CN104983772B - Blue lotus oral solution and preparation method thereof for animal warm heat disease initial stage - Google Patents
Blue lotus oral solution and preparation method thereof for animal warm heat disease initial stage Download PDFInfo
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- CN104983772B CN104983772B CN201510327121.1A CN201510327121A CN104983772B CN 104983772 B CN104983772 B CN 104983772B CN 201510327121 A CN201510327121 A CN 201510327121A CN 104983772 B CN104983772 B CN 104983772B
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Abstract
The present invention relates to a kind of blue lotus oral solutions for animal warm heat disease initial stage, are made of the raw material of following parts by weight：0.8~1.2 part of Herba Andrographitis, 0.8~1.2 part of folium isatidis, 1.6~2.4 parts of Radix Isatidis.The invention further relates to the preparation methods of the indigo plant lotus oral solution, 75% ethyl alcohol, 40 DEG C of temperature extractions are carried out to Herba Andrographitis to take 2 times, purified water is first used to impregnate to folium isatidis and Radix Isatidis, water decoction-alcohol sedimentation extraction, it is efficient to the extraction of blue lotus oral solution, complete, simplify prescription, reduce production cost, and make the finite elements such as Herba Andrographitis, Radix Isatidis, folium isatidis to greatest extent while be utilized.
Description
Technical field
The invention belongs to field of traditional Chinese veterinary, and in particular to a kind of indigo plant lotus oral solution and preparation method thereof, which has
The function of preventing, treating animal warm heat disease, the daily maintenence particularly for pig or chicken are treated.
Background technology
Chinese herbal medicine is rich in diversified nutritional ingredient, and bioactive substance is also very abundant, is provided simultaneously with nutrition and medicine
The double effects of object, not only preventable disease, but also illness can be treated, while having that natural, toxic side effect is small, is not likely to produce drug resistance
And the features such as medicament residue, it can be not only used for individual and cure the disease, and can be used for group's prevention, adapt to intensive, scale
The needs of raising, and the Times ' Demand for meeting nuisanceless animal husbandry, producing safe animal products.Traditional Chinese medicine oral liquid includes not only original
Have an intrinsic characteristic of decoction, and good, rapid-action with retention, effect is apparent, medication and it is easy to carry the advantages that,
It not only maintains decoction and acts on rapid feature, and overcome decoction and face the disadvantage that the used time decocts inconvenience, and is small, take,
Storage and transport are more convenient, are applicable in domestic animal, poultry and other animals.
Warm heat disease is that using thermal image weighting as main feature and have seasonal and different degrees of communicable a kind of disease,
It is larger to the harm of livestock and poultry cultivation,《Republic of China Veterinary Pharmacopoeia 2010 editions two》In included " removing summer-heat mixture ", " double Huangs
The prescriptions such as oral solution " have the effect of clearing heat and detoxicating, treatment warm heat disease, but in these prescriptions, as removing summer-heat mixture by Radix Isatidis,
The 12 taste Chinese medicinal composition such as Fructus Forsythiae, radix scutellariae, honeysuckle, radix scrophulariae, ingredient is more, preparation and Quality Control Procedure are cumbersome, medicinal material cost
Too high, especially Shuanghuanglian oral liquid cost of material limits its use in breeding production just in 50 yuan/kg.
Invention content
For current treatment animal warm heat disease prescription prescription it is larger, cost is higher, technique is less, preparation lacks etc. asks
Topic, the present invention overcomes traditional technology prejudice, have recombinated prescription, greatly reduce active compound type, reduce production cost, provide one
The blue lotus oral solution of kind, and with water decoction-alcohol sedimentation extraction and alcohol leaching technology, solve the problems, such as to encounter in extraction process, and make punching
The active ingredient of lotus, Radix Isatidis, folium isatidis etc. is utilized.
To solve the above problems, the invention is realized by the following technical scheme：
A kind of blue lotus oral solution for animal warm heat disease initial stage is designed, is made of the raw material of following parts by weight：Herba Andrographitis
0.8~1.2 part, 0.8~1.2 part of folium isatidis, 1.6~2.4 parts of Radix Isatidis
Preferably, the blue lotus oral solution is made of the raw material of following parts by weight：1 part of Herba Andrographitis, 1 part of folium isatidis, plate are blue
2 parts of root.
