CN104940785A - Medicine composition for preventing and treating malnourished anemia of piglets and preparation method of medicine composition - Google Patents
Medicine composition for preventing and treating malnourished anemia of piglets and preparation method of medicine composition Download PDFInfo
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Abstract
The invention discloses a medicine composition for preventing and treating malnourished anemia of piglets and a preparation method of the medicine composition. The medicine composition comprises the following active pharmaceutical ingredients: angelica, colla corii asini, ventilago leiocarpa benth, iron chippings, dwarf burnet root, loranthus parasiticus, silverweed cinquefoil root, radix codonopsitis, shiitake, changium smyrnioides, gynostemma pentaphylla, caulis spatholobi, spina date seed, rhizoma dioscoreae, white hyacinth beans, silkworm excrement, fructus amomi, radix aucklandiae, endothelium corneum gigeriae galli, fructus psoraleae, deer-horn glue, pine nuts and boxthorn fruits. The medicine composition has the benefits that the treatment on malnourished anemia of the piglets mainly relies on qi replenishing, blood nourishing, and spleen strengthening for activation, and is supplemented by liver soothing to regulate qi, and kidney invigorating to replenish essence, so that the harmony between yin and yang as well as qi and blood of the piglets can be realized; the treatment course is short, the treatment effect is relatively good, and the immunity and the disease resistance of the piglets can be enhanced while the quantity of medicine residues is low, so that the medicine composition is environmentally friendly.
Description
Technical field
The present invention relates to field of veterinary, particularly relating to pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition and preparation method thereof.
Background technology
Piglet nutrition anemia is a kind of nutrition metabolic diseases of pig, and sick pig lacks ferrum element and cause anemia due to body, visual mucosa is slight xanthochromia or pale, and injection ferrum element can be used to treat, and how in winter-spring season mass-sending, case fatality rate is higher.
General introduction
Piglet nutrition anemia (Nutritional Anemia of Piglet) refers to that in 5 ~ 28d, suckling pig is due to undernutrition and trace element deficiency, the particularly shortage of ferrum and the anemia caused, light with visual mucosa color clinically, slight xanthochromia or pale; In blood circulation erythrocyte number decline, hemoglobin significantly reduce wait be feature, be also called iron deficiency anemia or microcytic hypochromic anemia.The multiple drylot feeding piglet, particularly pig house being born in season at the beginning of cold winter Mo, spring with plank or cement for ground and do not take the Intensive Farm of Pig Raising of iron supplement measure.Primary disease has mass-sending in a given area, and sickness rate, mortality rate are higher, and all may occur every year, causes serious economic loss to pig industry.
The cause of disease
The physiological cause of disease
Mainly ferrum deficiency or shortage, the first few weeks after piglet birth, growth promoter is rapid, and whole blood volume growth soon, needs ferrum 7 ~ 15mg every day, and the ferrum of breast milk supply is only 1mg, so employ storage ferrum (being about 40 ~ 47mg) extremely meagre in body every day.And if this phase piglet growth can not contact with soil in the pig house being ground with cement or plank, lose and originate to the picked-up of ferrum, do not take again artificial iron supplement measure simultaneously, and make piglet iron deficiency serious; Add achyli hydrochloric acid in the rear 7d of piglet birth, the ferrum of acquisition is just less, and the synthesis of result hemoglobin is not enough and occur physiologic anemia.
The conditionality cause of disease
In piglet Dietary Supplement Dietary, the content of calcium carbonate and manganese too much can cause conditionality iron deficiency and anemia, and this is mainly because calcium carbonate and manganese all have antagonism to the absorption of ferrum.When protein, copper, cobalt, zinc, vitamin B12, folic acid, nicotinic acid, thiamine, riboflavin in daily ration etc. lack, can cause or promote the generation of piglet nutrition anemia.Phosphoric acid, phytic acid, tannic acid, oxalic acid etc. all can be combined with ferrum, and hinder the absorption of ferrum, the too high levels of these materials in daily ration, also can promote the generation of primary disease.
Other
In addition, as many, dark and damp in pig house atmosphere draught-free, dust, dense stocking of environmental factors etc. all can increase the weight of anemia.If piglet take in poisonous, containing alkaloidal feedstuff and repeatedly or life-time service certain medicine (chloromycetin as national regulation food animal forbidding) also can accelerate the generation of anemia.
Harm
In body, most ferrum is for the synthesis of hemoglobin, and therefore iron deficiency will cause content of hemoglobin decline and erythropoiesis reduce and anemia occurs.Anemia lasts till that the regular period just can destroy the oxidation-reduction process of body, simultaneously piglet digest and assimilate miopragia, increased the weight of the generation of anemia, and then brought out digestive system and respiratory illness etc. because immunity of organism reacts reduction, mortality rate can reach 10% ~ 15%.
Clinical symptoms
Sick pig spirit is depressed, peels off and lies prostrate, loss of appetite, inverse vertical by hair, lacks gloss, poor growth or stopping.Body temperature is not high, accompanies diarrhoea more.Visual mucosa color is light, slight xanthochromia or pale.Illumination auricular concha is canescence, almost can not see obvious blood vessel, and acupuncture is also seldom hemorrhage.Breathe and increase number, pulse rapidly, can hear anemicus intracardial accentuated; Light exercise then Herzschlag is prosperous and powerful, gasps for breath.Can there is edema in head and front body, sometimes phrenospasm occurs.Some piglet outward appearances are very fat, and growth promoter is also very fast, can in running sudden death.Some piglet outward appearances are become thin, and constipation dysentery alternately occurs, different from, exhaustion; Stomach wall is crispaturaed, and its build is olive-shaped.
Pathological change
Liver fat is out of shape and enlargement, in light gray, sometimes has petechia.Blood is thin poor in water sample, coagulability; Meat color is thin out, and particularly gluteus and cardiac muscle present the change of typical anemia.Spleen enlargement, tunicle thickens, and color is shallow, and quality is slightly solid.Nephrolithotomy degeneration, in canescence, tunicle is easily peeled off, tangent plane cortex and medullary substance boundary clear.Abdominal cavity, thoracic cavity, pericardial effusion, cardiac dilatation, visceral pericardium has point hemorrhage.Pulmonary edema, interstitial is obvious, and tangent plane has transudate to overflow.Mesenteric lymph node edema, congestion; Harmonization of the stomach acoprosis, its mucosa has focal disease to become.
Histological examination: in bone marrow, erythropoiesis is strengthened, and has extramedullary hemopoiesis function at liver, spleen and lymph.
