CN104877042B - 一种类肝素的制备方法 - Google Patents

一种类肝素的制备方法 Download PDF

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Publication number
CN104877042B
CN104877042B CN201510316035.0A CN201510316035A CN104877042B CN 104877042 B CN104877042 B CN 104877042B CN 201510316035 A CN201510316035 A CN 201510316035A CN 104877042 B CN104877042 B CN 104877042B
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CN
China
Prior art keywords
heparan
preparation
exchange resin
sulfonating
sediment
Prior art date
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CN201510316035.0A
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English (en)
Chinese (zh)
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CN104877042A (zh
Inventor
贾春祥
黄锋
盛景新
陈文斌
王涛
方国华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang Hengkang Pharmaceutical Co., Ltd
Original Assignee
ZHEJIANG SANMEN HYGECON PHARMACEUTICAL Co Ltd
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Application filed by ZHEJIANG SANMEN HYGECON PHARMACEUTICAL Co Ltd filed Critical ZHEJIANG SANMEN HYGECON PHARMACEUTICAL Co Ltd
Priority to CN201510316035.0A priority Critical patent/CN104877042B/zh
Publication of CN104877042A publication Critical patent/CN104877042A/zh
Priority to KR1020177032344A priority patent/KR101966435B1/ko
Priority to PCT/CN2016/082482 priority patent/WO2016197799A1/zh
Priority to JP2018507767A priority patent/JP6486554B2/ja
Priority to DE112016001603.4T priority patent/DE112016001603T5/de
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Publication of CN104877042B publication Critical patent/CN104877042B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B45/00—Formation or introduction of functional groups containing sulfur
    • C07B45/02—Formation or introduction of functional groups containing sulfur of sulfo or sulfonyldioxy groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201510316035.0A 2015-06-10 2015-06-10 一种类肝素的制备方法 Active CN104877042B (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN201510316035.0A CN104877042B (zh) 2015-06-10 2015-06-10 一种类肝素的制备方法
KR1020177032344A KR101966435B1 (ko) 2015-06-10 2016-05-18 헤파리노이드의 제조방법
PCT/CN2016/082482 WO2016197799A1 (zh) 2015-06-10 2016-05-18 一种类肝素的制备方法
JP2018507767A JP6486554B2 (ja) 2015-06-10 2016-05-18 ヘパリノイドの製造方法
DE112016001603.4T DE112016001603T5 (de) 2015-06-10 2016-05-18 Herstellungsverfahren von Heparinoid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510316035.0A CN104877042B (zh) 2015-06-10 2015-06-10 一种类肝素的制备方法

Publications (2)

Publication Number Publication Date
CN104877042A CN104877042A (zh) 2015-09-02
CN104877042B true CN104877042B (zh) 2017-08-29

Family

ID=53944744

Family Applications (1)

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CN201510316035.0A Active CN104877042B (zh) 2015-06-10 2015-06-10 一种类肝素的制备方法

Country Status (5)

Country Link
JP (1) JP6486554B2 (ko)
KR (1) KR101966435B1 (ko)
CN (1) CN104877042B (ko)
DE (1) DE112016001603T5 (ko)
WO (1) WO2016197799A1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104877042B (zh) * 2015-06-10 2017-08-29 浙江三门恒康制药有限公司 一种类肝素的制备方法
CN107987184A (zh) * 2017-12-04 2018-05-04 唐财坤 一种类肝素的制备方法
IT202000004564A1 (it) * 2020-03-04 2021-09-04 Lesaffre & Cie Processo per la solfatazione diretta di polisaccaridi in solvente ecologicamente accettabile
CN111825777B (zh) * 2020-07-13 2022-05-27 山东众山生物科技有限公司 一种由软骨素制备类肝素的方法
CN112279936B (zh) * 2020-11-12 2023-06-30 上海辉文生物技术股份有限公司 一种类肝素的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB796737A (en) * 1954-09-10 1958-06-18 Hoffmann La Roche A process for the production of glycan poly-(sulphuric acid esters)
EP1634893A1 (en) * 2004-09-13 2006-03-15 Laboratori Derivati Organici S.P.A. Process for the sulfation of chondroitin
CN101717455A (zh) * 2009-12-15 2010-06-02 武汉大学 一种类肝素多糖的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0699485B2 (ja) * 1984-08-14 1994-12-07 生化学工業株式会社 合成コンドロイチン多硫酸の製造法
US6388060B1 (en) * 1998-11-06 2002-05-14 Vascular Therapeutics Inc. Process for the sulfation of uronic acid-containing polysaccharides
CN1789287A (zh) * 2005-12-20 2006-06-21 山东大学 一种多硫酸化硫酸软骨素及其制备方法
GB201001203D0 (en) * 2010-01-25 2010-03-10 Anamar Medical Ab Use of pharmaceutically active compounds
EA023370B1 (ru) * 2011-05-20 2016-05-31 Ньосис С.П.А. Хондроитинсульфат акульего типа и способ его получения
CN104877042B (zh) * 2015-06-10 2017-08-29 浙江三门恒康制药有限公司 一种类肝素的制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB796737A (en) * 1954-09-10 1958-06-18 Hoffmann La Roche A process for the production of glycan poly-(sulphuric acid esters)
EP1634893A1 (en) * 2004-09-13 2006-03-15 Laboratori Derivati Organici S.P.A. Process for the sulfation of chondroitin
CN101717455A (zh) * 2009-12-15 2010-06-02 武汉大学 一种类肝素多糖的制备方法

Also Published As

Publication number Publication date
JP2018514641A (ja) 2018-06-07
JP6486554B2 (ja) 2019-03-20
DE112016001603T5 (de) 2018-01-04
WO2016197799A1 (zh) 2016-12-15
KR20170136584A (ko) 2017-12-11
KR101966435B1 (ko) 2019-04-05
CN104877042A (zh) 2015-09-02

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C06 Publication
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SE01 Entry into force of request for substantive examination
CB03 Change of inventor or designer information

Inventor after: Jia Chunxiang

Inventor after: Huang Feng

Inventor after: Sheng Jingxin

Inventor after: Chen Wenbin

Inventor after: Wang Tao

Inventor after: Fang Guohua

Inventor before: Jia Chunxiang

COR Change of bibliographic data
GR01 Patent grant
GR01 Patent grant
CP01 Change in the name or title of a patent holder
CP01 Change in the name or title of a patent holder

Address after: Longxiang three county Hareon street 317100 Taizhou Road, Zhejiang province No. 1

Patentee after: Zhejiang Hengkang Pharmaceutical Co., Ltd

Address before: Longxiang three county Hareon street 317100 Taizhou Road, Zhejiang province No. 1

Patentee before: ZHEJIANG SANMEN HYGECON PHARMACEUTICAL CO., LTD.