditional Chinese Medicine of " equilibrium is taken good care of ", spleen, the dirty same main principle that is adjusted to of kidney three), adopt the Chinese medical extract elite of a kind of above medicine-food two-purpose, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, amino acid, multivitamin and mineral matter auxiliary material, not only can be used as the nutritional need that single source of nutrition meets rheumatoid arthritis patients, also has blood-nourishing myospasm relaxing, except numbness pain relieving, dispel rheumatism, warming channel and expelling cold, spleen-invigorating and kidney-strengthening, the full nutrient formulation food of the effect of swelling and pain relieving and enhancing immunity, specific full nutrient formulation food or non-full nutrient formulation food (compound prescription being combined into).
The main component of the present invention's formula is:
Chinese medical extract is that the liver,spleen,kidney from theory of traditional Chinese medical science three is dirty with being adjusted to main principle according to the constitutive character of rheumatoid arthritis patients, utilize the function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function to build up resistance, and choose following several large class medicine and carry out compatibility, wherein: Cordyceps sinensis main active is cordycepin, it has adjusting function of immune system, antitumor, antifatigue, invigorate the lung and the kidney, hemostasis and phlegm, the multiple efficacies such as secret lean gas, luffa taste is sweet, cool in nature, clearing and activating the channels and collaterals, clearing heat and detoxicating, inducing diuresis to reduce edema, hemostasis, the distinctive target antirheumatic factor in the formic acid of silky ant, dispels rheumatism, anti-inflammatory and antalgic, to rheumatism, rheumatoid arthritis, redness and swelling of joints, dysarthrasis, muscular atrophy has special efficacy, rhizoma cibotii wines used as antirheumatic, and filling liver kidney, strong waist knee, safflower has promoting blood circulation and removing blood stasis, and loose wetting gone swollen effect, when attribution, enriches blood and invigorates blood circulation, swelling and pain relieving, the effect of apocenosis myogenic, therefore can be used for traumatic injury, the cards such as ulcer sores, cortex acanthopanacis activating blood circulation and reducing swelling, controls rheumatic arthritis, eczema of scrotum, traumatic injury, oedema, difficult urination, windproof expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolysis, antipruritic, cure mainly and catch cold, headache bodily pain, arthralgia due to wind-dampness, joint is ached, stomachache is had loose bowels, discharging fresh blood stool, lockjaw, rubella itch, the bark of eucommia tonifies the liver and kidney, strengthen muscles and bones, coordinating Chong and Conception Vessels, Gu through antiabortive, Ligusticum wallichii is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, Psoralea corylifolia has tonifying kidney and strengthening yang, the function of tonifying spleen stomach invigorating,
Medicinal and edible Chinese medicine extract of the present invention refers to Cordyceps sinensis (aweto mycelium), lucidum spore powder (broken wall), long-nosed pit viper, luffa, silky ant, rhizoma cibotii, safflower, Radix Angelicae Sinensis, cortex acanthopanacis, windproof, the Radix Astragali, the bark of eucommia, Ligusticum wallichii, Psoralea corylifolia, Cordyceps militaris, zaocys dhumnade, the root of Dahurain angelica, Radix et Rhizoma Gynurae divaricatae, peach kernel, Poria cocos, pawpaw, Radix Glycyrrhizae, Chinese cassia tree, ginseng, sea-buckthorn, raspberry
Wherein a kind is above or whole, adopts biological enzymolysis or prehydrolysis SBE to extract and microencapsulation, the mixture after spray-dried and cryodesiccated extract.