The not optimum anemia of western medical treatment piglet nutrition is generally supplemented with exogenous chalybeate, as iron dextran, dextran iron cobalt etc., and irony deposit in filling cells.
Summary of the invention
Technical problem to be solved by this invention is to provide one to have vigorate qi and replenish the blood, spleen invigorating to help fortune, the not optimum anemia for the treatment of piglet nutrition, pig yang blood and qi can be made to be in harmonious proportion, treatment short treating period, effect is better, toxic and side effects is low, with low cost, residual quantity low while can strengthen immunity and the resistance against diseases of piglet, green non-pollution, and this medicine belongs to pure Chinese medicinal preparation, have no drug resistance and drug residue.
In order to realize foregoing invention object, the invention provides a kind of pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition, described pharmaceutical composition comprises following raw medicinal material: Radix Angelicae Sinensis, Colla Corii Asini, Radix seu Caulis Verntilaginis Leiocarpae, pulvis ferri (ferrosic oxide), Radix Sanguisorbae Filiformis, Herba Taxilli, Radix potentillae anserinae, Radix Codonopsis, Lentinus Edodes, Radix Changii, Herb Gynostemmae Pentaphylli, Caulis Spatholobi, Semen Ziziphi Spinosae, Rhizoma Dioscoreae, Semen Lablab Album, Bombyx mori L., Fructus Amomi, the Radix Aucklandiae, Endothelium Corneum Gigeriae Galli, Fructus Psoraleae, Colla cornus cervi, Semen Pini and Fructus Lycii.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 22-34 part, Colla Corii Asini 15-26 part, Radix seu Caulis Verntilaginis Leiocarpae 10-18 part, pulvis ferri (ferrosic oxide) 18-29 part, Radix Sanguisorbae Filiformis 8-14 part, Herba Taxilli 9-19 part, Radix potentillae anserinae 13-24 part, Radix Codonopsis 20-33 part, Lentinus Edodes 12-21 part, Radix Changii 20-35 part, Herb Gynostemmae Pentaphylli 17-26 part, Caulis Spatholobi 21-34 part, Semen Ziziphi Spinosae 12-28 part, Rhizoma Dioscoreae 18-30 part, Semen Lablab Album 15-26 part, Bombyx mori L. 15-32 part, Fructus Amomi 11-23 part, Radix Aucklandiae 10-21 part, Endothelium Corneum Gigeriae Galli 11-19 part, Fructus Psoraleae 13-23 part, Colla cornus cervi 18-27 part, Semen Pini 15-26 part and Fructus Lycii 20-32 part.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 31 parts, 22 parts, Colla Corii Asini, Radix seu Caulis Verntilaginis Leiocarpae 16 parts, pulvis ferri (ferrosic oxide) 23 parts, Radix Sanguisorbae Filiformis 12 parts, Herba Taxilli 17 parts, Radix potentillae anserinae 19 parts, Radix Codonopsis 30 parts, 13 parts, Lentinus Edodes, Radix Changii 27 parts, Herb Gynostemmae Pentaphylli 22 parts, Caulis Spatholobi 26 parts, Semen Ziziphi Spinosae 23 parts, Rhizoma Dioscoreae 27 parts, Semen Lablab Album 22 parts, Bombyx mori L. 31 parts, Fructus Amomi 14 parts, the Radix Aucklandiae 13 parts, Endothelium Corneum Gigeriae Galli 15 parts, Fructus Psoraleae 18 parts, Colla cornus cervi 19 parts, 23 parts, Semen Pini and Fructus Lycii 25 parts.
Described pharmaceutical composition also comprises Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Nardostachyos, Cornu Cervi Pantotrichum, Herba Pyrolae, Herba Agrimoniae, Semen Juglandis and Semen Cuscutae.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 22-34 part, Colla Corii Asini 15-26 part, Radix seu Caulis Verntilaginis Leiocarpae 10-18 part, pulvis ferri (ferrosic oxide) 18-29 part, Radix Sanguisorbae Filiformis 8-14 part, Herba Taxilli 9-19 part, Radix potentillae anserinae 13-24 part, Radix Codonopsis 20-33 part, Lentinus Edodes 12-21 part, Radix Changii 20-35 part, Herb Gynostemmae Pentaphylli 17-26 part, Caulis Spatholobi 21-34 part, Semen Ziziphi Spinosae 12-28 part, Rhizoma Dioscoreae 18-30 part, Semen Lablab Album 15-26 part, Bombyx mori L. 15-32 part, Fructus Amomi 11-23 part, Radix Aucklandiae 10-21 part, Endothelium Corneum Gigeriae Galli 11-19 part, Fructus Psoraleae 13-23 part, Colla cornus cervi 18-27 part, Semen Pini 12-20 part, Fructus Lycii 14-27 part, Pericarpium Citri Reticulatae Viride 3-9 part, Radix Et Rhizoma Nardostachyos 7-12 part, Cornu Cervi Pantotrichum 5-11 part, Herba Pyrolae 7-12 part, Herba Agrimoniae 4-8 part, Semen Juglandis 12-19 part and Semen Cuscutae 15-21 part.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 31 parts, 22 parts, Colla Corii Asini, Radix seu Caulis Verntilaginis Leiocarpae 16 parts, pulvis ferri (ferrosic oxide) 23 parts, Radix Sanguisorbae Filiformis 12 parts, Herba Taxilli 17 parts, Radix potentillae anserinae 19 parts, Radix Codonopsis 30 parts, 13 parts, Lentinus Edodes, Radix Changii 27 parts, Herb Gynostemmae Pentaphylli 22 parts, Caulis Spatholobi 26 parts, Semen Ziziphi Spinosae 23 parts, Rhizoma Dioscoreae 27 parts, Semen Lablab Album 22 parts, Bombyx mori L. 31 parts, Fructus Amomi 14 parts, the Radix Aucklandiae 13 parts, Endothelium Corneum Gigeriae Galli 15 parts, Fructus Psoraleae 18 parts, Colla cornus cervi 19 parts, 13 parts, Semen Pini, Fructus Lycii 20 parts, 7 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Nardostachyos 11 parts, 8 parts, Cornu Cervi Pantotrichum, Herba Pyrolae 10 parts, Herba Agrimoniae 6 parts, Semen Juglandis 14 parts and Semen Cuscutae 18 parts.
