CN104840883A - Traditional Chinese medicine for treating decompensated liver cirrhosis - Google Patents

Abstract

The invention discloses traditional Chinese medicine for treating decompensated liver cirrhosis. With the weight part as the unit, effective components of the traditional Chinese medicine are prepared by the bulk drugs: 10 to 20 parts of Angelica sinensis, 10 to 15 parts of radix paeoniae alba, 10 to 15 parts of roasted Rhizoma Atractylodis Macrocephalae, 20 to 25 parts of Poria cocos, 6 to 10 parts of Chinese thorowax roots, 10 to 15 parts of rhizoma cyperi, 8 to 10 parts of radix curcumae, 15 to 20 parts of turtle shells, 8 to 10 parts of pangolins, 10 to 15 parts of medlar, 12 to 15 parts of polygonatum sibiricum, 15 to 20 parts of alisma plantago-aquatica, 10 to 15 parts of polyporus umbellatus, 15 to 20 parts of plastron of chinemys reevesiss, 3 to 5 parts of liquorice, 30 to 35 parts of corn stigma, 25 to 30 parts of semen raphani, 30 to 32 parts of radix pseudostellariae, 13 to 15 parts of fruit of keiske Wormwood, 25 to 30 parts of fructus broussonetiae and 15 to 18 parts of Caulis Dendrobii. The traditional Chinese medicine for treating decompensated liver cirrhosis can soothe the liver and regulate vital energy, activate the spleen and dissipate dampness, clear damp and promote diuresis, and nourish yin and clear liver, has an obvious therapeutic effect for qi stagnation and damp obstruction symptoms of decompensated liver cirrhosis, and enables alcoholic cirrhosis to recover to the normal level. The traditional Chinese medicine for treating decompensated liver cirrhosis has no toxic and side effects, has a total effective rate of 92.85 percent and is a first choice drug for treating decompensated liver cirrhosis.

Description

The Chinese medicine for the treatment of cirrhosis patients in decompensation

technical field:

The present invention relates to a kind of Chinese medicine effectively can treating the cirrhosis patients in decompensation caused by hepatitis B, hepatitis C, alcoholic liver and fatty liver, belong to technical field of Chinese medicines.

background technology:

Cirrhosis patients in decompensation is exactly the Symptoms in liver cirrhosis late period, refers generally to cirrhosis progress to a certain extent, exceeds the compensatory capacity of liver function, and clinical have obvious pathological change.Main manifestations is liver function injury, has portal hypertension, splenomegaly, ascites, hepatic encephalopathy or upper gastrointestinal hemorrhage, and this period is called cirrhosis patients in decompensation.

one, hepatocirrhosis symptoms general introduction:

Be in different pathological stages, the Symptoms of liver cirrhosis patient also can there are differences, such as cirrhosis patients in decompensation Symptoms is just different from the performance of liver cirrhosis early symptom, and this difference can be that symptom is different, also can be that the light and heavy degree of performance is different.

1, General Symptoms performance:

Liver cirrhosis patient inappetence, weight loss, sleepy weak symptom are more obvious, severe patient or even be unable to leave the bed, and can't take care of oneself.Cutaneous manifestations withered coarse, complexion is gloomy pitch-dark, and health has the Symptoms such as anemia, glossitis, angular cheilitis, nyctalopia, polyneuritis and edema in addition.

2, endocrine disturbance:

Endocrine disturbance is that estrogen, aldosterone and vassopressin increase at cirrhosis patients in decompensation Symptoms, and occur dysequilibrium between estrogen and androgen, male patient often has breast development, hyposexuality, atrophy of testis, alopecia etc.; Female patient has menoxenia, amenorrhea etc.

3, symptom of digestive tract performance:

Disease makes it digest to the intestines and stomach congestion etc., obstacle appears in absorption function, patient's appetite is caused obviously to go down, feed after a few minutes will feel epigastric discomfort and glutted, occur feel sick even vomit, to fat and protein toleration poor, enter greasy food and easily cause fatty diarrhea.

two, the cause of disease:

Cause the cause of disease of liver cirrhosis a lot, China is the most common with viral hepatitis, then in the majority with alcoholism abroad.

1, secondly viral hepatitis: be mainly hepatitis B is the third type or B-modely add fourth type superinfection and penta type does not generally develop into liver cirrhosis.

2, schistosomiasis japanica: China's Schistosomiasis in Yangtze River Valley Endemic Area is common.Repeatedly or Long-term Infection schistosomicide patient, worm's ovum and toxic product thereof stimulate connective tissue proliferation in liver portal area, cause hepatic fibrosis and portal hypertension, are called schistosomicide characteristic of disease fibrosis.

3, alcoholism: long-term heavy drinker, ethanol and mesostate (acetaldehyde) thereof directly damage hepatocyte, reduce the resistance to some toxicant, and the long-term nutrition imbalance caused by excessive drinking also plays certain detrimental effect to liver.

4, medicine or chemical toxicant: long-term taking some drugs can cause toxic hepatitis as oxyphenisatin acetate (isaphenin), methyldopa etc., finally develops into liver cirrhosis.

5, cholestasis: when sustainable existence extrahepatic bile ducts blocks or liver inner bag deposits, bile acid and the bilirubin of high concentration have detrimental effect to hepatocyte, and hepatocellular degeneration is downright bad, and proliferation of fibrous tissue, causes liver cirrhosis.

6, chronic heart failure, constrictive pericarditis, hepatic vein or inferior vena cava obstruction etc. make the long-term congestion of liver, hepatocyte anoxia, necrosis and connective tissue proliferation, finally develop into liver cirrhosis.

One or more cause of disease long terms are in liver above, and hepatocellular degeneration all can be caused downright bad, and regenerated nodule is formed, diffusivity connective tissue proliferation, and pseudolobuli is formed.

three, sign:

1, hepatic facies: have a dark complexion, has sunken cheeks, the hepatic facies that cheekbone is outstanding, and even in bronze-colored, the degree that complexion changes parallels with hepatic insufficiency degree, then indicates prognosis bona in bronze-colored face

2, spider angioma and telangiectasis: spider angioma differs in size, is mainly distributed in the region of superior vena cava drain, with face, and cervical region, and upper breast is common, the shoulder back of the body, rare below nipple, the reason of this regularity of distribution it be unclear that.

3, liver tongue: the congested change of house edge vasoganglion can appear in early stage liver cirrhosis, liver cirrhosis further develops rear lingual surface in the red or reddish blue of paint, congested swelling, and smooth few tongue or no fur, shape is as cow tongue.

4, jaundice; About half patient has jaundice, and light and heavy degree is not etc., general how not too serious.

5, xanthoma: the patient of biliary cirrhosis can see, is nodositas or flat, is more common in eyelid, inside and outside adjoin or extremities joint stretching, extension place, many simultaneously with skin pruritus.

6, liver palm: liver palm is confined between the large hypothenar of facies palmaris and the cerise of finger base portion changes.

7, hepatomegaly: the size of liver and the course of disease, the cause of disease and pathological change all have relation, and be comprehensive function result.

8, endocrine disturbance: male shows as atrophy of testis, alopecia, cyclomastopathy etc.The secretion of some patient's adrenocortical hormone reduces, and therefore pigmentation appears in face, cervical region upper limb and mucosa place, has certain specificity.

four, clinical manifestation:

Bleeding tendency: as epistaxis, gingival hemorrhage when brushing teeth, there is petechia or ecchymosis in skin, even forms hematoma, and blood coagulation system also can be caused to occur obstacle.

Chronic hepatopathy face: show as xerosis cutis more, complexion is gloomy pitch-dark, also can there is pigmentation in the skin of the face of some patients and other exposure portion, the pigmentation especially around eye socket is more obvious.

Upper gastrointestinal hemorrhage: this is that cirrhosis patients in decompensation patient shows common syndrome, and has higher mortality rate.Mainly because portal hypertension causes esophageal varix, blood vessel wall is thinning, and very easily breaking causes massive hemorrhage.How and not easily stop cirrhosis patients in decompensation upper gastrointestinal hemorrhage often breaks with tremendous force, hemorrhage anxious and.Rescue if having little time, normal threat to life, a lot of patient dies from massive hemorrhage first.

Hepatic ascites: hepatic ascites is the modal complication of cirrhosis patients in decompensation.Once occur that hepatic ascites represents that liver cirrhosis enters the Decompensated stage stage.In general hepatic ascites amount is larger, and the number of occurrence is more, more bad.So person should treat timely and effectively to occur hepatic ascites.