A kind of preparation method of above-mentioned blue lotus oral solution is designed, is included the following steps：
（1）Herba Andrographitis is taken, is taken 1 hour in 40 DEG C of temperature extractions with 75% ethanol solution of its 3 times of weight, is then rinsed and squeeze
Go out extracting solution, filter, recycles filtrate；
（2）By step（1）Gained filter residue is added in 75% ethanol solution of its 2 times of weight, is taken 1 hour in 40 DEG C of temperature extractions,
Then it rinses and squeezes out extracting solution, filter, recycle filtrate, merge filtrate twice, obtain Herba Andrographitis extracting solution；
（3）Folium isatidis, Radix Isatidis are taken, is added water to cook respectively, collecting decoction, filtering, it is 1.05 to concentrate the filtrate to density
~1.20g/cm3Medicinal extract；
（4）Ethyl alcohol is added into gained medicinal extract, until the final concentration of 70wt% of ethyl alcohol, then stir evenly, stand, filter, gained filtrate
Ethyl alcohol is recycled, concentrate is obtained；
（5）By step（2）Gained Herba Andrographitis extracting solution and step（4）Gained concentrate mixes, and adds Herba Andrographitis raw material
Then the benzyl alcohol that 0.15~0.50 times of weight adds water that the solution of 3.5~4.0 times of Herba Andrographitis raw material weight is made, stirs evenly, stand
12~15 hours to get blue lotus oral solution.
The usage and dosage of blue lotus oral solution is in the present invention：0.5~1mL of chicken.
The positive beneficial effect of the present invention compared with the prior art is：
（1）The present invention is taken 2 times by carrying out 75% ethyl alcohol, 40 DEG C of temperature extractions to Herba Andrographitis, is first adopted to folium isatidis and Radix Isatidis
It is impregnated with purified water, water decoction-alcohol sedimentation extraction, it is efficient to the extraction of blue lotus oral solution, complete；Comparison prior art Herba Andrographitis carries
Take mode（95% alcohol reflux）, operating procedure is simplified, to save production cost.
（2）It is recorded according to existing document, the Chinese prescription for preventing, treating animal warm heat disease is mostly more generous of flavour of a drug
Agent（Such as removing summer-heat mixture and qingwen baidu powder）Or the higher prescription of crude drug cost（Such as Shuanghuanglian oral liquid）, to limit its
Use in clinic.The lower Herba Andrographitis of price is extracted and is introduced into prophylactic treatment animal warm heat disease by the present invention, to
Greatly reduce production cost.
（3）By first high temperature and humidity again low temperature wind in the way of establish the animal model at warm heat disease initial stage, this is also this hair
Bright improvements；Because there is the modeling method of saccharomycete and lipopolysaccharides for document report, there are animal heating continuing time is short,
Measurement body temperature is complicated for operation, and basal body temperature has differences between animal individual；For attacking the modeling method of poison with bacterium or virus, deposit
It is transient or attack toxic dose and the problem of mode is difficult to hold in reaction of animals；Thus by many experiments, find to use 8 ages in days
Chicken, first high temperature is raised 2 hours at 45 DEG C, after give the depressed chicken of picking spirit after 20 DEG C of cold wind stimulate 1 hour, 4 hours,
Made animal model meets warm disease type, this is also had no record in the prior art.
（4）The present invention has carried out a series of experiments, through existing saccharomycete and fat in prescription flavour of a drug composition and ratio-dependent
The High fever model mouse that polysaccharide makes, the prescription screened by a large number of experiments and its proportioning, i.e.,：1 part of Herba Andrographitis, folium isatidis
1 part, 2 parts of Radix Isatidis.This is also had no record in the prior art.
（5）The present invention overcomes traditional technology prejudice, recombinate prescription, greatly reduce active compound type, only selected Radix Isatidis,
Folium isatidis, three taste Chinese medicine of Herba Andrographitis（Cost of material is within 10 yuan/kg）Again prescription and extract oral solution, density is made
Not less than 1.05g/cm3, pH value is in 5.0~6.5 ranges, wherein saponin component content is 20% or more, andrographolide
It is not less than 0.2% with Dehydro and drographolide total content, and utilizes the chicken of manual creation and mouse warm disease initial stage animal model, card
Real its has good therapeutic effect to livestock and poultry warm heat disease initial stage.