In order to better realize goal of the invention, the invention provides a kind of preparation method of the pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition, when the dosage form of described pharmaceutical composition is granule, its preparation method comprises the following steps:
Step one: get Colla Corii Asini in described ratio and Colla cornus cervi is ground into 120 order-150 object fine powders, described raw medicinal material will be remained mix in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder, by the mixture 1 that described fine powder and dried cream powder mix,
Step 2: the dextrin adding cane sugar powder relative to mixture 1 quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the mixture 1 obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
In order to better realize goal of the invention, the invention provides a kind of preparation method of the pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition, when the dosage form of described pharmaceutical composition is powder, its preparation method comprises the following steps:
Step one, get Colla Corii Asini in described ratio and Colla cornus cervi is ground into 120 order-150 object fine powders, described surplus stock medicine is dropped in proportion stirring in blender, mixing, pulverize in rear feeding pulverizer, the Chinese medicine composition after pulverizing is loaded in multi-function extractor, add relative to its quality 5-7 times amount water, boil 2-4 hour, steam pressure is 0.6-1Mpa process, filter, obtain the first filtrate and filtering residue;
Step 2, the filtering residue of acquisition added again relative to its quality 5-7 times amount water, boil 2-4 hour, steam pressure is 0.6Mpa-1Mpa process, filter and obtain the second filtrate and filtering residue;
Step 3, the first filtrate and the second filtrate merged, concentrated removing moisture, obtains and gets dry extract, employing super-fine powder mill is pulverized, be crushed to less than 30 μm, obtain pharmaceutical composition powder, described pharmaceutical composition powder is mixed homogeneously with the fine powder of step one and obtains powder.
The invention has the beneficial effects as follows: based on vigorate qi and replenish the blood, spleen invigorating, fortune is helped to the treatment of the pig suffering from the not optimum anemia of piglet nutrition, be auxiliary with depressed liver-energy dispersing and QI regulating, kidney tonifying, essence replenishing, the not optimum anemia for the treatment of piglet nutrition has adjustment yang blood and qi, treatment short treating period, effect is better, toxic and side effects is low, with low cost, residual quantity low while can strengthen immunity and the resistance against diseases of piglet, green non-pollution, and this medicine belongs to pure Chinese medicinal preparation, have no drug resistance and drug residue.
Detailed description of the invention
The present invention helps fortune for Therapeutic Principle with vigorate qi and replenish the blood, spleen invigorating, while the not optimum anemia for the treatment of piglet nutrition, improve the pharmaceutical composition of pigling immunity, comprise following raw medicinal material: Radix Angelicae Sinensis, Colla Corii Asini, Radix seu Caulis Verntilaginis Leiocarpae, pulvis ferri (ferrosic oxide), Radix Sanguisorbae Filiformis, Herba Taxilli, Radix potentillae anserinae, Radix Codonopsis, Lentinus Edodes, Radix Changii, Herb Gynostemmae Pentaphylli, Caulis Spatholobi, Semen Ziziphi Spinosae, Rhizoma Dioscoreae, Semen Lablab Album, Bombyx mori L., Fructus Amomi, the Radix Aucklandiae, Endothelium Corneum Gigeriae Galli, Fructus Psoraleae, Colla cornus cervi, Semen Pini and Fructus Lycii.Preferably, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Nardostachyos, Cornu Cervi Pantotrichum, Herba Pyrolae, Herba Agrimoniae, Semen Juglandis and Semen Cuscutae can also be comprised.Wherein, Radix Angelicae Sinensis, Colla Corii Asini, Radix seu Caulis Verntilaginis Leiocarpae, pulvis ferri (ferrosic oxide), Radix Sanguisorbae Filiformis, Herba Taxilli, Radix potentillae anserinae are enriched blood, and the gas of Radix Codonopsis, Lentinus Edodes, Radix Changii, Herb Gynostemmae Pentaphylli spleen reinforcing lung helps the biochemistry of QI and blood; Caulis Spatholobi, Semen Ziziphi Spinosae nourishing the liver blood, help blood stored in the liver, liver deposit blood, such as river in lake, water rises and can receive, and water thanks to can be mended; Rhizoma Dioscoreae, Semen Lablab Album, Bombyx mori L., Fructus Amomi regulating qi-flowing for strengthening spleen; The Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Nardostachyos, Endothelium Corneum Gigeriae Galli dispersing the stagnated liver-QI for regulating the stomach, help fortune to help digestion; Cornu Cervi Pantotrichum, Fructus Psoraleae, Colla cornus cervi, Herba Pyrolae, Herba Agrimoniae, Semen Juglandis, Semen Pini, Semen Cuscutae, Fructus Lycii kidney tonifying, essence replenishing, gain the foundation of acquired constitution, if the official having a grain ， Cang Lin having this army a day after tomorrow also can flexible dispatching, coordinating the actions of various ingredients in a prescription.
The pharmacological property of above-mentioned each raw medicinal material is as follows:
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Colla Corii Asini: sweet is flat.Return lung, liver, kidney channel.To enrich blood YIN nourishing, moisturize, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
Radix seu Caulis Verntilaginis Leiocarpae: sweet; Temperature.Return lung; Spleen channel.Fill blood; Bone and muscle strengthening; Relax meridians.Main deficient qi and blood; Have through uncomfortable; Blood deficiency amenorrhea; Rheumatalgia; Traumatic injury; Lumbar muscle strain.
Pulvis ferri (ferrosic oxide): the swarf hit down because of outer oxide during for forging iron, or side-product iron filings during ironworks's wrought iron.Pungent; Cool.GUIXIN; Liver Channel.Checking hyperfunction of the liver for relieving convulsion; Removing toxic substances sore; Enrich blood.Main demented; Febrile delirium; Palpitation and being susceptible to fright; Rheumatic arthralgia; Anemia; Sore swollen toxin.
Radix Sanguisorbae Filiformis: the short Radix Sanguisorbae of Rosaceae burnet plant, is used as medicine with root.Pungent, temperature.Tonifying blood and regulating menstruation.For menoxenia, dysmenorrhea.
Herba Taxilli: this product is the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli.Bitter, sweet, flat.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension.
Radix potentillae anserinae: sweet is flat.Fill blood, strengthening the spleen and stomach, promoting the production of body fluid to quench thirst, dampness removing.For anemia after being ill, malnutrition, insufficiency of the spleen diarrhoea, rheumatic arthralgia.
Radix Codonopsis: sweet is flat.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Lentinus Edodes: be the sporophore of Pleurotaceae plant Lentinus Edodes.Sweet, flat.Return stomach warp.Stomach reinforcing gas, holder varioliform exanthema.
Radix Changii: sweet, micro-hardship, is slightly cold.Return lung, spleen, Liver Channel.Moistening the lung and resolving phlegm, yin nourishing stomach function regulating, suppressing the hyperactive liver, removing toxic substances.For cough due to lung-heat, vomiting regurgitation, lack of appetite xerostomia, conjunctival congestion is dizzy, furunculosis skin infection.