2, multiple probio: make probio arrive enteron aisle by most of strong acid environment by stomach, to promote the propagation of probio, regulate microecological balance in intestines, promotion is to micro-absorption, strengthen taste motor function, accelerate the absorption of drug effect, improve the micropopulation of mucous membrane surface or the balance of enzyme, or stimulate body specificity or nonspecific immunity mechanism, improve body field planting drag or immunity; Xing etc., with Bifidobacterium and Bacillus acidi lactici pretreatment law during ischemia/reperfusion rat, can obviously reduce the level of intestinal endotoxemia the generation of preventing liver injury; It is also the important measures of adjusting intestinal microecology that selective enteron aisle decontamination is dyed, and has research application enteron aisle not absorb rifamycin antibiotic former times bright (rifaximin), by suppressing urease-producing in enteron aisle and producing the growth of ammonium bacteria, builds up resistance;
Multiple probio of the present invention all adopts the probio after microencapsulation, except streptococcus thermophilus, Bifidobacterium wherein: refer to that bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum are wherein a kind of, several or all mix; Lactobacillus refers to: lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus be a kind of, several or all mixing wherein.
3, small peptide: be oligopeptide, refer to the small molecule protein that utilizes bio-enzyme engineering technology separation and Extraction from animal or vegetable protein, its mean molecule quantity is below 1000Dalton, soluble in water, to acid, thermally-stabilised, can not need through digestion and directly absorb, bioavailability is high, in absorption and utilization, be better than free amino acid and complete protein, can be applicable in Protein intake food, especially for the low crowd of abilities of digestive and absorption, small peptide is splendid nitrogenous source, except trophic function, small peptide also has a series of physiological active functions: the digestion and absorption function that improves small intestine, strengthen immunity of organisms, anti-oxidant, auxiliary adjustment blood sugar, auxiliary adjustment of blood fat, aided blood pressure-lowering, radioresistance, promote mineral absorption, strengthen the action effect of function factor in medicine-food two-purpose Chinese herbal medicine,
Small peptide of the present invention refers to wherein a kind of, several or all mixing of maize oligopeptide, wheat oligopeptide, marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide.
4, prebiotics: to urge the field planting of probio enteron aisle, enteron aisle convergence, to reduce enteron aisle pH environment, by most enteron aisle spoilage organisms, do not utilized yet, but can promote beneficial bacteria---the growth and breeding of lactobacillus, Bifidobacterium in human body, thereby can suppress spoilage organisms growth, contribute to improve and maintain enteron aisle normal function; Long-term edible can delay senility, defaecation, raising immunity, alleviate burden of liver, improve the absorptivity of nutrient, particularly can improve the absorption of body to metal ions such as calcium, iron, zinc; Optionally promote outside the growth and breeding of beneficial bacterium (bifid, lactic acid), also can metabolism be acid product as organic acids such as lactic acid, pH value in colon is reduced, the growth of inhibition harmful intestinal tract bacterium; Make Water-Electrolyte in small intestine be trapped in enteric cavity, produce the high effect of oozing, stimulate enterocinesia to cause laxative, thereby promote the discharge of intestinal endotoxin and other toxicants, lactulose also directly endotoxin in deactivation enteron aisle, reduce enteron aisle pH value, extensively model is applied to strengthen the treatment of rheumatoid arthritis resistance;
Prebiotics of the present invention is 2 classes
A. external source probio is had to very strong field planting effect prebiotics: several or all mixing wherein of the extract of Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, jerusalem artichoke, stachyose, yeast;
B. common prebiotics: wherein a kind of, several of oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide or all mix;
Originally refer to a kind of, several or all mixing wherein of oligoisomaltose, stachyose, FOS, soyabean oligosaccharides, xylo-oligosaccharide.
5, carbohydrate: carbohydrate is by carbon, three kinds of elements of hydrogen and oxygen form, it be for human body provide three kinds of heat energy main nutrient in the most cheap nutrient, while taking in abundance, can be oxidized rapidly energy is provided in time in vivo, avoid valuable protein to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the important composition composition of the glycolipid of nerve fiber and the DNA conveying hereditary information (DNA), and the glycogen containing in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin of some poisonous chemical substance and the generation of various pathogenic microorganisms,
Carbohydrate of the present invention refers to a kind of, several or all mixing wherein of Arabinose, glucose, fructose, galactolipin, lactose, maltose, water-soluble dietary fiber, starch, glycogen.
