CN107823484A - A kind of Chinese medicine composition for treating chronic nephritis and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating chronic nephritis and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to technical field of traditional Chinese medicines, a kind of Chinese medicine composition for treating chronic nephritis, in parts by weight, the Chinese medicine composition is made up of the raw material of following parts by weight：15~20 parts of rhizoma atractylodis macrocephalae, 20~40 parts of damp sunset, 10~20 parts of umbellate pore furgus, 20~30 parts of rhizoma imperatae, 15~25 parts of the Fen, pivots of the stem pith of the rice-paper plant 10~15 storage, 10~15 parts of akebi, 10~30 parts of plantain seed, 15~30 parts of Hedyotidis Diffusae, 15~20 parts of Radix Angelicae Sinensis, 10~20 parts of the radix paeoniae rubrathe, 20~40 parts of the red sage root, 10~15 parts of motherwort, 10~20 parts of Radix Notoginseng, 10~15 parts of amber；The present invention is using the rhizoma atractylodis macrocephalae of strengthening the spleen and replenishing qi as monarch drug in a prescription, using the damp sunset and umbellate pore furgus of clearing damp and promoting diuresis as ministerial drug, using the rhizoma imperatae of reducing fever and causing diuresis, stem pith of the rice-paper plant, pivots storage, akebi, plantain seed, Hedyotidis Diffusae, Radix Angelicae Sinensis, the radix paeoniae rubrathe, the red sage root, motherwort, Radix Notoginseng as adjutant, using tranquillizing the mind by relieving convulsion, dissipate stasis of blood hemostasis, promoting diuresis for stranguria amber to make medicine, compatibility is reasonable, have no toxic side effect, can fundamentally dispel it is damp and hot discharge it is wet turbid, treat chronic kidney disease.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating chronic nephritis and its preparation side
Method.
Background technology
In clinic, glomerulonephritis, latent nephritis, pyelonephritis, Henoch Schonlein purpura nephritis, lupus erythematosus kidney are diagnosed as
Scorching, ventilation kidney, iga nephrosis, nephrotic syndrome, membranous nephropathy, nephrotic syndrome, diabetic nephropathy, hypertensive nephropathy, more capsules
Kidney, etc., when the morbidity delay of these nephrosis is refractory, the time, patient urine and related physiochemical indice occurred more than three months
Abnormal, Renal Paphology, iconography note abnormalities, or the glomerulus effective filtration rate of kidney is less than 60%, all can be collectively referred to as " slow
Property nephrosis ".Chronic kidney disease such as fails timely and effective treatment, causes sb.'s illness took a turn for the worse to be in progress, then delays with the course of disease, Patients with Chronic Renal Disease
Chronic renal insufficiency, kidney failure will be developed into, ultimately form uremia.Chronic kidney disease characteristics of incidence has " three high ", " three
It is low "：Incidence of disease height, the cardiovascular disease illness rate to occur together is high, case fatality rate is high；The whole society is low to the awareness of chronic kidney disease, preventing and treating
It is low that rate is low, the painstaking effort that occur together close sick awareness.Investigation display, the illness rate of more than the 40 years old crowd's chronic kidney disease in China are more than
10%, awareness is but less than 5%.In China, it is most to betide the Patients with Chronic Renal Disease of glomerulonephritis, accounts for 40%.With China
Crowd's dietary structure and the change of habits and customs, other subsequent chronic nephrosis are just on the increase.Plus the existing medical treatment in China
It is horizontal still limited, cause the preventing and controlling situation of China's chronic kidney disease to face a severe challenge.It is to be difficult once suffering from chronic kidney disease
Radical cure.Early stage typically carries out intervening control treatment to chronic kidney disease, prevents from deteriorating, can not effect a radical cure.