Endocrine disturbance: liver cirrhosis has arrived Decompensated stage, the function of liver is more obvious with regard to what fail, and make the minimizing that the deactivation of proper interior estrogen is a large amount of, estrogen secretory volume will increase, and with phenomenons such as androgen are suppressed.

five, cirrhosis patients in decompensation symptoms:

1, whole body cirrhosis patients in decompensation symptom:

Become thin weak, lassitude, cirrhosis patients in decompensation serious symptom person is weak and be unable to leave the bed.Xerosis cutis is coarse, and complexion is gloomy pitch-dark.Often there are the cirrhosis patients in decompensation symptoms such as anemia, glossitis, angular cheilitis, nyctalopia, polyneuritis and edema.Cirrhosis patients in decompensation can have irregular low grade fever, and the toxin that possible cause is hepatic necrosis, liver detoxification function goes down intestinal absorption enters body circulation, portal vein thrombosis or the cirrhosis patients in decompensation such as intimitis, secondary infection reason to be caused.

2, digestive tract cirrhosis patients in decompensation symptom:

Appetite obviously goes down, and namely feels epigastric discomfort and glutted after feed, feels sick, even vomits, cirrhosis patients in decompensation to fat and protein toleration poor, enter greasy food, easily cause diarrhoea.Cirrhosis patients in decompensation patient feels abdominal distention unbearably because of ascites and gastrointestinal pneumatosis, and toxic intestinal tympanites can appear in late period.Cirrhosis patients in decompensation patient more than half has slight jaundice, and minority cirrhosis patients in decompensation patient has moderate or severe jaundice, and the latter points out hepatocyte to have Progressive symmetric erythrokeratodermia or extensive necrosis.

3, bleeding tendency and anemia cirrhosis patients in decompensation symptom:

Cirrhosis patients in decompensation symptom osler disease, gingiva bleeding gingival hemorrhage, skin ecchymosis stomach function regulating mucosal erosion are hemorrhage.Cirrhosis patients in decompensation patient Shang You anemia in various degree, how low by malnutrition, intestinal absorption ability, Hypersplenism and the gastrointestinal tract factor such as to lose blood causes.

4, endocrine disturbance's cirrhosis patients in decompensation symptom:

Endocrine regulation has estrogen, aldosterone and vassopressin to increase.This cirrhosis patients in decompensation symptom main cause hypofunction of liver weakens its deactivation, and accumulate in vivo, urinate in drain and increase; When cirrhosis patients in decompensation estrogen increases, suppress antepituitary function by feedback mechanism, thus affect the function of hypophysis one gonad axis and hypophysis one adrenal cortex axle, cause androgen to reduce, adrenocortical hormone also reduces sometimes.

5, spider angioma, liver palm are the symptoms than being easier to the liver cirrhosis found:

Some skin small artery expanded can be there is in general patient at places such as face, neck, breast, shoulder, forearm and the back of the hand, the tiny branch of branch sample of oriented surrounding radiation around, form picture is little Aranea one by one, in cerise, the central point of nevus is oppressed with nib, pin or thin excellent one end, nevus and peripheral ramifications thereof can be made to disappear, Here it is spider angioma.

six, check:

Cirrhosis patients in decompensation, because be diagnosed as liver cirrhosis late period, only need to do some unconventional inspections when being necessary, such as liver puncture inspection, 4 Fibrotic serology etc., but some routine examinations still must be done.

seven, conventional project inspection:

Imaging examination: B ultrasonic, CT and NMR (Nuclear Magnetic Resonance)-imaging etc. can find some sign of hepatic fibrosis, the reference of degree of cirrhosis is assessed when ultrasound diagnosis is early stage liver cirrhosis, the symptom such as can find that the liver rough surface of patient is uneven, liver echo display enhancing, hepatomegaly, increasing are thick, pinpoint the problems and also can do Hepatic contrast CT scan again, improve the accuracy rate of diagnosis.

Liver function test: the mensuration comprising serum albumin, show as albumin and reduce, globulin raises, and the ratio of albumin and globulin is inverted.Protein electrophoresis also shows albumin to be reduced, and gamma Globulin increases.Determination of bilirubin is at liver function Decompensated stage, and serum total bilirubin and bilirubin direct can have rising in various degree.Serum enzyme inspection shows that serum glutamic pyruvic transminase (ALT) and glutamic oxaloacetic transaminase, GOT (AsT) all can raise, the degree of reflection hepatocellular damage; Monoamine oxidase, MAO (MAO) is relevant with collagenic supersession, and its activity can reflect that fibrosis is formed and active level, and when being formed if any obvious fibrosis in liver, (MAO) all can raise; Gamma glutamyl transpeptidase: when liver function Decompensated stage or hepatic fibrosis, γ-GT raises, has the possibility of Complicated By Hepatoma when γ-GT significantly raises.

Procollagen III peptid (P III P) measures: the index being diagnosing liver fibrosis, normal value is 0.46 ± O.11 μ/ml.

Prothrombin time (PT): liver function Decompensated stage PT extends.

Immunologic test: IgG, IgA, IgM raise, raises the most obvious with IgG.The cause of disease is viral hepatitis person, can do the inspection such as five indexes of hepatitis b, antibody to hepatitis C.

Ascites checks: cirrhotic ascites is faint yellow omission timber, and as secondary infection then transparency reduction, leukocyte increases, and antibacterial culturing can be positive.Bloody ascites often points out merging hepatocarcinoma.

Routine blood test and routine urianlysis: how normal routine blood test in the liver function compensatory phase, Decompensated stage leukocyte and platelet reduce, routine urianlysis show Decompensated stage sometimes urinate in visible albumen, cast.

Nosetiology: comprise hepatitis B antigen antibody HBV"liang dui ban" and HBV-DNA.The HbsAg positive is the mark of HBVer, and as HbsAg is negative, HbsAb is positive, then have the ability that opposing is hepatitis B infected.This is also the lab testing of liver cirrhosis.

Lipid metabolism: compensatory phase patient blood cholesterol is normal or on the low side, and Decompensated stage T-CHOL particularly cholesteryl ester obviously reduces.

B ultrasonic: in the clinical examination of liver cirrhosis, ultrasound diagnosis is indispensable, can to understand inside and outside the profile variation of liver, liver position change, Glisson's capsule, corner change, liver parenchyma change, liver Vascular change etc. by ultrasound diagnosis.

When liver cirrhosis does ultrasound diagnosis, liver position change shows as the upper and lower footpath of right lobe of liver and shortens, and under rib asks the right rib of narrowed thickness, clino-diagonal not easily records.Leftlobe of liver Compensatory hypertrophy, causes compared with normal position, anterior axillary line, right side and raises.

When liver cirrhosis does ultrasound diagnosis, in liver parenchyma change performance liver parenchyma, echo is fine and close, and echo diffusivity strengthens, it is thick to increase; The visible liver parenchyma of greater tubercle liver cirrhosis B ultrasonic result is interior for reflecting uneven diffusivity plaque-like change or being rope strip, nodal-like light belt, the change of light group, and entrant sound is poor, low echo area little as seen between strong echo.

Glisson's capsule, corner change during liver cirrhosis, ultrasound diagnosis shows as Glisson's capsule and thickens, and loses smooth fiber bright line. Echoenhance, became uneven, liver edge angle rust or irregular.

eight, complication:

Infect: the easy concurrent various infection of liver cirrhosis is as bronchitis, pneumonia, tuberculous peritonitis, biliary tract infection, intestinal infection, spontaneous peritonitis and gram negative bacilli septicemia etc.Infect various virus, constantly produce injury to human body, people's resistivity also can decline further, and then causes human body constantly to weaken.

Upper gastrointestinal hemorrhage: common with Bleeding of Esophageal Gastric Varices, other causes of bleeding are as acute bleedingerosive gastritis, Mallory-Weiss Syndrome etc.General bleeding all can cause sanguinariness, until dead.

Hepatic encephalopathy (hepatic coma): be the modal cause of death of liver cirrhosis patient.Reason that this cirrhotic complications occurs the often intake of patient to protein too much causes.So be exactly control the protein amount of eating to the nursing key of this kind of patient, reduce ammonia concentration.In life, patient need take in protein in right amount, the fresh fruit that polyphagia Multivitamin content is high and thin dish, and follows the diet principle of a small amount of many meal, keeps the unobstructed of stool.

