CN104957147B - Bactericidal composition and its application - Google Patents
Bactericidal composition and its application Download PDFInfo
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- CN104957147B CN104957147B CN201510319355.1A CN201510319355A CN104957147B CN 104957147 B CN104957147 B CN 104957147B CN 201510319355 A CN201510319355 A CN 201510319355A CN 104957147 B CN104957147 B CN 104957147B
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- shenqinmycin
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- fludioxonil
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
- A01N57/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing acyclic or cycloaliphatic radicals
Abstract
The invention discloses a kind of bactericidal composition and its application, it is related to technical field of pesticide combination.The active ingredient of bactericidal composition of the present invention contains shenqinmycin A and remaining bactericide B, and wherein remaining bactericide B is selected from the phosethyl-Al of cyazofamid, the hymexazo of oxazole series bactericidal agent, the fludioxonil of pyrroles's series bactericidal agent or the organophosphorus fungicide of sulphaguanidine azoles fungicide.A is 1 with B weight ratio：100~100：1.Effective constituents A has obvious synergistic effect with B compoundings, can effectively reduce the amount of application of each single dose.To expanding fungicidal spectrum and delaying the plant resistance to the action of a drug to have preferable effect, moreover it is possible to extend the lasting period, with obvious promotional value.Said composition, which can be added, allows the auxiliary element used to be processed into any formulation in other agricultural chemicals.The bactericidal composition can effectively prevent and treat banded sclerotial blight, rice blast, false smut, rust, powdery mildew, root rot, sclerotiniose, smut, droop etc..
Description
Technical field
The present invention relates to a kind of bactericidal composition and its application, particularly relate to one kind and contain active ingredient shenqinmycin and work
The bactericidal composition of property bactericide and its application, belong to technical field of pesticide combination.
Background technology
In agricultural production, crops can healthy growth, in addition to being influenceed by worm, crop smothering, the preventing and treating to disease is also very heavy
Will.Reinforcement and sustainable development implementation with environmental protection ideas, efficient, low toxicity, high activity, low-residual have turned into agricultural chemicals and sent out
The inexorable trend of exhibition.However, even efficient germicide, long-term exclusive use, also easily makes disease develop immunity to drugs, causes to use
The problems such as dose is increased, preventive effect is reduced, the lasting period shortens, is unfavorable for environment sustainable development.Therefore, how Scientific Usage of Drugs, drop
The consumption of low chemical pesticide, improves drug effect, the problem for being badly in need of solving as plant protection art.
Cyazofamid (CyazofaMid) be also known as match seat go out, chloro- 2- cyano group-N, N- dimethyl -5- p-methylphenyl the imidazoles -1- of 4-
Sulfonamide, cyanogen azoles flusulfamide, section are good, belong to sulphaguanidine azoles fungicide.Cyazofamid is mitochondrial respiratory inhibitor, to oomycetes institute
There is growth phase to have effect, with other bactericide without cross tolerance, with certain interior suction and therapeutic activity, the lasting period is long, resistance to
Rain drop erosion, to crop, the mankind, Environmental security, but it is long-term it is single use, germ can be made to develop immunity to drugs it unavoidably.
Hymexazo (hymexazol), also known as hydroxyisoxazole, hymexazol, molecular formula are C4H5NO2, chemical name：3- hydroxyls-
5- methyl-isoxazoles.Hymexazo is systemic fungicide, while being a kind of soil sterilants again.The medicine and the iron in soil, aluminium
Ions binding, suppresses the germination of spore.Hymexazol can be absorbed by the root of plant and be moved in root system, be produced in plant intracellular metabolite
Two kinds of glucosides, the effect of physiologically active is improved to crop, so as to promote plant strain growth, point evil of root, the increase of root hair and
The activity raising of root.Hymexazo is that broad-spectrum germicide has higher preventing and treating knot to plant disease caused by a variety of disease funguses
Really, but it is long-term it is single use, germ can be made to develop immunity to drugs it unavoidably.
Fludioxonil (fludioxonil), also known as fluorine fludioxonil, cough up bacterium ester, 4- (2,2- bis- fluoro- 1,3- benzos dioxy -4-
Base) pyrroles -3- nitriles, do not fall bacterium dislike, it is suitable happy when, fludioxonil is new pyrrole class non-internal-absorting wide-spectrum bactericide, its mechanism of action
It is the transferase relevant by suppressing thalline glucose phosphorylated, the growth of fungal mycelium can be suppressed, causes germ dead.It is right
Disease caused by the pathogens such as Alternaria, Ascochyta, aspergillus, Fusarium, Helminthosporium, Rhizoctonia and Penicillium
With good protection and therapeutic action, for preventing and treating the rotten Fusariumsp of snow, wheat black rot, rhizoctonia solani etc..
Phosethyl-Al (phosethyl-Al), also known as Yimeiling, the white spirit of epidemic disease, aliette, net mould epidemic disease, methylpartricin sodium laurylsulfate, mould
Spirit, three second aluminum phosphates, fosetyl aluminium, be a kind of organic phosphates efficiently, wide spectrum, absorbability low toxicity bactericide, with treatment and protect
Effect.It can be with upper and lower Bidirectional Conduction in plant.The aqueous solubility is good, and interior sorptivety permeability is strong, and the lasting period is longer, uses
Safety.
Shenqinmycin, its structural formula is such as shown in (I), and shenqinmycin is to be secreted by pseudomonas fluorescens M18 through biological culture
A kind of antibiotic, while have wide spectrum suppress phytopathogen and promote Effects on Plant Growth dual-use function bactericide,
With wide spectrum, it is efficient the characteristics of.
Structural formula (I) shenqinmycin
Frequently using containing single-activity component bactericide, causes most germs to generate the resistance to the action of a drug, preventive effect is not
It is preferable.Therefore, it is badly in need of the sterilised products that a kind of novel product substitutes single-activity component, increase drug effect delays the resistance to the action of a drug of disease
Risk, reduces economic loss.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of component rationally, significantly, bactericidal effect is good, medication for synergistic effect
Low cost, is not likely to produce the resistance to the action of a drug, the bactericidal composition to crop safety and its application.
In order to solve the above technical problems, present invention offer technical scheme is as follows：
The bactericidal composition of the present invention, its active ingredient is shenqinmycin A and active bactericide B, shenqinmycin A and activity
Bactericide B weight ratio is 1:100~100:1, preferably weight ratio is 1：50~50：1, more preferably weight ratio is 1：25~
25：1.
In the bactericidal composition of the present invention, the active bactericide can be：The cyazofamid, Evil of sulphaguanidine azoles fungicide
It is any one in phosethyl-Al of the hymexazo of azoles fungicide, the fludioxonil of pyrroles's series bactericidal agent or organophosphorus fungicide etc.
Kind.
Pesticidal preparations auxiliary element can also be contained in bactericidal composition of the present invention, be adapted to agriculturally use to be made
Formulation.The pesticidal preparations auxiliary element is one kind in solvent, emulsifying agent, dispersant, stabilizer, antifreezing agent or wetting agent
Or it is several.
The bactericidal composition of the present invention can be prepared into any one formulation of suitable agricultural use with known method, than
Preferable formulation is dry suspending agent (DF), wettable powder (WP), water dispersible granules (WDG), suspending agent (SC), seed treatment
Or suspension seed-coating agent etc..
A wettable powders (WP), be can be dispersed in water solid powder preparation.Wettable powder of the present invention except
Into active compound plus such as white carbon, precipitated calcium carbonate, clay, diatomite, attapulgite diluent or inert substance outside, also from
Subtype or nonionic surface active agent (wetting agent, dispersant), wetting agent is for example, alkylbenzenesulfonate (DBS-Na), alkyl
Naphthalene sulfonate (pull open powder), alkylphenol-polyethenoxy base ether sulfate, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulfate,
Aliphatic alcohol sulfate, fatty alcohol ethylene oxide adduct sulfonate, alkyl amide taurate, aliphatic alcohol polyethenoxy base ether
(JFC), content 0.1~30%；Dispersant such as naphthalene sulfonate, naphthalene or alkyl naphthalene formaldehyde condensate sulfonates (NO, NN0, MF), wood
Quality and its derivative sulfonate (M-9, POLYFON etc.), polyoxyethylene poly-oxygen propylene aether block copolymer, alkyl phenol polyoxy second
Alkene ether formaldehyde condensation products sulfate (SOPA), PVA, CMC content 0.1~30%；Also containing penetrating agent JFC, azone, thiophene ketone,
One or more materials among penetrant t, content 0.3~30%；Stabilizer, foam inhibitor, anticaking agent etc. can also be contained
Other auxiliary agents.
B water dispersible granules (WDG), be can be comparatively fast disintegrated in water, the scattered granule for forming higher suspension dispersion.By
Active component, the key element such as auxiliary agent and carrier such as wetting agent, dispersant, interleaving agent, disintegrant, stabilizer, adhesive composition.It is helped
Agent and carrier, and the compound method of precursor (preformed objects before granulation) are analogous to wettable powder and suspending agent substantially.
C suspending agents (SC), are the not dispersion of water soluble solid agricultural chemicals or immiscible liquids agricultural chemicals in water or oil.By activity
Composition, auxiliary agent (wetting dispersing agent, thickener, stabilizer, pH adjusting agent, defoamer, antifreezing agent) are made through soybean dietary fiber.
Wetting dispersing agent can be naphthalene or alkyl naphthalene formaldehyde condensate sulfonates (NO, NN0, MF), lignin and its derivative sulfonate
(M-9, POLYFON etc.), alkylphenol-polyethenoxy base ether sulfonate, polyoxyethylene polyoxypropylene base ether block copolymers, alkyl
Phenol polyethenoxy base phosphate, carboxymethyl cellulose (CMC), polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), condensation phosphorus
One or more in hydrochlorate etc., content 0.1~12%；Thickener and stabilizer can be xanthan gum (XG), polyvinyl alcohol
(PVA), the one or more in Magnesiumaluminumsilicate etc., content 0.05~0.5%；PH adjusting agent and defoamer optionally can add in right amount
Plus.
D dry suspending agents (Dry Flowable, abbreviation DF), be can be comparatively fast disintegrated in water, the scattered higher suspension that formed disperses
The granule of system.Preparation method：The preparation obtained by the dehydration of suspending agent.Its auxiliary agent and carrier, and precursor (are dehydrated
Preceding preformed objects) compound method it is consistent with suspending agent.
Bactericidal composition of the present invention is applied to prepare the pesticidal preparations of controlling plant diseases.It is particularly useful for making
Prevent and treat rice sheath blight disease, rice blast, false smut, wheat rust, powdery mildew, root rotof flax, wheat sharp eyespot, rice banded sclerotial blight
The pesticidal preparations of disease, root rot, sclerotinia rot of colza, maize head smut, capsicum wilt, cucurbits fusarium wilt etc..
