IL237137B - pedf-derived polypeptides to promote regeneration of arteriole muscle or tendon - Google Patents
pedf-derived polypeptides to promote regeneration of arteriole muscle or tendonInfo
- Publication number
- IL237137B IL237137B IL237137A IL23713715A IL237137B IL 237137 B IL237137 B IL 237137B IL 237137 A IL237137 A IL 237137A IL 23713715 A IL23713715 A IL 23713715A IL 237137 B IL237137 B IL 237137B
- Authority
- IL
- Israel
- Prior art keywords
- arteriogenesis
- pedf
- derived polypeptides
- promoting muscle
- tendon regeneration
- Prior art date
Links
- 230000027746 artery morphogenesis Effects 0.000 title 1
- 210000003205 muscle Anatomy 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 230000001737 promoting effect Effects 0.000 title 1
- 230000008929 regeneration Effects 0.000 title 1
- 238000011069 regeneration method Methods 0.000 title 1
- 210000002435 tendon Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Marine Sciences & Fisheries (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/079897 WO2014023007A1 (en) | 2012-08-09 | 2012-08-09 | Use of pedf-derived polypeptides for promoting muscle or tendon regeneration or arteriogenesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL237137A0 IL237137A0 (en) | 2015-04-30 |
| IL237137B true IL237137B (en) | 2019-01-31 |
Family
ID=50067394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL237137A IL237137B (en) | 2012-08-09 | 2015-02-08 | pedf-derived polypeptides to promote regeneration of arteriole muscle or tendon |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9884012B2 (enExample) |
| EP (3) | EP3339317A1 (enExample) |
| JP (1) | JP6228977B2 (enExample) |
| KR (1) | KR101801198B1 (enExample) |
| CN (1) | CN104854129B (enExample) |
| AU (1) | AU2012387503B2 (enExample) |
| BR (1) | BR112015002828B1 (enExample) |
| CA (1) | CA2882479C (enExample) |
| EA (1) | EA033145B1 (enExample) |
| IL (1) | IL237137B (enExample) |
| MX (1) | MX360187B (enExample) |
| WO (1) | WO2014023007A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2895502B1 (en) * | 2012-09-17 | 2018-09-05 | Mackay Memorial Hospital | Use of pedf-derived polypeptides for treating alopecia and/or hair depigmentation |
| EP2897976B1 (en) | 2012-09-19 | 2017-08-09 | Mackay Memorial Hospital | Use of pedf-derived peptides for preventing and/or ameliorating skin aging |
| US9777048B2 (en) | 2012-09-20 | 2017-10-03 | Mackay Memorial Hospital | Use of PEDF-derived polypeptides for treating osteoarthritis |
| WO2018067244A1 (en) * | 2016-10-07 | 2018-04-12 | Brim Biotechnology, Inc. | Compositions comprising pedf-derived short peptides and uses thereof |
| JP2017165745A (ja) * | 2017-04-19 | 2017-09-21 | マクカイ メモリアル ホスピタル | 筋肉若しくは腱再生又は動脈形成を促進するためのｐｅｄｆ由来のポリペプチドの使用 |
| JP6522063B2 (ja) * | 2017-08-10 | 2019-05-29 | マクカイ メモリアル ホスピタル | 脱毛症及び／又は毛髪色素脱失を治療するためのｐｅｄｆ由来のポリペプチドの使用 |
| CN107602691A (zh) * | 2017-08-22 | 2018-01-19 | 徐州医科大学 | 色素上皮衍生因子的衍生多肽系列对于保护缺血心肌的用途 |
| CN113038929A (zh) * | 2018-04-08 | 2021-06-25 | 全福生物科技股份有限公司 | Pedf衍生的短肽在肌腱愈合中的应用 |
| CN115364199A (zh) * | 2021-05-19 | 2022-11-22 | 远大医药（中国）有限公司 | 包含pedf衍生的短肽的组合物及其制备方法和用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060189519A1 (en) * | 2002-09-26 | 2006-08-24 | Karl Volz | Anti-angiogenic fragments fo pigment epithelium-derived factor (pedf) |
| WO2007095350A2 (en) * | 2006-02-15 | 2007-08-23 | Yale University | Compositions and methods for use of pigment epithelial derived factor (pedf) peptide fragments |
| ES2329636B2 (es) * | 2006-02-17 | 2010-07-26 | Universitat De Valencia, Estudi General (Participa Con El 70%) | Uso del factor pedf para inducir la auto-renovacion de celulas madre. |
| WO2009116529A1 (ja) | 2008-03-18 | 2009-09-24 | 国立大学法人 北海道大学 | ポリペプチドおよび当該ポリペプチドを含む医薬組成物 |
| US20110318380A1 (en) | 2008-10-01 | 2011-12-29 | Dako Denmark A/S | MHC Multimers in Cancer Vaccines and Immune Monitoring |
| CN101544696A (zh) | 2009-04-24 | 2009-09-30 | 焦春 | 含色素上皮衍生因子的复合物及其制备方法和应用 |
| CN102183661B (zh) | 2011-03-16 | 2014-05-28 | 天津宝瑞生物技术有限公司 | 蛋白质及蛋白质组在制备肝硬化诊断试剂中的应用 |
| EP2508196B1 (en) | 2011-03-23 | 2018-09-26 | Mackay Memorial Hospital | Use of PEDF-derived polypeptides for promoting stem cells proliferation and wound healing |
-
2012
- 2012-08-09 EP EP17204179.0A patent/EP3339317A1/en not_active Withdrawn
- 2012-08-09 US US14/420,581 patent/US9884012B2/en active Active
- 2012-08-09 EP EP12882702.9A patent/EP2882772B1/en active Active
- 2012-08-09 EA EA201590329A patent/EA033145B1/ru not_active IP Right Cessation
- 2012-08-09 CN CN201280075699.7A patent/CN104854129B/zh active Active
- 2012-08-09 MX MX2015001721A patent/MX360187B/es active IP Right Grant
- 2012-08-09 KR KR1020157005611A patent/KR101801198B1/ko active Active
- 2012-08-09 AU AU2012387503A patent/AU2012387503B2/en active Active
- 2012-08-09 CA CA2882479A patent/CA2882479C/en active Active
- 2012-08-09 EP EP17204186.5A patent/EP3342781B1/en active Active
- 2012-08-09 JP JP2015525704A patent/JP6228977B2/ja active Active
- 2012-08-09 BR BR112015002828-4A patent/BR112015002828B1/pt active IP Right Grant
- 2012-08-09 WO PCT/CN2012/079897 patent/WO2014023007A1/en not_active Ceased
-
2015
- 2015-02-08 IL IL237137A patent/IL237137B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2882479C (en) | 2018-07-24 |
| BR112015002828A2 (enExample) | 2017-08-15 |
| BR112015002828B1 (pt) | 2022-09-13 |
| EP3339317A1 (en) | 2018-06-27 |
| EP3342781B1 (en) | 2019-07-24 |
| EP3342781A1 (en) | 2018-07-04 |
| US9884012B2 (en) | 2018-02-06 |
| KR20150058177A (ko) | 2015-05-28 |
| AU2012387503A1 (en) | 2015-03-19 |
| JP6228977B2 (ja) | 2017-11-15 |
| MX360187B (es) | 2018-10-24 |
| IL237137A0 (en) | 2015-04-30 |
| EA201590329A1 (ru) | 2015-07-30 |
| JP2015525786A (ja) | 2015-09-07 |
| MX2015001721A (es) | 2015-07-06 |
| EP2882772A1 (en) | 2015-06-17 |
| CN104854129B (zh) | 2019-12-31 |
| US20160000862A1 (en) | 2016-01-07 |
| WO2014023007A1 (en) | 2014-02-13 |
| CN104854129A (zh) | 2015-08-19 |
| EP2882772B1 (en) | 2017-12-20 |
| KR101801198B1 (ko) | 2017-11-24 |
| NZ705492A (en) | 2016-06-24 |
| EP2882772A4 (en) | 2016-01-27 |
| EA033145B1 (ru) | 2019-09-30 |
| AU2012387503B2 (en) | 2016-11-03 |
| CA2882479A1 (en) | 2014-02-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |