CN104997874A - Traditional Chinese medicine for treating pheochromocytoma - Google Patents
Traditional Chinese medicine for treating pheochromocytoma Download PDFInfo
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- CN104997874A CN104997874A CN201510511225.8A CN201510511225A CN104997874A CN 104997874 A CN104997874 A CN 104997874A CN 201510511225 A CN201510511225 A CN 201510511225A CN 104997874 A CN104997874 A CN 104997874A
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Abstract
The invention relates to a traditional Chinese medicine for treating pheochromocytoma. The traditional Chinese medicine is prepared from the crude drugs in parts by weight: 1 part of lithargyrum, 15 parts of stephania longa, 10 parts of potentilla fulgens, 15 parts of herb of canton salomonia, 15 parts of fructus liquidambaris, 12 parts of aechmanthera tomentosa, and 3 parts of aconitum nagarum Stapf. Clinical experiments prove that the traditional Chinese medicine can be used for safely and effectively treating pheochromocytoma.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine being used for the treatment of pheochromocytoma.
Background technology
Pheochromocytoma is risen in the chromaffin tissue at adrenal medulla, sympathetic ganglion, other sympathetic ganglion and other positions.Be that a rarer secondary hypertension is sick, clinically present paroxysmal or persistence hypertension, headache, perspiration, cardiopalmus and metabolism disorder disease group.The early stage diagnosis and treatment of primary disease can be cured.Account for less than 0.1% of hypertension.Any age all can be ill, in the majority with 20-40 year.
The traditional Chinese medical science is thought, and " person of fainting, inverse also QI rising in reverse order is then random, therefore sometimes faint due to vertigo is absolutely de-, is by name fainting." therefore imbalance of YIN and YANG, qi-movement disturbance is the understanding of the traditional Chinese medical science to primary disease occurrence cause.Primary disease is the card of deficiency of the liver and kindey or hyperactivity of fire caused by deficiency of YIN at stable phase main manifestations.Kidney storing essence is the congenital foundation, and about kidney each one, here attached the gate of vitality is, built-in nephroyin and nephroyang, is the residence of negative and positive, the mansion of extreme misery.Kidney essense should be stung and hidden and should not reveal, if natural endowment is frail, and overstrain, prolonged illness is lost foster, or exhaustion due to sexual indulgence does not save, kidney-jing deficiency all can be caused to consume, and damage of kidney-YIN, shows as back aching and limp, tiredly becomes thin, hectic fever hyperhidrosis, dysphoria with feverish sensation in the chest palms and soles, cardiopalmus is had palpitation, even distension related to the heart headache, and blurred vision is anxious etc.And once by direct stimulation, or the impact of Body Position Change, or tumor is squeezed, touches, and symptom increases the weight of suddenly, green around the gills, whole body hyperhidrosis, extreme cold of the limbs.
Medical material present Research involved in the present invention is as follows:
Lithargyrum's [another name] Lithargyrum, do not have at the bottom of many monks, furnace bottom, Yin Chi, light silver, golden furnace bottom, silver stove, golden Lithargyrum, sweet Lithargyrum.[source] is crude oxidation lead.[nature and flavor] sweet in the mouth is flat, nontoxic.[return through] enters liver, spleen channel.[function cures mainly] detumescence parasite killing, restrains anticorrosion, eliminating phlegm down to arrest convulsion.Control hemorrhoid, toxic swelling, ulcer, eczema, bromhidrosis, wound, chronic dysentery, infantile convulsion.[usage and dosage] takes orally: decoct soup, 0.5 ~ 1g.[attention] body void person avoids clothes.[extracts] " China's book on Chinese herbal medicine ".
