CN104905987B - A kind of children's toothpaste composition - Google Patents
A kind of children's toothpaste composition Download PDFInfo
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- CN104905987B CN104905987B CN201510288900.5A CN201510288900A CN104905987B CN 104905987 B CN104905987 B CN 104905987B CN 201510288900 A CN201510288900 A CN 201510288900A CN 104905987 B CN104905987 B CN 104905987B
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Abstract
The invention discloses a kind of children's toothpaste composition, each raw material components comprising following percentage by weight：0.1 5% thickener；0.5 4% solubilizer；1 60% NMF；10 90% water；0.1 2% essence；Surplus is other components.It does not add rubbing agent to the children's toothpaste composition of the present invention, and lotion is transparent, and foam is few or almost non-foam, lotion are easily extruded, and easily brush is opened, and reduces the friction to dental surface, safe, pH scopes 5.5 7.5.The toothpaste of the present invention can be used as the training toothpaste that 26 years old children uses.
Description
Technical field
The present invention relates to oral care product technical field, more particularly to one kind without rubbing agent, low bubble or non-foam,
Swallow harmless children's toothpaste composition.
Background technology
Ordinary toothpaste from square degree typically all containing rubbing agent, thickener, NMF, foaming agent, essence, water and other
Composition.By the friction of rubbing agent and dental surface, have the function that to remove dental surface bacterial plaque, dna exogenous pigment spot.
The foam of ordinary toothpaste usually requires to enrich very much to have the function that cleaning and preferable mouthfeel.
2-6 year Pediatric Oral Emergency development is in stage milk teeth period, and children's feature of brushing teeth in this stage is：Control ability is poor, brush
Tooth process is easily swallowed；Oral environment is tender and lovely, stimulates tolerance weak；Brush teeth firmly small, lotion is not easy brush and opened.And children make
During being brushed teeth with tooth paste product, some toothpaste can be swallowed unavoidably, and eating for a long time can negative unhealthy.
For above feature, the children's toothpaste product of prior art mainly focuses on the feature toothpaste such as mothproof, few excitant
The exploitation of product, but using effect is still undesirable, it is also necessary to further improve its recipe ingredient.
The content of the invention
It is an object of the present invention to the defects of overcoming existing children's toothpaste product to exist, and a kind of new children's tooth is provided
Composite cream, it is free of rubbing agent and foaming agent in being formulated, and excitant is low, and lotion yield stress is small, and easily brush is opened, not fluorine-containing, i.e.,
Make to swallow also harmless health during brushing teeth, be suitable as children training toothpaste.
The object of the invention to solve the technical problems is realized using following technical scheme.Itd is proposed according to the present invention
A kind of children's toothpaste composition, by weight percentage, solubilizer, the 1- of thickener, 0.5-4% containing 0.1-5%
60% NMF, 10-90% water, 0.1-2% essence, surplus are other components.
Preferably, children's toothpaste composition of the invention, by weight percentage, thickener, 1- containing 0.1-3%
3% solubilizer, 10-60% NMF, 10-90% water, 0.1-1% essence, surplus are other components.
The children's toothpaste composition of the present invention does not add such as：Calcium carbonate, silica, calcium monohydrogen phosphate, aluminum oxide etc. rub
Agent；And without the surface-active of the high foams such as laurilsulfate sodium, Cocoamidopropyl betaine, sodium lauroyl sarcosine
Agent.
The children's toothpaste composition of the present invention, thickener preferred cellulose glue, Sodium Polyacrylate, carragheen and the xanthan
One or more of mixtures in glue.
The children's toothpaste composition of the present invention, the preferred APEO rilanit special of the solubilizer, poloxamer, tell
One or several kinds of mixtures in temperature, sapn.
The children's toothpaste composition of the present invention, the preferred sorbierite of the NMF, glycerine, the one of propane diols and polyethylene glycol
Kind or several mixtures.
The children's toothpaste composition of the present invention, other described toothpaste components include preservative, nutritious supplementary pharmaceutical, pigment, sweet tea
Taste agent etc..In addition, the preservative of the present invention can be sodium benzoate, potassium sorbate, phenmethylol, nipagin esters etc.；The present invention's
Nutritious supplementary pharmaceutical can be vitamin C derivatives, vitamin e derivative or mineral matter；The preferred food grade colorant of pigment；Sweet taste
Agent can be saccharin sodium, Sucralose, Momordia grosvenori aglycone etc..