Hepatorenal syndrome: it is long that liver cirrhosis merges the refractory ascites persistent period, or concurrent infection, original hepatopathy such as to increase the weight of at the factor, occurs oliguria, anuria, azotemia, low blood sodium, hyponatruria, initial kidney often without organic disease, so be called functional renal failure.

Portal thrombosis: its reason is main causes portal venous flow slowly with pylemphraxis, and portal vein intimitis, harden relevant.As patient with liver cirrhosis there is suddenly tormina, abdominal distention, vomit, have blood in stool, the performance such as shock, then should consider portal thrombosis.In addition, spleen often increases rapidly, and ascites is accelerated to be formed, and often brings out hepatic encephalopathy.

Primary hepatocarcinoma: liver cirrhosis and Relations with Liver Cancer attract people's attention, infer that its mechanism may be that hepatitis B virus causes hepatocellular damage and the hypertrophy of secondary or atypical hyperplasia, and hepatitis B virus is relevant with factors such as hepatocellular integration regulating liver-QI hard patient immunologic function changes.

Ascites: have a small amount of liquid in normal person abdominal cavity, about 50ml, is called ascites when amount of liquid is greater than 200ml, and ascites is the common complication of decompensated liver cirrhosis.

Respiratory system damages: some scholars are referred to as hepatopulmonary syndrome the various pulmonarys change caused by hepatic disease, pulmonary vascular expansion and arterial oxygenation occurs extremely when its essence is hepatopathy, can cause hypoxemia.

nine, diet care:

The patient of cirrhosis patients in decompensation will note having many meals but little food at eath, must guard against eating and drinking too much at one meal, in order to avoid increase liver and gastrointestinal burden, and then has increased the weight of the state of an illness; Be good with high protein homovitamin, low fat, high-energy, low cholesterol, hold light diet and be advisable.

Liver cirrhosis patient should eat homovitamin, low fat, high protein, digestible thing food, such as egg, vegetable, lean meat, fish etc.; The concurrent hepatic coma person of end-age cirrhosis, should ensure low protein diet.Edema is heavier or have ascites should lack salt or on diet, and constipation can polyphagia Oleum Sesami, Mel, Semen Sesami, Fructus Musae etc., can keep free movement of the bowels, reduce gathering of ammonia and prevent hepatic coma.

End-age cirrhosis patient diet will note various and equalization, can improve patient's appetite, supplement needed for patient's body in time, is all helpful to the reparation of Patients ' Hepatocytes, the enhancing, prevention malnutrition etc. of system; Patient will avoid pungent irritable food and avoid and drink, and alcohol metabolism product can the liver that has been badly damaged of direct murder by poisoning, brings out destruction that abnormal liver function accelerates liver with downright bad etc., and therefore hepatopath should away from tobacco and wine, be advisable with light diet on diet.

ten, points for attention:

1, the careful amount of protein diet.Although emphasize that patient need enter high protein diet, hepatic encephalopathy person is had to answer low protein diet.

2, to take food careful amount.Food-intake is satisfied for good with eighty per cant, and it is excessive to be sure not, after taking food, do not feel that abdominal distention is for degree, has abdominal distention person after the meal, should reduce the soup amount before and after having meal.

3, suit the medicine to the illness.Food variety should based on light food, and that reduces protein during jaundice takes the photograph people, disappears and increases protein more gradually and take in, in order to avoid bring out cholecystitis outbreak, add icterus gravis or jaundice is not easily disappeared etc. jaundice.

4, avoid on an empty stomach.The available food of diet of liver cirrhosis is fish, green vegetable, bean sprout, bean product etc., and fruit is better with Fructus Citri junoris, Fructus Mali pumilae, but will note not taking food on an empty stomach fruit,

5, health.In liver cirrhosis conditioning process, all food all should fresh clean, in order to avoid decline because of resistance, occurs that diarrhoea waits intestinal infection show and increase the weight of the state of an illness.

6, avoid coarse.The dietetic food of liver cirrhosis should not be too coarse, in order to avoid bring out varicose esophageal vein Rupture haemorrhag.

summary of the invention:

Technical problem to be solved by this invention is: provide a kind of effective, Chinese medicine for the treatment of cirrhosis patients in decompensation of having no side effect, effectively can treat the cirrhosis patients in decompensation disease caused by hepatitis B, hepatitis C, alcoholic liver and fatty liver.

The technical scheme that the present invention takes for technical solution problem is:

A kind of Chinese medicine for the treatment of cirrhosis patients in decompensation, in units of weight portion, the crude drug making its effective ingredient is: Radix Angelicae Sinensis l0 ~ 20 part, the Radix Paeoniae Alba 10 ~ 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 ~ 15 parts, 20 ~ 25 parts, Poria, Radix Bupleuri 6 ~ 10 parts, Rhizoma Cyperi 10 ~ 15 parts, Radix Curcumae 8 ~ 10 parts, Carapax Trionycis (processed) 15 ~ 20 parts, Squama Manis 8 ~ 10 parts, Fructus Lycii 10 ~ 15 parts, Rhizoma Polygonati 12 ~ 15 parts, Rhizoma Alismatis 15 ~ 20 parts, Polyporus 10 ~ 15 parts, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 15 ~ 20 parts, 3 ~ 5 parts, Radix Glycyrrhizae, Stigma Maydis 30 ~ 35 parts, Semen Raphani 25 ~ 30 parts, Radix Pseudostellariae 30 ~ 32 parts, ANLV 13 ~ 15 parts, Fructus Broussonetiae 25 ~ 30 parts, Sichuan Herba Dendrobii 15 ~ 18 parts.

The Chinese medicine of described treatment cirrhosis patients in decompensation, in units of weight portion, the crude drug making its effective ingredient is: Radix Angelicae Sinensis l0 part, the Radix Paeoniae Alba 10 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 parts, 20 parts, Poria, Radix Bupleuri 6 parts, Rhizoma Cyperi 10 parts, Radix Curcumae 10 parts, Carapax Trionycis (processed) 15 parts, Squama Manis 8 parts, Fructus Lycii 15 parts, Rhizoma Polygonati 15 parts, Rhizoma Alismatis 15 parts, Polyporus 10 parts, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 15 parts, 3 parts, Radix Glycyrrhizae, Stigma Maydis 35 parts, Semen Raphani 30 parts, Radix Pseudostellariae 30 parts, ANLV 15 parts, Fructus Broussonetiae 30 parts, Sichuan Herba Dendrobii 15 parts.

The pharmaceutical dosage form of the Chinese medicine of described treatment cirrhosis patients in decompensation is soft capsule preparation.

The preparation method of the Chinese medicine of above-mentioned treatment cirrhosis patients in decompensation is:

1. in above-mentioned 21 taste Chinese medicines, add 6 times of water gagings, soak 30 minutes, heating decoction 2 hours; Add 4 times of water gagings 2nd time, decoct 1.5 hours; Add 2 times of water gagings 3rd time, decoct 45 minutes.Merge 3 decoction liquor, leave standstill 12 hours, supernatant crosses 200 mesh sieves, and filtrate is stand-by.

2. filtrate evaporated under reduced pressure is concentrated into paste, and stop heating, in thick paste, add 2 times amount 75% ethanols, stir evenly, hold over night, supernatant liquid filtering, filtrate is stand-by.

3. filtrate adds appropriate refining of edible vegetable oil or cod-liver oil (sloughing hard fat at 0 degrees centigrade) and dissolves, and adjusts concentration and should be more than 85.0% of expression amount to every ball containing Chinese medicine ingredients, stand-by as medicinal liquid.

4. glycerol is separately got and water is heated to 70 ~ 80 degrees Celsius, add gelatin, stirring is dissolved, insulation 1 ~ 2h, the foam that removing is floated, filter (holding temperature), add drop pill and carry out dripping, take liquid paraffin as liquid coolant, collect the soft gelatin capsule of condensation, the liquid coolant of sticking is wiped away with gauze, at room temperature blow a cold wind over 4h, 4h is dried under being put in 25 ~ 35 degrees Celsius, again through petroleum ether 2 times, each 3 ~ 5 minutes, the outer field liquid paraffin of removing soft gelatin capsule, use 95% washing with alcohol more once, finally dry about 2 hours at 30 ~ 35 degrees Celsius, screening, quality inspection, packaging, obtain.

in the present invention, the pharmacological action of each crude drug is as follows:

1, Radix Angelicae Sinensis:

Meridian distribution of property and flavor: sweet, acrid, warm.Return liver, the heart, spleen channel.