6. amino acid: being divided into essential amino acid and nonessential amino acid, is the base unit that forms protein, gives protein specific molecular morphosis, makes it have biochemical activity; Absorbing appropriate methionine contributes to the metabolism of various sulfur-containing compounds in human body and its contained methyl to methylate to Toxic or medicine and the effect of playing removing toxic substances; Leucine can be repaired muscle, controls blood sugar, and provides energy to bodily tissue, essential amino acid phenylalanine can suppress the growth of cancer knurl, can reduce again the toxic and side effect of medicine, and lysine can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development; Arginine contributes to the ammonia in blood change urea into and excrete out; For hyperammonemia, liver dysfunction etc. are all powerful; Histidine reduces gastric acidity, relaxes the pain of gastrointestinal procedures, alleviates gestational period vomiting and scorching hot sense, suppresses alimentary canal nervous by vegetative nerve and that cause and festers, to anaphylactia, as also powerful in asthma etc.; Tryptophan can prevent pellagra, depression, improves sleep and regulates mood;
Amino acid of the present invention refers to a kind of, several or all mixing wherein of Glu, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine.
7. vitamin and mineral matter:
Vitamin and mineral matter are the nutrients of needed by human, and the vitamin adding in the present invention is that vitamin and mineral matter are the nutrients of needed by human;
The vitamin adding in the present invention is a kind of, several or all mixing wherein of vitamin A, vitamin D, vitamin E, vitamin K, phytomenadione, vitamin C, vitamin B1, vitamin B2, pyridoxamine, cobalamin, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin;
The mineral matter adding in the present invention is a kind of, several or all mixing wherein of calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum, and mineral matter of the present invention is added to the organic or inorganic compound of this mineral matter;
In the present invention, the addition of vitamin and minerals is used sanitary standard > > with reference to GB14880 < < food enrichment, GB2760 < < food additives are used standard > > to carry out, and now take 1000g finished product as example, and addition is vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, phytomenadione 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, pyridoxamine 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g.
8. the present invention is dried and freeze drying integrated innovation with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, efficiently solves high temperature and the deactivation of strong acid gastric juice to probio in oral process; Adopt three layers of buried microcapsules technology of protein, mix with the Chinese medical extract after biological enzymolysis or the extraction of prehydrolysis SBE technology microencapsulation processing again, to solve the coexistence problems of " multiple probio " and " medicine among integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and by gastric juice, arrive in enteron aisle and stop field planting smoothly by oral, make the effect of product control rheumatoid arthritis compare significantly raising with market like product.
9. adopt above-mentioned integrated innovation technique various batchings to be mixed to solid beverage, the granule of making powdery, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding; Also can add appropriate attached material to make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if making beverage saves spray-dried, add less auxiliary material etc., be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day was respectively drunk 1 bottle, and all operations all carries out in the clean dried environment that meets the good production standard of < < special medicine purposes formula food > > requirement.
The characteristic of this full nutrient formulation food of filling a prescription and the effect of body is mainly manifested in to the following aspects:
1. the present invention is according to the requirement of < < special medicine purposes formula food general rule > >, constitutive character in conjunction with rheumatoid arthritis patients, the achievement in research developments such as advanced physiology, medicine, nutrition and clinical practice of comprehensive nowadays American Harvard University, vary with each individual, gold compatibility.
2. the present invention is according to the marrow of the Traditional Chinese Medicine of " the middle residence that disappears is mended ", " equilibrium is taken good care of " theoretical (liver,spleen,kidney three is dirty with being adjusted to main principle), adopting the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio, small peptide is primary raw material, take prebiotics, carbohydrate, amino acid, multivitamin and mineral matter as auxiliary material, the organic assembling of various batchings, various functions are merged, and by the synergy between active ingredient, humidification effect.