The children's toothpaste composition of the present invention, its pH scope is between 5.5-7.5.
The children's toothpaste composition of the present invention, it can be prepared by the following two kinds different process method.
A kind of production technology of the children's toothpaste product compounding system containing acrylic acid polymer, including following technique step
Suddenly：
1) deionized water, water-soluble substances (sweetener, pigment etc.) etc. are added, stirring is complete to dissolving；
2) under conditions of stirring is opened, acrylic acid polymer is slowly added to, is stirred until homogeneous；
If 3) also contain other thickeners, with glycerine or mixed with propylene glycol, added after being stirred until homogeneous in step 2)；
4) NMF, solubilizer, essence of surplus are sequentially added, vacuum is opened, is stirred until homogeneous；
5) nertralizer is added, stirring, opens vacuum；
6) deaerate, it is filling after the assay was approved；
In addition, a kind of production technology of the children's toothpaste product compounding system without acrylic acid polymer, including it is as follows
Processing step：
1) deionized water, water-soluble substances (sweetener, pigment etc.), the NMF such as sorbierite are added, stirring is to having dissolved
Entirely；
2) after propane diols or glycerine mix with thickener, stir, add in step 1), continue to be stirred until homogeneous；
3) solubilizer, essence are sequentially added, vacuum is opened, is stirred until homogeneous；
4) deaerate, it is filling after the assay was approved.
By above-mentioned technical proposal, children's toothpaste composition of the invention has the following advantages that and beneficial effect：
1) technology disclosed by the invention is different from prior art, is free of rubbing agent in formula, and lotion it is transparent (even in
Can also be kept under low temperature transparent), lotion has pseudoplastic behavior and thixotropy, and yield stress is small, while can be stood on toothbrush without
It sink, recipe ingredient is safe, and being swallowed immediately during brushing teeth does not have toxic side effect yet.
2) the formulation of tooth-paste system of rubbing agent is free of, pasty consistence tends not to take into account with lotion transparency, if lotion
Denseness is sufficiently large, but transparency is often inadequate, and lotion is coarse rough；Do not contain rubbing agent, lotion transparent foaming it is few or
Almost non-foam, and with the excellent rheological properties of toothpaste, there is certain denseness, lotion is easily extruded, and easily brush is opened, reduction pair
The friction of dental surface, pH scopes 5.5-7.5.
3) selection of the raw material components of tooth paste product of the present invention considers the security of raw material, and prioritizing selection food-grade is former
Material, final products are tested by oral cavity toxicology.The toothpaste of above-mentioned characteristic can be used as the training toothpaste that 2-6 year children use.
Brief description of the drawings
1-4 of the embodiment of the present invention and comparative example 1-3 yield stress control is shown in Fig. 1.
Embodiment
Below by way of specific preferred embodiment combination effete test embodiment content, the present invention is expressed in further detail, but
The present invention is not limited in following embodiment.
Rubbing agent is not contained the invention discloses a kind of children's toothpaste composition, and lotion is transparent (even if also at low temperature
Keep transparent), foam is few or almost non-foam, lotion are easily extruded, and easily brush is opened, and reduces the friction to dental surface, safe；
And with the excellent rheological properties of toothpaste, there is certain denseness, can be stood on toothbrush without sinking, lotion is easily extruded,
Easily brush is opened, and reduces the friction to dental surface, pH scopes 5.5-7.5.
The dentifrice composition of the present invention does not add rubbing agent, such as：Calcium carbonate, silica, calcium monohydrogen phosphate, aluminum oxide etc.,
Contain percentage by weight 0.1-5% thickeners, percentage by weight 0.5-4% solubilizer, percentage by weight 1-60% moisturizings
Agent, percentage by weight 10-90% water, percentage by weight 0.1-2% essence and other toothpaste components.And be free of dodecyl sulphur
The fizzy surfactant such as acid esters sodium, Cocoamidopropyl betaine, sodium lauroyl sarcosine.
RH40 in following examples refers to APEO rilanit special；F127 refers to oxirane and epoxy
Propane block copolymer.