Effect: promoting blood circulation and stopping pain, tonifying blood and regulating menstruation, loosening bowel to relieve constipation.

Cure mainly: for dizziness due to deficiency of blood, menoxenia, amenorrhea, dysmenorrhea, shallow complexion, asthenia cold abdominalgia, traumatic injury, rheumatic arthralgia, ulcer sores, dryness of the intestine constipation.

2, the Radix Paeoniae Alba:

Meridian distribution of property and flavor: bitter, sour, is slightly cold.Return liver, spleen channel.

Effect: nourish blood yin fluid astringing, easing the affected liver to relieve pain, suppressing liver-YANG.

Cure mainly: for menoxenia, metrorrhagia, sweating due to debility, gastral cavity abdomen shoot, the pain over the hypochondriac region, limb pain twin, has a headache dizzy.

3, Rhizoma Atractylodis Macrocephalae (parched):

Meridian distribution of property and flavor: bitter, sweet, temperature; Return spleen, stomach warp.

Effect: air making-up and spleen enlivening, dampness diuretic, hidroschesis, antiabortive.

Cure mainly: for deficiency-weakness of spleen-QI, anorexia and loose stool, phlegm retention edema, exterior deficiency spontaneous perspiration, frequent fetal movement.

4, Poria:

Meridian distribution of property and flavor: sweet, light is flat.GUIXIN, spleen, kidney channel.

Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating, calms the nerves.

Cure mainly: for edema, have loose bowels, dysuria, phlegm retention, cardiopalmus, insomnia.

5, Radix Bupleuri:

Meridian distribution of property and flavor: bitter, pungent, be slightly cold.GUIXIN envelope, liver, gallbladder, tri-jiao channel.

Effect: evacuate and bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.

Cure mainly: for cold, fever, alternate attack of chill and fever, distending pain over the hypochondrium, menoxenia, proctoptosis, uterine prolapse.

6, Rhizoma Cyperi:

Meridian distribution of property and flavor: pungent, micro-hardship, micro-sweet is flat.Return liver, spleen, tri-jiao channel.

Effect: dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.

Cure mainly: for stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, distending pain of the breast, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass is vexed, distension pain, menoxenia, amenorrhea dysmenorrhea.Pungent, micro-hardship, micro-sweet, flat.

7, Radix Curcumae:

Meridian distribution of property and flavor: pungent, bitter, cold.GUIXIN, liver, gallbladder meridian.

Effect: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clearing away heat and cooling blood, removing heat from the heart to restore the consciousness, dampness removing jaundice eliminating.

Cure mainly: for pain in chest and hypochondrium, menoxenia ， mass in the abdomen mass in the abdomen, spit blood, epistaxis, women's vicarious menstruation, epidemic febrile disease coma, the hot epilepsy of expectorant, warm jaundice.

8, Carapax Trionycis (processed):

Meridian distribution of property and flavor: salty, cold.Return Liver Channel.

Effect: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving.

Cure mainly: for consumption of YIN caused by febrile disease, stirring-up of pathogenic wind in the interior resulting from deficiency and in fever due to yin deficiency.Again for chronic malaria, malaria with splenomegaly, amenorrhea, mass in the abdomen.

9, Squama Manis:

Meridian distribution of property and flavor: salty, is slightly cold.Return liver, stomach warp.

Effect: promoting blood circulation to restore menstrual flow, stimulating milk secretion, detumescence and apocenosis.

Cure mainly: for amenorrhea ， mass in the abdomen, galactostasis, rheumatic arthralgia, spasm of the limbs, carbuncle, scrofula sucutaneous nodule.

10, Fructus Lycii:

Meridian distribution of property and flavor: sweet is flat.Return liver, kidney, lung meridian.

Effect: nourishing the liver and kidney, improving eyesight, lung moistening.

Cure mainly: for the hepatic and renal YIN deficiency, have a dizzy spell, visual deterioration, soreness of the waist and knees, seminal emission quench one's thirst and deficiency of YIN chronic cough.

11, Rhizoma Polygonati:

Meridian distribution of property and flavor: sweet in the mouth, property is put down.Return spleen, lung, kidney channel.

Effect: boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.

Cure mainly: for deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, chronic cough hemoptysis, asthenia of essence and blood, soreness of the waist and knees, early whitening of beard and hair, interior-heat is quenched one's thirst.

12, Rhizoma Alismatis:

Meridian distribution of property and flavor: sweet, light, cold.Return kidney, urinary bladder channel.

Effect: promoting diuresis to eliminate damp pathogen, expels the heat-evil.

Cure mainly: for dysuria, edema, have loose bowels, stranguria with turbid discharge, leukorrhagia.

13, Polyporus:

Meridian distribution of property and flavor: sweet in the mouth, light is flat.Enter the heart, spleen, stomach, lung, kidney, warp.

Effect: promoting diuresis to eliminate damp pathogen.

Cure mainly: for dysuria, edema, to have loose bowels.

14, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA:

Meridian distribution of property and flavor: sweet, salty, cold.Return liver, kidney, heart channel.

Effect: nourishing YIN for suppressing the hyperactive YANG, replenishing kidney and strengthening bone, reinforcing the heart of nourishing blood.

Cure mainly: for having a dizzy spell, hectic fever due to YIN-deficiency consumptive fever, soreness of the waist and knees, palpitation with fear insomnia.

15, Radix Glycyrrhizae:

Meridian distribution of property and flavor: sweet is flat.GUIXIN, spleen, lung, stomach warp.

Effect: invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, heat-clearing and toxic substances removing, alleviates pain relieving, relaxes the property of medicine.

Cure mainly: for weakness of the spleen and stomach, shortness of breath and fatigue, severe palpitation, cough expectorant is few, pathopyretic ulcer, and medicine food is poisoning, gastral cavity abdomen shoot, limb pain twin.

16, Stigma Maydis:

Meridian distribution of property and flavor: sweet, light, flat, returns bladder, liver, gallbladder meridian.

Effect: inducing diuresis to remove edema, dampness removing jaundice eliminating.

Cure mainly: for edema, dribbling urination, jaundice, cholecystitis, cholelithiasis, hypertension, diabetes, galactostasis.

17, Semen Raphani:

Meridian distribution of property and flavor: pungent, sweet is flat.Return lung, spleen, stomach warp.

Effect: help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.

Cure mainly: for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.

18, Radix Pseudostellariae:

Meridian distribution of property and flavor: sweet, micro-hardship, flat.Return spleen, lung meridian.

Effect: tonifying QI to produce body fluid.

Cure mainly: thirsty for lack of appetite, cough caused by dryness expectorant is few.

19, ANLV:

Meridian distribution of property and flavor: acrid in the mouth warm in nature, hardship.Enter meridian of Foot-JUE YIN.

Effect: clots absorbing, damp eliminating.

Cure mainly: for women's blood stasis amenorrhea, stop the stasis of blood stomachache puerperal, traumatic injury, rheumatic arthralgia.

20, Fructus Broussonetiae:

Meridian distribution of property and flavor: sweet, cold.Enter liver,spleen,kidney warp.

Effect: the kidney invigorating liver heat removing, improving eyesight, diuresis.

Cure mainly: to swoon blurred vision, the raw nebula film of order, edema distension for soreness of the waist and knees, asthenia hectic fever due to YIN-deficiency, sand.

21, Sichuan Herba Dendrobii:

Meridian distribution of property and flavor: sweet, is slightly cold.Return stomach, kidney channel.

Effect: nourishing the stomach to promote the production of body fluid, YIN nourishing heat extraction.

Cure mainly: thirsty for Tianjin wound, lack of appetite constipation, deficiency-heat is not moved back, and order is secretly dim-sighted.

in the present invention, the pick and process of each crude drug:

1, Radix Angelicae Sinensis: get crude drug, removing impurity, cleans, runs through, thinly slice, dry for subsequent use.

2, the Radix Paeoniae Alba: summer and autumn excavates, removes earth and supporting root, peeling, and boiling water soaks or slightly boils to being heated evenly, and dries.Used time runs through section.Life is used, stir-fry is used or wine is fried for subsequent use.

