CN104876979B - 一种具有抗Xa因子活性的磺酸化五糖化合物 - Google Patents

一种具有抗Xa因子活性的磺酸化五糖化合物 Download PDF

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Publication number
CN104876979B
CN104876979B CN201510345307.XA CN201510345307A CN104876979B CN 104876979 B CN104876979 B CN 104876979B CN 201510345307 A CN201510345307 A CN 201510345307A CN 104876979 B CN104876979 B CN 104876979B
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compound
added
solution
factor
aseptically
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Chinese (zh)
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CN104876979A (zh
Inventor
干浩
韩健
韩芙蓉
李振重
孙福亮
周喜泽
侯文锋
闫建合
姚小青
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Tianjin Chase Sun Pharmaceutical Co Ltd
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Tianjin Chase Sun Pharmaceutical Co Ltd
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Priority to CN201510345307.XA priority Critical patent/CN104876979B/zh
Publication of CN104876979A publication Critical patent/CN104876979A/zh
Priority to PCT/CN2016/095464 priority patent/WO2016202310A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201510345307.XA 2015-06-19 2015-06-19 一种具有抗Xa因子活性的磺酸化五糖化合物 Active CN104876979B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201510345307.XA CN104876979B (zh) 2015-06-19 2015-06-19 一种具有抗Xa因子活性的磺酸化五糖化合物
PCT/CN2016/095464 WO2016202310A1 (fr) 2015-06-19 2016-08-16 Composé de pentasaccharide sulfoné ayant une activité anti-facteur xa

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510345307.XA CN104876979B (zh) 2015-06-19 2015-06-19 一种具有抗Xa因子活性的磺酸化五糖化合物

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CN104876979A CN104876979A (zh) 2015-09-02
CN104876979B true CN104876979B (zh) 2018-10-09

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CN201510345307.XA Active CN104876979B (zh) 2015-06-19 2015-06-19 一种具有抗Xa因子活性的磺酸化五糖化合物

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CN (1) CN104876979B (fr)
WO (1) WO2016202310A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113461744B (zh) * 2020-03-30 2024-03-15 鲁南制药集团股份有限公司 一种磺达肝癸钠中间体的纯化方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1989146A (zh) * 2004-03-04 2007-06-27 普罗吉恩工业有限公司 硫酸化寡聚糖衍生物
US20140336369A1 (en) * 2011-06-28 2014-11-13 Apicore Us Llc Process for preparing heparinoids and intermediates useful in the synthesis thereof
CN104245718A (zh) * 2009-07-31 2014-12-24 可靠生物医药公司 制备磺达肝素钠的方法及其合成中使用的中间体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2009284A6 (es) * 1988-06-15 1989-09-16 Miret Lab Un procedimiento de obtencion de copolimeros con propiedades secuestrantes y dispersantes.
JP3169343B2 (ja) * 1997-03-14 2001-05-21 サノフィ アスピリンおよび抗−Ｘａオリゴ糖の組合せを含有する組成物ならびにアスピリンと任意的に組み合わせた抗−Ｘａオリゴ糖の使用
ES2423888T3 (es) * 2001-09-07 2013-09-25 Alchemia Limited Pentasacáridos de heparina sintéticos
EP2323605A4 (fr) * 2008-09-10 2014-02-05 Syneron Medical Ltd Libération transdermique d oligosaccharides
US20130262309A1 (en) * 2012-04-02 2013-10-03 Mpayme Ltd. Method and System for Secure Mobile Payment

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1989146A (zh) * 2004-03-04 2007-06-27 普罗吉恩工业有限公司 硫酸化寡聚糖衍生物
CN104245718A (zh) * 2009-07-31 2014-12-24 可靠生物医药公司 制备磺达肝素钠的方法及其合成中使用的中间体
US20140336369A1 (en) * 2011-06-28 2014-11-13 Apicore Us Llc Process for preparing heparinoids and intermediates useful in the synthesis thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Total Synthesis of Anticoagulant Pentasaccharide Fondaparinux;Tiehai Li，等;《ChemMedChem》;20140411;第9卷(第5期);第1071-1080页 *

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WO2016202310A1 (fr) 2016-12-22
CN104876979A (zh) 2015-09-02

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