Herb Gynostemmae Pentaphylli: bitter in the mouth; Micro-sweet; Cool in nature.Return lung; Spleen; Kidney channel.Heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.For chronic bronchitis, infectious hepatitis, nephritis is scorching, gastroenteritis.Heat clearing away; Tonify deficiency; Removing toxic substances.Main body void is weak; Nephrasthenia emission; Leukopenia; Hyperlipemia; Viral hepatitis; Chronic gastroenteritis; Chronic tracheitis.
Caulis Spatholobi: bitter, sweet, temperature.Return liver, kidney channel.Enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Semen Ziziphi Spinosae: sweet, sour, property is put down.GUIXIN warp, spleen channel, Liver Channel, gallbladder meridian.Shennong's Herbal: " invigorating middle warmer the liver benefiting, hard muscles and bones help cloudy gas, and all the merit of Semen Ziziphi Spinosae also." " herbal classic ": " main trusted subordinate's cold and heat, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen." " not Lu ": " main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong." " property of medicine opinion ": " main muscles and bones wind is fried end and is taken it as soup.Function " nourishing the liver, mind calming, calms the nerves, arresting sweating.There are calmness, hypnosis, analgesia, anticonvulsant action; There is certain hypotensive effect; Excitation is had to uterus.
Rhizoma Dioscoreae: sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red card such as swollen, fat of frequent micturition of quenching one's thirst, premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.
Semen Lablab Album: sweet light, tepor, flat; Return spleen channel, stomach warp.Spleen invigorating, removing dampness, relieves summer heat.Cure mainly insufficiency of the spleen resulting in production of dampness, anorexia and loose stool, leukorrhagia, heat-damp in summer is vomited and diarrhoea, and excessive thirst is uncomfortable in chest.。Semen Lablab Album control heat-damp in summer vomit and diarrhoea, summer heat usually accompanied with dampness, summer heat-damp in summer damaging the spleen and stomach, incoordination between the spleen and stomach, easily causes vomiting and diarrhoea.
Bombyx mori L.: acrid in the mouth, sweet, warm in nature.Compendium of Material Medica: " control and quench one's thirst, crux, and married woman's metrorrhagia, wind syndrome of head, blepharitis marginalis, goes wind to dehumidify." supplement to the Herbal: " parching to brown, infusing drugs in wine contained by bag, goes wind to delay all joints unsuccessful, the stupid paralysis of skin, Su Leng in abdomen, cold-blooded blood stasis, and waist foot pain is cold." dispeiling pathogenic wind and removing dampness, heat clearing and blood circulation promoting.Dispelling the wind and dampness pathogens, munbness, joint is unsuccessful, convulsion of sharply vomiting and diarrhoea, and muscles and bones is unsuccessful, blood stasis, wind syndrome of head acute conjunctivitis in lumbar and pedal pain, abdomen.This product pungent and sweet flavors can be used for dispersing, can Eradicates wind, warm-dryness syndrome and leading to, kind dehumidifying relaxing muscles and tendons again, and effect relaxes, and can be used for various arthromyodynia.
Fructus Amomi: acrid in the mouth, warm in nature; Return spleen channel, stomach warp, kidney channel.Function removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.Materia Medica of Decoction: " contracting sand, with Symplocoris Paniculatae, Fructus Amomi Rotundus for making, enters lung, with Radix Ginseng, Fructus Alpiniae Oxyphyllae for making, enters spleen, with Cortex Phellodendri, Poria for making, enters kidney, with red, Kaolin for making, enters large and small intestinal." " Japan hanako materia medica ": " control all gas, cramp caused by acute vomiting and diarrhea, cardiac and abdominal pain." function removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
The Radix Aucklandiae: acrid in the mouth is bitter, warm in nature.Energy promoting the circulation of QI to relieve pain, intestinal stasis relieving in tune.Compendium of Material Medica: " Radix Aucklandiae is the medicine of three burnt edema caused by disorder of QI, can be elevated all gas.All gas Fen are strongly fragrant, all belong to lung, therefore the person of QI stagnating in upper-JIAO use, be golden Yu Ze let out also; Middle gas is not transported, and all belongs to spleen, therefore the person that QI stagnating in middle-JIAO is suitable, taste happiness fragrance is also; QI stagnation of the large intestine then weighs afterwards, and bladder gas does not change then infirmity pouring, and hepatic depression is then pain, therefore stagnation of QI in lower-JIAO person should it, the person that is plug logical also." " Bencao Jingshu ": " deficiency of the lung has hot person, does not carefully violate it.Vigour collapse and yin asthenia generating intrinsic heat, all diseases have heat, pained genus fire person forbidding." can be used for born of the same parents and coerce distension foot, abdominal distention, tells and has loose bowels, heavy after dysentery.
Endothelium Corneum Gigeriae Galli: sweet in the mouth, cold in nature, enter spleen, stomach, small intestinal, urinary bladder channel, " Japan hanako materia medica ": " stopping leak essence, and hematuria, metrorrhagia, leukorrhagia, hemorrhoidal hamorrhage, dysentery." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " alleviating distention in middle-JIAO spleen invigorating, help digestion mill stomach.Control children's's breast food knot stagnant, the large muscle of tripe is blue or green, mass in the abdomen infantile malnutrition." have strengthening the spleen to promote digestion, arresting seminal emission to stop the effect of drowning, be mainly used in the distension and fullness in the abdomen of food stagnation stagnation, heating installation is suffered from diarrhoea, the symptoms such as infant malnutrition.
Fructus Psoraleae: acrid in the mouth, hardship, warm in nature, return kidney, spleen channel." property of medicine opinion ": " main man's pain in the lumbar region, the cold capsule of knee joint wets, stupid by all cold numbness, and only normal urination, cold in abdomen." " Kaibao Bencao ": " bone marrow wound loses for main five kinds of strain and seven kinds of impairment, wind cold caused by deficiency, the cold essence stream of kidney and the induced abortion of married woman's vim and vigour." kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha, helping inspiration to relieve asthma.Be used for the treatment of impotence due to deficiency of the kidney, soreness of the waist and knees cold type of pain, emission due to deficiency of the kidney, the enuresis, frequent micturition, the Diarrhoea that deficiency of spleen-YANG and kidneyYANG causes.
Colla cornus cervi: sweet, salty, temperature.Return kidney, Liver Channel.Temperature compensation Liver and kidney, beneficial intensive culture blood.For sexual impotence spermatorrhea, the acid of waist knee joint is cold, asthenia weakness and emaciation, metrostaxis, and hematuria of having blood in stool, carbuncle of yin nature swells and ache.