3. have efficient absorption, utilize formula of the present invention, various components adopt the food of suitable ratio collocation preparation, the state that oozes such as after a certain amount of water-soluble solution, be, can by stomach, arrive small intestine fast, absorption fast, completely, can supplement rapidly rheumatoid arthritis person desired nutritional.
4. in the present invention's formula, adopt the extract of various medicine-food two-purpose Chinese herbal medicines, contain several functions active component, not only improved the concentration of function factor, reduce the absorption of various impurity, contribute to alleviate liver kidney burden, there is the effect that strengthens resistance of human body, also have blood-nourishing myospasm relaxing, remove numbness pain relieving, dispel rheumatism, warming channel and expelling cold, spleen-invigorating and kidney-strengthening, swelling and pain relieving and enhancing efficacy of immunity.
5. contained probio in the present invention formula, multiple probio can be safeguarded enteron aisle normal bacteria colony balance, suppress the growth of pathogen, prevent gastrointestinal disorders etc., synthetic vitamin in enteron aisle, amino acid and the absorption of raising body to calcium ion, strengthen human immunologic function, prevent antibiotic side effect, improve the tolerance of host to radioactive ray, lactobacillus significantly increases intestinal mucosa immunoglobulin A (SIgA) content, body intestinal mucosa local immunity is had to regulating action, regulate stomach, the micro-ecology of intestines, can improve calcium, phosphorus, the utilization rate of iron, promote the absorption of iron and vitamin D, produce vitamin K and Cobastab, can also reduce the absorption of cholesterol.
6. to take the food source inhibition biological active small peptide in multiple source be nitrogenous source to formula food of the present invention, because small peptide does not need digestion to absorb, more be conducive to the utilization of body, the person's negative nitrogen balance of can effectively improving rheumatoid arthritis, and food source property small peptide can improve the 26S Proteasome Structure and Function of intestinal epithelial cell, the absorbability of raising intestinal mucosa.
7. this prescription adopts Liao Ben team by the achievement to the key technology research of probio field planting mechanism in enteron aisle over nearly 3 year, improve " medicine among integration of drinking and medicinal herbs " compound of probio field planting in enteron aisle, the existence that combines prebiotics can be played the reduction of field planting effect, enteron aisle pH environment and the key elements such as enteron aisle adhesive capacity of raising probiotic cell, so the composition of this food formula has strengthened the field planting effect to external source probio greatly.
8. contained prebiotics in the present invention formula; by promoting the growth and breeding of probio in intestines; suppress the growth of spoilage organisms; on intestinal mucosa surface, form one protective barrier simultaneously; can resist the damage of enteron aisle spoilage organisms to intestinal mucosa; reduce the absorption of intestinal toxic material; can also promote intestines peristalsis; accelerate the discharge of residuals in intestines; can prevent constipation; and by promoting the growth and breeding of beneficial bacteria of intestinal tract also can strengthen immunity of organisms, the bioactivators such as small peptide, carbohydrate and active polysaccharide have synergy.
9, in the present invention formula contained carbohydrate be for human body provide three kinds of heat energy main nutrient, can be oxidized rapidly energy is provided in time in vivo, avoid valuable protein to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the important composition composition of the glycolipid of nerve fiber and the DNA (DNA) that conveys hereditary information, and the glycogen containing in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin of some poisonous chemical substance and the generation of various pathogenic microorganisms.
10, contained amino acid in the present invention's formula, it is the base unit that forms protein, give protein specific molecular morphosis, make it have biochemical activity, contribute to the metabolism of various sulfur-containing compounds in human body and its contained methyl to methylate to Toxic or medicine and play the effect of removing toxic substances, can repair muscle, control blood sugar, and provide energy to bodily tissue, also can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development.
11, formula food of the present invention containing multivitamin and mineral matter, can supplement rapidly the required micronutrient of rheumatoid arthritis person, small peptide by the chelating with calcium, iron, zinc etc. after, more increased the absorptivity of mineral matter element.