Monarch drug in a prescription Radix Isatidis bitter cold in nature in prescription, the thoughts of returning home, liver, stomach have clearing heat and detoxicating, cool blood relieving sore-throat medicinal effect
Fruit, be clinically usually used in treat major part pestilence, pestilent maculae, high heat headache, influenza, rotten larynx pellet rash, varicella, sore swells,
The illnesss such as hepatitis, measles.Ministerial drug Herba Andrographitis is cold in nature, bitter, the thoughts of returning home, lung, large intestine, bladder warp, contained principle active component tool
There is the effects that heat-clearing, removing toxic substances, cool blood, detumescence, be clinical common medicine, be chiefly used in cold, fever, abscess of throat, aphthae pauses
Cough overstrain cough, dysentery, puckery pain of heat gonorrhea, the illnesss such as carbuncle swells sore.Folium isatidis is adjutant, cold in nature, bitter, and the thoughts of returning home, stomach have
The effect of heat-clearing, removing toxic substances, cool blood, relieving sore-throat.Three shares, gather altogether clearing heat and detoxicating, cool blood relieving sore-throat the effect of, it is outstanding to warm heat disease initial stage
It, which is the diseases such as fever, abscess of throat and the aphthae of anemopyretic cold, obvious therapeutic action.
Specific embodiment
With reference to embodiments, to the specific implementation mode that provides according to the present invention, details are as follows：
Embodiment 1
A kind of preparation method of indigo plant lotus oral solution, includes the following steps：
（1）Herba Andrographitis 10Kg is taken, is taken 1 hour in 40 DEG C of temperature extractions with 75% ethanol solution of its 3 times of weight, is then rinsed
Extracting solution is squeezed out, is filtered, filtrate is recycled；
（2）By step（1）Gained filter residue is added in 75% ethanol solution of its 2 times of weight, is taken 1 hour in 40 DEG C of temperature extractions,
Then it rinses and squeezes out extracting solution, filter, recycle filtrate, merge filtrate twice, obtain Herba Andrographitis extracting solution；
（3）Folium isatidis 10Kg, Radix Isatidis 20Kg are taken, is added water to cook respectively, collecting decoction, filters, concentrates the filtrate to close
Degree is 1.05~1.20g/cm3Medicinal extract；
（4）Ethyl alcohol is added into gained medicinal extract, until the final concentration of 70wt% of ethyl alcohol, then stir evenly, stand, filter, gained filtrate
Ethyl alcohol is recycled, concentrate is obtained；
（5）By step（2）Gained Herba Andrographitis extracting solution and step（4）Gained concentrate mixes, and adds the benzene of 1.5 Kg
Then methanol adds water that the solution of 35 Kg is made, stirs evenly, stand 12 hours to get blue lotus oral solution.Measuring its density is
1.05g/cm3, pH value 6.0, wherein saponin component content is 22%, andrographolide and Dehydro and drographolide total content
It is 0.3%.
Embodiment 2
A kind of preparation method of indigo plant lotus oral solution, includes the following steps：
（1）Herba Andrographitis 100Kg is taken, is taken 1 hour in 40 DEG C of temperature extractions with 75% ethanol solution of its 3 times of weight, is then rinsed
Extracting solution is squeezed out, is filtered, filtrate is recycled；
（2）By step（1）Gained filter residue is added in 75% ethanol solution of its 2 times of weight, is taken 1 hour in 40 DEG C of temperature extractions,
Then it rinses and squeezes out extracting solution, filter, recycle filtrate, merge filtrate twice, obtain Herba Andrographitis extracting solution；
（3）Folium isatidis 100Kg, Radix Isatidis 200Kg are taken, is added water to cook respectively, collecting decoction, filters, concentrates the filtrate to
Density is 1.05~1.20g/cm3Medicinal extract；
（4）Ethyl alcohol is added into gained medicinal extract, until the final concentration of 70wt% of ethyl alcohol, then stir evenly, stand, filter, gained filtrate
Ethyl alcohol is recycled, concentrate is obtained；
（5）By step（2）Gained Herba Andrographitis extracting solution and step（4）Gained concentrate mixes, and adds the benzene first of 50Kg
Then alcohol adds water that the solution of 400Kg is made, stirs evenly, stand 15 hours to get blue lotus oral solution.It is 1.10g/ to measure its density
cm3, pH value 6.5, wherein saponin component content is with Dehydro and drographolide total content in 21%, andrographolide
0.2%。
The blue lotus oral solution prepared with embodiment 1 carries out the pharmacodynamic study at warm heat disease initial stage
1. experimental method
The foundation of 1.1 yeast-mouse fever model
Mouse is in 25 DEG C of normal raisings at room temperature, and experiment evening before that day, which is fasted, can't help water, experimental day, modeling group
Every mouse subcutaneous injection 10mL/kg yeast suspension（Mass concentration is 10%, now with the current）, electronic thermometer measurement
Mouse temperature starts to warm up after 2h, and temperature continuously decreases after 5h.