Semen Pini: sweet, temperature.Lung moistening, laxation.For xeropulmonary cough, chronic constipation.Semen Pini has effect that is nourshing Yin and drynsessmoistening prescription, righting tonify deficiency, is particularly suitable for the patients such as body void, constipation, cough and eats.
Fructus Lycii: sweet is flat.Return liver, kidney channel.Nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.
Pericarpium Citri Reticulatae Viride: nature and flavor toil, temperature.Enter liver, gallbladder, stomach warp.Can soothing the liver dispelling the stagnated QI, removing food stagnancyization stagnant.For costa sternales gastral cavity distending pain, acute mastitis, colic, stagnation of QI due to dyspepsia.
Radix Et Rhizoma Nardostachyos: acrid in the mouth, sweet, warm in nature; Return spleen, stomach warp.Fragrance row is loose, warming spleen and stomach for dispelling cold, regulating QI to relieve pain, the effect of appetizing of being amusing.Compendium of Material Medica: " Radix Et Rhizoma Nardostachyos, it is strongly fragrant that fragrance can open spleen, adds in taste medicine less, gas of being very amusing "." Japan hanako materia medica ": " control abdominal distnetion, the therapeutic method to keep the adverse QI flowing downwards." to have fragrance row loose for Radix Et Rhizoma Nardostachyos, warming spleen and stomach for dispelling cold, regulating QI to relieve pain, the effect of appetizing of being amusing.Cure mainly coldness and pain in the epigastrium distension, anorexia, chest pain, toothache, tumbling down is grieved, beriberi edema, cramp caused by acute vomiting and diarrhea.
Cornu Cervi Pantotrichum: sweet, salty, temperature.Return kidney, Liver Channel.Invigorating kidney-YANG, benefiting essence-blood, bone and muscle strengthening, adjusts punching to appoint, holder sore.For sexual impotence spermatorrhea, cold womb is infertile, weakness and emaciation, Mental fatigue, fear of cold, and vertigo and tinnitus is deaf, and spinal column cold type of pain, muscles and bones flaccidity is soft, bleeding not during menses, and carbuncle of yin nature is not held back.
Herba Pyrolae: have another name called Herba pyrolae japonicae.Sweetness and bitterness, temperature.Enter lung meridian, stomach warp, Liver Channel, kidney channel." Zhiwu Mingshi Tukao ": " control haematemesis, stimulate the menstrual flow, strong muscle, strong bone, mends waist kidney, born fluid." can tonify deficiency, kidney tonifying, expelling wind and removing dampness, promoting blood flow to regulate menstruation, the kidney invigorating bone strengthening, expelling wind and removing dampness, cough-relieving, hemostasis.Main lumbago due to renal deficiency, rheumatic arthralgia, soft, the new chronic cough of muscles and bones flaccidity are coughed, spit blood, epistaxis, metrorrhagia, traumatic hemorrhage.
Herba Agrimoniae: bitter in the mouth, puckery, property is put down, GUIXIN, Liver Channel, " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control married woman's menstruation or before or after, leucorrhea with red and white discharge, the cold stomachache in face, with the passing of time red white dysentery." " BAICAO mirror ": " therapeutic method to keep the adverse QI flowing downwards is invigorated blood circulation, reason all kinds of diseases and ailments, loose feeling of fullness; Traumatic injury is spitted blood, metrorrhagia, dysentery, discharging fresh blood stool." astringing to arrest bleeding, dysentery relieving, parasite killing.
Semen Juglandis: sweet in the mouth, warm in nature, enter kidney, lung, large intestine channel, there is the kidney invigorating and essence nourishing, warming the lung Dingchuan, the effect of loosening bowel to relieve constipation, lumbago lower limb for kidney qi virtual loss is soft, dizzy weak, frequent micturition is passed out semen, and quenches one's thirst, the cough with asthma of deficiency of both the lung and kidney, few and the dryness of the intestine constipation caused of old people's deficiency of vital energy and anemia in puerperal Tianjin, traumatic injury, the cards such as skin infection carbuncle.
Semen Cuscutae: abnormal smells from the patient is pungent, sweet, flat, nontoxic.The kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion." not Lu ": " support flesh reinforcing YIN-essence, hard muscles and bones, stem invasion by pathogenic cold, essence is from going out, and drown and have the heeltap, bitter taste is yearningly dry, and cold blood is long-pending." " Japan hanako materia medica ": " mends five kinds of strain and seven kinds of impairment, controls and lets out essence, hematuria, profit cardiopulmonary." the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 pharmaceutical composition 1
Embodiments providing a kind of pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition, being made up of the raw medicinal material of following parts by weight: Radix Angelicae Sinensis 31 parts, 22 parts, Colla Corii Asini, Radix seu Caulis Verntilaginis Leiocarpae 16 parts, pulvis ferri (ferrosic oxide) 23 parts, Radix Sanguisorbae Filiformis 12 parts, Herba Taxilli 17 parts, Radix potentillae anserinae 19 parts, Radix Codonopsis 30 parts, 13 parts, Lentinus Edodes, Radix Changii 27 parts, Herb Gynostemmae Pentaphylli 22 parts, Caulis Spatholobi 26 parts, Semen Ziziphi Spinosae 23 parts, Rhizoma Dioscoreae 27 parts, Semen Lablab Album 22 parts, Bombyx mori L. 31 parts, Fructus Amomi 14 parts, the Radix Aucklandiae 13 parts, Endothelium Corneum Gigeriae Galli 15 parts, Fructus Psoraleae 18 parts, Colla cornus cervi 19 parts, 23 parts, Semen Pini and Fructus Lycii 25 parts.
Its preparation method comprises the following steps:
Step one: get Colla Corii Asini in described ratio and Colla cornus cervi is ground into 120 object fine powders, described raw medicinal material will be remained mix in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 95%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.09Mpa, relative density is the mastic of 1.10, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 85 DEG C, is ground into powder subsequently, makes dried cream powder; By the mixture 1 that described fine powder and dried cream powder mix;
Step 2: the dextrin adding cane sugar powder relative to mixture 1 quality 0.4 times and 0.2 times in the mixture 1 obtained, makes granule, in 50 DEG C of dryings, obtains granule.