12, not fatty and cholesterol in the present invention's formula can not increase the absorption of fat, cholesterol in supplementary protein, micronutrient, has avoided the adverse effect of the high protein diets such as meat, egg.
The specific embodiment
Below by following examples, the invention will be further described, and it will contribute to understand the present invention.
Embodiment mono-
Realizing the full nutrient formulation food of the object of the invention rheumatoid arthritis is with the constitutive character in conjunction with rheumatoid arthritis patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, it is primary raw material that gold compatibility be take Chinese medical extract elite, multiple probio, the small peptide of a kind of above medicine-food two-purpose, take the food that prebiotics, carbohydrate, amino acid, multivitamin, several mineral materials make as auxiliary material;
By following raw materials according and consumption thereof, fill a prescription: the extract of medicine-food two-purpose: Cordyceps sinensis (aweto mycelium) 12g, lucidum spore powder (broken wall) 12g, long-nosed pit viper 12g, luffa 12g, silky ant 10g, rhizoma cibotii 10g, safflower 10g, Radix Angelicae Sinensis 10g, cortex acanthopanacis 8g, windproof 8g, Radix Astragali 8g, bark of eucommia 8g, Ligusticum wallichii 8g, Psoralea corylifolia 8g, Cordyceps militaris 8g, zaocys dhumnade 6g, root of Dahurain angelica 6g, Radix et Rhizoma Gynurae divaricatae 6g, peach kernel 6g, Poria cocos 6g, pawpaw 6g, Radix Glycyrrhizae 4g, Chinese cassia tree 4g, ginseng 4g, sea-buckthorn 4g, raspberry 4g, Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, phytomenadione 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, pyridoxamine 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,
First will be to be long-nosed pit viper during making, luffa, silky ant, rhizoma cibotii, safflower, Radix Angelicae Sinensis, cortex acanthopanacis, windproof, the Radix Astragali, the bark of eucommia, Ligusticum wallichii, Psoralea corylifolia, zaocys dhumnade, the root of Dahurain angelica, Radix et Rhizoma Gynurae divaricatae, Poria cocos, Radix Glycyrrhizae, Chinese cassia tree, ginseng, sea-buckthorn, raspberry, the membrane of a chicken's gizzard, Chinese yam, heart of a lotus seed benevolence, Gorgon fruit adds cycloheptaamylose after soaking, after extracting by prehydrolysis SBE technology, spray-dried and preparation flour, add again the small peptide that biological enzymolysis extracts, prebiotics, amino acid, Cordyceps sinensis (aweto mycelium), lucidum spore powder (broken wall), Cordyceps militaris, peach kernel, pawpaw, carbohydrate, after being pulverized and mixed together, multivitamin and mineral matter carry out pasteurization 1 hour, then add the Bifidobacterium after microencapsulation, lactobacillus, streptococcus thermophilus also mixes the solid beverage of making powdery, granule, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding, also can add appropriate attached material to make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if making beverage saves spray-dried, add less auxiliary material etc., be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day was respectively drunk 1 bottle, and all operations all carries out in the clean dried environment that meets the good production standard of < < special medicine purposes formula food > > requirement.
Embodiment bis-
The full nutrient formulation food of above-mentioned rheumatoid arthritis also comprises following component by weight: the extract of medicine-food two-purpose: Cordyceps militaris 20g, zaocys dhumnade 20g, root of Dahurain angelica 20g, Radix et Rhizoma Gynurae divaricatae 18g, peach kernel 18g, Poria cocos 18g, pawpaw 16g, Radix Glycyrrhizae 16g, Chinese cassia tree 14g, ginseng 14g, sea-buckthorn 14g, raspberry 12g, Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, phytomenadione 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, pyridoxamine 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g.