Bactericidal composition of the present invention can be provided in finished product preparation form, i.e., each material has been mixed in bactericidal composition
Close, or the composition of bactericidal composition can also be provided with unit dose form, directly directly be mixed in bucket or tank using preceding, so
Required concentration is diluted to afterwards.
The method that bactericidal composition of the present invention is applied to controlling disease, active principle A and component B are with 1:100-
100:1 weight ratio is applied, and further dispenser ratio is 1:50-50:1, further dispenser ratio is 1:50-50:1, it can be pressed
Apply, be administered simultaneously in proportion or apply successively in proportion after aforementioned proportion mixing.Specific method of application can be powder injection process, spray
Mist method, smog method, fumigating system and Seed Treatment and soil treatment, ultra-low volume spray, mix fertilizer, spread fertilizer over the fields, pouring root.
Compared with prior art, the beneficial effects of the present invention are：
1st, compared with single dose, compounding has obvious synergistic function, improves prevention effect；
2nd, composition is made up of two kinds of different active ingredients of mechanism of action, and bactericidal effect is good, is conducive to overcoming and delays
Germ is drug-fast to be produced；
3rd, medicament mixture reduces dosage, so as to reduce cost and alleviate the pollution to environment.
Rationally, treatment plus protective effect, drug cost are low for instant component, and its activity and bactericidal effect are not each components
The simple superposition of activity, but have significant synergistic effect, it is good to crop safety, meet the security requirement of pesticidal preparations.
Embodiment
To make the technical problem to be solved in the present invention, technical scheme and advantage clearer, specific embodiment will be used below
It is described in detail, but the present invention is limited to absolutely not these examples.As described below is only the present invention preferably embodiment, is only used to
The present invention is explained, therefore the limitation to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that all the present invention's
Any modification, equivalent and improvement made within spirit and principle etc., should be included within the scope of the present invention.
Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Agricultural chemicals is made in the combination of active principles of different agricultural chemicals, is current exploitation and develops novel pesticide and prevent and treat agriculturally
A kind of effective and quick way of resistance germ.After the pestsides synthesis of different cultivars, a large amount of three kinds of effects classes are typically exhibited
Type：Summation action, synergistic effect and antagonism.Compound synergic is formulated well, can significantly improve actual prevention effect, drop
The usage amount of low agricultural chemicals, is the important means of integrated control disease so as to help to delay the drug-fast generation speed of germ.
The present composition is with shenqinmycin (A) for a kind of active ingredient, and active bactericide (B) is another active ingredient,
Being combined between them has obvious synergistic function to plant disease, and not exclusively two kinds the simple of pharmacy effect are folded
Plus, this can be clearly understood that from indoor virulence test result.
In order to prevent and treat the tomato late blight in agricultural production, inventor is with shenqinmycin and the cyanogen of sulphaguanidine azoles fungicide
The synergy that white azoles is compounded is studied, and specific method is：
Experiment uses tomato late blight for test object.
The test medicine that active compound is configured to need, test method (blade method) reference《People's Republic of China's agricultural row
Industry standard》.Experiment is cultivated with pathogen on suitable culture medium, after sporangium to be generated, with spore under sterile washing, used
Double gauze is filtered, and sporangia suspension is made, is placed under 4 DEG C of low temperature, dark processing 0.5h-3h, tries it and discharges travelling spore
Son, and spore concentration is adjusted to 1*105Individual spore/L, it is standby；Or directly prepare 1105Individual sporangium/ml, suspension is used as inoculation
Body.The test medicine that active compound is configured to need, medicament is uniformly sprayed in vacuum side of blade, after after decoction natural air drying, by respectively
Handle vacuum side of blade upward, be emitted on after being marked by processing in moisture preservation box.No less than 10 leaves of often processing, 4 repetitions, and set only
Blank control is done in the processing that effect composition is not contained containing solvent and surfactant.Sprayed with sporangium or zoospore suspension
Inoculation.Protectiveness experiment is generally 24h or so after chemicals treatment and is inoculated with；The general 24h before chemicals treatment of curative tests
Inoculation.In each 12H alternatings of daily continuous illumination/dark, temperature it is 18 DEG C after inoculation.And after inoculation there be holding blade face in 24H
Moisture film, later relative humidity be more than 90% under conditions of cultivate 7 days.When the sick leaf rate of blank control reaches more than 50%, point
Incidence is managed in level investigation everywhere.Stage division is：0 grade：Do not fall ill；1 grade：Only a small amount of small scab on blade, scab accounts for leaf
Below area 10%；3 grades：Scab accounts for leaf area 10%-25% on blade；5 grades：Scab accounts for leaf area 25%-50% on blade；
7 grades：Scab accounts for leaf area more than 50% on blade；9 grades：Full leaf morbidity is withered.
According to blank control incidence, each processing disease index is investigated, preventive effect is calculated.By the probit value of inhibiting rate and
Linear regression analysis between the logarithm value of series concentration, obtains the EC50 values of each medicament, mixture is calculated with co-toxicity coefficient meter
Co-toxicity coefficient (CTC), activity of the reagent agent to germ is evaluated with this.
The co-toxicity coefficient (CTC) >=120 of complex preparation shows as synergistic effect；CTC≤80 show as antagonism；80 ﹤
CTC ﹤ 120 show as summation action.
The shenqinmycin of table 1 and cyazofamid compound the Toxicity Determination to tomato late blight
| Chemicals treatment | Proportioning | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| Shenqinmycin (A) | —— | Y=1.6974X+3.8406 | 4.8198 | —— |
| Cyazofamid (B1) | —— | Y=1.1207X+3.0833 | 51.3205 | —— |
| A:B1 | 1:100 | Y=0.8133X+3.7145 | 38.0600 | 123.08 |
| A:B1 | 1:50 | Y=0.8392X+3.7158 | 33.9062 | 127.29 |
| A:B1 | 1:25 | Y=0.8094X+3.8296 | 27.9272 | 134.08 |
| A:B1 | 1:1 | Y=0.7258X+4.4771 | 5.2537 | 167.72 |
| A:B1 | 25:1 | Y=0.6666X+4.6275 | 3.6275 | 137.67 |
| A:B1 | 50:1 | Y=0.7039X+4.6006 | 3.6931 | 132.88 |
| A:B1 | 100:1 | Y=0.7284X+4.5749 | 3.83361 | 126.87 |
Toxicity Determination result table 1 is shown, compares 1 in weight:100-100:1, particularly 1:50-50:In the range of 1,
Especially compare 1 in weight：25-25：Shenqinmycin with cyazofamid compounding there is obvious synergy to make to plant disease in the range of 1
With the synergistic effect of compounding becomes apparent, and prevention effect is excellent and is better than single dose kind.
In order to prevent and treat the sclerotinia rot of colza in agricultural production, inventor is with shenqinmycin He oxazole series bactericidal agent hymexazos
The synergy compounded is studied, and specific method is：
Experiment uses sclerotinia rot of colza for test object.
The test medicine that active compound is configured to need, with reference to mycelial growth rate method, the preparation of strain：It is sterilized
About 10mLPDA culture mediums are poured into culture medium.Aseptically, a mycelia is taken from the strain inclined plane of Sclerotinia sclerotiorum
Block, is placed in the middle of culture dish.Continuous culture several generations, then before the test 3d, in inoculation once, trained under the conditions of 24~26 DEG C
Support, it is standby.The making of toxic flat board, after first the PDA culture medium prepared is dissolved, places cooling.Aseptically, will
Decoction 1mL is added in sterilized culture dish, is then added with pipette, extract 9mL culture mediums in the culture dish of existing decoction,
Rocking gently shakes up (left side 3 is enclosed, and the right side 3 is enclosed), and the uniform flat board of thin and thick is made.Connect bacterium：By the pathogen being ready for punching
Device makes bacteria cake, is then moved into transfer needle picking bacteria cake on the pastille flat board solidified, mycelia one is face-down.Mark, puts 24
Cultivated in~26 DEG C of incubators.Control group colony diameter length is treated to 6cm or so, crossing method investigates the data of other processing simultaneously
Record.
According to blank control incidence, lesion diameter is recorded, the percentage that each processing suppresses scab growth is calculated, passes through
Linear regression analysis between the probit value of inhibiting rate and the logarithm value of series concentration, obtains the EC50 values of each medicament, uses common poison
Coefficient table calculates the co-toxicity coefficient (CTC) of mixture, and activity of the reagent agent to germ is evaluated with this.
The co-toxicity coefficient (CTC) >=120 of complex preparation shows as synergistic effect；CTC≤80 show as antagonism；80 ﹤
CTC ﹤ 120 show as summation action.
The shenqinmycin of table 2 is He hymexazo compounds the Toxicity Determination to sclerotinia rot of colza
| Chemicals treatment | Proportioning | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| Shenqinmycin (A) | —— | Y=1.8279X+2.4389 | 25.1847 | —— |
| Hymexazo (B2) | —— | Y=1.9057X+1.1447 | 105.455 | —— |
| A：B2 | 1:100 | Y=1.7340X+1.944 | 58.0668 | 176.05 |
| A：B2 | 1:50 | Y=1.5407X+2.3249 | 54.4844 | 182。17 |
| A：B2 | 1:25 | Y=1.4931X+2.4716 | 49.3597 | 190.34 |
| A：B2 | 1:1 | Y=1.2617X+3.4027 | 18.4523 | 220.34 |
| A：B2 | 25:1 | Y=1.3371X+3.3476 | 17.2138 | 150.72 |
| A：B2 | 50:1 | Y=1.4700X+3.1080 | 19.3661 | 132.01 |
| A：B2 | 100:1 | Y=1.3654X+3.2150 | 20.2906 | 125.07 |
Toxicity Determination result table 2 is shown, compares 1 in weight:100-100:1, particularly 1:50-50:In the range of 1,
Especially compare 1 in weight：25-25：There is shenqinmycin Yu hymexazos compounding obvious synergy to make to plant disease in the range of 1
With prevention effect is excellent and is better than single dose kind.
In order to prevent and treat the wheat sharp eyespot in agricultural production, inventor is with shenqinmycin and the fludioxonil of pyrroles's series bactericidal agent
The synergy compounded is studied, and specific method is：
Experiment uses wheat sharp eyespot for test object.
The test medicine that active compound is configured to need, test method：Fungicide bioassay pattern -- Broad Bean Leaves method,
With reference to《People's Republic of China's agricultural industry criteria》.Choose broad bean susceptible variety potted plant, clip same section, growing way is consistent,
With petiolate blade, put in culture dish, moisturizing is standby, experimental pharmacy is diluted using active compound with water dissolves, 5 quality are set
Concentration, fully infiltrates 5S by blade in pre-configured good decoction, drains after unnecessary decoction, natural air drying, after processing mark
Moisturizing culture, experiment sets the processing without medicament as blank control.The one side that a diameter of 5mm bacteria cakes have mycelia is connect with inoculator
Plant in processing central vane, 30 leaves of each processing inoculation.Protectiveness experiment 24h after chemicals treatment is inoculated with, curative tests
24h is inoculated with before chemicals treatment.Growth cabinet or constant temperature are placed in after inoculation to be had in illumination humidistat in fact, Celsius in temperature 26
Cultivated under conditions of -28 degrees Celsius of degree, relative humidity 80%-90%.According to blank control incidence, recorded with kind of calliper
Each vaccination scab length and width, represents that lesion diameter records lesion diameter (unit mm) according to tune with length and width average value
Data are looked into, by preventing and treating result publicity：Preventive effect=(blank diameter-processing diameter)/blank diameter * 100, calculates each processing and suppresses disease
The percentage of spot growth, by the linear regression analysis between the probit value of inhibiting rate and the logarithm value of series concentration, is obtained each
The EC50 values of medicament, the co-toxicity coefficient (CTC) of mixture is calculated with co-toxicity coefficient meter, reagent agent is evaluated to germ with this
Activity.
According to blank control incidence, lesion diameter is recorded, the percentage that each processing suppresses scab growth is calculated, passes through
Linear regression analysis between the probit value of inhibiting rate and the logarithm value of series concentration, obtains the EC50 values of each medicament, uses common poison
Coefficient table calculates the co-toxicity coefficient (CTC) of mixture, and activity of the reagent agent to germ is evaluated with this.
The co-toxicity coefficient (CTC) >=120 of complex preparation shows as synergistic effect；CTC≤80 show as antagonism；80 ﹤
CTC ﹤ 120 show as summation action.
The shenqinmycin of table 3 and fludioxonil compound the Toxicity Determination to wheat sharp eyespot
| Chemicals treatment | Proportioning | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| Shenqinmycin (A) | —— | Y=1.9338X+2.0570 | 33.2586 | —— |
| Fludioxonil (B3) | —— | Y=1.9057X+2.2920 | 26.3637 | —— |
| A：B3 | 1:100 | Y=1.2830X+3.2849 | 21.5031 | 121.62 |
| A：B3 | 1:50 | Y=1.0906X+3.6234 | 18.2905 | 144.72 |
| A：B3 | 1:25 | Y=0.9393X+3.8792 | 15.6047 | 170.30 |
| A：B3 | 1:1 | Y=0.9717X+3.8323 | 15.6883 | 187.48 |
| A：B3 | 25:1 | Y=1.4046X+3.2208 | 18.4823 | 178.15 |
| A：B3 | 50:1 | Y=15701X+2.8471 | 23.5048 | 140.77 |
| A：B3 | 100:1 | Y=17365X+2.5490 | 25.7910 | 128.61 |
Toxicity Determination result table 3 is shown, compares 1 in weight:100-100:1, particularly 1:50-50:In the range of 1,
Especially compare 1 in weight：25-25：Shenqinmycin with fludioxonil compounding there is obvious synergy to make to plant disease in the range of 1
With prevention effect is excellent and is better than single dose kind.
In order to prevent and treat the downy mildew of lettuce in agricultural production, inventor is with shenqinmycin and the triethylphosphine of organophosphorus fungicide
The synergy that sour aluminium is compounded is studied, and specific method is：
Experiment uses downy mildew of lettuce for test object.
The test medicine that active compound is configured to need, test method (plate blade method) reference《People's Republic of China's agriculture
Industry professional standard》.Choose lettuce susceptible variety potted plant, clip same section, growing way is consistent, with petiolate blade, puts culture
In ware, moisturizing is standby.By single dose and each Mixed Pharmacy set 5 various concentrations gradients (on the basis of pilot study result, root
Combine different with proportioning according to different agents, concentration sets also different, and bacteriostasis rate is set in the range of 5%~95%).Will
Decoction is uniformly sprayed in vacuum side of blade, after after decoction natural air drying, by each processing blade and blade dorsad on, by being discharged after processing mark
Standby in moisture preservation box, experiment sets the processing without medicament as blank control.It is inoculated with ready Fresh spores drop 10uL
In vacuum side of blade, dripped per blade inoculation 4, no less than 5 leaves of often processing, protectiveness experiment is inoculated with for 24 hours after chemicals treatment,
Curative tests are inoculated with for 24 hours before chemicals treatment, then cover ware lid, and it is 17~22 DEG C of relative humidity 90% to be placed in temperature
5-7d, daily continuous illumination/night 12h alternatings are cultivated in constant temperature and humidity incubator above；According to blank control morbidity feelings
Condition, records lesion diameter, calculates the percentage that each processing suppresses scab growth, passes through the probit value of inhibiting rate and series concentration
Linear regression analysis between logarithm value, obtains the EC50 values of each medicament, the co-toxicity coefficient of mixture is calculated with co-toxicity coefficient meter
(CTC) activity of the reagent agent to germ, is evaluated with this.
According to blank control incidence, lesion diameter is recorded, the percentage that each processing suppresses scab growth is calculated, passes through
Linear regression analysis between the probit value of inhibiting rate and the logarithm value of series concentration, obtains the EC50 values of each medicament, uses common poison
Coefficient table calculates the co-toxicity coefficient (CTC) of mixture, and activity of the reagent agent to germ is evaluated with this.
The co-toxicity coefficient (CTC) >=120 of complex preparation shows as synergistic effect；CTC≤80 show as antagonism；80 ﹤
CTC ﹤ 120 show as summation action.
The shenqinmycin of table 4 and phosethyl-Al compound the Toxicity Determination to downy mildew of lettuce
| Chemicals treatment | Proportioning | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| Shenqinmycin (A) | —— | Y=1.8664X+1.9415 | 43.5238 | —— |
| Phosethyl-Al (B4) | —— | Y=1.8435X+1.2674 | 105.8708 | —— |
| A：B4 | 1:100 | Y=1.7797X+1.7255 | 69.1631 | 150.93 |
| A：B4 | 1:50 | Y=1.5902X+2.2177 | 56.1834 | 183.29 |
| A：B4 | 1:25 | Y=1.2482X+2.8734 | 50.5453 | 198.54 |
| A：B4 | 1:1 | Y=1.3733X+3.1105 | 23.7598 | 259.62 |
| A：B4 | 25:1 | Y=1.3500X+3.0151 | 29.5324 | 150.79 |
| A：B4 | 50:1 | Y=1.0815X+3.3718 | 32.0268 | 137.49 |
| A：B4 | 100:1 | Y=0.8909X+3.6372 | 33.8661 | 129.27 |
Toxicity Determination result table 4 is shown, compares 1 in weight:100-100:1, particularly 1:50-50:In the range of 1,
Especially compare 1 in weight：25-25：Shenqinmycin has obvious synergy to plant disease with phosethyl-Al compounding in the range of 1
Effect, prevention effect is excellent and is better than single dose kind.
The result of Toxicity Determination table 1- tables 4 is shown, compares 1 in weight:100-100:1, particularly 1:50-50:1 scope
Interior, shenqinmycin is with cyazofamid, shenqinmycin Yu hymexazo, shenqinmycin and fludioxonil, shenqinmycin and phosethyl-Al are multiple
Pairing plant disease has obvious synergistic effect, and prevention effect is excellent and is better than single dose kind.Especially compare 1 in weight：25-
25：In the range of 1, shenqinmycin is with cyazofamid, shenqinmycin Yu hymexazo shenqinmycin and fludioxonil, shenqinmycin and three second
The synergistic effect of aluminum phosphate compounding becomes apparent.
To make the technical problem to be solved in the present invention, technical scheme and advantage clearer, compare 1 in weight:100~100:
In the range of 1, the embodiment that shenqinmycin is compounded with cyazofamid, hymexazos, fludioxonil or phosethyl-Al respectively is built, is carried out detailed
Thin description, but the present invention is limited to absolutely not these examples.
In addition, inventor is also found through experiments that, shenqinmycin respectively with cyazofamid, hymexazos, fludioxonil or triethylphosphine
The compounding effect of sour aluminium, better than the compounding of other antibioticses bactericide and cyazofamid, hymexazos, fludioxonil or phosethyl-Al
Effect.In order to clearly demonstrate this problem, compare 1 in weight:100~100:In the range of 1, other antibioticses bactericide are built
The comparative example compounded with cyazofamid, hymexazos, fludioxonil or phosethyl-Al, is described in detail.But because length is limited, only
Representative several comparative examples can be enumerated.It should be pointed out that not being limited in limited comparative example.
The bactericidal composition of the present invention can be prepared into any one formulation of suitable agricultural use with known method, than
Preferable formulation is wettable powder, aqueous suspension agent, oil-suspending agent, suspended emulsion, water dispersible granules.Percentage in all formulas
It is weight percentage.The processing technology of the various formulations of the present composition is prior art, can be had according to different situations
Changed.
Present invention is described further with reference to embodiment.
First, shenqinmycin and cyazofamid are compounded
Embodiment 1：20.2% shenqinmycin cyazofamid suspending agent (1:100)
Component:Shenqinmycin 0.2%, cyazofamid 20%, polycarboxylic acids sodium 3%, fatty alcohol oxygen vinethene 4%, 1,2- the third two
Alcohol 6%, XG0.32%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water complements to 100%.
Preparation method：Each component is mixed, it is well mixed through high speed shear, then be sanded 2-3 hours by sand mill, make to put down
Equal particle diameter reaches 1-5 microns, you can 20.2% shenqinmycin cyazofamid suspending agent is made.
Comparative example 1:20.2% polyoxin cyazofamid suspending agent (1:100)
Component:Polyoxin 0.2%, cyazofamid 20%, polycarboxylic acids sodium 3%, fatty alcohol oxygen vinethene 4%, 1,2- the third two
Alcohol 6%, XG0.32%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water complements to 100%.Preparation method：Ibid.
Embodiment 2:16.8% shenqinmycin cyazofamid water dispersible granules (1:55)
Component:Shenqinmycin 0.3%, cyazofamid 16.5%, lignin sodium naphthalene sulfonate 6%, polycarboxylic acids sodium 3%, anhydrous sulphur
Sour sodium 10%, kaolin complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 16.8% shenqinmycin cyazofamid water dispersible granules are made.
Embodiment 3:25.5% shenqinmycin cyazofamid wettable powder (1:50)
Component:Shenqinmycin 0.5%, cyazofamid 25%, lauryl sodium sulfate 4%, sodium lignin sulfonate 6%, hard charcoal
Black 6%, precipitated calcium carbonate complements to 100%.
Preparation method：Each component is well mixed, mechanical crushing is first passed through, then after air-flow crushing, is well mixed, i.e.,
25.5% shenqinmycin cyazofamid wettable powder can be made.
