CN104926701A - 一种蛋氨酸纯化的工艺 - Google Patents
一种蛋氨酸纯化的工艺 Download PDFInfo
- Publication number
- CN104926701A CN104926701A CN201510374789.1A CN201510374789A CN104926701A CN 104926701 A CN104926701 A CN 104926701A CN 201510374789 A CN201510374789 A CN 201510374789A CN 104926701 A CN104926701 A CN 104926701A
- Authority
- CN
- China
- Prior art keywords
- methionine
- met
- resin
- purifying according
- technique
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/12—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/265—Adsorption chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/282—Porous sorbents
- B01J20/285—Porous sorbents based on polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
实施例 | 母液pH | 树脂吸附容量(g/L) |
实施例3 | 1.0 | 192.1 |
实施例4 | 2.0 | 195.9 |
实施例5 | 3.0 | 194.1 |
实施例6 | 5.0 | 172.5 |
实施例7 | 7.0 | 159.4 |
实施例8 | 9.0 | 102.1 |
实施例9 | 10.0 | 80.2 |
实施例 | 流速(BV/h) | 树脂吸附容量(g/L) |
实施例10 | 1 | 229.6 |
实施例11 | 2 | 225.1 |
实施例12 | 3 | 211.9 |
实施例13 | 5 | 139.2 |
实施例14 | 7 | 91.4 |
实施例15 | 10 | 55.8 |
实施例 | 解吸液 | 解吸液蛋氨酸浓度(%) | 解吸收率(%) |
实施例25 | 1%(w/w)氨水 | 6.03 | 85.59 |
实施例26 | 2%(w/w)氨水 | 6.69 | 95.02 |
实施例27 | 4%(w/w)氨水 | 6.97 | 99.00 |
实施例28 | 8%(w/w)氨水 | 6.95 | 98.73 |
实施例29 | 10%(w/w)氨水 | 6.55 | 93.04 |
实施例 | 解吸体积 | 解吸液蛋氨酸浓度(%) | 解吸收率(%) |
实施例30 | 1BV | 12.47 | 58.03 |
实施例31 | 2BV | 8.75 | 81.47 |
实施例32 | 3BV | 6.99 | 97.79 |
实施例33 | 5BV | 4.21 | 98.02 |
实施例 | 解吸流速(BV/h) | 解吸液蛋氨酸浓度(%) | 解吸收率(%) |
实施例34 | 1 | 6.79 | 98.72 |
实施例35 | 3 | 6.78 | 98.55 |
实施例36 | 7 | 5.55 | 80.71 |
实施例37 | 10 | 4.84 | 70.36 |
Claims (17)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510374789.1A CN104926701B (zh) | 2015-06-30 | 2015-06-30 | 一种蛋氨酸纯化的工艺 |
PCT/CN2016/087428 WO2017000867A1 (zh) | 2015-06-30 | 2016-06-28 | 一种蛋氨酸纯化的工艺 |
KR1020177037896A KR102045531B1 (ko) | 2015-06-30 | 2016-06-28 | 메티오닌을 정제하는 방법 |
EP16817231.0A EP3318552A4 (en) | 2015-06-30 | 2016-06-28 | PROCESS FOR CLEANING METHIONINE |
JP2017567237A JP6691557B2 (ja) | 2015-06-30 | 2016-06-28 | メチオニンの精製プロセス |
SG11201710689TA SG11201710689TA (en) | 2015-06-30 | 2016-06-28 | Process of purifying methionine |
US15/740,792 US10287244B2 (en) | 2015-06-30 | 2016-06-28 | Process of purifying methionine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510374789.1A CN104926701B (zh) | 2015-06-30 | 2015-06-30 | 一种蛋氨酸纯化的工艺 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104926701A true CN104926701A (zh) | 2015-09-23 |
CN104926701B CN104926701B (zh) | 2017-05-03 |
Family
ID=54114159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510374789.1A Active CN104926701B (zh) | 2015-06-30 | 2015-06-30 | 一种蛋氨酸纯化的工艺 |
Country Status (7)
Country | Link |
---|---|
US (1) | US10287244B2 (zh) |
EP (1) | EP3318552A4 (zh) |
JP (1) | JP6691557B2 (zh) |