3, Rhizoma Atractylodis Macrocephalae (parched): winter excavates, removes earth and aerial parts, dries or dries.Used time macerates section through water or rice-washed water.Raw with or parched with bran, parching with earth for subsequent use.

4, Poria: 7 ~ October excavates, banks up after " diaphoresis ", spreads out and dry in the air to dry tack free, then " diaphoresis ", repeated multiple times, and to showing wrinkle, internal moisture major part is dried in the shade after scattering and disappearing; Or fresh Poria is cut into slices, dry in the shade.Raw use.

5, Radix Bupleuri: removing impurity and residual stem, cleans, runs through, cut sheet, dry.Raw use, or use fried by vinegar, or wine is fried for subsequent use.

6, Rhizoma Cyperi: autumn excavates, sing the hair must, put in boiling water after slightly boiling or steaming and dry, or burn rear directly dry for subsequent use.

7, Radix Curcumae: excavate when autumn and winter, plant withered.Win tuber, removing fibrous root, cleans earth, enters in boiling water and boil to the saturating heart, taking-up, dry, cut into serving pieces.

8, Carapax Trionycis (processed): put in pot by sandy soil and heat, loosens to sandy soil, puts into clean Carapax Trionycis and fries to the micro-yellow of epidermis, takes out sieve and removes sandy soil, and put into vinegar basin and slightly soak (every 100 jin with vinegar 30 jin), taking-up is dried for subsequent use.

9, Squama Manis: the carapace cutting off whole after seizure, insert in boiling water and scalded, take off scale, edulcoration dries, mothproof.Same stir-fry to loose bubble is yellow with sand simultaneously; Or after frying, add vinegar slightly leaching, dry for subsequent use.

10, Fructus Lycii: pluck when summer, autumn fruit maturation, removing fruit stem, puts after shady and cool place dries in the air and corrugate to peel, then be exposed to the sun stiff to crust, sarcocarp is soft and get final product.

11, Rhizoma Polygonati: spring, Qiu Erji excavate, removing fibrous root, cleans, and puts in boiling water and slightly scalds or steam to the saturating heart, drying for standby.

12, Rhizoma Alismatis: winter excavates, cleans, and low baking temperature is dried, and hits fibrous root and rough bark, and the section of water profit, dries.Parched with bran or saline are fried and are used.

13, Polyporus: remove silt particle after digging out, dries for subsequent use.

14, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA: kill and remove muscles, gets its sternite, cleans and dries, be called " blood version "; As scalded the sternite after death taken out with boiling water, be called " scalding plate ".Raw use, stir-baking with sand big gun use, or stir-baking with sand quench in vinegar is used.

15, Radix Glycyrrhizae: spring and autumn excavates, remove residual stem and fibrous root, or remove crust, section is dried.Life is used or processed with honey is used.

16, Stigma Maydis: gather during harvesting corn in autumn.Dry or dry for standby.

17, Semen Raphani: tap plant during fruit maturation in summer, dry, rub seed, removing impurity, then dry for subsequent use.

18, Radix Pseudostellariae: summer excavates when major part stem and leaf is withered.Remove tiny fibrous root, insert in water slightly to scald and dry, or directly dry, raw use.

19, ANLV: be the fruit of feverfew ANLV, winter gathers for subsequent use.

20, Fructus Broussonetiae: pluck during fruit maturation in autumn, clean, dry, removing the membranaceous Constellation calyx of canescence and impurity for subsequent use.

21, Sichuan Herba Dendrobii: the fresh goods of returning of gathering, can scalding solarization method method or oven drying method by boiling water, to carry out processing for subsequent use.

the chemical composition of each crude drug:

1, Radix Angelicae Sinensis: Radix Angelicae Sinensis has got the chemical composition of plurality of classes, mainly contains ligustilide class and isomeric compound, Coumarins, flavonoid and organic acid etc.

2, the Radix Paeoniae Alba: the Radix Paeoniae Alba is mainly containing chemical compositions such as volatile oil, single card class, triterpenes and flavonoids.

3, Rhizoma Atractylodis Macrocephalae (parched): Rhizoma Atractylodis Macrocephalae master is containing volatile oil, content is about 1.4%, its main component is atractylone, atractylol etc., wherein atractylone accounts for 32%-61%, the terpenoids such as the mainly caryophyllene that other content are relatively high, γ-elemene, cnidium monnieri-4 (14), 11-diene, gima ethylenic B.From the Rhizoma Atractylodis Macrocephalae, be separated the lactone composition obtained have atractylenolide Ⅰ, atractylenolideⅡ, atractylenolideⅢ, biatractylolide, 8,9-epoxy atractylodes lactones, 4,15-epoxy hydroxyl atractylodes lactones etc.In addition, still containing polysaccharide composition, the materials such as the several amino acids such as glutamic acid and resin, Rhizoma Atractylodis Macrocephalae triol, vitamin A.

4, Poria: Poria is mainly containing terpenoid, steroid compound, polysaccharide compound, protein etc.

5, Radix Bupleuri: main containing saikoside in Radix Bupleuri root, secondly containing plant sterol, adonite and a small amount of volatile oil, polysaccharide; Aerial parts is mainly containing compositions such as flavonoid, a small amount of saponins, lignanoids, Coumarinses.

6, Rhizoma Cyperi: Rhizoma Cyperi is mainly containing volatile oil composition, and other chemical compositions also have flavonoid, saccharide, triterpenes etc.

7, Radix Curcumae: main containing compositions such as volatile oil, curcumin, polysaccharide, a small amount of trace element in Radix Curcumae, wherein volatile oil is Radix Curcumae antineoplastic effective composition, and curcumin is the principle active component of its blood fat reducing, antioxidation, antiinflammatory.

8, Carapax Trionycis (processed): main containing compositions such as animal glue, keratin, iodine matter, vitamin D, calcium phosphate, calcium carbonate in Carapax Trionycis, and be also rich in 17 seed amino acids.

9, Squama Manis: Squama Manis is mainly containing protein, calcium, the aminoacid of needed by human and trace element etc.

10, Fructus Lycii: the chemical composition that Chinese wolfberry fruit mainly contains comprises: saccharide, aminoacid, trace element, vitamin, superoxide dismutase, alkaloids, fat and fatty acid, alcohols, inorganic salt and volatile ingredient etc.

11, Rhizoma Polygonati: Rhizoma Polygonati is mainly containing compositions such as polygonatum polysaccharide, steroid saponin, lignanoids and other compositions.

12, Rhizoma Alismatis: the main chemical compositions of Rhizoma Alismatis is triterpene and sesquiterpenoids composition, also containing chemical compositions such as diterpene, plant sterol, volatile oil, alkaloid, asparagine, steroline, fatty acid, protein and starch.

13, Polyporus: the Polyporus chemical composition reported mainly contains polysaccharide, steroid, nonsteroidal (except polysaccharide), amino acids, vitamins and small-scale inorganic element etc.

14, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA: protein is the principle active component of Carapax et Plastrum Testudinis.

15, Radix Glycyrrhizae: Radix Glycyrrhizae is mainly containing triterpene saponin, flavones ingredient, coumarin, aminoacid, alkaloid and a small amount of volatile ingredient and polysaccharide.

16, Stigma Maydis: the chemical composition of Stigma Maydis is very abundant, mainly containing number of chemical compositions such as inorganic elements, saccharide, aminoacid, flavonoid, volatile chemical component, organic acid, sterol, alkaloid, saponin.

17, Semen Raphani: be also Radix Raphani kind, Semen Raphani.The main fatty acids of Semen Raphani, volatile oil.In volatile oil containing methanthiol, α-, β-hexenoic aldehyde and β-, γ-hexenol.Containing erucic acid, linoleic acid, linolenic acid, glycerol sinapate etc. in fatty oil, also containing antibiotic substance raphanin etc.

18, Radix Pseudostellariae: Radix Pseudostellariae is mainly containing compositions such as saponin, volatile oil, sterol, aminoacid, mineral, starch.

19, ANLV: the sub-chemical composition of ANLV is still not clear at present, but drug effect fancy effect is better.

20, Fructus Broussonetiae: modern pharmacological research finds that Fructus Broussonetiae contains the chemical compositions such as abundant aminoacid, fatty acid, red pigment, alkaloid, mineral, polysaccharide.