Comparative example 2：25.5% kasugarnycin cyazofamid wettable powder (1:50)
Component:Kasugarnycin 0.5%, cyazofamid 25%, lauryl sodium sulfate 4%, sodium lignin sulfonate 6%, hard charcoal
Black 6%, precipitated calcium carbonate complements to 100%.Preparation method：Ibid.
Embodiment 4:35% shenqinmycin cyazofamid dry suspending agent (1:34)
Component:Shenqinmycin 1%, cyazofamid 34%, lignin sodium naphthalene sulfonate 10%, sodium lignin sulfonate 8%, white carbon
10%, organic silicon defoamer 0.4%, Sodium Benzoate 0.1%, kaolin complements to 100%.Soft water 150-200%.
Preparation method：The water of 1.5-2.0 times of preparation amount of preparation is added, each component is mixed, mixes equal through high speed shear
It is even, then be sanded 2-3 hours by sand mill, average grain diameter is reached 1-5 microns, dehydrate that to can be prepared by 35% Shen piperazine mould
Plain cyazofamid dry suspending agent.
Embodiment 5:26% shenqinmycin cyazofamid water dispersible granules (1:25)
Component:Shenqinmycin 1%, cyazofamid 25%, sodium naphthalene sulfonate 4%, polycarboxylic acids sodium 4%, anhydrous sodium sulfate 8% is sliding
Stone flour complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 26% shenqinmycin cyazofamid water dispersible granules are made.
Comparative example 3:26% Ningnanmycin cyazofamid water dispersible granules (1:25)
Component:Ningnanmycin 1%, cyazofamid 25%, sodium naphthalene sulfonate 4%, polycarboxylic acids sodium 4%, anhydrous sodium sulfate 8% is sliding
Stone flour complements to 100%.Preparation method：Ibid.
Embodiment 6:32% shenqinmycin cyazofamid suspending agent (1:15)
Component:Shenqinmycin 2%, cyazofamid 30%, acrylic acid-acrylic acid hydroxypropyl ester copolymer 4%, fatty alcohol polyoxy second
Alkene ether 3%, ethylene glycol 6%, XG0.25%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water complements to 100%.
Preparation method：Each component is mixed, it is well mixed through high speed shear, then be sanded 2-3 hours by sand mill, make to put down
Equal particle diameter reaches 1-5 microns, you can 16% shenqinmycin cyazofamid suspending agent is made.
Embodiment 7：20% shenqinmycin cyazofamid wettable powder (1:1)
Component:Shenqinmycin 10%, cyazofamid 10%, neopelex 4%, dodecyl naphthalene sulphonate formaldehyde
Condensation product 6%, white carbon 6%, precipitated calcium carbonate complements to 100%.
Preparation method：Each component is well mixed, mechanical crushing is first passed through, then after air-flow crushing, is well mixed, i.e.,
20% shenqinmycin cyazofamid wettable powder can be made.
Comparative example 4：20% polyoxin cyazofamid wettable powder (1:1)
Component:Polyoxin 10%, cyazofamid 10%, neopelex 4%, dodecyl naphthalene sulphonate formaldehyde
Condensation product 6%, white carbon 6%, precipitated calcium carbonate complements to 100%.Preparation method：Ibid.
Comparative example 5：20% kasugarnycin cyazofamid wettable powder (1:1)
Component:Kasugarnycin 10%, cyazofamid 10%, neopelex 4%, dodecyl naphthalene sulphonate formaldehyde
Condensation product 6%, white carbon 6%, precipitated calcium carbonate complements to 100%.Preparation method：Ibid.
Embodiment 8:21% shenqinmycin cyazofamid water dispersible granules (19:2)
Component:Shenqinmycin 19%, cyazofamid 2%, lauryl sodium sulfate 3%, polycarboxylic acids sodium 4%, anhydrous sodium sulfate
6%, talcum powder complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 21% shenqinmycin cyazofamid water dispersible granules are made.
Embodiment 9：16% shenqinmycin cyazofamid dry suspending agent (15:1)
Component:Shenqinmycin 15%, cyazofamid 1%, lignin sodium naphthalene sulfonate 8%, sodium lignin sulfonate 8%, white carbon
6%, organic silicon defoamer 0.4%, Sodium Benzoate 0.1%, kaolin complements to 100%.Soft water 150-200%.
Preparation method：The water of 1.5-2.0 times of preparation amount of preparation is added, each component is mixed, mixes equal through high speed shear
It is even, then be sanded 2-3 hours by sand mill, average grain diameter is reached 1-5 microns, dehydrate that to can be prepared by 16% Shen piperazine mould
Plain cyazofamid dry suspending agent.
Embodiment 10:26% shenqinmycin cyazofamid water dispersible granules (25:1)
Component:Shenqinmycin 25%, cyazofamid 1%, lauryl sodium sulfate 3%, lignin sodium naphthalene sulfonate 6% is anhydrous
Sodium sulphate 8%, kaolin complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 26% shenqinmycin cyazofamid water dispersible granules are made.
Comparative example 6:26% Ningnanmycin cyazofamid water dispersible granules (25:1)
Component:Ningnanmycin 25%, cyazofamid 1%, lauryl sodium sulfate 3%, lignin sodium naphthalene sulfonate 6% is anhydrous
Sodium sulphate 8%, kaolin complements to 100%.Preparation method：Ibid.
Embodiment 11:23% shenqinmycin cyazofamid suspending agent (45:1)
Component:Shenqinmycin 22.5%, cyazofamid 0.5%, polycarboxylic acids sodium 4%, fatty alcohol oxygen vinethene 3%, ethylene glycol
5%, XG0.3%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water complements to 100%.
Preparation method：Each component is mixed, it is well mixed through high speed shear, then be sanded 2-3 hours by sand mill, make to put down
Equal particle diameter reaches 1-5 microns, you can 23% shenqinmycin cyazofamid suspending agent is made.
Embodiment 12:20.4% shenqinmycin cyazofamid suspending agent (50:1)
Component:Shenqinmycin 20%, cyazofamid 0.4%, polycarboxylic acids sodium 3%, fatty alcohol oxygen vinethene 3%, 1,2- the third two
Alcohol 5%, XG0.3%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water complements to 100%.
Preparation method：Each component is mixed, it is well mixed through high speed shear, then be sanded 2-3 hours by sand mill, make to put down
Equal particle diameter reaches 1-5 microns, you can 20.4% shenqinmycin cyazofamid suspending agent is made.
Comparative example 7：20.4% kasugarnycin cyazofamid suspending agent (50:1)
Component:Kasugarnycin 20%, cyazofamid 0.4%, polycarboxylic acids sodium 3%, fatty alcohol oxygen vinethene 3%, 1,2- the third two
Alcohol 5%, XG0.3%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water complements to 100%.Preparation method：Ibid.
Embodiment 13:20.2% shenqinmycin cyazofamid wettable powder (100:1)
Component：Shenqinmycin 20%, cyazofamid 0.2%, neopelex 3%, lignin sodium naphthalene sulfonate 6%,
White carbon 6%, talcum powder complements to 100%.
Preparation method：Each component is well mixed, mechanical crushing is first passed through, then after air-flow crushing, is well mixed, i.e.,
20.2% shenqinmycin cyazofamid wettable powder can be made.
Comparative example 8：20.2% polyoxin cyazofamid wettable powder (100:1)
Component：Polyoxin 20%, cyazofamid 0.2%, neopelex 3%, lignin sodium naphthalene sulfonate 6%,
White carbon 6%, talcum powder complements to 100%.Preparation method：Ibid.
2nd, shenqinmycin is Yu hymexazo is compounded
Embodiment 14：20.2% Shen piperazine Mei Su hymexazos water dispersible granules (1:100)
Component:The , hymexazos 20% of shenqinmycin 0.2%, lauryl sodium sulfate 3%, polycarboxylic acids sodium 4%, anhydrous slufuric acid
Sodium 8%, kaolin complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 20.2% Shen piperazine Mei Su hymexazo water dispersible granules are made.
Comparative example 9:The Mei Su hymexazos of Kang Duo in the of 20.2% water dispersible granules (1:100)
Component:The , hymexazos 20% of polyoxin 0.2%, lauryl sodium sulfate 3%, polycarboxylic acids sodium 4%, anhydrous slufuric acid
Sodium 8%, kaolin complements to 100%.Preparation method：Ibid.
Embodiment 15:16.8% Shen piperazine Mei Su hymexazos suspending agent (1:55)
Component:Shenqinmycin 0.3%, hymexazo 16.5%, acrylic acid-acrylic acid hydroxypropyl ester copolymer 3%, poly alkyl alcohol
Oxygen vinethene 3%, ethylene glycol 6%, XG 0.32%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water is complemented to
100%.
Preparation method：Each component is mixed, it is well mixed through high speed shear, then be sanded 2-3 hours by sand mill, make to put down
Equal particle diameter reaches 1-5 microns, you can 16.8% Shen piperazine Mei Su hymexazo suspending agents are made.
Embodiment 16:25.5% Shen piperazine Mei Su hymexazos wettable powder (1:50)
Component:The , hymexazos 25% of shenqinmycin 0.5%, sodium naphthalene sulfonate 5%, lauryl sodium sulfate 3%, white carbon
10%, talcum powder complements to 100%.
Preparation method：Each component is well mixed, mechanical crushing is first passed through, then after air-flow crushing, is well mixed, i.e.,
25.5% Shen piperazine Mei Su hymexazo wettable powders can be made.
Comparative example 10：The peaceful Mei Su hymexazos wettable powder (1 of 25.5% Chinese parasol tree:50)
Component:The , hymexazos 25% of tetramycin 0.5%, sodium naphthalene sulfonate 5%, lauryl sodium sulfate 3%, white carbon
10%, talcum powder complements to 100%.Preparation method：Ibid.
Embodiment 17:35% Shen piperazine Mei Su hymexazos dry suspending agent (1:34)
Component:The , hymexazos 34% of shenqinmycin 1%, sodium lignin sulfonate 6%, lignin sodium naphthalene sulfonate 8%, organosilicon
Defoamer 0.4%, Sodium Benzoate 0.1%, white carbon 10%, kaolin complements to 100%.Soft water 150-200%.
Preparation method：The water of 1.5-2.0 times of preparation amount of preparation is added, each component is mixed, mixes equal through high speed shear
It is even, then be sanded 2-3 hours by sand mill, average grain diameter is reached 1-5 microns, dehydrate that to can be prepared by 35% Shen piperazine mould
Su hymexazo dry suspending agents.
Embodiment 18:26% Shen piperazine Mei Su hymexazos water dispersible granules (1:25)
Component:The , hymexazos 25% of shenqinmycin 1%, neopelex 4%, polycarboxylic acids sodium 4%, anhydrous slufuric acid
Sodium 8%, talcum powder complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 26% Shen piperazine Mei Su hymexazo water dispersible granules are made.