Embodiment 2 pharmaceutical composition 2
Embodiments provide a kind of pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition, be made up of the raw medicinal material of following parts by weight: Radix Angelicae Sinensis 31 parts, 22 parts, Colla Corii Asini, Radix seu Caulis Verntilaginis Leiocarpae 16 parts, pulvis ferri (ferrosic oxide) 23 parts, Radix Sanguisorbae Filiformis 12 parts, Herba Taxilli 17 parts, Radix potentillae anserinae 19 parts, Radix Codonopsis 30 parts, 13 parts, Lentinus Edodes, Radix Changii 27 parts, Herb Gynostemmae Pentaphylli 22 parts, Caulis Spatholobi 26 parts, Semen Ziziphi Spinosae 23 parts, Rhizoma Dioscoreae 27 parts, Semen Lablab Album 22 parts, Bombyx mori L. 31 parts, Fructus Amomi 14 parts, the Radix Aucklandiae 13 parts, Endothelium Corneum Gigeriae Galli 15 parts, Fructus Psoraleae 18 parts, Colla cornus cervi 19 parts, 13 parts, Semen Pini, Fructus Lycii 20 parts, 7 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Nardostachyos 11 parts, 8 parts, Cornu Cervi Pantotrichum, Herba Pyrolae 10 parts, Herba Agrimoniae 6 parts, Semen Juglandis 14 parts and Semen Cuscutae 18 parts.
Its preparation method is as follows:
Step one, get Colla Corii Asini in described ratio and Colla cornus cervi is ground into 150 object fine powders, described surplus stock medicine is dropped in proportion stirring in blender, mixing, pulverize in rear feeding pulverizer, the Chinese medicine composition after pulverizing is loaded in multi-function extractor, add relative to its quality 6 times amount water, boil 3 hours, steam pressure is 1Mpa process, filter, obtain the first filtrate and filtering residue;
Step 2, the filtering residue of acquisition added again relative to its quality 6 times amount water, boil 3 hours, steam pressure is 1Mpa process, filter and obtain the second filtrate and filtering residue;
Step 3, the first filtrate and the second filtrate merged, concentrated removing moisture, obtains and gets dry extract, employing super-fine powder mill is pulverized, be crushed to less than 30 μm, obtain pharmaceutical composition powder, described pharmaceutical composition powder is mixed homogeneously with the fine powder of step one and obtains powder.
The toxicity test of pharmaceutical composition:
1, trial drug
Choose Radix Angelicae Sinensis 31g, Colla Corii Asini 22g, Radix seu Caulis Verntilaginis Leiocarpae 16g, pulvis ferri (ferrosic oxide) 23g, Radix Sanguisorbae Filiformis 12g, Herba Taxilli 17g, Radix potentillae anserinae 19g, Radix Codonopsis 30g, Lentinus Edodes 13g, Radix Changii 27g, Herb Gynostemmae Pentaphylli 22g, Caulis Spatholobi 26g, Semen Ziziphi Spinosae 23g, Rhizoma Dioscoreae 27g, Semen Lablab Album 22g, Bombyx mori L. 31g, Fructus Amomi 14g, Radix Aucklandiae 13g, Endothelium Corneum Gigeriae Galli 15g, Fructus Psoraleae 18g, Colla cornus cervi 19g, Semen Pini 23g and Fructus Lycii 25g to mix, be ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.
2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
The toxicity test of pharmaceutical composition:
Get Radix Angelicae Sinensis 31g, Colla Corii Asini 22g, Radix seu Caulis Verntilaginis Leiocarpae 16g, pulvis ferri (ferrosic oxide) 23g, Radix Sanguisorbae Filiformis 12g, Herba Taxilli 17g, Radix potentillae anserinae 19g, Radix Codonopsis 30g, Lentinus Edodes 13g, Radix Changii 27g, Herb Gynostemmae Pentaphylli 22g, Caulis Spatholobi 26g, Semen Ziziphi Spinosae 23g, Rhizoma Dioscoreae 27g, Semen Lablab Album 22g, Bombyx mori L. 31g, Fructus Amomi 14g, Radix Aucklandiae 13g, Endothelium Corneum Gigeriae Galli 15g, Fructus Psoraleae 18g, Colla cornus cervi 19g, Semen Pini 13g, Fructus Lycii 20g, Pericarpium Citri Reticulatae Viride 7g, Radix Et Rhizoma Nardostachyos 11g, Cornu Cervi Pantotrichum 8g, Herba Pyrolae 10g, Herba Agrimoniae 6g, Semen Juglandis 14g and Semen Cuscutae 18g.Mixing, is ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.
2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
Contrast test
Chaohu, Anhui Province, China pig farm, since in February, 2010, in the piglet group that 7-28 age in days does not wean, more than 200 piglet, continues to occur lethargy, poor growth, has bad physiques, some baby pig diarrheas, feces stench, and it is ice-cold that hands touches skin, and what have is even dead.
Cut open the dead piglet of inspection: blood is thin, light, and skin color shoals, and has hydrops in pleural space.Gastrointestinal membranes color is light, cardiac dilatation, parenchymal viscera steatosis, and skin and mucosa are significantly pale.
Sick pig blood inspection: hemoglobin 4%, RBC number is down to 2,800,000/mm
3; Leukocyte moderate increases, and its medium-sized lymphocyte significantly increases, and eosinophil reduces, and loses alkaline granulocyte; Blood is thin, and erythrocyte sedimentation rate is accelerated, and blood clotting time extends; Red cell morphology is abnormal, less, and size is uneven, and Reticulocyte increases.
The not optimum anemia of piglet nutrition is diagnosed as according to checking and cuing open inspection result.
Choose the ill piglet 66 that 20 ages in days are made a definite diagnosis, 66 ill piglets are divided into three groups at random, be respectively embodiment group 1, embodiment group 2 and matched group, the ill piglet of three groups all without significant difference, has comparability in body weight, the state of an illness etc.Embodiment group 1, embodiment group 2 and matched group use the powder of the granule of the embodiment of the present invention 1, embodiment 2 and conventional medicament to treat respectively;
Wherein, the using method of granule and powder is that the agent 3g that gets it filled is dissolved in 1000ml warm water and drinks to piglet, drinks 4 days continuously; Conventional medicament is by ferrous sulfate 2.5g, copper sulfate 1g, and iron chloride 0.2g is dissolved in 1000ml warm water and drinks to piglet, drinks 4 days continuously; Take each group of ill pig weight respectively before and after experiment, period records recovery from illness situation and the death toll of ill piglet, and calculate average daily gain and cure rate, result as shown in Table 1 and Table 2.Wherein, cure: energetic, feces is normal, bouncing, sampling cut open inspection and blood test normal; Invalid: clinical symptoms is not improved and even increased the weight of or death.