Embodiment tri-
The full nutrient formulation food of above-mentioned rheumatoid arthritis also comprises following component by weight: the extract of medicine-food two-purpose: Cordyceps militaris 20g, zaocys dhumnade 20g, root of Dahurain angelica 20g, Radix et Rhizoma Gynurae divaricatae 18g, peach kernel 18g, Poria cocos 18g, pawpaw 16g, Radix Glycyrrhizae 16g, Chinese cassia tree 14g, ginseng 14g, sea-buckthorn 14g, raspberry 12g, Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, small peptide 200g, amino acid/11 50g, prebiotics 100g, multiple kinds of carbohydrate 100g.
The present invention is dried and freeze drying integrated innovation with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, efficiently solves high temperature and the deactivation of strong acid gastric juice to probio in oral process; Adopt three layers of buried microcapsules technology of protein, mix with the Chinese medical extract after biological enzymolysis or the extraction of prehydrolysis SBE technology microencapsulation processing again, to solve the coexistence problems of " multiple probio " and " medicine among integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and by gastric juice, arrive in enteron aisle and stop field planting smoothly by oral, make the effect of product control rheumatoid arthritis compare significantly raising with market like product.
Claims (9)
1. the full nutrient formulation food of rheumatoid arthritis, it is characterized in that with the constitutive character in conjunction with rheumatoid arthritis patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, it is primary raw material that gold compatibility be take Chinese medical extract elite, multiple probio, the small peptide of a kind of above medicine-food two-purpose, take the food that prebiotics, carbohydrate, amino acid, multivitamin, several mineral materials make as auxiliary material;
By following raw materials according and consumption thereof, fill a prescription: the extract of medicine-food two-purpose: Cordyceps sinensis (aweto mycelium) 12g, lucidum spore powder (broken wall) 12g, long-nosed pit viper 12g, luffa 12g, silky ant 10g, rhizoma cibotii 10g, safflower 10g, Radix Angelicae Sinensis 10g, cortex acanthopanacis 8g, windproof 8g, Radix Astragali 8g, bark of eucommia 8g, Ligusticum wallichii 8g, Psoralea corylifolia 8g, Cordyceps militaris 8g, zaocys dhumnade 6g, root of Dahurain angelica 6g, Radix et Rhizoma Gynurae divaricatae 6g, peach kernel 6g, Poria cocos 6g, pawpaw 6g, Radix Glycyrrhizae 4g, Chinese cassia tree 4g, ginseng 4g, sea-buckthorn 4g, raspberry 4g, Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, phytomenadione 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, pyridoxamine 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,
Its preparation method is for first will be to be long-nosed pit viper, luffa, silky ant, rhizoma cibotii, safflower, Radix Angelicae Sinensis, cortex acanthopanacis, windproof, the Radix Astragali, the bark of eucommia, Ligusticum wallichii, Psoralea corylifolia, zaocys dhumnade, the root of Dahurain angelica, Radix et Rhizoma Gynurae divaricatae, Poria cocos, Radix Glycyrrhizae, Chinese cassia tree, ginseng, sea-buckthorn, raspberry, the membrane of a chicken's gizzard, Chinese yam, heart of a lotus seed benevolence, after soaking, Gorgon fruit adds cycloheptaamylose, after extracting by prehydrolysis SBE technology, and the spray-dried and flour of preparation, then add the small peptide that biological enzymolysis extracts, prebiotics, amino acid, Cordyceps sinensis (aweto mycelium), lucidum spore powder (broken wall), Cordyceps militaris, peach kernel, pawpaw, carbohydrate, multivitamin and mineral matter carry out pasteurization 1 hour after mixing, and then add the Bifidobacterium after microencapsulation, lactobacillus, the various batchings that streptococcus thermophilus also adds appropriate carbohydrate mixing again mix the solid beverage of making powdery, granule, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding, also can add appropriate attached material to make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if making beverage saves spray-dried, add less auxiliary material etc., be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day was respectively drunk 1 bottle, and all operations all carries out in the clean dried environment that meets the good production standard of < < special medicine purposes formula food > > requirement.