Comparative example 11:The Mei Su hymexazos of Kang Duo in the of 26% water dispersible granules (1:25)
Component:The , hymexazos 25% of polyoxin 1%, neopelex 4%, polycarboxylic acids sodium 4%, anhydrous slufuric acid
Sodium 8%, talcum powder complements to 100%.Preparation method：Ibid.
Embodiment 19:32% Shen piperazine Mei Su hymexazos suspending agent (1:15)
Component:The , hymexazos 30% of shenqinmycin 2%, polycarboxylic acids sodium 4%, AEO 3%, ethylene glycol
6%, XG 0.26%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water complements to 100%.
Preparation method：Each component is mixed, it is well mixed through high speed shear, then be sanded 2-3 hours by sand mill, make to put down
Equal particle diameter reaches 1-5 microns, you can 32% Shen piperazine Mei Su hymexazo suspending agents are made.
Embodiment 20：20% Shen piperazine Mei Su hymexazos wettable powder (1:1)
Component:The , hymexazos 10% of shenqinmycin 10%, lignin sodium naphthalene sulfonate 6%, neopelex 3%, in vain
Carbon black 10%, kaolin complements to 100%.
Preparation method：Each component is well mixed, mechanical crushing is first passed through, then after air-flow crushing, is well mixed, i.e.,
20% Shen piperazine Mei Su hymexazo wettable powders can be made.
Comparative example 12：The Mei Su hymexazos of Kang Duo in the of 20% wettable powder (1:1)
Component:The , hymexazos 10% of polyoxin 10%, lignin sodium naphthalene sulfonate 6%, neopelex 3%, in vain
Carbon black 10%, kaolin complements to 100%.Preparation method：Ibid.
Embodiment 21:21% Shen piperazine Mei Su hymexazos water dispersible granules (19:2)
Component:The , hymexazos 2% of shenqinmycin 19%, dodecyl sodium sulfate 4%, lauryl sodium sulfate 4% is anhydrous
Sodium sulphate 10%, talcum powder complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 21% Shen piperazine Mei Su hymexazo water dispersible granules are made.
Embodiment 22：16% Shen piperazine Mei Su hymexazos dry suspending agent (15:1)
Component:The , hymexazos 1% of shenqinmycin 15%, polycarboxylic acids sodium 4%, lignin sodium naphthalene sulfonate 10%, organosilicon froth breaking
Agent 0.4%, Sodium Benzoate 0.1%, white carbon 10%, kaolin complements to 100%.Soft water 150-200%.
Preparation method：The water of 1.5-2.0 times of preparation amount of preparation is added, each component is mixed, mixes equal through high speed shear
It is even, then be sanded 2-3 hours by sand mill, average grain diameter is reached 1-5 microns, dehydrate that to can be prepared by 16% Shen piperazine mould
Su hymexazo dry suspending agents.
Embodiment 23:26% Shen piperazine Mei Su hymexazos water dispersible granules (25:1)
Component:The , hymexazos 1% of shenqinmycin 25%, polycarboxylic acids sodium 4%, lauryl sodium sulfate 4%, anhydrous sodium sulfate
10%, kaolin complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 26% Shen piperazine Mei Su hymexazo water dispersible granules are made.
Comparative example 13:The peaceful Mei Su hymexazos water dispersible granules (25 of 26% Chinese parasol tree:1)
Component:The , hymexazos 1% of tetramycin 25%, polycarboxylic acids sodium 4%, lauryl sodium sulfate 4%, anhydrous sodium sulfate
10%, kaolin complements to 100%.Preparation method：Ibid.
Embodiment 24:23% Shen piperazine Mei Su hymexazos suspending agent (45:1)
Component:The , hymexazos 0.5% of shenqinmycin 22.5%, polycarboxylic acids sodium 3%, OPEO sodium sulfonate
3%, ethylene glycol 6%, XG 0.3%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water complements to 100%.
Preparation method：Each component is mixed, it is well mixed through high speed shear, then be sanded 2-3 hours by sand mill, make to put down
Equal particle diameter reaches 1-5 microns, you can 23% Shen piperazine Mei Su hymexazo suspending agents are made.
Embodiment 25:20.4% Shen piperazine Mei Su hymexazos dry suspending agent (50:1)
Component:The , hymexazos 0.4% of shenqinmycin 20%, sodium lignin sulfonate 6%, lignin sodium naphthalene sulfonate 10% is organic
Silicon defoaming agent 0.4%, Sodium Benzoate 0.1%, white carbon 6%, talcum powder complements to 100%.Soft water 150-200%.
Preparation method：The water of 1.5-2.0 times of preparation amount of preparation is added, each component is mixed, mixes equal through high speed shear
It is even, then be sanded 2-3 hours by sand mill, average grain diameter is reached 1-5 microns, dehydrate that to can be prepared by 20.4% Shen piperazine mould
Su hymexazo dry suspending agents.
Comparative example 14：The Mei Su hymexazos of Kang Duo in the of 20.4% dry suspending agent (50:1)
Component:The , hymexazos 0.4% of polyoxin 20%, sodium lignin sulfonate 6%, lignin sodium naphthalene sulfonate 10% is organic
Silicon defoaming agent 0.4%, Sodium Benzoate 0.1%, white carbon 6%, talcum powder complements to 100%.Soft water 150-200%.Preparation side
Method：Ibid.
Embodiment 26:20.2% Shen piperazine Mei Su hymexazos wettable powder (100:1)
Component：The , hymexazos 0.2% of shenqinmycin 20%, neopelex 3%, lignin sodium naphthalene sulfonate 6%,
White carbon 8%, kaolin complements to 100%.
Preparation method：Each component is well mixed, mechanical crushing is first passed through, then after air-flow crushing, is well mixed, i.e.,
20.2% Shen piperazine Mei Su hymexazo wettable powders can be made.
Comparative example 15：The peaceful Mei Su hymexazos wettable powder (100 of 20.2% Chinese parasol tree:1)
Component：The , hymexazos 0.2% of tetramycin 20%, neopelex 3%, lignin sodium naphthalene sulfonate 6%,
White carbon 8%, kaolin complements to 100%.Preparation method：Ibid.
3rd, shenqinmycin and fludioxonil are compounded
Embodiment 27：20.2% shenqinmycin fludioxonil suspending agent (1:100)
Component:Shenqinmycin 0.2%, fludioxonil 20%, polycarboxylic acids sodium 3%, AEO 3%, ethylene glycol
6%, XG 0.32%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water complements to 100%.
Preparation method：Each component is mixed, it is well mixed through high speed shear, then be sanded 2-3 hours by sand mill, make to put down
Equal particle diameter reaches 1-5 microns, you can 20.2% shenqinmycin fludioxonil suspending agent is made.
Comparative example 16:20.2% polyoxin fludioxonil suspending agent (1:100)
Component:Polyoxin 0.2%, fludioxonil 20%, polycarboxylic acids sodium 3%, AEO 3%, ethylene glycol
6%, XG 0.32%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water complements to 100%.Preparation method：Ibid.
Embodiment 28:16.8% shenqinmycin fludioxonil water dispersible granules (1:55)
Component:Shenqinmycin 0.3%, fludioxonil 16.5%, neopelex 4%, polycarboxylic acids sodium 4% is anhydrous
Sodium sulphate 8%, talcum powder complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 16.8% shenqinmycin fludioxonil water dispersible granules are made.
Comparative example 17:16.8% jinggangmeisu fludioxonil water dispersible granules (1:55)
Component:Jinggangmeisu 0.3%, fludioxonil 16.5%, neopelex 4%, polycarboxylic acids sodium 4% is anhydrous
Sodium sulphate 8%, talcum powder complements to 100%.Preparation method：Ibid.
Embodiment 29:25.5% shenqinmycin fludioxonil wettable powder (1:50)
Component:Shenqinmycin 0.5%, fludioxonil 25%, neopelex 4%, naphthalenesulfonic acid-formaldehyde condensate
8%, white carbon 6%, precipitated calcium carbonate complements to 100%.
Preparation method：Each component is well mixed, mechanical crushing is first passed through, then after air-flow crushing, is well mixed, i.e.,
25.5% shenqinmycin fludioxonil wettable powder can be made.
Comparative example 18：25.5% kasugarnycin fludioxonil wettable powder (1:50)
Component:Kasugarnycin 0.5%, fludioxonil 25%, neopelex 4%, naphthalenesulfonic acid-formaldehyde condensate
8%, white carbon 6%, precipitated calcium carbonate complements to 100%.Preparation method：Ibid.
Embodiment 30:35% shenqinmycin fludioxonil dry suspending agent (1:34)
Component:Shenqinmycin 1%, fludioxonil 34%, lignin sodium naphthalene sulfonate 10%, polycarboxylic acids sodium 4%, white carbon 5%,
Organic silicon defoamer 0.4%, Sodium Benzoate 0.1%, talcum powder complements to 100%.Soft water 150-200%.
Preparation method：The water of 1.5-2.0 times of preparation amount of preparation is added, each component is mixed, mixes equal through high speed shear
It is even, then be sanded 2-3 hours by sand mill, average grain diameter is reached 1-5 microns, dehydrate that to can be prepared by 35% Shen piperazine mould
Plain fludioxonil dry suspending agent.
Embodiment 31:26% shenqinmycin fludioxonil water dispersible granules (1:25)
Component:Shenqinmycin 1%, fludioxonil 25%, sodium naphthalene sulfonate 4%, polycarboxylic acids sodium 4%, anhydrous sodium sulfate 10% is sliding
Stone flour complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 26% shenqinmycin fludioxonil water dispersible granules are made.
Comparative example 19:26% Ningnanmycin fludioxonil water dispersible granules (1:25)
Component:Ningnanmycin 1%, fludioxonil 25%, sodium naphthalene sulfonate 4%, polycarboxylic acids sodium 4%, anhydrous sodium sulfate 10% is sliding
Stone flour complements to 100%.Preparation method：Ibid.
Embodiment 32:32% shenqinmycin fludioxonil suspending agent (1:15)
Component:Shenqinmycin 2%, fludioxonil 30%, polycarboxylic acids sodium 3%, OPEO sodium sulfonate 3%, second
Glycol 6%, XG 0.25%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water complements to 100%.
Preparation method：Each component is mixed, it is well mixed through high speed shear, then be sanded 2-3 hours by sand mill, make to put down
Equal particle diameter reaches 1-5 microns, you can 32% shenqinmycin fludioxonil suspending agent is made.
Comparative example 20:32% tetramycin fludioxonil suspending agent (1:15)
Component:Tetramycin 2%, fludioxonil 30%, polycarboxylic acids sodium 3%, OPEO sodium sulfonate 3%, second
Glycol 6%, XG 0.25%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water complements to 100%.Preparation method：Together
On.
