CN108815265A - A kind of compound Chinese medicinal preparation and preparation method thereof preventing and treating pheochromocytoma - Google Patents

A kind of compound Chinese medicinal preparation and preparation method thereof preventing and treating pheochromocytoma Download PDF

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Publication number
CN108815265A
CN108815265A CN201811107418.7A CN201811107418A CN108815265A CN 108815265 A CN108815265 A CN 108815265A CN 201811107418 A CN201811107418 A CN 201811107418A CN 108815265 A CN108815265 A CN 108815265A
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parts
preparation
chinese medicinal
pheochromocytoma
compound chinese
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刘洪旭
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FUJIAN ACADEMY OF MEDICAL SCIENCES
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FUJIAN ACADEMY OF MEDICAL SCIENCES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/68—Plantaginaceae (Plantain Family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/748—Oldenlandia or Hedyotis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention belongs to technical field of traditional Chinese medicine preparation, and in particular to a kind of compound Chinese medicinal preparation and preparation method thereof for preventing and treating pheochromocytoma.Its raw material includes by weight：10 ~ 12 parts of radix tetrastigme, 10-20 parts of garden radish leaf, 8-15 parts of oldenlandia diffusa, 4-6 parts of endothelium corneum gigeriae galli, 5-9 parts of Asiatic plantain, 8-10 parts of dewdrop grass, 4-9 parts of Mao Xu Cao, 4-9 parts of radix rubi parvifol, 20-30 parts of pueraria lobata, 10-15 parts of oriental wormwood, 5-8 parts of Siraitia grosvenorii.The present invention is with clearly defined objective, and monarch's assistant is clearly demarcated, is methodically arranged, both symptoms and root causes, effect is comprehensive, effective；By selecting suitable medicinal material and its proportion, achieve the purpose that safely and effectively to prevent and treat pheochromocytoma.