Embodiment 1
A kind of children's toothpaste composition, it is made up of the following raw material component：
The preparation method technique of the embodiment of the present invention 1 can be expressed as follows：
Deionized water, xylitol, vitamin C phosphoric ester are added, stirring is complete to dissolving；Under conditions of stirring is opened,
Sodium Polyacrylate is uniformly added into, is stirred until homogeneous；Glycerine, sorbierite, Vitwas E, RH40, essence are sequentially added, is opened
Vacuum is opened, is stirred until homogeneous；Add sodium hydroxide to neutralize, stirring, open vacuum；Degassing, it is filling after the assay was approved.
Embodiment 2
A kind of children's toothpaste composition, it is made up of the following raw material component：
The preparation method technique of the embodiment of the present invention 2 can be expressed as follows：
Deionized water, sodium benzoate, vitamin C phosphoric ester, xylitol etc. are added, stirring is complete to dissolving；Stirred in unlatching
Under conditions of mixing, Sodium Polyacrylate is uniformly added into, is stirred until homogeneous；Sequentially add Vitwas E, sorbierite, glycerine,
F127, essence, vacuum is opened, is stirred until homogeneous；Add sodium hydroxide to neutralize, stirring, open vacuum；Degassing, after the assay was approved
It is filling.
Embodiment 3
A kind of children's toothpaste composition, it is made up of the following raw material component：
The preparation method technique of the embodiment of the present invention 3 can be expressed as follows：
Deionized water, sodium benzoate, xylitol, vitamin C phosphoric ester, sodium acid carbonate are added, stirring is complete to dissolving；
After CMC is well mixed with glycerine, it is added in deionized water, is stirred until homogeneous；Sequentially add Vitwas E, sorbierite,
RH40, essence, vacuum is opened, is stirred until homogeneous；Degassing, it is filling after the assay was approved.
Comparative example 1-3
The comparative example 1-3 of table 1 raw material components composition
Comparative example 1-3 of the present invention preparation method technique can be expressed as follows：
1) deionized water, water-soluble substances are added, stirring is complete to dissolving；
2) NMF glycerine, sorbierite, polyethylene glycol -12 are added, are stirred until homogeneous；
3) hydrated silica, CMC are added, is added after mixing in step 2), continues to be stirred until homogeneous；
4) laruyl alcohol sodium sulfovinate, essence are sequentially added, vacuum is opened, is stirred until homogeneous；Degassing, is filled after the assay was approved
Dress.
Application effect test example
1st, dentin abrasion is tested
This test is with reference to ISO11609-2010Annex B.
The dentin abrasion test result of table 2
| Sample | Dentin abrasion (RDA) |
| Embodiment 1 | 14.6 |
| Embodiment 2 | 13.4 |
| Embodiment 3 | 14.1 |
| Comparative example 1 | 103.9 |
| Comparative example 2 | 110.2 |
| Comparative example 3 | 84.1 |
As can be seen from Table 2, embodiments of the invention 1-3 dentin abrasion value is substantially less than comparative example.And embodiment
Rubbing agent is free of in 1-3, the dentin abrasion shown is probably caused by toothbrush is to dentin abrasion.
2nd, lotion yield stress is tested
By can be seen that in Fig. 1, embodiment 1-3 yield stress is substantially less than comparative example 1-3.Yield stress is smaller, explanation
It is easier to flow under certain shear stress, scrubs dispersed more preferable, it is easier to extruded from dentifrice tube.
3rd, the oral toxicity test of chmice acute
This test reference《Cosmetics health specification》2007 editions
Detect environment：SPF level Animal Houses；22 ± 1 DEG C of room temperature, humidity 60 ± 5%.
Experimental animal：10 SPF levels kunming mices (5 males and 5 females), 18-20 grams of body weight.
Sample treatment：Weighing embodiment 125.0g samples adds ultra-pure water to mix to 100ml, as experiment liquid.
Experimental procedure：
1) dosage：During prerun, it is dead not find that 5000mg/kg body weight doses occur, therefore formal test design dosage is
5000mg/kg body weight；
2) contaminate：Experiment liquid is given by the oral gavage of the amount of 0.2%ml/10g body weight, animal fasting 16 is small before gavage
When, free water.Normal diet is given after gavage；
3) observe：Germicidal efficacy 14 days, poisoning symptom and death condition are recorded daily, calculate LD50.
