CN104937423B - 凝血反应的评价方法 - Google Patents

凝血反应的评价方法 Download PDF

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Publication number
CN104937423B
CN104937423B CN201380061538.7A CN201380061538A CN104937423B CN 104937423 B CN104937423 B CN 104937423B CN 201380061538 A CN201380061538 A CN 201380061538A CN 104937423 B CN104937423 B CN 104937423B
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coagulation factor
blood coagulation
activity
blood
activated
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Chinese (zh)
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CN104937423A (zh
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添田哲弘
北泽刚久
岛绿伦
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Chugai Pharmaceutical Co Ltd
Nara Medical University PUC
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Chugai Pharmaceutical Co Ltd
Nara Medical University PUC
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6443—Coagulation factor XIa (3.4.21.27)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96452—Factor XI (3.4.21.27)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/224—Haemostasis or coagulation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201380061538.7A 2012-09-28 2013-09-26 凝血反应的评价方法 Active CN104937423B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012217925 2012-09-28
JP2012-217925 2012-09-28
PCT/JP2013/075978 WO2014050926A1 (ja) 2012-09-28 2013-09-26 血液凝固反応の評価方法

Publications (2)

Publication Number Publication Date
CN104937423A CN104937423A (zh) 2015-09-23
CN104937423B true CN104937423B (zh) 2017-05-24

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CN201380061538.7A Active CN104937423B (zh) 2012-09-28 2013-09-26 凝血反应的评价方法

Country Status (13)

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US (1) US11078518B2 (https=)
EP (1) EP2902787B1 (https=)
JP (1) JP6284481B2 (https=)
KR (1) KR102134305B1 (https=)
CN (1) CN104937423B (https=)
BR (1) BR112015006634B1 (https=)
CA (1) CA2886326C (https=)
ES (1) ES2668455T3 (https=)
MX (1) MX358997B (https=)
PL (1) PL2902787T3 (https=)
RU (1) RU2683933C2 (https=)
TW (1) TWI609083B (https=)
WO (1) WO2014050926A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI452136B (zh) 2010-11-17 2014-09-11 中外製藥股份有限公司 A multiple specific antigen-binding molecule that replaces the function of Factor VIII in blood coagulation
TWI700300B (zh) 2014-09-26 2020-08-01 日商中外製藥股份有限公司 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體
TWI701435B (zh) 2014-09-26 2020-08-11 日商中外製藥股份有限公司 測定ｆｖｉｉｉ的反應性之方法
CN107533071A (zh) 2015-04-24 2018-01-02 公立大学法人奈良县立医科大学 血液受试体的凝固能力的评价方法、以及用于在该方法中使用的试剂、试剂盒及装置
CR20180554A (es) 2016-04-28 2019-01-10 Chugai Pharmaceutical Co Ltd Preparaciones que contienen anticuerpos
JP7101351B2 (ja) * 2016-04-28 2022-07-15 シスメックス株式会社 血液検体の分析方法、血液検体分析用試薬及び試薬キット、並びに血液検体分析装置
CN110461358A (zh) 2017-03-31 2019-11-15 公立大学法人奈良县立医科大学 可用于预防和/或治疗凝血因子ⅸ异常、包含代替凝血因子ⅷ的功能的多特异性抗原结合分子的药物组合物
CN119161488A (zh) 2017-11-01 2024-12-20 中外制药株式会社 具有降低的生物活性的抗体变体和同种型
RU2699798C1 (ru) * 2019-05-22 2019-09-11 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр гематологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ гематологии" Минздрава России) Способ выявления дефицитов факторов свертывания крови методом тромбоэластометрии
JP6883899B1 (ja) * 2020-12-07 2021-06-09 株式会社血栓トランスレーショナルリサーチラボ 血液凝固検査試薬、および血液凝固検査方法
US12588235B2 (en) 2022-01-27 2026-03-24 Vanguard International Semiconductor Corporation Semiconductor structure and manufacturing method of the same
WO2024143525A1 (ja) 2022-12-28 2024-07-04 積水メディカル株式会社 血液検体の血液凝固能の分析方法
WO2024143524A1 (ja) 2022-12-28 2024-07-04 積水メディカル株式会社 血液検体の血液凝固能の分析方法

Citations (5)

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Publication number Priority date Publication date Assignee Title
CN1051732A (zh) * 1989-11-09 1991-05-29 诺沃工业联合股票公司 分离生物活性化合物的方法
JP2746386B2 (ja) * 1988-09-07 1998-05-06 清水製薬株式会社 全血を用いた血液凝固能検査法
CN1890369A (zh) * 2003-10-10 2007-01-03 中外制药株式会社 替代功能蛋白质的双特异性抗体
CN101415445A (zh) * 2006-03-31 2009-04-22 巴克斯特国际公司 聚乙二醇化的因子ⅷ
US20100003254A1 (en) * 2005-04-08 2010-01-07 Chugai Seiyaku Kabushiki Kaisha Antibody Substituting for Function of Blood Coagulation Factor VIII

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WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
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JPH08509612A (ja) 1993-04-26 1996-10-15 ジェンファーム インターナショナル インコーポレイテッド 異種抗体を産生することができるトランスジェニック非ヒト動物
FR2707189B1 (fr) 1993-07-09 1995-10-13 Gradient Ass Procédé de traitement de résidus de combustion et installation de mise en Óoeuvre dudit procédé.
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JP2746386B2 (ja) * 1988-09-07 1998-05-06 清水製薬株式会社 全血を用いた血液凝固能検査法
CN1051732A (zh) * 1989-11-09 1991-05-29 诺沃工业联合股票公司 分离生物活性化合物的方法
CN1890369A (zh) * 2003-10-10 2007-01-03 中外制药株式会社 替代功能蛋白质的双特异性抗体
US20100003254A1 (en) * 2005-04-08 2010-01-07 Chugai Seiyaku Kabushiki Kaisha Antibody Substituting for Function of Blood Coagulation Factor VIII
CN101415445A (zh) * 2006-03-31 2009-04-22 巴克斯特国际公司 聚乙二醇化的因子ⅷ

Also Published As

Publication number Publication date
CA2886326C (en) 2021-11-02
TWI609083B (zh) 2017-12-21
BR112015006634B1 (pt) 2022-06-14
EP2902787B1 (en) 2018-03-28
US11078518B2 (en) 2021-08-03
PL2902787T3 (pl) 2018-08-31
HK1212443A1 (en) 2016-06-10
CA2886326A1 (en) 2014-04-03
CN104937423A (zh) 2015-09-23
KR102134305B1 (ko) 2020-07-15
MX2015003740A (es) 2015-09-23
WO2014050926A1 (ja) 2014-04-03
MX358997B (es) 2018-09-12
BR112015006634A2 (https=) 2017-09-05
RU2683933C2 (ru) 2019-04-03
KR20150068406A (ko) 2015-06-19
TW201418470A (zh) 2014-05-16
EP2902787A4 (en) 2016-03-23
EP2902787A1 (en) 2015-08-05
US20150240287A1 (en) 2015-08-27
JPWO2014050926A1 (ja) 2016-08-22
JP6284481B2 (ja) 2018-02-28
ES2668455T3 (es) 2018-05-18
RU2015115277A (ru) 2016-11-20

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