2. the full nutrient formulation food formula of rheumatoid arthritis according to claim 1, is characterized in that described medicine-food two-purpose Chinese herbal medicine extract is: wherein a kind of Cordyceps sinensis (aweto mycelium), lucidum spore powder (broken wall), long-nosed pit viper, luffa, silky ant, rhizoma cibotii, safflower, Radix Angelicae Sinensis, cortex acanthopanacis, windproof, the Radix Astragali, the bark of eucommia, Ligusticum wallichii, Psoralea corylifolia, Cordyceps militaris, zaocys dhumnade, the root of Dahurain angelica, Radix et Rhizoma Gynurae divaricatae, peach kernel, Poria cocos, pawpaw, Radix Glycyrrhizae, Chinese cassia tree, ginseng, sea-buckthorn, raspberry is above or all mix.
3. the full nutrient formulation food formula of rheumatoid arthritis according to claim 1, is characterised in that according to described formula and mixes and can be prepared into powdery, graininess, capsule shape, tablet shape, beverage based food.
4. the full nutrient formulation food formula of rheumatoid arthritis according to claim 1, is characterized in that described prebiotics is. to external source probio, to have very strong field planting effect prebiotics be wherein several of extract, stachyose, yeast and common prebiotics of Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, jerusalem artichoke or all mix.
5. require the full nutrient formulation food formula of rheumatoid arthritis described in 1, it is characterized in that described amino acid is a kind of, several or all mixing wherein of Glu, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine.
6. the full nutrient formulation food formula of rheumatoid arthritis according to claim 1, is characterized in that described carbohydrate is a kind of, several or all mixing wherein of Arabinose, glucose, fructose, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen.
7. the full nutrient formulation food formula of rheumatoid arthritis according to claim 1, is characterized in that being dried and freeze drying integrated innovation with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying the key technology that the industrialization of formation is produced; Microencapsulation resist technology, efficiently solves high temperature and the deactivation of strong acid gastric juice to probio in oral process; Adopt three layers of buried microcapsules technology of protein, mix with the Chinese medical extract after biological enzymolysis or the extraction of prehydrolysis SBE technology microencapsulation processing again, to solve the coexistence problems of " multiple probio " and " medicine among integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and by gastric juice, arrive in enteron aisle and stop field planting smoothly by oral, product control rheumatoid arthritis effect is compared with market like product significantly and improved.
8. the full nutrient formulation food formula of rheumatoid arthritis according to claim 1, is characterized in that described vitamin is a kind of, several or all mixing wherein of vitamin A, vitamin D, vitamin E, vitamin K, phytomenadione, vitamin C, vitamin B1, vitamin B2, pyridoxamine, cobalamin, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin; Described mineral matter is a kind of, several or all mixing wherein of calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum.
9. the full nutrient formulation food formula of rheumatoid arthritis according to claim 1, is characterized in that described small peptide is wherein a kind of, several or all mixing of marine collagen peptide, maize oligopeptide, wheat oligopeptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide.
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CN105031407A (en) * | 2015-08-27 | 2015-11-11 | 北京新世纪达康生物科技开发有限责任公司 | Traditional Chinese medicine formula for treating rheumatism and rheumatoid, preparation method and application of traditional Chinese medicine formula |
CN110432483A (en) * | 2019-07-05 | 2019-11-12 | 上海奥医高科技实业有限公司 | A kind of rheumatoid arthritis tailored version clinical nutrition formula and preparation method thereof |
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CN103637214A (en) * | 2013-11-01 | 2014-03-19 | 胡安然 | Edible special meal for patients with deficiency of both qi and yin |
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JP4906254B2 (en) * | 2004-09-08 | 2012-03-28 | 三生医薬株式会社 | Buckwheat extract-containing solid composition |
CN103637214A (en) * | 2013-11-01 | 2014-03-19 | 胡安然 | Edible special meal for patients with deficiency of both qi and yin |
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