21, Sichuan Herba Dendrobii: alkaloids composition is separated the chemicals obtained the earliest from Dendrobium Sw, in addition, also containing compositions such as polysaccharide, luxuriant and rich with fragrance class and bibenzyl, aminoacid and trace element.

clinical observation on the therapeutic effect:

1, case selection:

In 98 routine cirrhosis patients in decompensation patients, man 63 example, female 35 example, minimum 27 years old of age, maximum 70 years old, wherein the shortest 3 months of the course of disease, the longest 3 years, all patients was typical cirrhosis patients in decompensation, and protopathy is respectively hepatitis B, hepatitis C, fatty liver, alcoholic liver.

2, the diagnosis basis of cirrhosis patients in decompensation and Standards of Chinese Medical Syndrome Differentiation:

Diagnose according to " internal medicine " (national higher medical education teaching material the 8th edition).

The diagnostic criteria of cirrhosis patients in decompensation:

One, hypofunction of liver:

1. digest and assimilate bad, comprise loss of appetite, feel sick, easily suffer from diarrhoea after anorexia, abdominal distention, animal food.

2. malnutrition, comprises and becomes thin, weak, lassitude, to be even unable to leave the bed.

3. jaundice, mostly is hepatocellular jaundice.

4. hemorrhage and anemia, comprises nasal cavity, gingival hemorrhage, skin mucosa petechia, ecchymosis, digestive tract hemorrhage.

5. endocrine disturbance, comprises the abnormal spider angioma that causes of sex hormone metabolism and liver palm, hypoadrenocorticism, thyroxin is abnormal.

6. irregular low grade fever.

7. hypoalbuminemia.

Two, portal hypertension:

1. ascites.

2. door-chamber Doppler flow mapping is open, comprises ramus anastomoticus varicose after esophagus fundus ventricularis varication, abdominal wall varicosis, haemorrhoidal vein expansion, peritoneum, splenorenal shunt.

Three, hypersplenism and splenomegaly:

All dialectical according to " Chinese Internal Medicine " (national Higher TCM institute school programming textbook the 9th edition) is syndrome of blockade of dampness due to qi stagnation:

(1) primary symptom:

What 1. abdominal distention was pressed is not hard.

2. the lower distension of the side of body or pain.

(2) secondary disease:

1. diet reduces.

2. very swollen after food, obtain belch or vow that gas slightly subtracts.

3. oliguria.

4. thin white fur of tongue is greasy.

5. stringy pulse.

Primary symptom 2 and secondary disease 2 is had to make a definite diagnosis.Symptom integral by without, light, in, heavy, primary symptom remembers 0,2,4,6 point respectively, and secondary disease remembers 0,1,2,3 respectively.

3, efficacy assessment standard:

According to China Medical Science Press in 2002 publish " new Chinese medicine guideline of clinical investigations " in pass judgment on about the criterion of therapeutical effect of cirrhosis patients in decompensation:

(1) clinical cure:

1. laboratory Index for examination returns to normally;

2. color ultrasound ascites disappears, and spleen returns to normally, and liver cirrhosis is unchanged even to be alleviated;

3. symptom integral reduces more than 80%.

(2) effective:

1. laboratory Index for examination obviously improves;

2. color ultrasound ascites obviously reduces, and spleen obviously reduces, and liver cirrhosis is substantially unchanged;

3. symptom integral reduces 60%--79%.

(3) effective:

1. laboratory Index for examination improves;

2. color ultrasound ascites reduces, and spleen reduces, and liver cirrhosis is without increasing the weight of;

3. symptom integral reduces 40%--59%;

(4) invalid:

1. laboratory Index for examination is without improvement or deterioration;

2. color ultrasound ascites even increases without minimizing, and spleen is large, and liver cirrhosis increases the weight of;

3. symptom integral reduces less than 39%.

4, using method: each by soft capsule of the present invention 5, warm water 100 ~ 150ml, oral, every day 3 times 15 days is a course for the treatment of, all treats 3 ~ 6 courses for the treatment of.

5, points for attention:

Period in a medicine is avoided and is eaten raw food, greasy, over-salty, fish raw meat and maror.In addition, due to conditions of patients weight and course of disease length difference, also there is individual variation to drug susceptibility, most of patients can take effect within 3 courses for the treatment of, clinical recovery in 3-6 the course for the treatment of; Few patients then needs just can reach clinical cure 6-8 the course for the treatment of.If desired in conjunction with the auxiliary treating method of western medical treatment cirrhosis patients in decompensation

6, therapeutic outcome:

In 98 examples in cirrhosis patients in decompensation patient, clinical cure 37 people, effective 22 people, effective 32 people, invalid 7 people, total effective rate 92.85%.

7, conclusion:

The present invention has obvious therapeutic effect for cirrhosis patients in decompensation, has no side effect during treatment, and take medicine conveniently, total effective rate 82.65% is the choice drug of cirrhosis patients in decompensation patient.

8, model case:

A, Liu, man, 65 years old, retired worker, there are more than 30 years of hepatitis B medical history, main suit's nearly 1 month loss of appetite, feel sick, anorexia, one's belly is tight as a drum, easily suffer from diarrhoea after animal food, become thin, weak, lassitude, skin mucosa petechia, ecchymosis, look into liver function 9 display glutamic oxaloacetic transaminase, GOT 66U/L, glutamate pyruvate transaminase 56U/L, albumin 32.6g/L, the weak positive of AFP, color doppler ultrasonography display liver volume reduces, superficial echo is coarse, splenomegaly, ascites degree of depth 18cm, health check-up abdominal part has succussion splash, skin surface is dispersed in spider angioma, hepatitis B surface antigen and core antibody positive, antibody to hepatitis C is negative, oliguria, thin white fur of tongue is greasy, stringy pulse.After 5 courses for the treatment of of oral soft capsule, loss of appetite, feel sick, anorexia, the symptom such as one's belly is tight as a drum, easily suffer from diarrhoea after animal food, become thin, weak, lassitude obviously alleviate, albumin 38.7g/L, color doppler ultrasonography display liver volume is little, and superficial echo is coarse, spleen normal in size, ascites degree of depth 5cm, health check-up abdominal part succussion splash disappears, and advises patient to adhere to treatment, follow up a case by regular visits to 3 years, symptom does not increase the weight of again.

B, Zhang, female, 38 years old, state-owned enterprise workman, hepatitis C medical history 8 years, nearly 2 weeks loss of appetite, one's belly is tight as a drum, become thin, weak, lassitude, darkish complexion, look into liver function 9 display glutamic oxaloacetic transaminase, GOT 57U/L, glutamate pyruvate transaminase 62U/L, albumin 39.0g/L, AFP are positive, color doppler ultrasonography display liver volume reduces, superficial echo is coarse, splenomegaly, ascites degree of depth 20cm, health check-up abdominal part has succussion splash, hepatitis B surface antigen is negative, and antibody to hepatitis C is positive, oliguria, thin white fur of tongue is greasy, stringy pulse.After 3 courses for the treatment of of oral soft capsule, loss of appetite, one's belly is tight as a drum, become thin, weak, lassitude, and the symptoms such as darkish complexion are obviously alleviated, albumin 42g/L, color doppler ultrasonography display liver volume is little, superficial echo is coarse, spleen normal in size, ascites degree of depth 8cm, health check-up abdominal part succussion splash disappears, advise patient to adhere to treatment, follow up a case by regular visits to 5 years, symptom does not increase the weight of again.

C, Lee, man, 58 years old, state-owned enterprise middle-ranking officials, fatty liver medical history 5 years, triglyceride and T-CHOL, low-density lipoprotein white level were all higher, usually eating greasy and surfeit flavour and drinking, each drink more than Chinese liquor 250ml.Feel loss of appetite more than nearly January, one's belly is tight as a drum, weak, lassitude, shallow complexion, look into liver function 9 display glutamic oxaloacetic transaminase, GOT 60U/L, glutamate pyruvate transaminase 72U/L, albumin 35.6g/L, AFP are positive, and color doppler ultrasonography display liver volume reduces, superficial echo is coarse, splenomegaly, ascites degree of depth 13cm, health check-up abdominal part has weak succussion splash, hepatitis B surface antigen is negative, and antibody to hepatitis C is negative, oliguria, thin white fur of tongue is greasy, stringy pulse.Advise light diet, alleviating alcohol addiction, after 3 courses for the treatment of of oral soft capsule, the symptoms such as loss of appetite, one's belly is tight as a drum, weak, lassitude, shallow complexion are clearly better, albumin 42g/L, and color doppler ultrasonography display liver volume is little, superficial echo is coarse, spleen normal in size, ascites degree of depth 3cm, advises patient to adhere to treatment, follow up a case by regular visits to 7 years, symptom does not increase the weight of again.