1.2 prevent experiment
Experiment measures a mouse temperature in first 1 hour every half an hour, chooses the normal mouse 50 of body temperature, is randomly divided into
5 groups, every group 10, the 1st group is Shuanghuanglian oral liquid medication group, gavage 0.6mL Shuanghuanglian oral liquids；2, it is taken orally for blue lotus for 3 groups
Liquid medication group, difference gavage 0.4,0.6mL indigo plant lotus oral solutions；4 groups are positive controls, and 5 groups are blank control group, respectively gavage
Yeast suspension is subcutaneously injected in 0.6mL physiological saline, 1~4 group of gavage after 3 hours, 1h, 2h, 3h, 4h, 5h, 6h distinguish after injection
It is primary to measure body temperature, observes and records each mouse temperature variation.
1.3 Experiment on therapy
Experiment packet and processing method are the same as gavage is given immediately after above-mentioned 1.2,1~4 groups of hypodermic injection yeast suspensions
Medicine, it is primary to measure body temperature respectively by 1h, 2h, 3h, 4h, 5h, 6h after injection, observe and record each mouse temperature variation.
2. experimental result
2.1 prevent experimental result
Table 1 is the results show that body temperature gradually rises after mouse injection yeast 2h, and temperature starts to reduce after 5h；Three groups of medications are small
Mouse is in the body temperature at each time point and the body temperature difference unobvious of blank control group, the body of medication group mouse and positive controls mouse
The temperature difference is not different also notable（P >0.05）；But the mouse temperature of each medication group is below positive controls.
1 saccharomyces model of table prevents experiment
。
2.2 Experiment on therapy results
2 result of table is as it can be seen that the body temperature of each medication group mouse is below positive controls, but effect is not notable（P ＞ 0.05）,
The difference of each group mouse temperature and blank control group is not also notable（P ＞ 0.05）, 2 groups and 3 groups of antipyretic response is wanted after medication 4h
It is better than 1 group and positive controls.
2 saccharomyces model Experiment on therapy of table
。
The blue lotus oral solution prepared with embodiment 1 carries out the clinical experimental study at warm heat disease initial stage
1. experimental method
8 Day-old Broiler Chickens first raise 2 hours at 45 DEG C by high temperature, after give picking after 20 DEG C of cold wind stimulate 1 hour, 4 hours
The depressed chicken of spirit.4 groups are randomly divided into, every group 20, the 1st group is Shuanghuanglian oral liquid medication group, gavage 0.6mL swap buffers mouths
Take liquid；2,3 groups are blue lotus oral solution medication group, respectively gavage 0.4,0.6mL indigo plant lotus oral solutions；4 groups are positive controls, are separately taken
20 normal chickens are as the 5th group of blank control group, and gavage 0.6mL physiological saline, observes and records each group chicken state respectively,
It is used in conjunction 5 days, checks all chickens within the 7th day.
2. experimental result
First high temperature again low temperature stimulation when, see larynx redness bleeding after the spirit depressed chicken inspection selected.But through 5 days use
After medicine, 1~3 group of medication group chicken spirit and larynx restore normal, the 4th group of positive controls spirit is still depressed and larynx still have it is red
Swollen bleeding, and individual symptoms are still than more serious.