Herba Stephaniae Longae [another name] Ha Soft-Fleece grass, Rana nigromaculata careless, Lei Portland mouth, dustpan grass, flying apsaras Thunder God, mouldboard rattan, iron plate plaster grass.The herb that [source] is menispermaceous plants Herba Stephaniae Longae or rhizome and root.The whole year can adopt.Generally how to extract rattan leaf in the fall or to grub out and get, wash away silt particle, removing radicula, dries or using fresh herb.[nature and flavor] taste raw meat, property is put down.Hardship, cold.[return through] returns liver; Gallbladder; Large intestine channel.[function cures mainly] heat-clearing and toxic substances removing, dampness removing relieving constipation, the skin ulcer that disappears swells.Control calentura to go mad, jaundice, gastroenteritis, dysentery, constipation, hematuria, sore and toxic.[usage and dosage] takes orally: decoct soup, 3 ~ 9g.[attention] deficiency of YIN cough caused by dryness and chronic cough deficiency of vital energy person should not take.[extracts] " China's book on Chinese herbal medicine ".
Folium potentillae velutinae (Radix Potentillae Fulgentis) [another name] little Herba potentillae fulgentis, land for building wind, little reddish black.[source] is the root of rosaceous plant velutinous cinquefoil.Spring, autumn, winter excavate, and clean, section is dried.[nature and flavor] puckery micro-hardship, flat.[return through] returns spleen, stomach, large intestine channel.[function cures mainly] dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm.Stop in stagnant, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest; Gastroptosis, proctoptosis, uterine prolapse.[usage and dosage] takes orally: decoct soup, 10 ~ 15g.[attention] anemia of pregnant woman is cautious use of.[extracts] " China's book on Chinese herbal medicine ".
Herba Salomoniae Cantoniensis [another name] blows soul grass, Gong Ercao, one bowl of bubble, river wind, the Serpentis that passes by one's way, little greasy medicine, thin xanthate.[source] is the herb of milk wort tooth fruit grass, gathers and stores: herb of gathering in summer, autumn, cleans, using fresh herb or dry.[nature and flavor] taste is micro-pungent; Property is put down.[return through] enters the heart; Liver Channel.[function cures mainly] removing toxic substances and promoting subsidence of swelling; Eliminating stasis to stop pain.Main carbuncle skin infection; Innominate toxic swelling; Sore throat; Venom; Traumatic injury; Rheumatic arthritis; Toothache.[usage and dosage] takes orally: decoct soup, 3 ~ 10g.[attention] carbuncle has been burst and should not have been taken, and variola insufficiency of primordial QI can not play originator, should not take.[extracts] " China's book on Chinese herbal medicine ".
Ball, sweetgum fruit, maple fruit, Nie Zi, wolf order, maple ball, wolves' eyes, maple ball, nine gaps in Fructus Liquidambaris [another name] maple reality, maple.[source] this product is the drying and ripening infructescence of Hamamelidaceae Plants Chinese sweet gum.Winter gathers after fruit maturation, removing impurity, dry.[nature and flavor] are bitter, flat.[return through] returns liver, kidney channel.[function cures mainly] dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.[usage and dosage] takes orally: decoct soup, 5 ~ 9g.[attention] all menorrhagia and contraindication in pregnancy.[extracts] " China's book on Chinese herbal medicine ".
Point medicine flower [another name] Pericarpium Arecae leaf, bluet.[source] medical material Ji Yuan: be the herb of acanthaceous plant point medicine flower.Gather and store: summer, autumn gather, clean, cutting is dried or using fresh herb.[nature and flavor] sweet in the mouth; Property is put down.[function cures mainly] QI invigorating tonify deficiency; Promoting blood circulation and detumescence; Removing toxic substances.Main body deadhead is swooned; Traumatic injury; Fracture; Aphtha of the mouth and tongue; Venom.[usage and dosage] takes orally: decoct soup, 9 ~ 15g.[extracts] " China's book on Chinese herbal medicine ".
Spread and send out [another name] Baoshan Radix Aconiti Lateralis Preparata, little black cattle, Radix Aconiti Kusnezoffii, Water Aconitum carmichaeli Debx., mountain Aconitum carmichjaelii Debx..[source] medical material Ji Yuan: be the tuber of ranunculaceae plant Baoshan Aconitum carmichjaelii Debx..Gather and store: autumn, winter excavate tuber, cleaning, dry.[nature and flavor] acrid in the mouth; Bitter; Hot in nature; [return through] Liver Channel.[function cures mainly] expelling wind and dampness; Removing obstruction in the collateral to relieve pain.Main anemofrigid-damp arthralgia; Headache.[usage and dosage] takes orally: decoct soup, 1.5 ~ 3g.[extracts] " China's book on Chinese herbal medicine ".