Experimental result：
All animal subjects have no obvious poisoning symptom and death in 14 day observation period.Therefore its mouse oral acute LD 50>
5000mg/kg。
The tested material of table 3 is to chmice acute Oral toxicity result of the test
Chmice acute Oral toxicity result of the test is shown it can be seen from the result of table 3, and embodiment 1 is actual nontoxic level,
Hint is swallowed harmless.
The above described is only a preferred embodiment of the present invention, any formal limitation not is made to the present invention, therefore
It is every without departing from technical solution of the present invention content, what the technical spirit according to the present invention was made to above example any simply repaiies
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (3)
1. a kind of children's toothpaste composition, it is characterised in that it is made up of following materials by weight：
2. a kind of children's toothpaste composition, it is characterised in that it is made up of each raw material components of following percentage by weight：
The preparation technology of above-mentioned children's toothpaste composition is as follows：
Deionized water, sodium benzoate, vitamin C phosphoric ester, xylitol are added, stirring is complete to dissolving；Opening the bar of stirring
Under part, Sodium Polyacrylate is uniformly added into, is stirred until homogeneous；Sequentially add Vitwas E, sorbierite, glycerine, oxirane
With propylene oxide block copolymer, essence, vacuum is opened, is stirred until homogeneous；Add sodium hydroxide to neutralize, stirring, open vacuum；
Degassing, it is filling after the assay was approved.
3. a kind of children's toothpaste composition, it is characterised in that it is made up of following materials by weight：
The preparation technology of above-mentioned children's toothpaste composition is as follows：
Deionized water, sodium benzoate, xylitol, vitamin C phosphoric ester, sodium acid carbonate are added, stirring to dissolving must mix completely
Thing；After carboxymethyl cellulose is well mixed with glycerine, it is added in said mixture, is stirred until homogeneous；Sequentially add vitamin E
Acetate, sorbierite, APEO rilanit special, essence, vacuum is opened, is stirred until homogeneous；Degassing, is filled after the assay was approved
Dress.
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| CN201510288900.5A CN104905987B (en) | 2015-05-29 | 2015-05-29 | A kind of children's toothpaste composition |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105147583B (en) * | 2015-09-30 | 2018-01-02 | 福建春辉生物工程有限公司 | A kind of children special-purpose toothpaste containing Sasanguasaponin and preparation method thereof |
| CN106236610A (en) * | 2016-08-17 | 2016-12-21 | 林少英 | A kind of toothpaste |
| CN106214591A (en) * | 2016-09-07 | 2016-12-14 | 马鞍山纽盟知识产权管理服务有限公司 | A kind of children special-purpose high-efficiency tooth paste |
| CN106606455A (en) * | 2017-01-22 | 2017-05-03 | 福建农林大学 | Konjac glucomannan child toothpaste and preparation method thereof |
| CN110709049A (en) * | 2017-05-31 | 2020-01-17 | 株式会社Lg生活健康 | Pump type toothpaste composition |
| CN108685719B (en) * | 2018-07-16 | 2020-05-26 | 纳爱斯集团有限公司 | Degassing composition and application thereof, fluoride-free transparent children toothpaste and preparation method thereof |
| CN114028273B (en) * | 2021-12-03 | 2023-07-14 | 广州立白企业集团有限公司 | Tooth cleaning composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077884A (en) * | 1992-04-25 | 1993-11-03 | 尹长斌 | Liquid colour-changeable toothpaste and production method thereof |
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| JP3959639B2 (en) * | 2003-03-19 | 2007-08-15 | ライオン株式会社 | Toothpaste composition |
| US9561160B2 (en) * | 2013-03-15 | 2017-02-07 | Colgate-Palmolive Company | Oral care composition and processes for preparing same |
| CN103599000B (en) * | 2013-11-20 | 2016-01-20 | 杭州皎洁口腔保健用品有限公司 | A kind of All-food-grade infant toothpaste and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077884A (en) * | 1992-04-25 | 1993-11-03 | 尹长斌 | Liquid colour-changeable toothpaste and production method thereof |
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