Table 1 each experimental group piglet average weight synopsis
| Group | Sum | Average weight before experiment | Average weight after test | Average daily gain |
| Embodiment group 1 | 22 | 2268g | 3296g | 257g/d |
| Embodiment group 2 | 22 | 2305g | 3589g | 321g/d |
| Matched group | 22 | 2312g | 3121g | 202g/d |
Data from table 1: compared with matched group, use the ill piglet of Drug therapy of the present invention, during to piglet 24 age in days, the piglet that its average weight is treated than traditional therapy exceeds 175g and 468g respectively, and average daily gain exceeds 55g/d and 119g/d respectively.
The therapeutic effect synopsis of each experimental group piglet of table 2
| Group | Sum | Cure number | Invalid number | Cure rate |
| Embodiment group 1 | 22 | 22 | 0 | 100% |
| Embodiment group 2 | 22 | 22 | 0 | 100% |
| Matched group | 22 | 20 | 2 | 90.9% |
Data from table 2: compared with conventional medicament, the medicine of the embodiment of the present invention 1 and 2 has advantage that is evident in efficacy, cheap, that have no side effect in the not optimum anemia for the treatment of piglet nutrition.
Known by contrast test: compared with conventional medicament, the pharmaceutical composition of the embodiment of the present invention 1 and 2 has toxic and side effects advantage little, evident in efficacy in the not optimum anemia for the treatment of piglet nutrition, but also can be good at the normal growth ensureing piglet.
Model case
The piglet of 36 7-28 ages in days that in March, 2013, Hefei ,Anhui self-employed pig raiser raised, occur becoming thin, asthenia universalis, often lies prostrate, inappetence, poor growth.Cut open the dead pig blood of inspection thin, light, skin color shoals, and has hydrops in pleural space.Gastrointestinal membranes color is light, cardiac dilatation, parenchymal viscera steatosis, and skin and mucosa are significantly pale.Sick pig blood inspection: hemoglobin 4%, RBC number is down to 2,000,000/mm
3; Leukocyte moderate increases, and its medium-sized lymphocyte significantly increases, and eosinophil reduces, and loses alkaline granulocyte; Blood is thin, and erythrocyte sedimentation rate is accelerated, and blood clotting time extends; Red cell morphology is abnormal, less, and size is uneven, and Reticulocyte increases.Be diagnosed as the not optimum anemia of piglet nutrition.Example 2 powder 3g is dissolved in 1000ml warm water and drinks to piglet, and within the 3rd day, ill piglet symptom is obviously improved, and within the 4th day, piglet is all fully recovered, and after continuing to drink 6 days, compared with sodium selenite, average weight is substantially identical.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. for preventing and treating the pharmaceutical composition of the not optimum anemia of piglet nutrition, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Radix Angelicae Sinensis, Colla Corii Asini, Radix seu Caulis Verntilaginis Leiocarpae, pulvis ferri (ferrosic oxide), Radix Sanguisorbae Filiformis, Herba Taxilli, Radix potentillae anserinae, Radix Codonopsis, Lentinus Edodes, Radix Changii, Herb Gynostemmae Pentaphylli, Caulis Spatholobi, Semen Ziziphi Spinosae, Rhizoma Dioscoreae, Semen Lablab Album, Bombyx mori L., Fructus Amomi, the Radix Aucklandiae, Endothelium Corneum Gigeriae Galli, Fructus Psoraleae, Colla cornus cervi, Semen Pini and Fructus Lycii.
2. the pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition according to claim 1, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 22-34 part, Colla Corii Asini 15-26 part, Radix seu Caulis Verntilaginis Leiocarpae 10-18 part, pulvis ferri (ferrosic oxide) 18-29 part, Radix Sanguisorbae Filiformis 8-14 part, Herba Taxilli 9-19 part, Radix potentillae anserinae 13-24 part, Radix Codonopsis 20-33 part, Lentinus Edodes 12-21 part, Radix Changii 20-35 part, Herb Gynostemmae Pentaphylli 17-26 part, Caulis Spatholobi 21-34 part, Semen Ziziphi Spinosae 12-28 part, Rhizoma Dioscoreae 18-30 part, Semen Lablab Album 15-26 part, Bombyx mori L. 15-32 part, Fructus Amomi 11-23 part, Radix Aucklandiae 10-21 part, Endothelium Corneum Gigeriae Galli 11-19 part, Fructus Psoraleae 13-23 part, Colla cornus cervi 18-27 part, Semen Pini 15-26 part and Fructus Lycii 20-32 part.
3. the pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 31 parts, 22 parts, Colla Corii Asini, Radix seu Caulis Verntilaginis Leiocarpae 16 parts, pulvis ferri (ferrosic oxide) 23 parts, Radix Sanguisorbae Filiformis 12 parts, Herba Taxilli 17 parts, Radix potentillae anserinae 19 parts, Radix Codonopsis 30 parts, 13 parts, Lentinus Edodes, Radix Changii 27 parts, Herb Gynostemmae Pentaphylli 22 parts, Caulis Spatholobi 26 parts, Semen Ziziphi Spinosae 23 parts, Rhizoma Dioscoreae 27 parts, Semen Lablab Album 22 parts, Bombyx mori L. 31 parts, Fructus Amomi 14 parts, the Radix Aucklandiae 13 parts, Endothelium Corneum Gigeriae Galli 15 parts, Fructus Psoraleae 18 parts, Colla cornus cervi 19 parts, 23 parts, Semen Pini and Fructus Lycii 25 parts.
4. the pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition according to any one of claim 1-3, it is characterized in that, described pharmaceutical composition also comprises Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Nardostachyos, Cornu Cervi Pantotrichum, Herba Pyrolae, Herba Agrimoniae, Semen Juglandis and Semen Cuscutae.
5. the pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition according to any one of claim 1-4, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 22-34 part, Colla Corii Asini 15-26 part, Radix seu Caulis Verntilaginis Leiocarpae 10-18 part, pulvis ferri (ferrosic oxide) 18-29 part, Radix Sanguisorbae Filiformis 8-14 part, Herba Taxilli 9-19 part, Radix potentillae anserinae 13-24 part, Radix Codonopsis 20-33 part, Lentinus Edodes 12-21 part, Radix Changii 20-35 part, Herb Gynostemmae Pentaphylli 17-26 part, Caulis Spatholobi 21-34 part, Semen Ziziphi Spinosae 12-28 part, Rhizoma Dioscoreae 18-30 part, Semen Lablab Album 15-26 part, Bombyx mori L. 15-32 part, Fructus Amomi 11-23 part, Radix Aucklandiae 10-21 part, Endothelium Corneum Gigeriae Galli 11-19 part, Fructus Psoraleae 13-23 part, Colla cornus cervi 18-27 part, Semen Pini 12-20 part, Fructus Lycii 14-27 part, Pericarpium Citri Reticulatae Viride 3-9 part, Radix Et Rhizoma Nardostachyos 7-12 part, Cornu Cervi Pantotrichum 5-11 part, Herba Pyrolae 7-12 part, Herba Agrimoniae 4-8 part, Semen Juglandis 12-19 part and Semen Cuscutae 15-21 part.