Description

A kind of compound Chinese medicinal preparation and preparation method thereof preventing and treating pheochromocytoma
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, and in particular to it is a kind of prevent and treat pheochromocytoma compound Chinese medicinal preparation and Preparation method.
Background technique
Pheochromocytoma（Pheochromocytoma, PHEO) it is initiated by the neuroendocrine tumor of chromaffin tissue.By It can be located at outside the adrenal gland such as abdominal aorta side in the tumour of neural crest origin, therefore extra-adrenal pheochromocytoma is known as secondary mind again Through Gangliocytoma（Paraganglioma, PGL）, most pheochromocytomas are located at the adrenal gland of side, but can also be located at double Side adrenal gland or extra-adrenal sympathetic ganglion.Pheochromocytoma can continue or discontinuously release catecholamine acts on kidney Adrenergic receptor causes duration or paroxysmal hypertension companioned with headache, hidrosis, palpitaition triad shape, while can be with anxiety, body Mitigate again, To Be Protected from Heat, shakes, pale complexion, thorax abdomen pain, Nausea and vomiting, orthostatic hypotension, constipation, transience electrocardiogram Change the performance with sympathetic activations such as hyperglycemias, multiple organ dysfunctions and metabolic disorder can be caused, also there are some patientss Performance is slightly even without clinical symptoms.Chinese medicine thinks that " person of fainting, inverse, the circulation of vital energy in the wrong direction is then random, therefore sometimes dizzy fall forward takes off absolutely, is entitled It faints." therefore imbalance of yin and yang, qi-movement disturbance is understanding of the Chinese medicine to this disease occurrence cause.This disease is mainly shown as liver kidney in stationary phase Insufficient or fire excess from yin deficiency card.Kidney storing essence, be the congenital foundation, kidney or so each one, the gate of vitality it is attached here, built-in nephroyin and nephroyang, be yin-yang Residence, the mansion of extreme misery.Kidney essense, which is preferably stung, hides and should not reveal, if natural endowment is frail, overstrain or prolonged illness dystrophy or sexual strain are not saved, All can lead to kidney-jing deficiency consumption, damage of kidney-YIN shows as that back is aching and limp, and tired syntexis, hectic fever hidrosis is dysphoria in chestpalms-soles, and palpitaition is nervous, Even distention related to the heart headache, blurred vision are anxious etc..And once by direct stimulation or Body Position Change influence or tumour by It squeezes, touch, symptom aggravates suddenly, pale, whole body hidrosis, peripheral coldness.
Summary of the invention
The purpose of the present invention is to provide a kind of compound Chinese medicinal preparations and preparation method thereof for preventing and treating pheochromocytoma.
To achieve the above object, the present invention adopts the following technical scheme that：
A kind of compound Chinese medicinal preparation preventing and treating pheochromocytoma, raw material include by weight：10 ~ 20 parts of radix tetrastigme, 10-20 parts of garden radish leaf, 8-15 parts of oldenlandia diffusa, 4-6 parts of endothelium corneum gigeriae galli, 5-9 parts of Asiatic plantain, 8-10 parts of dewdrop grass, Mao Xu Cao 4-9 Part, 4-9 parts of radix rubi parvifol, 20-30 parts of pueraria lobata, 10-15 parts of oriental wormwood, 5-8 parts of Siraitia grosvenorii.
The preparation method of the compound Chinese medicinal preparation, specially：
（1）Compound composition：Each raw material is weighed according to above-mentioned formula rate；
（2）According to the above ratio plus the water of 2-3 times of quality, it decocts to the 30-40% of volume.
Instructions of taking：Twice a day.
Radix tetrastigme have clearing heat and detoxicating, promoting blood circulation and stopping pain, dispelling pathogenic wind and eliminating phlegm effect, modern research suggests that its tool it is antitumor, antiviral, Adjust the definite pharmacological action such as immune.
Cymose buckwheat rhizome, clearing heat and detoxicating, the carbuncle that disappears of invigorating blood circulation have anticancer and promote immunity function.Cymose buckwheat rhizome root element to adenocarcinoma of lung, Cervical squamous cell carcinoma, nasopharyngeal squamous cell carcinoma inhibitory rate of cell growth are most strong, and film RNA, DNA of cancer cell can be made to be metabolized nuclear fission and be damaged, right Gastric adenocarcinoma cells also have obvious inhibiting effect.It has been reported and claims under environment in vitro, Rhizoma Fagopyri Dibotryis extract, which has, inhibits liver cancer thin The growth of tumour cell in the Various Tissues sources such as born of the same parents' strain HepG2, lung cancer cell line H460, colon cancer cell line HCT116.
Garden radish leaf contains-interferon inducers (dsRNA), is a kind of active material of anti-tumor virus.Experiment card Bright, this substance has significant inhibiting effect to cells such as the cancer of the esophagus of people, gastric cancer, nasopharyngeal carcinoma, cervix cancers.
Endothelium corneum gigeriae galli is sweet in flavor, mild-natured, cures mainly reinforcing spleen to promote digestion；Arresting seminal emission；Eliminating mass fossil.Main indigestion；Eating accumulation；It vomits Spit gastric disorder causing nausea；Diarrhea diarrhea；Infantile malnutrition；Spermatorrhea；The enuresis；Frequent urination；Stone in urinary system and gall stone；Abdominal mass menostasis；Sore throat Acute tonsillitis；Noma aphtha.
Asiatic plantain：Reducing fever and causing diuresis, eliminating the phlegm, cool blood, removing toxic substances.For edema and little urine, puckery pain of heat gonorrhea, summer-heat and damp dysentery, phlegm heat-syndrome cough It coughs, hematemesis and epistaxis, carbuncle sore tumefacting virus.
Oriental wormwood：Meridian distribution of property and flavor：It is slightly cold；It is bitter；Returns spleen, stomach, liver, gallbladder channel, major function：Clearing away damp-heat, removing jaundice subcutaneous ulcer.For jaundice Oliguria, itchy sore；Infectious jaundice type hepatitis.
Remarkable advantage of the invention is：
The present invention is with clearly defined objective, and monarch's assistant is clearly demarcated, is methodically arranged, both symptoms and root causes, effect is comprehensive, effective；It is suitable by selecting Medicinal material and its proportion, achieve the purpose that safely and effectively to prevent and treat pheochromocytoma.
Specific embodiment
Further to disclose rather than the present invention is limited, the present invention is described in further detail below in conjunction with example.
Embodiment 1
A kind of compound Chinese medicinal preparation preventing and treating pheochromocytoma, raw material include by weight：10 parts of radix tetrastigme, radish 10 parts of leaf, 8 parts of oldenlandia diffusa, 4 parts of endothelium corneum gigeriae galli, 5 parts of Asiatic plantain, 8 parts of dewdrop grass, 4 parts of Mao Xu Cao, 4 parts of radix rubi parvifol, pueraria lobata 20 Part, 10 parts of oriental wormwood, 5 parts of Siraitia grosvenorii.
The preparation method of the compound Chinese medicinal preparation, specially：
（1）Compound composition：Each raw material is weighed according to above-mentioned formula rate；
（2）According to the above ratio plus the water of 2 times of quality, it decocts to the 30% of volume.
Instructions of taking：Twice a day.
Embodiment 2
A kind of compound Chinese medicinal preparation preventing and treating pheochromocytoma, raw material include by weight：15 parts of radix tetrastigme, radish 15 parts of leaf, 10 parts of oldenlandia diffusa, 5 parts of endothelium corneum gigeriae galli, 7 parts of Asiatic plantain, 9 parts of dewdrop grass, 5 parts of Mao Xu Cao, 5 parts of radix rubi parvifol, pueraria lobata 25 parts, 12 parts of oriental wormwood, 7 parts of Siraitia grosvenorii.
The preparation method of the compound Chinese medicinal preparation, specially：
（1）Compound composition：Each raw material is weighed according to above-mentioned formula rate；
（2）According to the above ratio plus the water of 3 times of quality, it decocts to the 40% of volume.
Instructions of taking：Twice a day.
Embodiment 3
A kind of compound Chinese medicinal preparation preventing and treating pheochromocytoma, raw material include by weight：20 parts of radix tetrastigme, radish 20 parts of leaf, 15 parts of oldenlandia diffusa, 6 parts of endothelium corneum gigeriae galli, 9 parts of Asiatic plantain, 10 parts of dewdrop grass, 9 parts of Mao Xu Cao, 9 parts of radix rubi parvifol, pueraria lobata 30 parts, 15 parts of oriental wormwood, 8 parts of Siraitia grosvenorii.
The preparation method of the compound Chinese medicinal preparation, specially：
（1）Compound composition：Each raw material is weighed according to above-mentioned formula rate；
（2）According to the above ratio plus the water of 2 times of quality, it decocts to the 40% of volume.
Instructions of taking：Twice a day.
The foregoing is merely presently preferred embodiments of the present invention, all equivalent changes done according to scope of the present invention patent with Modification, is all covered by the present invention.