KR (1) | KR102045531B1 (zh) |
CN (1) | CN104926701B (zh) |
SG (1) | SG11201710689TA (zh) |
WO (1) | WO2017000867A1 (zh) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017000867A1 (zh) * | 2015-06-30 | 2017-01-05 | 西安蓝晓科技新材料股份有限公司 | 一种蛋氨酸纯化的工艺 |
CN108623504A (zh) * | 2017-03-16 | 2018-10-09 | 诺华赛分离技术(上海)有限公司 | 用色谱法纯化2-羟基-4-(甲基硫代)丁酸 |
CN109232338A (zh) * | 2018-11-09 | 2019-01-18 | 禄丰天宝磷化工有限公司 | 一种蛋氨酸羟基类似物的分离纯化方法 |
CN110382461A (zh) * | 2017-03-16 | 2019-10-25 | 安迪苏法国联合股份有限公司 | 用于制备2-羟基-4-(甲硫基)丁酸的方法 |
US10669233B2 (en) | 2017-12-28 | 2020-06-02 | Sunresin New Materials Co. Ltd., Xi'an | Process of purifying methionine |
CN115819381A (zh) * | 2022-12-21 | 2023-03-21 | 中国科学院青岛生物能源与过程研究所 | 一种生物催化体系中糠胺的分离纯化方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10995065B2 (en) | 2017-07-19 | 2021-05-04 | Sumitomo Chemical Company, Limited | Method for producing purified methionine and method for preventing caking of methionine |
Citations (4)
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US20080045746A1 (en) * | 2004-04-07 | 2008-02-21 | Asahi Kasei Chemicals Corporation | Method for Purification of Amino Acid |
CN103641758A (zh) * | 2013-11-19 | 2014-03-19 | 重庆紫光化工股份有限公司 | 廉价的高纯度的d,l-蛋氨酸的制备方法 |
US20140213819A1 (en) * | 2011-02-23 | 2014-07-31 | Evonik Degussa Gmbh | Method for the production of 2-hydroxy-4-(methylthio)butyronitrile from 3-(methylthio)propanal and hydrogen cyanide |
CN104177280A (zh) * | 2013-05-23 | 2014-12-03 | 厦门世达膜科技有限公司 | 一种蛋氨酸生产工艺 |
Family Cites Families (13)
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SU914548A1 (en) * | 1980-06-11 | 1982-03-23 | Inst Elementoorganicheskikh So | Process for isolating methionine |
JPS60104052A (ja) * | 1983-11-08 | 1985-06-08 | Mitsubishi Chem Ind Ltd | フエニルアラニンと桂皮酸の分離方法 |
JPH04193861A (ja) * | 1990-11-27 | 1992-07-13 | Sumitomo Chem Co Ltd | メチオニンの製造法 |
DE4217203C2 (de) * | 1992-05-23 | 1995-09-21 | Degussa | Verfahren zum Abtrennen von Aminosäuren aus wäßrigen Lösungen |
ZA949059B (en) * | 1993-11-19 | 1995-07-19 | Aeci Ltd | Recovery of an amino acid |
FR2772026A1 (fr) * | 1997-12-05 | 1999-06-11 | Rhone Poulenc Nutrition Animal | Procede de preparation de la methionine ou de l'hydroxyanalogue |
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CN103772246A (zh) * | 2014-03-03 | 2014-05-07 | 重庆紫光化工股份有限公司 | 离子交换酸化蛋氨酸盐制备蛋氨酸的方法及专用设备 |
CN104693082A (zh) * | 2015-04-03 | 2015-06-10 | 重庆紫光化工股份有限公司 | 一种制备蛋氨酸的方法 |
CN104926701B (zh) * | 2015-06-30 | 2017-05-03 | 西安蓝晓科技新材料股份有限公司 | 一种蛋氨酸纯化的工艺 |
CN104910055A (zh) * | 2015-06-30 | 2015-09-16 | 西安蓝晓科技新材料股份有限公司 | 一种蛋氨酸提取的方法 |
-
2015
- 2015-06-30 CN CN201510374789.1A patent/CN104926701B/zh active Active
-
2016
- 2016-06-28 WO PCT/CN2016/087428 patent/WO2017000867A1/zh active Application Filing
