CN105017368B - 人参二醇衍生物及其制备方法与应用 - Google Patents
人参二醇衍生物及其制备方法与应用 Download PDFInfo
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- CN105017368B CN105017368B CN201510363498.2A CN201510363498A CN105017368B CN 105017368 B CN105017368 B CN 105017368B CN 201510363498 A CN201510363498 A CN 201510363498A CN 105017368 B CN105017368 B CN 105017368B
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- formula
- pananxadiol
- derivatives
- panoxadiol
- carbonyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/20—Preparation of steroids containing heterocyclic rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Position | 化合物Ⅰ | 化合物Ⅱ | 化合物Ⅲ | 化合物Ⅳ | 化合物Ⅴ | 化合物Ⅵ |
1 | 39.3 | 39.3 | 39.8 | 39.8 | 38.9 | 38.5 |
2 | 33.9 | 33.9 | 34.1 | 34.1 | 33.9 | 34.0 |
3 | 217.2 | 217.3 | 217.8 | 217.7 | 217.0 | 217.0 |
4 | 45.2 | 45.2 | 47.3 | 47.3 | 47.0 | 47.0 |
5 | 52.7 | 52.7 | 55.0 | 55.0 | 53.1 | 52.8 |
6 | 29.4 | 29.4 | 19.6 | 19.6 | 29.5 | 29.7 |
7 | 74.3 | 74.3 | 34.9 | 34.9 | 74.6 | 74.6 |
8 | 47.0 | 47.0 | 40.2 | 40.2 | 43.7 | 40.8 |
9 | 50.0 | 50.0 | 49.2 | 49.3 | 49.0 | 53.3 |
10 | 36.6 | 36.6 | 36.8 | 36.8 | 36.8 | 36.7 |
11 | 30.7 | 30.7 | 30.8 | 30.8 | 31.8 | 30.8 |
12 | 69.4 | 69.4 | 69.4 | 69.4 | 67.8 | 72.2 |
13 | 48.7 | 48.7 | 47.5 | 47.4 | 52.3 | 46.5 |
14 | 50.9 | 50.9 | 51.9 | 51.9 | 56.8 | 40.7 |
15 | 34.4 | 34.4 | 72.9 | 72.9 | 129.4 | 19.4 |
16 | 25.5 | 25.8 | 35.0 | 25.1 | 144.8 | 31.5 |
17 | 53.3 | 53.3 | 52.0 | 52.0 | 59.2 | 51.0 |
18 | 9.5 | 9.5 | 15.4 | 15.4 | 13.6 | 15.5 |
19 | 15.9 | 15.9 | 16.1 | 16.1 | 15.5 | 15.3 |
20 | 75.7 | 76.7 | 76.0 | 76.1 | 75.3 | 75.9 |
21 | 19.8 | 19.2 | 20.0 | 19.3 | 20.9 | 19.7 |
22 | 28.7 | 36.4 | 28.6 | 36.3 | 36.9 | 36.2 |
23 | 23.2 | 25.2 | 23.1 | 25.1 | 25.2 | 25.3 |
24 | 69.6 | 74.6 | 69.5 | 74.6 | 74.8 | 74.7 |
25 | 76.9 | 77.2 | 76.5 | 77.2 | 77.2 | 77.2 |
26 | 27.3 | 29.6 | 27.1 | 29.5 | 29.5 | 29.7 |
27 | 27.4 | 21.2 | 27.3 | 21.1 | 21.0 | 21.3 |
28 | 26.8 | 26.8 | 26.7 | 26.6 | 26.7 | 26.7 |
29 | 21.0 | 21.0 | 21.0 | 21.0 | 21.1 | 21.1 |
30 | 16.8 | 16.8 | 10.0 | 10.0 | 15.5 | 6.99 |
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510363498.2A CN105017368B (zh) | 2015-06-26 | 2015-06-26 | 人参二醇衍生物及其制备方法与应用 |
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CN201510363498.2A CN105017368B (zh) | 2015-06-26 | 2015-06-26 | 人参二醇衍生物及其制备方法与应用 |
Publications (2)
Publication Number | Publication Date |
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CN105017368A CN105017368A (zh) | 2015-11-04 |
CN105017368B true CN105017368B (zh) | 2016-09-28 |
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CN201510363498.2A Active CN105017368B (zh) | 2015-06-26 | 2015-06-26 | 人参二醇衍生物及其制备方法与应用 |
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Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105367619A (zh) * | 2015-11-13 | 2016-03-02 | 昆明医科大学 | 3-去氧-3-氨基-人参二醇及其制备方法和应用 |
CN105949265B (zh) * | 2016-05-19 | 2017-11-17 | 南通大学 | 20(r)‑人参三醇衍生物的制备方法与应用 |
CN105853444B (zh) * | 2016-05-19 | 2019-04-19 | 南通大学 | 20(r)-人参三醇衍生物在制备预防或治疗肝病药物中的应用 |
CN109988217B (zh) * | 2019-03-18 | 2021-07-13 | 南通大学 | 白桦醇衍生物及其制备方法与应用 |
CN111471018A (zh) * | 2020-04-01 | 2020-07-31 | 南通华山药业有限公司 | 一种替米沙坦衍生物及其制备方法与应用 |
CN112057499A (zh) * | 2020-08-20 | 2020-12-11 | 武汉自在生物科技有限公司 | 一种抗肿瘤药物的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ME02488B (me) * | 2010-04-27 | 2017-02-20 | Pharma Mar Sa | Antikancerski steroidni laktoni nezasićeni na poziciji 7(8) |
CN102766184B (zh) * | 2012-08-01 | 2014-08-13 | 南通大学 | 原人参二醇过氧化衍生物及其制备方法与应用 |
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2015
- 2015-06-26 CN CN201510363498.2A patent/CN105017368B/zh active Active
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Effective date of registration: 20200323 Address after: 226019 Jiangsu city of Nantong province sik Road No. 9 Patentee after: Center for technology transfer, Nantong University Address before: 226019 Jiangsu city of Nantong province sik Road No. 9 Patentee before: NANTONG University |
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Application publication date: 20151104 Assignee: Nantong Pharmaceutical Co.,Ltd. Assignor: Center for technology transfer, Nantong University Contract record no.: X2021980016783 Denomination of invention: Panaxadiol derivative and its preparation method and Application Granted publication date: 20160928 License type: Common License Record date: 20211229 |
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Effective date of registration: 20220613 Address after: 518057, No. 18, hi tech Zone, Nanshan District hi tech Zone, Shenzhen, Guangdong, China Patentee after: Shenzhen Sun Biological Technology Stock Co.,Ltd. Address before: 226019 Jiangsu city of Nantong province sik Road No. 9 Patentee before: Center for technology transfer, Nantong University |
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