CN105949265B - 20(r)‑人参三醇衍生物的制备方法与应用 - Google Patents
20(r)‑人参三醇衍生物的制备方法与应用 Download PDFInfo
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- CN105949265B CN105949265B CN201610335371.4A CN201610335371A CN105949265B CN 105949265 B CN105949265 B CN 105949265B CN 201610335371 A CN201610335371 A CN 201610335371A CN 105949265 B CN105949265 B CN 105949265B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/12—Acting on D ring
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/20—Preparation of steroids containing heterocyclic rings
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- Chemical Kinetics & Catalysis (AREA)
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- General Chemical & Material Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Position | 式I | 式II | 式III | 式IV | 式Ⅴ | 式VI | 式VII | 式VIII | 式IX | 式X | 式XI | 式XII |
1 | 41.1 | 23.8 | 40.7 | 41.1 | 30.9 | 41.4 | 41.3 | 41.0 | 43.5 | 41.5 | 74.1 | 36.3 |
2 | 33.6 | 35.4 | 33.6 | 30.8 | 33.9 | 39.9 | 33.7 | 33.8 | 33.9 | 31.2 | 42.4 | 33.4 |
3 | 214.4 | 214.9 | 213.6 | 214.4 | 214.3 | 214.4 | 214.5 | 214.2 | 214.4 | 214.4 | 212.9 | 214.0 |
4 | 47.0 | 47.0 | 46.9 | 46.9 | 47.0 | 46.9 | 46.9 | 46.8 | 46.9 | 52.1 | 52.6 | 51.9 |
5 | 65.3 | 65.5 | 64.9 | 65.2 | 65.6 | 65.1 | 65.3 | 65.2 | 65.6 | 65.3 | 58.1 | 84.9 |
6 | 210.7 | 211.0 | 209.9 | 210.8 | 210.6 | 211.0 | 210.9 | 210.3 | 210.7 | 210.6 | 212.2 | 213.4 |
7 | 52.3 | 52.4 | 39.8 | 52.4 | 52.3 | 53.3 | 50.1 | 51.5 | 52.4 | 50.0 | 53.0 | 47.3 |
8 | 51.0 | 50.2 | 42.9 | 46.2 | 46.1 | 46.3 | 47.4 | 45.0 | 48.5 | 52.4 | 46.8 | 76.9 |
9 | 49.8 | 49.7 | 53.7 | 49.7 | 49.2 | 49.9 | 50.4 | 49.8 | 49.6 | 50.6 | 40.7 | 41.5 |
10 | 43.5 | 43.4 | 77.2 | 43.4 | 43.3 | 43.1 | 43.2 | 42.8 | 45.3 | 43.3 | 45.5 | 45.9 |
11 | 31.1 | 41.2 | 51.9 | 33.8 | 41.2 | 30.8 | 30.5 | 30.8 | 30.8 | 28.0 | 42.5 | 30.7 |
12 | 69.3 | 69.2 | 209.8 | 68.8 | 69.3 | 68.9 | 69.7 | 67.7 | 68.6 | 70.0 | 68.8 | 69.1 |
13 | 48.9 | 54.6 | 55.8 | 54.4 | 49.7 | 51.6 | 45.5 | 47.4 | 46.7 | 44.7 | 47.1 | 47.2 |
14 | 46.0 | 46.2 | 54.9 | 51.1 | 51.1 | 47.1 | 53.6 | 58.2 | 45.8 | 54.5 | 51.9 | 77.2 |
15 | 30.9 | 31.1 | 31.9 | 30.8 | 30.8 | 72.4 | 78.8 | 216.3 | 43.6 | 78.5 | 72.6 | 72.4 |
16 | 25.1 | 30.9 | 24.2 | 25.9 | 25.0 | 35.4 | 39.3 | 40.2 | 71.6 | 40.3 | 30.6 | 34.6 |