6. the pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition according to any one of claim 1-5, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 31 parts, 22 parts, Colla Corii Asini, Radix seu Caulis Verntilaginis Leiocarpae 16 parts, pulvis ferri (ferrosic oxide) 23 parts, Radix Sanguisorbae Filiformis 12 parts, Herba Taxilli 17 parts, Radix potentillae anserinae 19 parts, Radix Codonopsis 30 parts, 13 parts, Lentinus Edodes, Radix Changii 27 parts, Herb Gynostemmae Pentaphylli 22 parts, Caulis Spatholobi 26 parts, Semen Ziziphi Spinosae 23 parts, Rhizoma Dioscoreae 27 parts, Semen Lablab Album 22 parts, Bombyx mori L. 31 parts, Fructus Amomi 14 parts, the Radix Aucklandiae 13 parts, Endothelium Corneum Gigeriae Galli 15 parts, Fructus Psoraleae 18 parts, Colla cornus cervi 19 parts, 13 parts, Semen Pini, Fructus Lycii 20 parts, 7 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Nardostachyos 11 parts, 8 parts, Cornu Cervi Pantotrichum, Herba Pyrolae 10 parts, Herba Agrimoniae 6 parts, Semen Juglandis 14 parts and Semen Cuscutae 18 parts.
7. the pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition according to any one of claim 1-6, it is characterized in that, the dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:
Step one: get Colla Corii Asini in described ratio and Colla cornus cervi is ground into 120 order-150 object fine powders, described raw medicinal material will be remained mix in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder, by the mixture 1 that described fine powder and dried cream powder mix,
Step 2: the dextrin adding cane sugar powder relative to mixture 1 quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the mixture 1 obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
8. the pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition according to any one of claim 1-6, it is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
Step one, get Colla Corii Asini in described ratio and Colla cornus cervi is ground into 120 order-150 object fine powders, described surplus stock medicine is dropped in proportion stirring in blender, mixing, pulverize in rear feeding pulverizer, the Chinese medicine composition after pulverizing is loaded in multi-function extractor, add relative to its quality 5-7 times amount water, boil 2-4 hour, steam pressure is 0.6-1Mpa process, filter, obtain the first filtrate and filtering residue;
Step 2, the filtering residue of acquisition added again relative to its quality 5-7 times amount water, boil 2-4 hour, steam pressure is 0.6Mpa-1Mpa process, filter and obtain the second filtrate and filtering residue;
Step 3, the first filtrate and the second filtrate merged, concentrated removing moisture, obtains and gets dry extract, employing super-fine powder mill is pulverized, be crushed to less than 30 μm, obtain pharmaceutical composition powder, described pharmaceutical composition powder is mixed homogeneously with the fine powder of step one and obtains powder.
9. a preparation method for the pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition as described in any one of claim 1-6, it is characterized in that, the dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:
Step one: get Colla Corii Asini in described ratio and Colla cornus cervi is ground into 120 order-150 object fine powders, described raw medicinal material will be remained mix in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder, by the mixture 1 that described fine powder and dried cream powder mix,
Step 2: the dextrin adding cane sugar powder relative to mixture 1 quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the mixture 1 obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
10. a preparation method for the pharmaceutical composition for preventing and treating the not optimum anemia of piglet nutrition as described in any one of claim 1-6, it is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
Step one, get Colla Corii Asini in described ratio and Colla cornus cervi is ground into 120 order-150 object fine powders, described surplus stock medicine is dropped in proportion stirring in blender, mixing, pulverize in rear feeding pulverizer, the Chinese medicine composition after pulverizing is loaded in multi-function extractor, add relative to its quality 5-7 times amount water, boil 2-4 hour, steam pressure is 0.6-1Mpa process, filter, obtain the first filtrate and filtering residue;
Step 2, the filtering residue of acquisition added again relative to its quality 5-7 times amount water, boil 2-4 hour, steam pressure is 0.6Mpa-1Mpa process, filter and obtain the second filtrate and filtering residue;
Step 3, the first filtrate and the second filtrate merged, concentrated removing moisture, obtains and gets dry extract, employing super-fine powder mill is pulverized, be crushed to less than 30 μm, obtain pharmaceutical composition powder, described pharmaceutical composition powder is mixed homogeneously with the fine powder of step one and obtains powder.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109699843A (en) * | 2019-03-05 | 2019-05-03 | 广东驱动力生物科技股份有限公司 | A kind of jelly and preparation method thereof improving piglet anaemia |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417951A (en) * | 2013-09-03 | 2013-12-04 | 天津生机集团股份有限公司 | Traditional Chinese medicine composite for curing alimentary anemia of piglets |
| CN104258139A (en) * | 2014-09-28 | 2015-01-07 | 山东新希望六和集团有限公司 | Pharmaceutical composition for preventing and treating chronic swine plague and preparation method of pharmaceutical composition |
| CN104474440A (en) * | 2014-11-27 | 2015-04-01 | 山东新希望六和集团有限公司 | Pharmaceutical composition for treatment of nutritional anemia of piglets and preparation method thereof |
-
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417951A (en) * | 2013-09-03 | 2013-12-04 | 天津生机集团股份有限公司 | Traditional Chinese medicine composite for curing alimentary anemia of piglets |
| CN104258139A (en) * | 2014-09-28 | 2015-01-07 | 山东新希望六和集团有限公司 | Pharmaceutical composition for preventing and treating chronic swine plague and preparation method of pharmaceutical composition |
| CN104474440A (en) * | 2014-11-27 | 2015-04-01 | 山东新希望六和集团有限公司 | Pharmaceutical composition for treatment of nutritional anemia of piglets and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 丁永丰: "《猪常见病中西医简便疗法》", 31 July 2011 * |
| 王振生: "《家畜疾病防治》", 31 August 1988 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109699843A (en) * | 2019-03-05 | 2019-05-03 | 广东驱动力生物科技股份有限公司 | A kind of jelly and preparation method thereof improving piglet anaemia |
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