Embodiment 33：20% shenqinmycin fludioxonil wettable powder (1:1)
Component:Shenqinmycin 10%, fludioxonil 10%, polycarboxylic acids sodium 5%, lauryl sodium sulfate 3%, white carbon 8%,
Precipitated calcium carbonate complements to 100%.
Preparation method：Each component is well mixed, mechanical crushing is first passed through, then after air-flow crushing, is well mixed, i.e.,
20% shenqinmycin fludioxonil wettable powder can be made.
Comparative example 21：20% polyoxin fludioxonil wettable powder (1:1)
Component:Polyoxin 10%, fludioxonil 10%, polycarboxylic acids sodium 5%, lauryl sodium sulfate 3%, white carbon 8%,
Precipitated calcium carbonate complements to 100%.Preparation method：Ibid.
Comparative example 22：20% kasugarnycin fludioxonil wettable powder (1:1)
Component:Kasugarnycin 10%, fludioxonil 10%, polycarboxylic acids sodium 5%, lauryl sodium sulfate 3%, white carbon 8%,
Precipitated calcium carbonate complements to 100%.Preparation method：Ibid.
Embodiment 34:21% shenqinmycin fludioxonil water dispersible granules (19:2)
Component:Shenqinmycin 19%, fludioxonil 2%, neopelex 4%, polycarboxylic acids sodium 4%, anhydrous slufuric acid
Sodium 10%, talcum powder complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 21% shenqinmycin fludioxonil water dispersible granules are made.
Embodiment 35：16% shenqinmycin fludioxonil dry suspending agent (15:1)
Component:Shenqinmycin 15%, fludioxonil 1%, lignin sodium naphthalene sulfonate 8%, sodium lignin sulfonate 8%, white carbon
6%, organic silicon defoamer 0.4%, Sodium Benzoate 0.1%, kaolin complements to 100%.Soft water 150-200%.
Preparation method：The water of 1.5-2.0 times of preparation amount of preparation is added, each component is mixed, mixes equal through high speed shear
It is even, then be sanded 2-3 hours by sand mill, average grain diameter is reached 1-5 microns, dehydrate that to can be prepared by 16% Shen piperazine mould
Plain fludioxonil dry suspending agent.
Comparative example 23：16% jinggangmeisu fludioxonil dry suspending agent (15:1)
Component:Jinggangmeisu 15%, fludioxonil 1%, lignin sodium naphthalene sulfonate 8%, sodium lignin sulfonate 8%, white carbon
6%, organic silicon defoamer 0.4%, Sodium Benzoate 0.1%, kaolin complements to 100%.Soft water 150-200%.Preparation method：
Ibid.
Embodiment 36:26% shenqinmycin fludioxonil water dispersible granules (25:1)
Component:Shenqinmycin 25%, fludioxonil 1%, lauryl sodium sulfate 3%, lignin sodium naphthalene sulfonate 6% is anhydrous
Sodium sulphate 8%, kaolin complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 26% shenqinmycin fludioxonil water dispersible granules are made.
Comparative example 24:26% Ningnanmycin fludioxonil water dispersible granules (25:1)
Component:Ningnanmycin 25%, fludioxonil 1%, lauryl sodium sulfate 3%, lignin sodium naphthalene sulfonate 6% is anhydrous
Sodium sulphate 8%, kaolin complements to 100%.Preparation method：Ibid.
Embodiment 37:23% shenqinmycin fludioxonil suspending agent (45:1)
Component:Shenqinmycin 22.5%, fludioxonil 0.5%, polycarboxylic acids sodium 4%, fatty alcohol oxygen vinethene 3%, ethylene glycol
5%, XG0.3%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water complements to 100%.
Preparation method：Each component is mixed, it is well mixed through high speed shear, then be sanded 2-3 hours by sand mill, make to put down
Equal particle diameter reaches 1-5 microns, you can 23% shenqinmycin fludioxonil suspending agent is made.
Embodiment 38:20.4% shenqinmycin fludioxonil dry suspending agent (50:1)
Component:Shenqinmycin 20%, fludioxonil 0.4%, sodium lignin sulfonate 6%, lignin sodium naphthalene sulfonate 10% is organic
Silicon defoaming agent 0.4%, Sodium Benzoate 0.1%, white carbon 6%, talcum powder complements to 100%.Soft water 150-200%.
Preparation method：The water of 1.5-2.0 times of preparation amount of preparation is added, each component is mixed, mixes equal through high speed shear
It is even, then be sanded 2-3 hours by sand mill, average grain diameter is reached 1-5 microns, dehydrate that to can be prepared by 20.4% Shen piperazine mould
Plain fludioxonil dry suspending agent.
Comparative example 25：20.4% kasugarnycin fludioxonil dry suspending agent (50:1)
Component:Kasugarnycin 20%, fludioxonil 0.4%, sodium lignin sulfonate 6%, lignin sodium naphthalene sulfonate 10% is organic
Silicon defoaming agent 0.4%, Sodium Benzoate 0.1%, white carbon 6%, talcum powder complements to 100%.Soft water 150-200%.Preparation side
Method：Ibid.
Embodiment 39:20.2% shenqinmycin fludioxonil wettable powder (100:1)
Component：Shenqinmycin 20%, fludioxonil 0.2%, neopelex 3%, lignin sodium naphthalene sulfonate 6%,
White carbon 6%, talcum powder complements to 100%.
Preparation method：Each component is well mixed, mechanical crushing is first passed through, then after air-flow crushing, is well mixed, i.e.,
20.2% shenqinmycin fludioxonil wettable powder can be made.
Comparative example 26：20.2% polyoxin fludioxonil wettable powder (100:1)
Component：Polyoxin 20%, fludioxonil 0.2%, neopelex 3%, lignin sodium naphthalene sulfonate 6%,
White carbon 6%, talcum powder complements to 100%.
Preparation method：Ibid.
Comparative example 27：20.2% tetramycin fludioxonil wettable powder (100:1)
Component：Tetramycin 20%, fludioxonil 0.2%, neopelex 3%, lignin sodium naphthalene sulfonate 6%,
White carbon 6%, talcum powder complements to 100%.Preparation method：Ibid.
4th, shenqinmycin and phosethyl-Al are compounded
Embodiment 40：20.2% shenqinmycin phosethyl-Al wettable powder (1:100)
Component:Shenqinmycin 0.2%, phosethyl-Al 20%, neopelex 3%, lignin sodium naphthalene sulfonate
6%, white carbon 10%, kaolin complements to 100%.
Preparation method：Each component is well mixed, mechanical crushing is first passed through, then after air-flow crushing, is well mixed, i.e.,
20.2% shenqinmycin phosethyl-Al wettable powder can be made.
Comparative example 28:20.2% polyoxin phosethyl-Al wettable powder (1:100)
Component:Polyoxin 0.2%, phosethyl-Al 20%, neopelex 3%, lignin sodium naphthalene sulfonate
6%, white carbon 10%, kaolin complements to 100%.Preparation method：Ibid.
Embodiment 41:16.8% shenqinmycin phosethyl-Al water dispersible granules (1:55)
Component:Shenqinmycin 0.3%, phosethyl-Al 16.5%, lauryl sodium sulfate 4%, polycarboxylic acids sodium 4%, nothing
Aqueous sodium persulfate 15%, talcum powder complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 16.8% shenqinmycin phosethyl-Al water dispersible granules are made.
Embodiment 42:25.5% shenqinmycin phosethyl-Al wettable powder (1:50)
Component:Shenqinmycin 0.5%, phosethyl-Al 25%, neopelex 5%, lignin sodium naphthalene sulfonate
8%, white carbon 10%, precipitated calcium carbonate complements to 100%.
Preparation method：Each component is well mixed, mechanical crushing is first passed through, then after air-flow crushing, is well mixed, i.e.,
25.5% shenqinmycin phosethyl-Al wettable powder can be made.
Comparative example 29：25.5% kasugarnycin phosethyl-Al wettable powder (1:50)
Component:Kasugarnycin 0.5%, phosethyl-Al 25%, neopelex 5%, lignin sodium naphthalene sulfonate
8%, white carbon 10%, precipitated calcium carbonate complements to 100%.Preparation method：Ibid.
Embodiment 43:35% shenqinmycin phosethyl-Al dry suspending agent (1:34)
Component:Shenqinmycin 1%, phosethyl-Al 34%, lignin sodium naphthalene sulfonate 10%, sodium lignin sulfonate 6%, in vain
Carbon black 12%, organic silicon defoamer 0.4%, Sodium Benzoate 0.1%, talcum powder complements to 100%.Soft water 150-200%.
Preparation method：The water of 1.5-2.0 times of preparation amount of preparation is added, each component is mixed, mixes equal through high speed shear
It is even, then be sanded 2-3 hours by sand mill, average grain diameter is reached 1-5 microns, dehydrate that to can be prepared by 35% Shen piperazine mould
Plain phosethyl-Al dry suspending agent.
Embodiment 44:26% shenqinmycin phosethyl-Al water dispersible granules (1:25)
Component:Shenqinmycin 1%, phosethyl-Al 25%, neopelex 4%, polycarboxylic acids sodium 4% is anhydrous
Sodium sulphate 15%, talcum powder complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 26% shenqinmycin phosethyl-Al water dispersible granules are made.
Comparative example 30:26% jinggangmeisu phosethyl-Al water dispersible granules (1:25)
Component:Jinggangmeisu 1%, phosethyl-Al 25%, neopelex 4%, polycarboxylic acids sodium 4% is anhydrous
Sodium sulphate 15%, talcum powder complements to 100%.Preparation method：Ibid.
Embodiment 45:32% shenqinmycin phosethyl-Al wettable powder (1:15)
Component:Shenqinmycin 2%, phosethyl-Al 30%, neopelex 3%, polycarboxylic acids sodium 5%, hard charcoal
Black 12%, talcum powder complements to 100%.
Preparation method：Each component is well mixed, mechanical crushing is first passed through, then after air-flow crushing, is well mixed, i.e.,
32% shenqinmycin phosethyl-Al wettable powder can be made.
Embodiment 46：20% shenqinmycin phosethyl-Al dry suspending agent (1:1)
Component:Shenqinmycin 10%, phosethyl-Al 10%, polycarboxylic acids sodium 5%, sodium lignin sulfonate 10%, organosilicon
Defoamer 0.4%, Sodium Benzoate 0.1%, white carbon 8%, kaolin complements to 100%.Soft water 150-200%.
Preparation method：The water of 1.5-2.0 times of preparation amount of preparation is added, each component is mixed, mixes equal through high speed shear
It is even, then be sanded 2-3 hours by sand mill, average grain diameter is reached 1-5 microns, dehydrate that to can be prepared by 25% Shen piperazine mould
Plain phosethyl-Al dry suspending agent.