17 | 54.3 | 49.4 | 45.9 | 48.6 | 54.3 | 52.5 | 54.9 | 50.0 | 58.2 | 52.4 | 52.5 | 52.5 |
18 | 16.4 | 16.3 | 16.3 | 15.8 | 15.7 | 27.1 | 18.8 | 13.3 | 24.2 | 18.5 | 21.5 | 15.9 |
19 | 15.7 | 16.4 | 15.8 | 16.4 | 16.3 | 16.6 | 16.6 | 16.2 | 16.4 | 16.9 | 19.5 | 32.8 |
20 | 76.9 | 79.8 | 75.1 | 77.9 | 77.7 | 76.0 | 76.4 | 75.6 | 76.8 | 77.5 | 76.1 | 75.8 |
21 | 19.2 | 15.5 | 29.2 | 23.7 | 21.7 | 15.9 | 19.4 | 18.7 | 23.3 | 26.5 | 19.4 | 19.5 |
22 | 25.1 | 74.3 | 40.5 | 44.0 | 50.9 | 34.9 | 35.5 | 35.7 | 34.8 | 33.9 | 35.5 | 35.6 |
23 | 36.4 | 33.8 | 65.0 | 63.5 | 206.9 | 16.1 | 16.1 | 16.0 | 16.1 | 16.2 | 17.1 | 16.2 |
24 | 74.8 | 26.7 | 42.6 | 43.5 | 51.5 | 36.3 | 36.2 | 36.2 | 36.4 | 36.3 | 36.4 | 34.8 |
25 | 76.6 | 73.2 | 71.2 | 74.1 | 80.1 | 73.4 | 73.4 | 73.8 | 73.1 | 74.5 | 73.5 | 73.4 |
26 | 21.2 | 15.9 | 31.2 | 31.9 | 32.2 | 32.9 | 27.3 | 33.0 | 33.4 | 32.5 | 26.9 | 27.0 |
27 | 29.6 | 26.9 | 32.4 | 31.2 | 29.9 | 19.6 | 33.0 | 27.2 | 27.9 | 28.1 | 32.9 | 18.2 |
28 | 21.6 | 24.3 | 21.5 | 24.2 | 24.2 | 21.7 | 24.1 | 24.2 | 21.6 | 24.1 | 23.8 | 23.9 |
29 | 24.2 | 21.2 | 24.2 | 21.7 | 21.5 | 24.1 | 21.7 | 21.6 | 16.5 | 21.6 | 21.5 | 10.0 |
30 | 17.1 | 17.7 | 17.1 | 17.3 | 17.2 | 10.4 | 17.6 | 18.8 | 19.2 | 18.9 | 10.4 | 10.2 |
Claims (4)
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CN201610335371.4A CN105949265B (zh) | 2016-05-19 | 2016-05-19 | 20(r)‑人参三醇衍生物的制备方法与应用 |
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CN105949265A CN105949265A (zh) | 2016-09-21 |
CN105949265B true CN105949265B (zh) | 2017-11-17 |
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Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109988217B (zh) * | 2019-03-18 | 2021-07-13 | 南通大学 | 白桦醇衍生物及其制备方法与应用 |
CN109985044B (zh) * | 2019-03-18 | 2021-06-29 | 南通大学 | 白桦醇及其衍生物在制备抗肿瘤药物中的应用 |
CN111116698B (zh) * | 2020-01-07 | 2021-03-02 | 北京大学 | 达玛烷型三萜化合物及制备和应用 |
CN111471018A (zh) * | 2020-04-01 | 2020-07-31 | 南通华山药业有限公司 | 一种替米沙坦衍生物及其制备方法与应用 |
CN112898371B (zh) * | 2021-03-20 | 2022-03-29 | 延边大学 | 一类人参三醇类化合物及其制备方法和医用用途 |
CN113134006B (zh) * | 2021-04-19 | 2021-11-30 | 南通大学 | 熊果酸衍生物在制备抗肿瘤药物中的应用 |
Citations (1)
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CN105017368A (zh) * | 2015-06-26 | 2015-11-04 | 南通大学 | 人参二醇衍生物及其制备方法与应用 |
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