At warm heat disease initial stage, sick position is in fur and lung（I.e. in table）, notably enter internal organs, primary symptom fever, cough, runny nose.Dry,
Pharyngalgia, thin white fur of tongue or thin Huang；The medicine of a cold nature is so that heat is gone and yin-fluid is not hindered by consumption for antipyretic, there is heat-clearing Bao Jin effects.Plate is blue
Root and Herba Andrographitis have effects that heat-clearing, removing toxic substances, cool blood, relieving sore-throat, blue lotus oral solution have warm heat disease initial symptoms exact anti-
Control effect.This research selects KM mouse to establish warm heat disease initial stage（Based on Wei phase syndrome+Qi phase syndrome）It is selected in model, with other documents
Rat fever model compare have easy to operate, the apparent advantage of pathological symptom.
It generates heat after mouse subcutaneous injection yeast slow, heating continuing time is long, can from the experimental result of prevention and treatment
To see that three dosage indigo plant lotus oral solutions have certain control effect, the antipyretic response of each medication group to be not easy fever caused by yeast
It distinguishes, in addition Chinese medicine preparation is longer from the time for being absorbed into performance drug effect, and after mouse injects yeast 4h, blue lotus oral solution is to yeast
The preventive effect of fever is significantly better than therapeutic effect.It is exact anti-that pharmacodynamic experiment shows that blue lotus oral solution has warm heat disease initial stage
Control effect.
Pharmacodynamics and clinical test results show that blue lotus oral solution has preferably warm heat disease initial stage mouse and chicken
Prophylactic treatment acts on.
Claims (3)
1. a kind of blue lotus oral solution for animal warm heat disease initial stage, which is characterized in that be made of the raw material of following parts by weight：It wears
0.8~1.2 part of heart lotus, 0.8~1.2 part of folium isatidis, 1.6~2.4 parts of Radix Isatidis；
Saponin component content is 21%~22% in the indigo plant lotus oral solution, andrographolide and Dehydro and drographolide total content
It is 0.2%~0.3%.
2. indigo plant lotus oral solution according to claim 1, which is characterized in that be made of the raw material of following parts by weight：Herba Andrographitis 1
Part, 1 part of folium isatidis, 2 parts of Radix Isatidis.
3. the preparation method of blue lotus oral solution described in a kind of claim 1, which is characterized in that include the following steps：
（1）Herba Andrographitis is taken, is taken 1 hour in 40 DEG C of temperature extractions with 75% ethanol solution of its 3 times of weight, then flushing, which squeezes out, carries
Liquid is taken, is filtered, filtrate is recycled；
（2）By step（1）Gained filter residue is added in 75% ethanol solution of its 2 times of weight, takes 1 hour in 40 DEG C of temperature extractions, then
Flushing squeezes out extracting solution, and filtrate is recycled in filtering, is merged filtrate twice, is obtained Herba Andrographitis extracting solution；
（3）Take folium isatidis, Radix Isatidis, add water to cook respectively, collecting decoction, filtering, concentrate the filtrate to density be 1.05~
1.20g/cm3Medicinal extract；
（4）Ethyl alcohol is added into gained medicinal extract, until the final concentration of 70wt% of ethyl alcohol, then stir evenly, stand, filter, the recycling of gained filtrate
Ethyl alcohol obtains concentrate；
（5）By step（2）Gained Herba Andrographitis extracting solution and step（4）Gained concentrate mixes, and adds Herba Andrographitis raw material weight
Then 0.15~0.50 times of benzyl alcohol adds water that the solution of 3.5~4.0 times of Herba Andrographitis raw material weight is made, stirs evenly, and standing 12~
15 hours to get blue lotus oral solution.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1146904A (en) * | 1995-09-14 | 1997-04-09 | 黎明星 | Antibacterial herb medicine tablet |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20110123639A1 (en) * | 2009-11-26 | 2011-05-26 | Chan Agnes Sui-Yin | Compound for improving brain functioning and/or treatment of brain disorders |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1146904A (en) * | 1995-09-14 | 1997-04-09 | 黎明星 | Antibacterial herb medicine tablet |
Non-Patent Citations (1)
| Title |
|---|
| 中华鳖常见病防治方法;李贵雄;《水产科技情报》;20051231;第32卷(第1期);第12-14页 * |
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