CN104854129B - 色素上皮衍生因子衍生之多肽于促进肌肉或肌腱再生或动脉血管生成的用途 - Google Patents

色素上皮衍生因子衍生之多肽于促进肌肉或肌腱再生或动脉血管生成的用途 Download PDF

Info

Publication number
CN104854129B
CN104854129B CN201280075699.7A CN201280075699A CN104854129B CN 104854129 B CN104854129 B CN 104854129B CN 201280075699 A CN201280075699 A CN 201280075699A CN 104854129 B CN104854129 B CN 104854129B
Authority
CN
China
Prior art keywords
mer
muscle
tendon
pedf
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201280075699.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN104854129A (zh
Inventor
曹友平
何宗权
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CN104854129A publication Critical patent/CN104854129A/zh
Application granted granted Critical
Publication of CN104854129B publication Critical patent/CN104854129B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Marine Sciences & Fisheries (AREA)
CN201280075699.7A 2012-08-09 2012-08-09 色素上皮衍生因子衍生之多肽于促进肌肉或肌腱再生或动脉血管生成的用途 Active CN104854129B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2012/079897 WO2014023007A1 (en) 2012-08-09 2012-08-09 Use of pedf-derived polypeptides for promoting muscle or tendon regeneration or arteriogenesis

Publications (2)

Publication Number Publication Date
CN104854129A CN104854129A (zh) 2015-08-19
CN104854129B true CN104854129B (zh) 2019-12-31

Family

ID=50067394

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280075699.7A Active CN104854129B (zh) 2012-08-09 2012-08-09 色素上皮衍生因子衍生之多肽于促进肌肉或肌腱再生或动脉血管生成的用途

Country Status (12)

Country Link
US (1) US9884012B2 (enExample)
EP (3) EP3339317A1 (enExample)
JP (1) JP6228977B2 (enExample)
KR (1) KR101801198B1 (enExample)
CN (1) CN104854129B (enExample)
AU (1) AU2012387503B2 (enExample)
BR (1) BR112015002828B1 (enExample)
CA (1) CA2882479C (enExample)
EA (1) EA033145B1 (enExample)
IL (1) IL237137B (enExample)
MX (1) MX360187B (enExample)
WO (1) WO2014023007A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101754674B1 (ko) * 2012-09-17 2017-07-06 맥케이 메모리얼 호스피탈 탈모증 및/또는 모발 탈색소를 치료하기 위해 사용되는 pedf-유도 폴리펩티드의 용도
EP2897976B1 (en) 2012-09-19 2017-08-09 Mackay Memorial Hospital Use of pedf-derived peptides for preventing and/or ameliorating skin aging
EP2897974B1 (en) * 2012-09-20 2018-03-28 Mackay Memorial Hospital Use of pedf-derived polypeptides for treating osteoarthritis
JP7573967B2 (ja) * 2016-10-07 2024-10-28 ブリム バイオテクノロジー インク Ｐｅｄｆ由来短ペプチドを含む組成物およびその使用
JP2017165745A (ja) * 2017-04-19 2017-09-21 マクカイ メモリアル ホスピタル 筋肉若しくは腱再生又は動脈形成を促進するためのｐｅｄｆ由来のポリペプチドの使用
JP6522063B2 (ja) * 2017-08-10 2019-05-29 マクカイ メモリアル ホスピタル 脱毛症及び／又は毛髪色素脱失を治療するためのｐｅｄｆ由来のポリペプチドの使用
CN107602691A (zh) * 2017-08-22 2018-01-19 徐州医科大学 色素上皮衍生因子的衍生多肽系列对于保护缺血心肌的用途
US20210244791A1 (en) * 2018-04-08 2021-08-12 Brim Biotechnology, Inc. Application of pedf-derived short peptides in tendon healing
CN115364199A (zh) * 2021-05-19 2022-11-22 远大医药（中国）有限公司 包含pedf衍生的短肽的组合物及其制备方法和用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101544696A (zh) * 2009-04-24 2009-09-30 焦春 含色素上皮衍生因子的复合物及其制备方法和应用
CN101977931A (zh) * 2008-03-18 2011-02-16 国立大学法人北海道大学 多肽及包含该多肽的药物组合物
CN102183661A (zh) * 2011-03-16 2011-09-14 天津宝瑞生物技术有限公司 蛋白质及蛋白质组在制备肝硬化诊断试剂中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060189519A1 (en) * 2002-09-26 2006-08-24 Karl Volz Anti-angiogenic fragments fo pigment epithelium-derived factor (pedf)
US20090069241A1 (en) * 2006-02-15 2009-03-12 Yale University Compositions and Methods for Use of Pigment Epithelial Derived Factor (PEDF) Peptide Fragments
ES2329636B2 (es) 2006-02-17 2010-07-26 Universitat De Valencia, Estudi General (Participa Con El 70%) Uso del factor pedf para inducir la auto-renovacion de celulas madre.
WO2010037395A2 (en) 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
EP2508196B1 (en) 2011-03-23 2018-09-26 Mackay Memorial Hospital Use of PEDF-derived polypeptides for promoting stem cells proliferation and wound healing