Summary of the invention
The present invention aims to provide a kind of Chinese medicine being used for the treatment of pheochromocytoma, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing pheochromocytoma.
In order to achieve the above object, the present invention is by the following technical solutions:
Be used for the treatment of a Chinese medicine for pheochromocytoma, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Lithargyrum 1 part, Herba Stephaniae Longae 15 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 10 parts, Herba Salomoniae Cantoniensis 15 parts, Fructus Liquidambaris 15 parts, sharp medicine are spent 12 parts, spread and send out 3 parts.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Outpatient service is collected and Patients With Pheochromocytoma 70 example of being in hospital altogether in inventor in October, 2012 ~ 2013 between year October, be divided into treatment group 35 example and matched group 35 example at random, treatment group man 17 example, female 18 example, 37 years old mean age; Matched group man 19 example, female 16 example, 35.81 years old mean age.2 groups of sexes, age and course of disease comparing difference not statistically significants, have comparability.
Diagnostic criteria
Diagnostic criteria according to the meeting of national pheochromocytoma clinical speciality:
(1), be mostly ictal hypertension, also can be lasting associated or high and low blood pressure alternately outbreak.Having headache, Nausea and vomiting, pale complexion, tachycardia, cold sweat etc. during outbreak, can there is the heart, cerebrovas-cularaccident in serious attack.Course of disease elder can have arteriosclerosis, catecholamine cardiomyopathy and impaired renal function.
(2), twenty-four-hour urine catecholamine and metabolite thereof such as VMA, metanephrine (MN), methoxy norepinephrine (NMN) and plasma Catecholamine Content raise, catecholamine qualitative positive during outbreak.
(3), phentolamine drop test and the blood pressure stage of stable development glicentin provocative test positive during hypertensive episode.
(4), localization examination such as adrenal gland's B ultrasound whole body CT examination can find adrenal gland or the outer tumor of gland.Get rid of the hypertension of other reason.
2, test method
2.1 Therapeutic Method
After treatment group tumor resection, the capsule that oral the present invention obtains according to specific embodiment 3, every day 3 times.One month course for the treatment of.
After matched group tumor resection, oral phenoxybenzamine, 10 ~ 20mg, 2 times/d; Prazosin, 1 ~ 2mg, 2 times/d; Metoprolol (metoprolol), 50mg, 2 ~ 3 times/d.One month course for the treatment of.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Cure: blood pressure recovers normal; Various clinical manifestation disappears; Blood, polyamines determination and metabolite VMA, NMN, MN content thereof recover normal.
Effective: blood, polyamines determination and metabolite content thereof recovery or close normal; But hypertension is recovered not yet completely, arteriosclerosis and the heart, renal damage do not recover completely; Clinical symptoms need be improved with medicine.
Invalid: sign, lab testing are without improvement.
3.2 therapeutic outcomes are in table 1.
Table 1 liang group comparitive study
Visible, the medicine that the present invention obtains can safe and effective treatment pheochromocytoma, has promotional value.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take: Lithargyrum 1 gram, Herba Stephaniae Longae 15 grams, Folium potentillae velutinae (Radix Potentillae Fulgentis) 10 grams, Herba Salomoniae Cantoniensis 15 grams, Fructus Liquidambaris 15 grams, sharp medicine are spent 12 grams, spread and send out 3 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of pheochromocytoma.Oral, every bu Morning Afternoon Evening is taken for three times.
Embodiment 2
Take: Lithargyrum 1 gram, Herba Stephaniae Longae 15 grams, Folium potentillae velutinae (Radix Potentillae Fulgentis) 10 grams, Herba Salomoniae Cantoniensis 15 grams, Fructus Liquidambaris 15 grams, sharp medicine are spent 12 grams, spread and send out 3 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of pheochromocytoma.Oral, every bu Morning Afternoon Evening is taken for three times.
Embodiment 3
Take: Lithargyrum 1 gram, Herba Stephaniae Longae 15 grams, Folium potentillae velutinae (Radix Potentillae Fulgentis) 10 grams, Herba Salomoniae Cantoniensis 15 grams, Fructus Liquidambaris 15 grams, sharp medicine are spent 12 grams, spread and send out 3 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of pheochromocytoma.Oral, every bu Morning Afternoon Evening is taken for three times.
Claims (4)
1. one kind is used for the treatment of the Chinese medicine of pheochromocytoma, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Lithargyrum 1 part, Herba Stephaniae Longae 15 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 10 parts, Herba Salomoniae Cantoniensis 15 parts, Fructus Liquidambaris 15 parts, sharp medicine are spent 12 parts, spread and send out 3 parts.
2. a kind of Chinese medicine being used for the treatment of pheochromocytoma as claimed in claim 1, it is characterized in that, its preparation method is: take: Lithargyrum 1 part, Herba Stephaniae Longae 15 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 10 parts, Herba Salomoniae Cantoniensis 15 parts, Fructus Liquidambaris 15 parts, sharp medicine are spent 12 parts, spread and send out 3 parts; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
3. a kind of Chinese medicine being used for the treatment of pheochromocytoma as claimed in claim 1, it is characterized in that, its preparation method is: take: Lithargyrum 1 part, Herba Stephaniae Longae 15 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 10 parts, Herba Salomoniae Cantoniensis 15 parts, Fructus Liquidambaris 15 parts, sharp medicine are spent 12 parts, spread and send out 3 parts; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
4. a kind of Chinese medicine being used for the treatment of pheochromocytoma as claimed in claim 1, it is characterized in that, its preparation method is: take: Lithargyrum 1 part, Herba Stephaniae Longae 15 parts, Folium potentillae velutinae (Radix Potentillae Fulgentis) 10 parts, Herba Salomoniae Cantoniensis 15 parts, Fructus Liquidambaris 15 parts, sharp medicine are spent 12 parts, spread and send out 3 parts; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.
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| CN201510511225.8A CN104997874A (en) | 2015-08-19 | 2015-08-19 | Traditional Chinese medicine for treating pheochromocytoma |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769927A (en) * | 2016-03-17 | 2016-07-20 | 南京多宝生物科技有限公司 | Venenum Bufonis extraction method and Venenum Bufonis product |
| CN108815265A (en) * | 2018-09-21 | 2018-11-16 | 福建省医学科学研究院 | A kind of compound Chinese medicinal preparation and preparation method thereof preventing and treating pheochromocytoma |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102988577A (en) * | 2012-10-15 | 2013-03-27 | 李正梅 | Preparation method and application of brain-soothing hypertension pill |
| CN103816368A (en) * | 2014-03-12 | 2014-05-28 | 李正梅 | Extraction method and application of ginseng-containing plant composition |
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2015
- 2015-08-19 CN CN201510511225.8A patent/CN104997874A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988577A (en) * | 2012-10-15 | 2013-03-27 | 李正梅 | Preparation method and application of brain-soothing hypertension pill |
| CN103816368A (en) * | 2014-03-12 | 2014-05-28 | 李正梅 | Extraction method and application of ginseng-containing plant composition |
Non-Patent Citations (1)
| Title |
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| 蔡永敏等: "《现代中西医临床内分泌病学》", 30 November 2001 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769927A (en) * | 2016-03-17 | 2016-07-20 | 南京多宝生物科技有限公司 | Venenum Bufonis extraction method and Venenum Bufonis product |
| CN108815265A (en) * | 2018-09-21 | 2018-11-16 | 福建省医学科学研究院 | A kind of compound Chinese medicinal preparation and preparation method thereof preventing and treating pheochromocytoma |
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Application publication date: 20151028 |