- 2016-06-28 JP JP2017567237A patent/JP6691557B2/ja active Active
- 2016-06-28 EP EP16817231.0A patent/EP3318552A4/en active Pending
- 2016-06-28 US US15/740,792 patent/US10287244B2/en active Active
- 2016-06-28 SG SG11201710689TA patent/SG11201710689TA/en unknown
- 2016-06-28 KR KR1020177037896A patent/KR102045531B1/ko active IP Right Grant
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CN104177280A (zh) * | 2013-05-23 | 2014-12-03 | 厦门世达膜科技有限公司 | 一种蛋氨酸生产工艺 |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017000867A1 (zh) * | 2015-06-30 | 2017-01-05 | 西安蓝晓科技新材料股份有限公司 | 一种蛋氨酸纯化的工艺 |
US10287244B2 (en) * | 2015-06-30 | 2019-05-14 | Sunresin New Materials Co. Ltd., Xi'an | Process of purifying methionine |
CN108623504A (zh) * | 2017-03-16 | 2018-10-09 | 诺华赛分离技术(上海)有限公司 | 用色谱法纯化2-羟基-4-(甲基硫代)丁酸 |
CN110382461A (zh) * | 2017-03-16 | 2019-10-25 | 安迪苏法国联合股份有限公司 | 用于制备2-羟基-4-(甲硫基)丁酸的方法 |
CN108623504B (zh) * | 2017-03-16 | 2020-09-01 | 诺华赛分离技术(上海)有限公司 | 用色谱法纯化2-羟基-4-(甲基硫代)丁酸 |
CN110382461B (zh) * | 2017-03-16 | 2021-12-21 | 安迪苏法国联合股份有限公司 | 用于制备2-羟基-4-(甲硫基)丁酸的方法 |
US10669233B2 (en) | 2017-12-28 | 2020-06-02 | Sunresin New Materials Co. Ltd., Xi'an | Process of purifying methionine |
CN109232338A (zh) * | 2018-11-09 | 2019-01-18 | 禄丰天宝磷化工有限公司 | 一种蛋氨酸羟基类似物的分离纯化方法 |
CN115819381A (zh) * | 2022-12-21 | 2023-03-21 | 中国科学院青岛生物能源与过程研究所 | 一种生物催化体系中糠胺的分离纯化方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2017000867A1 (zh) | 2017-01-05 |
US20180194723A1 (en) | 2018-07-12 |
KR20180038421A (ko) | 2018-04-16 |
US10287244B2 (en) | 2019-05-14 |
CN104926701B (zh) | 2017-05-03 |
EP3318552A1 (en) | 2018-05-09 |
KR102045531B1 (ko) | 2019-12-02 |
EP3318552A4 (en) | 2019-02-20 |
JP6691557B2 (ja) | 2020-04-28 |
JP2018520146A (ja) | 2018-07-26 |
SG11201710689TA (en) | 2018-01-30 |
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Inventor after: Kou Xiaokang Inventor after: Wang Risheng Inventor after: Wang Gang Inventor after: Liu Qiong Inventor after: Ren Wanping Inventor after: Julian Bute Inventor after: Yang Yuanbin Inventor after: Valentin Zidar Inventor before: Kou Xiaokang Inventor before: Wang Risheng Inventor before: Wang Gang Inventor before: Liu Qiong Inventor before: Ren Wanping |
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Effective date of registration: 20161019 Address after: High tech Zone technology two road 710075 Shaanxi city of Xi'an province No. 72 Chak tower 4 Applicant after: Sunresin New Materials Co., Ltd., Xi'an Applicant after: LAN-STAR Andy Su Nanjing Co., Ltd. Address before: High tech Zone technology two road 710075 Shaanxi city of Xi'an province No. 72 Chak tower 4 Applicant before: Sunresin New Materials Co., Ltd., Xi'an |
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