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101977931A (zh) * 2008-03-18 2011-02-16 国立大学法人北海道大学 多肽及包含该多肽的药物组合物
CN101544696A (zh) * 2009-04-24 2009-09-30 焦春 含色素上皮衍生因子的复合物及其制备方法和应用
CN102183661A (zh) * 2011-03-16 2011-09-14 天津宝瑞生物技术有限公司 蛋白质及蛋白质组在制备肝硬化诊断试剂中的应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
腺病毒介导的色素上皮衍生因子对大鼠视网膜缺血再灌注损伤的保护作用;徐旭;《中国博士学位论文 医药卫生科技辑》;20080930;E073-12 *
色素上皮衍生因子对视网膜微血管周细胞保护作用及对MAPKs信号通路影响的研究;刘辉;《中国博士学位论文 医药卫生科技辑》;20081130;E073-5 *

Also Published As

Publication number Publication date
BR112015002828B1 (pt) 2022-09-13
JP6228977B2 (ja) 2017-11-15
US20160000862A1 (en) 2016-01-07
AU2012387503B2 (en) 2016-11-03
NZ705492A (en) 2016-06-24
KR20150058177A (ko) 2015-05-28
IL237137B (en) 2019-01-31
US9884012B2 (en) 2018-02-06
BR112015002828A2 (enExample) 2017-08-15
MX2015001721A (es) 2015-07-06
EP2882772A4 (en) 2016-01-27
EA201590329A1 (ru) 2015-07-30
WO2014023007A1 (en) 2014-02-13
EP2882772A1 (en) 2015-06-17
AU2012387503A1 (en) 2015-03-19
JP2015525786A (ja) 2015-09-07
EP2882772B1 (en) 2017-12-20
CN104854129A (zh) 2015-08-19
CA2882479C (en) 2018-07-24
MX360187B (es) 2018-10-24
EP3342781A1 (en) 2018-07-04
CA2882479A1 (en) 2014-02-13
EA033145B1 (ru) 2019-09-30
IL237137A0 (en) 2015-04-30
EP3339317A1 (en) 2018-06-27
KR101801198B1 (ko) 2017-11-24
EP3342781B1 (en) 2019-07-24

Similar Documents

Publication Publication Date Title
CN104854129B (zh) 色素上皮衍生因子衍生之多肽于促进肌肉或肌腱再生或动脉血管生成的用途
CN102690344B (zh) 色素上皮衍生因子衍生的多肽对于促进干细胞增殖与伤口愈合的用途
JP5607176B2 (ja) 新規ペプチドおよびその用途
US20180207240A1 (en) Collagen iv replacement
JP6208763B2 (ja) 変形性関節症を治療するためのｐｅｄｆ−由来のポリペプチドの使用
CA3144419A1 (en) Methods of promoting vasculogenesis
CN110229215A (zh) 一种药物缓释多肽水凝胶及其制备方法和用途
CN111184856B (zh) 小分子多肽tp-7在制备治疗慢性肾脏病药物中的用途
TWI491616B (zh) 色素上皮衍生因子衍生之多胜肽於促進肌肉或肌腱再生或動脈血管生成之用途
JP2024054273A (ja) 腱治癒に対するｐｅｄｆ由来短鎖ペプチドの使用
JP2017165745A (ja) 筋肉若しくは腱再生又は動脈形成を促進するためのｐｅｄｆ由来のポリペプチドの使用
CN113134078B (zh) 含有kgf-2的温敏凝胶剂及其对骨关节炎的治疗作用
TWI491407B (zh) 色素上皮衍生因子衍生之多胜肽於治療骨性關節炎之用途
TWI902659B (zh) Ｐｅｄｆ衍生之短肽在肌腱癒合中的應用
US20250326799A1 (en) Agents inducing vascularisation
CN118542875A (zh) Conivaptan在制备抗腹主动脉瘤和/或血管平滑肌细胞衰老的药物中的应用
US20070010436A1 (en) Remedy for cardiomyopathy
CN119367513A (zh) 神经肽S在促进EMSCs治疗脊髓损伤中的应用
JPWO1999016463A1 (ja) 虚血性疾患の予防または治療剤

Legal Events

Date Code Title Description
PB01 Publication
EXSB Decision made by sipo to initiate substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant