CN104854113A - 2-烷基头孢烯化合物的中间体的生产方法 - Google Patents

2-烷基头孢烯化合物的中间体的生产方法 Download PDF

Info

Publication number
CN104854113A
CN104854113A CN201380066959.9A CN201380066959A CN104854113A CN 104854113 A CN104854113 A CN 104854113A CN 201380066959 A CN201380066959 A CN 201380066959A CN 104854113 A CN104854113 A CN 104854113A
Authority
CN
China
Prior art keywords
compound
formula
salt
chemical formula
defined above
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380066959.9A
Other languages
English (en)
Chinese (zh)
Inventor
横尾克己
久川伸也
山胁健二
青木俊明
横田优贵
竹尾正敏
浅井干人
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of CN104854113A publication Critical patent/CN104854113A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201380066959.9A 2012-10-29 2013-10-29 2-烷基头孢烯化合物的中间体的生产方法 Pending CN104854113A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261719523P 2012-10-29 2012-10-29
US61/719523 2012-10-29
US201261720520P 2012-10-31 2012-10-31
US61/720520 2012-10-31
PCT/JP2013/079803 WO2014069649A1 (en) 2012-10-29 2013-10-29 Processes for production of intermediates for 2-alkyl cephem compounds

Publications (1)

Publication Number Publication Date
CN104854113A true CN104854113A (zh) 2015-08-19

Family

ID=50627541

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380066959.9A Pending CN104854113A (zh) 2012-10-29 2013-10-29 2-烷基头孢烯化合物的中间体的生产方法

Country Status (10)

Country Link
US (1) US9527866B2 (https=)
EP (1) EP2912040A4 (https=)
JP (1) JP2015535210A (https=)
KR (1) KR20150076223A (https=)
CN (1) CN104854113A (https=)
AU (1) AU2013339040A1 (https=)
BR (1) BR112015008905A2 (https=)
CA (1) CA2888543A1 (https=)
RU (1) RU2015120084A (https=)
WO (1) WO2014069649A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110590811A (zh) * 2019-09-27 2019-12-20 广州白云山天心制药股份有限公司 一种头孢呋辛酯-3-烯异构体的制备方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY35103A (es) 2012-10-29 2014-05-30 Glaxo Group Ltd Compuestos de cefem 2-sustituidos
WO2016035847A1 (ja) * 2014-09-04 2016-03-10 塩野義製薬株式会社 セファロスポリン誘導体の中間体およびその製造方法
WO2017029104A1 (en) * 2015-08-20 2017-02-23 Unilever Plc Process for the preparation of lactams from glyoxylic acid

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4081595A (en) * 1975-11-11 1978-03-28 Shionogi & Co., Ltd. Reduction giving 3-cephem compounds
US4463172A (en) * 1980-02-25 1984-07-31 Takeda Chemical Industries, Ltd. Process for producing 2-methyl cephem-2-em and 2-methylcephem-3-em derivitaves
CN1705673A (zh) * 2002-10-02 2005-12-07 日本曹达株式会社 有机化合物的制造方法
CN104884460A (zh) * 2012-10-29 2015-09-02 葛兰素集团有限公司 2-取代的头孢烯化合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3487079A (en) 1966-01-14 1969-12-30 Bristol Myers Co Certain alpha-amino bicyclic beta-lactam carboxylic acids
US3660396A (en) * 1970-03-04 1972-05-02 Lilly Co Eli Cephalosporin intermediates and process therefor
JPH0228185A (ja) 1988-04-14 1990-01-30 Tanabe Seiyaku Co Ltd セファロスポリン化合物及びその合成中間体
PH25965A (en) 1988-06-06 1992-01-13 Fujisawa Pharmaceutical Co New cephem compounds which have antimicrobial activities
GB8813945D0 (en) 1988-06-13 1988-07-20 Fujisawa Pharmaceutical Co New cephem compounds & process for preparation thereof
GB8817653D0 (en) 1988-07-25 1988-09-01 Fujisawa Pharmaceutical Co New cephem compounds & processes for preparation thereof
US5143910A (en) 1989-09-07 1992-09-01 Shionogi & Co., Ltd. Piperaziniocephalosporins
GB9005246D0 (en) 1990-03-08 1990-05-02 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
US5095012A (en) 1990-08-23 1992-03-10 Bristol-Myers Squibb Company Antibiotic c-7 catechol-substituted cephalosporin compounds, compositions, and method of use thereof
GB9111406D0 (en) 1991-05-28 1991-07-17 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
GB9118672D0 (en) 1991-08-30 1991-10-16 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
TW200305422A (en) 2002-03-18 2003-11-01 Shionogi & Co Broad spectrum cefem compounds
WO2007096740A2 (en) 2006-02-20 2007-08-30 Orchid Research Laboratories Limited Novel cephalosporins
EP1994035A1 (en) 2006-03-16 2008-11-26 Astellas Pharma Inc. Cephem compounds and use as antimicrobial agents
CN102203100B (zh) 2008-10-31 2014-08-27 盐野义制药株式会社 具有邻苯二酚基团的头孢菌素
KR20130018845A (ko) 2010-04-05 2013-02-25 시오노기세야쿠 가부시키가이샤 카테콜기를 갖는 세펨 화합물
WO2011125966A1 (ja) 2010-04-05 2011-10-13 塩野義製薬株式会社 擬似カテコール基を有するセフェム化合物
JP5852562B2 (ja) 2010-04-28 2016-02-03 塩野義製薬株式会社 新規なセフェム誘導体

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4081595A (en) * 1975-11-11 1978-03-28 Shionogi & Co., Ltd. Reduction giving 3-cephem compounds
US4463172A (en) * 1980-02-25 1984-07-31 Takeda Chemical Industries, Ltd. Process for producing 2-methyl cephem-2-em and 2-methylcephem-3-em derivitaves
CN1705673A (zh) * 2002-10-02 2005-12-07 日本曹达株式会社 有机化合物的制造方法
CN104884460A (zh) * 2012-10-29 2015-09-02 葛兰素集团有限公司 2-取代的头孢烯化合物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
I. G. WRIGHT等，: ""Chemistry of Cephalosporin Antibiotics. 23. 2-Methyl- and 2-Methylenecephalosporins"", 《JOURNAL OF MEDICINAL CHEMISTRY》 *
郭雷等，: ""4-甲基化头孢菌素类化合物的合成和生物活性"", 《中国抗生素杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110590811A (zh) * 2019-09-27 2019-12-20 广州白云山天心制药股份有限公司 一种头孢呋辛酯-3-烯异构体的制备方法

Also Published As

Publication number Publication date
US20150291619A1 (en) 2015-10-15
AU2013339040A1 (en) 2015-04-30
EP2912040A4 (en) 2016-06-01
BR112015008905A2 (pt) 2017-07-04
CA2888543A1 (en) 2014-05-08
RU2015120084A (ru) 2016-12-27
JP2015535210A (ja) 2015-12-10
US9527866B2 (en) 2016-12-27
WO2014069649A1 (en) 2014-05-08
KR20150076223A (ko) 2015-07-06
EP2912040A1 (en) 2015-09-02

Similar Documents

Publication Publication Date Title
ES2562080T3 (es) Proceso y compuestos intermedios para preparar inhibidores de integrasa
JP6523334B2 (ja) 置換サイクロセリンの調製のための方法
US10550087B2 (en) Process for the preparation of kinase inhibitors and intermediates thereof
JP2022516530A (ja) ベンペド酸の新規塩及び多形体
KR20190018021A (ko) 치환된 5-플루오로-1h-피라졸로피리딘의 제조 방법
CN107074776B (zh) Copanlisib及其二盐酸盐的合成
RU2742005C2 (ru) Способы получения 4-алкокси-3-(ацил или алкил)оксипиколинамидов
JP6873053B2 (ja) タンパク質脱アセチル化阻害剤の製造方法
JP5102002B2 (ja) アセナピン合成中間体の製造方法
CN104854113A (zh) 2-烷基头孢烯化合物的中间体的生产方法
CN112218856A (zh) 制备阿帕鲁胺的方法
CN120329264A (zh) 3-甲基-1,2,4-噻二唑-5-碳酰肼及其甲基-d3氘代形式的合成
TWI545114B (zh) 製備聯苯基咪唑化合物之方法
CN101668736B (zh) 用于制备组织蛋白酶k抑制剂的酰胺化反应
WO2009119700A1 (ja) ピペリジン－３－イルカーバメート化合物の製造方法およびその光学分割方法
CN103328471A (zh) 制备氮杂吲唑衍生物的方法
CN105073759A (zh) 头孢烯化合物
WO2017043563A1 (ja) ピリジンカルボキサミドの製造方法
US20070037854A1 (en) Process for preparing sulfonamide-containing indole compounds
JP4968602B2 (ja) ベンズアミド誘導体の製造方法
JP6719369B2 (ja) ２’−フルオロ−５−メチル−４’−チオアラビノウリジンの製造方法及びその一部の工程を含む方法
CN105384660A (zh) 一种α-氨基酸的制备方法
CA3214107A1 (en) New process for the synthesis of 5-{5-chloro-2-[(3s)-3- [(morpholin-4-yl)methyl]-3,4-dihydroisoquinoline-2(1h)- carbonyl]phenyl}-1,2-dimethyl-1h-pyrrole-3-carboxylic acid derivatives and its application for the production of pharmaceutical compounds
EA023057B1 (ru) Способ получения прасугреля, промежуточное соединение в кристаллической форме и способ его получения
WO2008139576A1 (ja) ラクタム化合物の製造方法及びその製造中間体

Legal Events

Date Code Title Description
PB01 Publication
EXSB Decision made by sipo to initiate substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20150819

WD01 Invention patent application deemed withdrawn after publication