D, Zhang, man, 56 years old, teacher, in more than 20 years of hepatitis B medical history, did not take the medicine such as Entecavir, adefovir ester, often stays up late, drink once in a while, non-smoking.One's belly is tight as a drum in nearly 3 months of main suit sense, loss of appetite, weak, lassitude, darkish complexion, look into liver function 9 display glutamic oxaloacetic transaminase, GOT 78U/L, glutamate pyruvate transaminase 62U/L, albumin 33.2g/L, AFP are positive, and color doppler ultrasonography display liver volume reduces, superficial echo is coarse, splenomegaly, ascites degree of depth 26cm, health check-up abdominal part has succussion splash, hepatitis b surface antigen positive, and hepatitis B virus core antigen is positive, antibody to hepatitis C is negative; oliguria, thin white fur of tongue is greasy, stringy pulse.Advise take a good rest, alleviating alcohol addiction, after 6 courses for the treatment of of oral soft capsule, the symptoms such as loss of appetite, one's belly is tight as a drum, weak, lassitude, darkish complexion are clearly better, albumin 45g/L, and color doppler ultrasonography display liver volume is little, superficial echo is coarse, spleen normal in size, ascites degree of depth 6cm, advises patient to adhere to treatment, follow up a case by regular visits to 5 years, symptom does not increase the weight of again.

E, Zhang, man, 28 years old, usually healthy, happiness is drunk, and drinks Chinese liquor 400-more than 500ml every day, and one's belly is tight as a drum, loss of appetite, weak, lassitude for main suit's sense in nearly 3 months, look into liver function 9 display glutamate-oxaloacetate transaminase 79U/L, glutamate pyruvate transaminase 236U/L, albumin 30.1g/L, AFP are positive, color doppler ultrasonography display liver volume reduces, superficial echo is coarse, splenomegaly, ascites degree of depth 21cm, health check-up abdominal part has succussion splash, hepatitis B surface antigen is negative, and antibody to hepatitis C is negative, oliguria, thin white fur of tongue is greasy, stringy pulse.Advise take a good rest, alleviating alcohol addiction, after 6 courses for the treatment of of oral soft capsule, loss of appetite, the transference cure such as one's belly is tight as a drum, weak, lassitude, albumin 45g/L, color doppler ultrasonography display liver volume is little, and superficial echo is coarse, spleen normal in size, ascites disappears, and advises patient to adhere to treatment, follows up a case by regular visits to 1 year, color doppler ultrasonography display liver volume recovers normal, liver surface is starlike echo, and spleen normal in size, ascites does not occur again.

F, Liu, female, 48 years old, first visit on January 5 in 2014.Hepatitis B medical history 5 years, usually short-tempered, eating is pungent.Main suit feels that one's belly is tight as a drum, loss of appetite, weak, lassitude nearly January, looks into liver function 9 display glutamic oxaloacetic transaminase, GOT 89U/L, glutamate pyruvate transaminase 36U/L, the weak positive of albumin 40.1g/L, AFP, color doppler ultrasonography display liver volume reduces, superficial echo is coarse, splenomegaly, ascites degree of depth 24cm, health check-up abdominal part has succussion splash, hepatitis b surface antigen positive, antibody to hepatitis C is negative, oliguria, thin white fur of tongue is greasy, stringy pulse.Advise regulating spirit and emotion by oneself, guard against pungent, after 4 courses for the treatment of of oral soft capsule, loss of appetite, the transference cure such as one's belly is tight as a drum, weak, lassitude, albumin 42g/L, color doppler ultrasonography display liver volume is little, and superficial echo is coarse, spleen normal in size, ascites disappears, advise patient to adhere to treatment, follow up a case by regular visits to 1 year, symptom is without increasing the weight of.

G, Wang, female, 80 years old, hepatitis B medical history 23 years, liver cirrhosis medical history 3 years, there is abdominal distention, loss of appetite, weak, the symptoms such as lassitude, feel abdominal distention nearly February to increase the weight of, loss of appetite, feel sick, weakly to increase the weight of, then be in hospital with cirrhosis patients in decompensation income, look into liver function 9 display glutamic oxaloacetic transaminase, GOT 97U/L, glutamate pyruvate transaminase 86U/L, albumin 32.1g/L, AFP is positive, color doppler ultrasonography display liver volume obviously reduces, superficial echo is coarse, splenomegaly, ascites degree of depth 33cm, health check-up abdominal part has obvious succussion splash, hepatitis b surface antigen positive, hepatitis B virus core antigen is positive, antibody to hepatitis C is negative, oliguria, thin white fur of tongue is greasy, stringy pulse.Doctor trained in Western medicine gives corresponding treatment, weak curative effect, please the traditional Chinese medical science hold a consultation, after 1 course for the treatment of of oral soft capsule, the symptoms such as loss of appetite, one's belly is tight as a drum, weak, lassitude slightly alleviate, please the doctor trained in Western medicine consultation of doctors, use heavy dose of activating blood and removing stasis drug, conditions of patients increases the weight of, dead after 1 week.

detailed description of the invention:

Embodiment 1: a kind of soft capsule for the treatment of cirrhosis patients in decompensation, in units of weight portion, the crude drug making its effective ingredient is: Radix Angelicae Sinensis l0 part, the Radix Paeoniae Alba 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, 20 parts, Poria, Radix Bupleuri 6 parts, Rhizoma Cyperi 15 parts, Radix Curcumae 10 parts, Carapax Trionycis (processed) 15 parts, Squama Manis 10 parts, Fructus Lycii 15 parts, Rhizoma Polygonati 15 parts, Rhizoma Alismatis 20 parts, Polyporus 15 parts, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 15 parts, 3 parts, Radix Glycyrrhizae, Stigma Maydis 35 parts, Semen Raphani 30 parts, Radix Pseudostellariae 32 parts, ANLV 15 parts, Fructus Broussonetiae 30 parts, Sichuan Herba Dendrobii 15 parts, each composition is for subsequent use after being processed into soft capsule according to medically conventional processing method above.

During use: by soft capsule of the present invention 5, warm water 100 ~ 150ml, oral, every day 3 times 15 days is a course for the treatment of, all treats 3 courses for the treatment of.Period in a medicine is avoided and is eaten raw food, greasy, fish raw meat and maror, continues to take after 1 month and stop using effectively.In addition, due to conditions of patients weight and course of disease length difference, also there is individual variation to drug susceptibility, most of patients can take effect within 2 courses for the treatment of, clinical recovery in 2-4 the course for the treatment of; Few patients then needs just can reach clinical cure 4-6 the course for the treatment of.If desired in conjunction with the Therapeutic Method of western medical treatment cirrhosis patients in decompensation

Embodiment 2: the using method of the present embodiment and points for attention are with embodiment 1, and something in common does not repeat,

Difference is: a kind of soft capsule for the treatment of cirrhosis patients in decompensation, in units of weight portion, the crude drug making its effective ingredient is: Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 parts, 25 parts, Poria, Radix Bupleuri 10 parts, Rhizoma Cyperi 15 parts, Radix Curcumae 8 parts, Carapax Trionycis (processed) 20 parts, Squama Manis 10 parts, Fructus Lycii 15 parts, Rhizoma Polygonati 15 parts, Rhizoma Alismatis 15 parts, Polyporus 15 parts, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 15 parts, 5 parts, Radix Glycyrrhizae, Stigma Maydis 30 parts, Semen Raphani 25 parts, Radix Pseudostellariae 30 parts, ANLV 13 parts, Fructus Broussonetiae 25 parts, Sichuan Herba Dendrobii 18 parts, each composition is for subsequent use after being processed into soft capsule according to medically conventional processing method above.

Embodiment 3: the using method of the present embodiment and points for attention are with embodiment 1, and something in common does not repeat,

Difference is: a kind of soft capsule for the treatment of cirrhosis patients in decompensation, in units of weight portion, the crude drug making its effective ingredient is: Radix Angelicae Sinensis 15 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Atractylodis Macrocephalae (parched) 13 parts, 22 parts, Poria, Radix Bupleuri 8 parts, Rhizoma Cyperi 12 parts, Radix Curcumae 9 parts, Carapax Trionycis (processed) 17 parts, Squama Manis 9 parts, Fructus Lycii 12 parts, Rhizoma Polygonati 13 parts, Rhizoma Alismatis 17 parts, Polyporus 12 parts, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 17 parts, 4 parts, Radix Glycyrrhizae, Stigma Maydis 33 parts, Semen Raphani 28 parts, Radix Pseudostellariae 31 parts, ANLV 14 parts, Fructus Broussonetiae 27 parts, Sichuan Herba Dendrobii 16 parts, each composition is for subsequent use after being processed into soft capsule according to medically conventional processing method above.

Embodiment 4: the using method of the present embodiment and points for attention are with embodiment 1, and something in common does not repeat,

Difference is: a kind of soft capsule for the treatment of cirrhosis patients in decompensation, in units of weight portion, the crude drug making its effective ingredient is: Radix Angelicae Sinensis 22 parts, the Radix Paeoniae Alba 17 parts, Rhizoma Atractylodis Macrocephalae (parched) 18 parts, 28 parts, Poria, Radix Bupleuri 12 parts, Rhizoma Cyperi 16 parts, Radix Curcumae 12 parts, Carapax Trionycis (processed) 22 parts, Squama Manis 15 parts, Fructus Lycii 20 parts, Rhizoma Polygonati 17 parts, Rhizoma Alismatis 22 parts, Polyporus 18 parts, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 23 parts, 7 parts, Radix Glycyrrhizae, Stigma Maydis 39 parts, Semen Raphani 35 parts, Radix Pseudostellariae 35 parts, ANLV 16 parts, Fructus Broussonetiae 33 parts, Sichuan Herba Dendrobii 20 parts, each composition is for subsequent use after being processed into soft capsule according to medically conventional processing method above.

Embodiment 5: the using method of the present embodiment and points for attention are with embodiment 1, and something in common does not repeat,

Difference is: a kind of soft capsule for the treatment of cirrhosis patients in decompensation, in units of weight portion, the crude drug making its effective ingredient is: Radix Angelicae Sinensis 8 parts, the Radix Paeoniae Alba 8 parts, Rhizoma Atractylodis Macrocephalae (parched) 8 parts, 15 parts, Poria, Radix Bupleuri 5 parts, Rhizoma Cyperi 8 parts, Radix Curcumae 5 parts, Carapax Trionycis (processed) 13 parts, Squama Manis 7 parts, Fructus Lycii 10 parts, Rhizoma Polygonati 10 parts, Rhizoma Alismatis 15 parts, Polyporus 10 parts, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 16 parts, 3 parts, Radix Glycyrrhizae, Stigma Maydis 25 parts, Semen Raphani 20 parts, Radix Pseudostellariae 25 parts, ANLV 10 parts, Fructus Broussonetiae 20 parts, Sichuan Herba Dendrobii 10 parts, each composition is for subsequent use after being processed into soft capsule according to medically conventional processing method above.

Embodiment 6: the using method of the present embodiment and points for attention are with embodiment 1, and something in common does not repeat,

Difference is: a kind of soft capsule for the treatment of cirrhosis patients in decompensation, in units of weight portion, the crude drug making its effective ingredient is: Radix Angelicae Sinensis 15 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Atractylodis Macrocephalae (parched) 12 parts, 24 parts, Poria, Radix Bupleuri 8 parts, Rhizoma Cyperi 11 parts, Radix Curcumae 9 parts, Carapax Trionycis (processed) 18 parts, Squama Manis 9 parts, Fructus Lycii 10 parts, Rhizoma Polygonati 13 parts, Rhizoma Alismatis 16 parts, Polyporus 12 parts, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 16 parts, 3 parts, Radix Glycyrrhizae, Stigma Maydis 35 parts, Semen Raphani 26 parts, Radix Pseudostellariae 31 parts, ANLV 15 parts, Fructus Broussonetiae 28 parts, Sichuan Herba Dendrobii 17 parts, each composition is for subsequent use after being processed into soft capsule according to medically conventional processing method above.

Embodiment 7: the using method of the present embodiment and points for attention are with embodiment 1, and something in common does not repeat,

Difference is: a kind of soft capsule for the treatment of cirrhosis patients in decompensation, in units of weight portion, the crude drug making its effective ingredient is: Radix Angelicae Sinensis l0 part, the Radix Paeoniae Alba 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 parts, 25 parts, Poria, Radix Bupleuri 6 parts, Rhizoma Cyperi 15 parts, Radix Curcumae 8 parts, Carapax Trionycis (processed) 20 parts, Squama Manis 8 parts, Fructus Lycii 15 parts, Rhizoma Polygonati 12 parts, Rhizoma Alismatis 20 parts, Polyporus 10 parts, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 20 parts, 3 parts, Radix Glycyrrhizae, Stigma Maydis 35 parts, Semen Raphani 25 parts, Radix Pseudostellariae 32 parts, ANLV 13 parts, Fructus Broussonetiae 30 parts, Sichuan Herba Dendrobii 15 parts, each composition is for subsequent use after being processed into soft capsule according to medically conventional processing method above.

Embodiment 8; The using method of the present embodiment and points for attention are with embodiment 1, and something in common does not repeat,

Difference is: a kind of soft capsule for the treatment of cirrhosis patients in decompensation, in units of weight portion, the crude drug making its effective ingredient is: Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, 20 parts, Poria, Radix Bupleuri 6 parts, Rhizoma Cyperi 15 parts, Radix Curcumae 10 parts, Carapax Trionycis (processed) 15 parts, Squama Manis 10 parts, Fructus Lycii 10 parts, Rhizoma Polygonati 15 parts, Rhizoma Alismatis 15 parts, Polyporus 15 parts, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 15 parts, 5 parts, Radix Glycyrrhizae, Stigma Maydis 30 parts, Semen Raphani 30 parts, Radix Pseudostellariae 30 parts, ANLV 15 parts, Fructus Broussonetiae 25 parts, Sichuan Herba Dendrobii 18 parts, each composition is for subsequent use after being processed into soft capsule according to medically conventional processing method above.

Claims (3)

1. treat the Chinese medicine of cirrhosis patients in decompensation for one kind, it is characterized in that: in units of weight portion, the crude drug making its effective ingredient is: Radix Angelicae Sinensis l0 ~ 20 part, the Radix Paeoniae Alba 10 ~ 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 ~ 15 parts, 20 ~ 25 parts, Poria, Radix Bupleuri 6 ~ 10 parts, Rhizoma Cyperi 10 ~ 15 parts, Radix Curcumae 8 ~ 10 parts, Carapax Trionycis (processed) 15 ~ 20 parts, Squama Manis 8 ~ 10 parts, Fructus Lycii 10 ~ 15 parts, Rhizoma Polygonati 12 ~ 15 parts, Rhizoma Alismatis 15 ~ 20 parts, Polyporus 10 ~ 15 parts, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 15 ~ 20 parts, 3 ~ 5 parts, Radix Glycyrrhizae, Stigma Maydis 30 ~ 35 parts, Semen Raphani 25 ~ 30 parts, Radix Pseudostellariae 30 ~ 32 parts, ANLV 13 ~ 15 parts, Fructus Broussonetiae 25 ~ 30 parts, Sichuan Herba Dendrobii 15 ~ 18 parts.

2. the Chinese medicine for the treatment of cirrhosis patients in decompensation according to claim 1, is characterized in that: in units of weight portion, and the crude drug making its effective ingredient is: Radix Angelicae Sinensis l0 part, the Radix Paeoniae Alba 10 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 parts, 20 parts, Poria, Radix Bupleuri 6 parts, Rhizoma Cyperi 10 parts, Radix Curcumae 10 parts, Carapax Trionycis (processed) 15 parts, Squama Manis 8 parts, Fructus Lycii 15 parts, Rhizoma Polygonati 15 parts, Rhizoma Alismatis 15 parts, Polyporus 10 parts, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 15 parts, 3 parts, Radix Glycyrrhizae, Stigma Maydis 35 parts, Semen Raphani 30 parts, Radix Pseudostellariae 30 parts, ANLV 15 parts, Fructus Broussonetiae 30 parts, Sichuan Herba Dendrobii 15 parts.

3. the Chinese medicine for the treatment of cirrhosis patients in decompensation according to claims 1 to 2, is characterized in that: described Chinese medicine is soft capsule preparation.