CN104892537A - 依折麦布中间体以及依折麦布的合成方法 - Google Patents
依折麦布中间体以及依折麦布的合成方法 Download PDFInfo
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- CN104892537A CN104892537A CN201510249078.1A CN201510249078A CN104892537A CN 104892537 A CN104892537 A CN 104892537A CN 201510249078 A CN201510249078 A CN 201510249078A CN 104892537 A CN104892537 A CN 104892537A
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- compound
- methylene dichloride
- ezetimibe
- mass ratio
- fluorophenyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Description
Claims (12)
Priority Applications (1)
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CN201510249078.1A CN104892537B (zh) | 2015-05-15 | 2015-05-15 | 依折麦布中间体以及依折麦布的合成方法 |
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CN201510249078.1A CN104892537B (zh) | 2015-05-15 | 2015-05-15 | 依折麦布中间体以及依折麦布的合成方法 |
Publications (2)
Publication Number | Publication Date |
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CN104892537A true CN104892537A (zh) | 2015-09-09 |
CN104892537B CN104892537B (zh) | 2018-07-17 |
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CN201510249078.1A Active CN104892537B (zh) | 2015-05-15 | 2015-05-15 | 依折麦布中间体以及依折麦布的合成方法 |
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105566375A (zh) * | 2015-12-31 | 2016-05-11 | 山西普德药业股份有限公司 | 一种依折麦布中间体的催化合成方法 |
CN105566374A (zh) * | 2015-12-31 | 2016-05-11 | 山西普德药业股份有限公司 | 一种依折麦布中间体的浆态床连续生产方法 |
CN109293547A (zh) * | 2018-12-10 | 2019-02-01 | 无锡福祈制药有限公司 | 一类新的依折麦布衍生物及其制备方法 |
CN109369491A (zh) * | 2018-12-10 | 2019-02-22 | 无锡福祈制药有限公司 | 一类新的依替米贝衍生物及其制备方法 |
CN109384700A (zh) * | 2018-12-10 | 2019-02-26 | 无锡福祈制药有限公司 | 一类新的依折麦布类似物及其制备方法 |
CN111153844A (zh) * | 2018-11-08 | 2020-05-15 | 罗欣药业(上海)有限公司 | 一种依折麦布光学异构体的制备方法 |
CN112441959A (zh) * | 2020-12-07 | 2021-03-05 | 石家庄市华新药业有限责任公司 | 一种依折麦布原料药合成工艺 |
CN114621126A (zh) * | 2020-12-12 | 2022-06-14 | 重庆圣华曦药业股份有限公司 | 一种改进的依折麦布的制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1137634B1 (en) * | 1998-12-07 | 2005-06-15 | Schering Corporation | Process for the synthesis of azetidinones |
CN101346349A (zh) * | 2005-12-20 | 2009-01-14 | 吉瑞工厂 | 依泽替米贝的制备方法及该方法中所用的中间体 |
CN101423511A (zh) * | 2007-11-05 | 2009-05-06 | 中山奕安泰医药科技有限公司 | 依泽替米贝中间体及依泽替米贝的合成方法 |
CN103102297A (zh) * | 2012-09-28 | 2013-05-15 | 北京赛林泰医药技术有限公司 | 一种新的依折麦布的合成方法 |
-
2015
- 2015-05-15 CN CN201510249078.1A patent/CN104892537B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1137634B1 (en) * | 1998-12-07 | 2005-06-15 | Schering Corporation | Process for the synthesis of azetidinones |
CN101346349A (zh) * | 2005-12-20 | 2009-01-14 | 吉瑞工厂 | 依泽替米贝的制备方法及该方法中所用的中间体 |
CN101423511A (zh) * | 2007-11-05 | 2009-05-06 | 中山奕安泰医药科技有限公司 | 依泽替米贝中间体及依泽替米贝的合成方法 |
CN103102297A (zh) * | 2012-09-28 | 2013-05-15 | 北京赛林泰医药技术有限公司 | 一种新的依折麦布的合成方法 |
Non-Patent Citations (2)
Title |
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KATARZYNA FILIP ET AL.: "Physicochemical characterization of ezetimibe and its impurities", 《JOURNAL OF MOLECULAR STRUCTURE》 * |
马军营 等: "《有机合成化学与路线设计策略》", 31 August 2008, 科学出版社 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105566375A (zh) * | 2015-12-31 | 2016-05-11 | 山西普德药业股份有限公司 | 一种依折麦布中间体的催化合成方法 |
CN105566374A (zh) * | 2015-12-31 | 2016-05-11 | 山西普德药业股份有限公司 | 一种依折麦布中间体的浆态床连续生产方法 |
CN105566374B (zh) * | 2015-12-31 | 2018-05-25 | 山西普德药业有限公司 | 一种依折麦布中间体的浆态床连续生产方法 |
CN105566375B (zh) * | 2015-12-31 | 2018-07-10 | 山西普德药业有限公司 | 一种依折麦布中间体的催化合成方法 |
CN111153844A (zh) * | 2018-11-08 | 2020-05-15 | 罗欣药业(上海)有限公司 | 一种依折麦布光学异构体的制备方法 |
CN109293547A (zh) * | 2018-12-10 | 2019-02-01 | 无锡福祈制药有限公司 | 一类新的依折麦布衍生物及其制备方法 |
CN109369491A (zh) * | 2018-12-10 | 2019-02-22 | 无锡福祈制药有限公司 | 一类新的依替米贝衍生物及其制备方法 |
CN109384700A (zh) * | 2018-12-10 | 2019-02-26 | 无锡福祈制药有限公司 | 一类新的依折麦布类似物及其制备方法 |
CN112441959A (zh) * | 2020-12-07 | 2021-03-05 | 石家庄市华新药业有限责任公司 | 一种依折麦布原料药合成工艺 |
CN114621126A (zh) * | 2020-12-12 | 2022-06-14 | 重庆圣华曦药业股份有限公司 | 一种改进的依折麦布的制备方法 |
CN114621126B (zh) * | 2020-12-12 | 2023-07-25 | 重庆圣华曦药业股份有限公司 | 一种改进的依折麦布的制备方法 |
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CN104892537B (zh) | 2018-07-17 |
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Address after: 331800 Jiangxi city of Fuzhou province Dongxiang county rich industrial park Applicant after: Jiangxi Shi Mei pharmaceutical Limited by Share Ltd Applicant after: GUANGZHOU SHIMEI PHARMACEUTICAL TECHNOLOGY CO., LTD. Address before: 331800 Jiangxi city of Fuzhou province Dongxiang county rich industrial park Applicant before: Jiangxi SM Pharmaceutical Co., Ltd. Applicant before: GUANGZHOU SHIMEI PHARMACEUTICAL TECHNOLOGY CO., LTD. |
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Effective date of registration: 20190304 Address after: Room 1601, Block B, No. 1 Yaogu Building, North Gangxing Third Road, Jinan High-tech Zone, Jinan City, Shandong Province, 250101 Patentee after: Shandong Chuangxin Pharmaceutial Research and Development Co., Ltd. Address before: 331800 Dafu Industrial Park, Dongxiang County, Fuzhou City, Jiangxi Province Co-patentee before: GUANGZHOU SHIMEI PHARMACEUTICAL TECHNOLOGY CO., LTD. Patentee before: Jiangxi Shi Mei pharmaceutical Limited by Share Ltd |
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