Claims (3)

1. a kind of compound Chinese medicinal preparation for preventing and treating pheochromocytoma, it is characterised in that：Raw material includes by weight：Radix tetrastigme 10 ~ 20 parts, 10-20 parts of garden radish leaf, 8-15 parts of oldenlandia diffusa, 4-6 parts of endothelium corneum gigeriae galli, 5-9 parts of Asiatic plantain, 8-10 parts of dewdrop grass, cat 4-9 parts of moss, 4-9 parts of radix rubi parvifol, 20-30 parts of pueraria lobata, 10-15 parts of oriental wormwood, 5-8 parts of Siraitia grosvenorii.
2. a kind of compound Chinese medicinal preparation for preventing and treating pheochromocytoma according to claim 1, it is characterised in that：Its raw material is pressed Parts by weight meter includes：15 parts of radix tetrastigme, 15 parts of garden radish leaf, 10 parts of oldenlandia diffusa, 5 parts of endothelium corneum gigeriae galli, 7 parts of Asiatic plantain, dewdrop grass 9 Part, 5 parts of Mao Xu Cao, 5 parts of radix rubi parvifol, 25 parts of pueraria lobata, 12 parts of oriental wormwood, 7 parts of Siraitia grosvenorii.
3. a kind of method for preparing compound Chinese medicinal preparation as described in claim 1, specially：
（1）Compound composition：Each raw material is weighed according to above-mentioned formula rate；
（2）According to the above ratio plus the water of 2-3 times of quality, it decocts to the 30-40% of volume.
CN201811107418.7A 2018-09-21 2018-09-21 A kind of compound Chinese medicinal preparation and preparation method thereof preventing and treating pheochromocytoma Pending CN108815265A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104997874A (en) * 2015-08-19 2015-10-28 陆茹姣 Traditional Chinese medicine for treating pheochromocytoma

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104997874A (en) * 2015-08-19 2015-10-28 陆茹姣 Traditional Chinese medicine for treating pheochromocytoma

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FARRUGIA FA ET AL.: "Pheochromocytoma, diagnosis and treatment: Review of the literature", 《ENDOCRINE REGULATIONS》 *

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Application publication date: 20181116

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