Comparative example 31：20% tetramycin phosethyl-Al dry suspending agent (1:1)
Component:Tetramycin 10%, phosethyl-Al 10%, polycarboxylic acids sodium 5%, sodium lignin sulfonate 10%, organosilicon
Defoamer 0.4%, Sodium Benzoate 0.1%, white carbon 8%, kaolin complements to 100%.Soft water 150-200%.Preparation method：
Ibid.
Comparative example 32：20% kasugarnycin phosethyl-Al dry suspending agent (1:1)
Component:Kasugarnycin 10%, phosethyl-Al 10%, polycarboxylic acids sodium 5%, sodium lignin sulfonate 10%, organosilicon
Defoamer 0.4%, Sodium Benzoate 0.1%, white carbon 8%, kaolin complements to 100%.Soft water 150-200%.Preparation method：
Ibid.
Embodiment 47:21% shenqinmycin phosethyl-Al water dispersible granules (19:2)
Component:Shenqinmycin 19%, phosethyl-Al 2%, polycarboxylic acids sodium 4%, lauryl sodium sulfate 4%, anhydrous sulphur
Sour sodium 10%, talcum powder complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 21% shenqinmycin phosethyl-Al water dispersible granules are made.
Embodiment 48：16% shenqinmycin phosethyl-Al suspending agent (15:1)
Component:Shenqinmycin 15%, phosethyl-Al 1%, polycarboxylic acids sodium 4%, fatty alcohol oxygen vinethene 3%, ethylene glycol
5%, XG0.35%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water complements to 100%.
Preparation method：Each component is mixed, it is well mixed through high speed shear, then be sanded 2-3 hours by sand mill, make to put down
Equal particle diameter reaches 1-5 microns, you can 16% shenqinmycin phosethyl-Al suspending agent is made.
Embodiment 49:26% shenqinmycin phosethyl-Al water dispersible granules (25:1)
Component:Shenqinmycin 25%, phosethyl-Al 1%, neopelex 3%, lignin sodium naphthalene sulfonate
6%, anhydrous sodium sulfate 6%, kaolin complements to 100%.
Preparation method：Each component is mixed, through mechanical crushing, then through air-flow crushing, is well mixed, then through wet granulation simultaneously
Drying, you can 26% shenqinmycin phosethyl-Al water dispersible granules are made.
Comparative example 33:26% tetramycin phosethyl-Al water dispersible granules (25:1)
Component:Shenqinmycin 25%, phosethyl-Al 1%, neopelex 3%, lignin sodium naphthalene sulfonate
6%, anhydrous sodium sulfate 6%, kaolin complements to 100%.Preparation method：Ibid.
Embodiment 50:23% shenqinmycin phosethyl-Al suspending agent (45:1)
Component:Shenqinmycin 22.5%, phosethyl-Al 0.5%, acrylic acid-acrylic acid hydroxypropyl ester copolymer 3%, fat
Alcohol oxygen vinethene 3%, ethylene glycol 5%, XG0.3%, organic silicon defoamer 0.2%, Sodium Benzoate 0.4%, soft water is complemented to
100%.
Preparation method：Each component is mixed, it is well mixed through high speed shear, then be sanded 2-3 hours by sand mill, make to put down
Equal particle diameter reaches 1-5 microns, you can 23% shenqinmycin phosethyl-Al suspending agent is made.
Embodiment 51:20.4% shenqinmycin phosethyl-Al dry suspending agent (50:1)
Component:Shenqinmycin 20%, phosethyl-Al 0.4%, sodium lignin sulfonate 8%, lignin sodium naphthalene sulfonate 8%,
Organic silicon defoamer 0.4%, Sodium Benzoate 0.1%, white carbon 6%, talcum powder complements to 100%.Soft water 150-200%.
Preparation method：The water of 1.5-2.0 times of preparation amount of preparation is added, each component is mixed, mixes equal through high speed shear
It is even, then be sanded 2-3 hours by sand mill, average grain diameter is reached 1-5 microns, dehydrate that to can be prepared by 20.4% Shen piperazine mould
Plain phosethyl-Al dry suspending agent.
Comparative example 34：20.4% kasugarnycin phosethyl-Al dry suspending agent (50:1)
Component:Kasugarnycin 20%, phosethyl-Al 0.4%, sodium lignin sulfonate 8%, lignin sodium naphthalene sulfonate 8%,
Organic silicon defoamer 0.4%, Sodium Benzoate 0.1%, white carbon 6%, talcum powder complements to 100%.Soft water 150-200%.System
Preparation Method：Ibid.
Embodiment 52:20.2% shenqinmycin phosethyl-Al wettable powder (100:1)
Component：Shenqinmycin 20%, phosethyl-Al 0.2%, neopelex 3%, naphthalene sulfonate formaldehyde contracting
Compound 6%, white carbon 6%, kaolin complements to 100%.
Preparation method：Each component is well mixed, mechanical crushing is first passed through, then after air-flow crushing, is well mixed, i.e.,
20.2% shenqinmycin phosethyl-Al wettable powder can be made.
Comparative example 35：20.2% polyoxin phosethyl-Al wettable powder (100:1)
Component：Shenqinmycin 20%, phosethyl-Al 0.2%, neopelex 3%, naphthalene sulfonate formaldehyde contracting
Compound 6%, white carbon 6%, kaolin complements to 100%.Preparation method：Ibid.
Found by experiment, cyazofamid, hymexazos, fludioxonil or the phosethyl-Al in above example can be replaced mutually
Generation, to form new embodiment.This is no longer carried out to repeat to enumerate, it is noted that for the ordinary skill people of the art
For member, on the premise of principle of the present invention is not departed from, some improvements and modifications can also be made, these improvements and modifications
Also it should be regarded as protection scope of the present invention.
Tested with pesticidal preparations preventing and treating cucumber downy mildew, tomato late blight made from above-described embodiment, comparative example.
1st, test process：Experiment is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This examination
Test dosing and three concentration for the treatment of are set according to the difference of each composition respectively, comparison medicament is the commercially available cyanogen of agricultural chemicals 20% frost respectively
Azole suspending agent, 1% shenqinmycin SC and blank clean water experiment.
2nd, test method：Each plot area is 50m2, it is repeated 4 times, the inspection drug effect side after investigating and preventing and treating before dispenser
Method is：It is classified and is investigated with blank control incidence, per the sampling of cell diagonal, often clicks 10 plants, record total strain number, diseased plant number
With sick series.
Cucumber downy mildew field investigation standard uses following stage division：
0 grade：It is disease-free；
1 grade：Lesion area accounts for less than the 5% of whole leaf area；
3 grades：Lesion area accounts for the 5% -10% of whole leaf area；
5 grades：Lesion area accounts for the 11% -25% of whole leaf area；
7 grades：Lesion area accounts for the 26% -50% of whole leaf area；
9 grades：Lesion area accounts for more than the 50% of whole leaf area；
Result of the test see the table below 5,6：
The shenqinmycin of table 5 (A) and cyazofamid (B) compound the prevention effect to cucumber downy mildew
The field efficacy result of table 5 shows, compares 1 in weight：100-100：In the range of 1, shenqinmycin is compounded with cyazofamid to be increased
Imitate effect substantially, particularly 1：50-50：In the range of 1, especially 1：25-25：In the range of 1, have to cucumber downy mildew excellent
Prevention effect, prevention effect is better than single dose kind.
Tomato late blight field investigation standard uses following stage division：
0 grade：It is disease-free；
1 grade：There are indivedual scabs on indivedual blades；
3 grades：1/3 with the ill spot of lower blade；
5 grades：1/3-1/2 blade has scab；
7 grades：Nearly all blade has scab；
9 grades：Whole blades go rotten almost without green portion；
Other statistics, experimental methods are ibid.
The embodiment of table 6 is compared the prevention effect of tomato late blight with comparative example
Inventor has found that other antibioticses bactericide are compounded with cyazofamid, compares 1 in weight：100-100：In the range of 1
With certain Complex synergism.Because length is limited, do not enumerate, only with most representational kasugarnycin, many anti-mildews
Element, Ningnanmycin construct comparative example and embodiment carries out preventive effect contrast, and such as field efficacy result of table 6 shows, compares 1 in weight：
100-100：In the range of 1, shenqinmycin substantially, is better than other antibioticses bactericide and cyanogen frost with cyazofamid Complex synergism
The prevention effect of azoles compounding.Particularly 1：50-50：In the range of 1, especially 1：25-25：In the range of 1, shenqinmycin and cyanogen frost
Azoles Complex synergism substantially, to the prevention effect of plant disease, is better than what other antibioticses bactericide were compounded with cyazofamid
Prevention effect.
Root rotof flax, root rot experiment are prevented and treated with pesticidal preparations made from above-described embodiment, comparative example.
1st, test process：Experiment is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This examination
Test dosing and three concentration for the treatment of are set according to the difference of each composition respectively, comparison medicament is that the commercially available Evil of agricultural chemicals 30% is mould respectively
Lingshui Spring agent, 1% shenqinmycin SC and blank clean water experiment.
2nd, test method：Each plot area is 50m2, it is repeated 4 times, the inspection drug effect side after investigating and preventing and treating before dispenser
Method is：It is classified and is investigated with blank control incidence, per the sampling of cell diagonal, often clicks 10 plants, record total strain number, diseased plant number
With sick series.
Using following stage division：
0 grade：Basal part of stem and master, the equal disease-free spot of fibrous root；
1 grade：There is a small amount of scab on basal part of stem and main root, lesion area is accounted for below a quarter of stem and the root gross area；
3 grades：Have more scab on basal part of stem and main root, lesion area account for stem and a quarter of the root gross area and two/
One；
5 grades：Have more scab on basal part of stem and main root, lesion area account for stem and 1/2nd of the root gross area and four/
Three；
7 grades：In flakes, but root system is not dead for scab on basal part of stem and main root；
9 grades：Root system necrosis, above-ground plant parts is wilted close to dead or dead；
Result of the test see the table below 7,8：
(A) are He hymexazo (B) compounds the prevention effect to root rotof flax to the shenqinmycin of table 7
The field efficacy result of table 5 shows, compares 1 in weight：100-100：In the range of 1, shenqinmycin Yu hymexazos compounding increases
Imitate effect substantially, particularly 1：50-50：In the range of 1, especially 1：25-25：In the range of 1, have to root rotof flax excellent
Prevention effect, prevention effect is better than single dose kind.
The embodiment of table 8 is compared the prevention effect of root rot with comparative example
Inventor has found other antibioticses bactericide Yu hymexazos compoundings, compares 1 in weight：100-100：In the range of 1
With certain Complex synergism.Because length is limited, do not enumerate, it is only rather mould with most representational polyoxin, Chinese parasol tree
Element constructs comparative example and carries out preventive effect contrast with embodiment, and such as field efficacy result of table 8 shows, compares 1 in weight：100-100：1
In the range of, shenqinmycin Yu hymexazos Complex synergism substantially, is better than other antibioticses bactericide Yu hymexazos compoundings
Prevention effect.Particularly 1：50-50：In the range of 1, especially 1：25-25：In the range of 1, shenqinmycin Yu hymexazos compounding increases
Imitate effect substantially, to the prevention effect of plant disease, be better than the prevention effect of other antibioticses bactericide Yu hymexazos compoundings.
Tested with pesticidal preparations preventing and treating grey mould fruit rot of strawberry, mango anthracnose made from above-described embodiment, comparative example.
1st, test process：Experiment is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This examination
Test dosing and three concentration for the treatment of are set according to the difference of each composition respectively, comparison medicament is that commercially available agricultural chemicals 25g/l is coughed up respectively
Bacterium nitrile wettable powder, 1% shenqinmycin SC and blank clean water experiment.
2nd, test method：Each plot area is 50m2, it is repeated 4 times, the inspection drug effect side after investigating and preventing and treating before dispenser
Method is：It is classified and is investigated with blank control incidence, per the sampling of cell diagonal, often clicks 10 plants, record total strain number, diseased plant number
With sick series.
Using following stage division：
0 grade：It is disease-free；
1 grade：Lesion area accounts for less than the 5% of whole leaf area；
3 grades：Lesion area accounts for the 6% -15% of whole leaf area；
5 grades：Lesion area accounts for the 16% -25% of whole leaf area；
7 grades：Lesion area accounts for less than the 26% -50% of whole leaf area；
9 grades：Lesion area accounts for more than the 50% of whole leaf area；
Result of the test see the table below 9,10：
The shenqinmycin of table 9 (A) and fludioxonil (B) compound the prevention effect to grey mould fruit rot of strawberry
The field efficacy result of table 9 shows, compares 1 in weight：100-100：In the range of 1, shenqinmycin is compounded with fludioxonil to be increased
Imitate effect substantially, particularly 1：50-50：In the range of 1, especially 1：25-25：In the range of 1, have to grey mould fruit rot of strawberry excellent
Prevention effect, prevention effect is better than single dose kind.
The embodiment of table 10 is compared the prevention effect of mango anthracnose with comparative example
Inventor has found that other antibioticses bactericide are compounded with fludioxonil, compares 1 in weight：100-100：In the range of 1
With certain Complex synergism.Because length is limited, do not enumerate, only with most representational kasugarnycin, many anti-mildews
Element, Ningnanmycin, jinggangmeisu, tetramycin construct comparative example and embodiment carries out preventive effect contrast, such as field efficacy of table 10
As a result show, compare 1 in weight：100-100：In the range of 1, shenqinmycin substantially, is better than other with fludioxonil Complex synergism
The prevention effect that antibioticses bactericide is compounded with fludioxonil.Particularly 1：50-50：In the range of 1, especially 1：25-25：1
In the range of, shenqinmycin substantially, to the prevention effect of plant disease, is better than other antibioticses with fludioxonil Complex synergism
The prevention effect that bactericide is compounded with fludioxonil.
Tested with pesticidal preparations preventing and treating Chinese cabbage downy mildew, tobacco black shank made from above-described embodiment, comparative example.
1st, test process：Experiment is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This examination
Test dosing and three concentration for the treatment of are set according to the difference of each composition respectively, comparison medicament is the commercially available second of agricultural chemicals 40% 3 respectively
Phosphonic acids aluminium wettable powder, 1% shenqinmycin SC and blank clean water experiment.
2nd, test method：Each plot area is 50m2, it is repeated 4 times, the inspection drug effect side after investigating and preventing and treating before dispenser
Method is：It is classified and is investigated with blank control incidence, per the sampling of cell diagonal, often clicks 10 plants, record total strain number, diseased plant number
With sick series.
Using following stage division：
0 grade：It is disease-free；
1 grade：Lesion area accounts for less than the 5% of whole leaf area；
3 grades：Lesion area accounts for the 5% -10% of whole leaf area；
5 grades：Lesion area accounts for the 11% -25% of whole leaf area；
7 grades：Lesion area accounts for the 26% -50% of whole leaf area；
9 grades：Lesion area accounts for more than the 50% of whole leaf area；
Result of the test see the table below 11,12：
The shenqinmycin of table 11 (A) and phosethyl-Al (B) compound the prevention effect to Chinese cabbage downy mildew
The field efficacy result of table 11 shows, compares 1 in weight：100-100：In the range of 1, shenqinmycin is answered with phosethyl-Al
With synergistic effect substantially, particularly 1：50-50：In the range of 1, especially 1：25-25：In the range of 1, have to Chinese cabbage downy mildew excellent
Good prevention effect, prevention effect is better than single dose kind.
Tobacco black shank investigates standard：
0 grade：Complete stool is disease-free；
1 grade：Stem's scab is no more than 1/2nd of stem girth, or the lower blade of half one is slightly wilting, or a small number of leaves in bottom
There is scab in piece；
3 grades：Stem's scab is more than 1/2nd of stem girth, or the blade of half one is slightly wilting；
5 grades：Stem's scab is around stem girth, or 2/3rds wilting with blade；
7 grades：Diseased plant whole blade is wilting or withered.
The embodiment of table 12 is compared the prevention effect of tobacco black shank with comparative example
Inventor has found that other antibioticses bactericide are compounded with phosethyl-Al, compares 1 in weight：100-100：1 scope
Inside also there is certain Complex synergism.Because length is limited, do not enumerate, only with most representational kasugarnycin, many
Antimycin, jinggangmeisu, tetramycin construct comparative example and embodiment carries out preventive effect contrast, such as the field efficacy result table of table 12
It is bright, compare 1 in weight：100-100：In the range of 1, shenqinmycin substantially, is better than other anti-with phosethyl-Al Complex synergism
The prevention effect that raw element series bactericidal agent is compounded with phosethyl-Al.Particularly 1：50-50：In the range of 1, especially 1：25-25：
In the range of 1, shenqinmycin substantially, to the prevention effect of plant disease, is better than other anti-with phosethyl-Al Complex synergism
The prevention effect that raw element series bactericidal agent is compounded with phosethyl-Al.
Inventor finds shenqinmycin and cyazofamid, Shen shenqinmycin Yu hymexazo, shenqinmycin and fludioxonil, Shen piperazine are mould
Element has obvious synergistic effect to plant disease with three second aluminum phosphates compounding.In identical proportion 1:100-100：In 1,
Particularly 1:50-50:In the range of 1, especially 1：25-25：In the range of 1, shenqinmycin and cyazofamid, shenqinmycin are found
Yu hymexazo, shenqinmycin and fludioxonil, shenqinmycin with three second aluminum phosphates compounding also with obvious synergistic effect.Due to a piece
It is limited, it is not repeated.
The above is the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, on the premise of principle of the present invention is not departed from, some improvements and modifications can also be made, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (7)
1. a kind of bactericidal composition, it is characterised in that containing active ingredient shenqinmycin and active bactericide, the activity is sterilized
Ji Wei hymexazos, the weight ratio of the shenqinmycin and active bactericide is 1：25~25：1.
2. bactericidal composition according to claim 1, it is characterised in that also contain pesticidal preparations in the bactericidal composition
Auxiliary element, so that the formulation for being adapted to agriculturally use is made.
3. bactericidal composition according to claim 2, it is characterised in that the pesticidal preparations auxiliary element is solvent, breast
One or more in agent, dispersant, stabilizer, antifreezing agent or wetting agent.
4. bactericidal composition according to claim 2, it is characterised in that the formulation of the bactericidal composition be suspending agent,
Dry suspending agent, water dispersible granules, wettable powder or seed treatment.
5. application of any described bactericidal composition of Claims 1-4 in the pesticidal preparations for preparing controlling plant diseases.
6. the application of bactericidal composition according to claim 5, it is characterised in that prevent and treat rice sheath blight disease, rice in preparation
Seasonal febrile diseases, false smut, wheat rust, powdery mildew, root rotof flax, wheat sharp eyespot, root rot, sclerotinia rot of colza, corn
Application in head smut, capsicum wilt, the pesticidal preparations of cucurbits fusarium wilt.
7. the method that any described bactericidal composition of Claims 1-4 is applied to controlling disease, it is characterised in that effective group
Point shenqinmycin and active bactericide are applied with above-mentioned weight ratio, it applies after mixing in proportion, be administered simultaneously in proportion or
Apply successively in proportion.
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| CN201610630815.7A CN106234408B (en) | 2015-01-08 | 2015-06-11 | Bactericidal composition and its application |
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| EP1358801A1 (en) * | 2002-04-30 | 2003-11-05 | Bayer CropScience S.A. | Fungicidal composition |
| CN101705265B (en) * | 2009-11-12 | 2011-07-27 | 上海交通大学 | Method for producing phenazine-1-carboxylic acid by using engineering bacterial strain M18G to carry plasmid pME6032Phz |
| CN101700015B (en) * | 2009-11-30 | 2012-06-13 | 青岛星牌作物科学有限公司 | Bactericidal composition containing cyazofamid and kasugamycin and application thereof |
| US9216455B2 (en) * | 2010-05-10 | 2015-12-22 | Abdulaziz A. Alkhedhairy | Methods for producing silver nanoparticles |
| CN102007934B (en) * | 2010-12-20 | 2013-08-14 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing phosethyl-Al and antibiotic compound |
| CN102249799A (en) * | 2011-04-27 | 2011-11-23 | 上海农安生物科技发展有限公司 | Method for controlling crop diseases with shenqinmycin and shenqinmycin preparation |
| EP2524601A1 (en) * | 2011-05-17 | 2012-11-21 | Bayer CropScience AG | Active compound combinations comprising a phosphorous acid derivative and cyazofamid |
| CN103155936B (en) * | 2011-12-18 | 2014-08-20 | 深圳诺普信农化股份有限公司 | Plant disease control composition containing phenazino-1-carboxylic acid |
| CN103155926B (en) * | 2011-12-18 | 2014-04-23 | 深圳诺普信农化股份有限公司 | Sterilization composite based on phenazino-1-carboxylicacid |
| CN103960244B (en) * | 2011-12-18 | 2015-09-02 | 深圳诺普信农化股份有限公司 | Bactericidal composition containing Shen piperazine mycin |
| CN103960245B (en) * | 2011-12-18 | 2015-06-24 | 深圳诺普信农化股份有限公司 | Sterilization composition containing phenazino-1-carboxylic acid |
| CN104542079A (en) * | 2013-10-16 | 2015-04-29 | 中国农业科学院蔬菜花卉研究所 | Method for processing drug-containing slow-release material and preventing and treating vegetable diseases and insect pests |
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| CN104957157A (en) | 2015-10-07 |
| CN106234408B (en) | 2018-11-02 |
| CN106818769B (en) | 2020-05-22 |
| CN111096325A (en) | 2020-05-05 |
| CN106818769A (en) | 2017-06-13 |
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