The content of the invention
To solve the above problems, the technical solution adopted by the present invention is：
A kind of Chinese medicine composition for treating chronic nephritis, in parts by weight, the Chinese medicine composition by following parts by weight original
Material composition：15~20 parts of rhizoma atractylodis macrocephalae, 20~40 parts of damp sunset, 10~20 parts of umbellate pore furgus, 20~30 parts of rhizoma imperatae, 10~15 parts of the stem pith of the rice-paper plant,
15~25 parts of pivot storage, 10~15 parts of akebi, 10~30 parts of plantain seed, 15~30 parts of Hedyotidis Diffusae, 15~20 parts of Radix Angelicae Sinensis, the radix paeoniae rubrathe 10
~20 parts, 20~40 parts of the red sage root, 10~15 parts of motherwort, 10~20 parts of Radix Notoginseng, 10~15 parts of amber.Preferred ingredient is：Fry
15~20 parts of the bighead atractylodes rhizome, 20~30 parts of damp sunset, 10~20 parts of umbellate pore furgus, 20~30 parts of rhizoma imperatae, the Fen, pivots of the stem pith of the rice-paper plant 10~15 store 20~25
Part, 10~15 parts of akebi, 10~20 parts of plantain seed, 15~30 parts of Hedyotidis Diffusae, 15~20 parts of Radix Angelicae Sinensis, 10~20 parts of the radix paeoniae rubrathe, pellet
20~30 parts of ginseng, 10~15 parts of motherwort, 10~20 parts of Radix Notoginseng, 10~15 parts of amber.Optimal component is：7 parts of rhizoma atractylodis macrocephalae, pool
25 parts of sunset, 15 parts of umbellate pore furgus, 25 parts of rhizoma imperatae, 20 parts of the Fen, pivots of the stem pith of the rice-paper plant 13 storage, 15 parts of akebi, 15 parts of plantain seed, Hedyotidis Diffusae 20
Part, 18 parts of Radix Angelicae Sinensis, 15 parts of the radix paeoniae rubrathe, 25 parts of the red sage root, 13 parts of motherwort, 15 parts of Radix Notoginseng, 15 parts of amber；Or, 20 parts of rhizoma atractylodis macrocephalae, pool
30 parts of sunset, 18 parts of umbellate pore furgus, 26 parts of rhizoma imperatae, 25 parts of the Fen, pivots of the stem pith of the rice-paper plant 17 storage, 12 parts of akebi, 18 parts of plantain seed, Hedyotidis Diffusae 25
Part, 17 parts of Radix Angelicae Sinensis, 16 parts of the radix paeoniae rubrathe, 17 parts of the red sage root, 12 parts of motherwort, 20 parts of Radix Notoginseng, 12 parts of amber.
Further, the Chinese medicine composition of described treatment chronic nephritis can be made any in pulvis, capsule and decoction
It is a kind of.
The invention also discloses a kind of preparation method of the Chinese medicine composition of described treatment chronic nephritis, formulation is glue
Capsule, comprise the following steps：
Step (1)：According to it is described treatment chronic nephritis Chinese medicine composition parts by weight of raw materials weigh rhizoma atractylodis macrocephalae, damp sunset,
Umbellate pore furgus, rhizoma imperatae, stem pith of the rice-paper plant, pivots storage, akebi, plantain seed, Hedyotidis Diffusae, Radix Angelicae Sinensis, the radix paeoniae rubrathe, the red sage root, motherwort, Radix Notoginseng, amber；
Step (2)：The Chinese medicine material weighed in step (1) is placed in clear water and soaks 10-15min, is removed miscellaneous in medicinal powder
Thing；
Step (3)：Chinese medicine material obtained by step (2) is pulled out from water, is placed under natural light and dries；Dry rear aqueous
Rate is controlled less than or equal to 98%；
Step (4)：Step (3) dried Chinese medicine is placed in grinding machine for Chinese herb medicines and pulverized, crosses 500-800 mesh sieves point
Afterwards, the sterilization processing 12-24 hours under UV light sterilization lamp；
Step (5)：The herb powder that step (4) obtains is filled in capsule, that is, the Chinese medicine for the chronic nephritis that obtains medical treatment
Capsule.
The invention also discloses second of preparation method of the Chinese medicine composition of described treatment chronic nephritis, formulation is powder
Agent, comprise the following steps：
Step (1)：According to it is described treatment chronic nephritis Chinese medicine composition parts by weight of raw materials weigh rhizoma atractylodis macrocephalae, damp sunset,
Umbellate pore furgus, rhizoma imperatae, stem pith of the rice-paper plant, pivots storage, akebi, plantain seed, Hedyotidis Diffusae, Radix Angelicae Sinensis, the radix paeoniae rubrathe, the red sage root, motherwort, Radix Notoginseng, amber；
Step (2)：The Chinese medicine material weighed in step (1) is placed in clear water and soaks 10-15min, is removed miscellaneous in medicinal powder
Thing；
Step (3)：Chinese medicine material obtained by step (2) is pulled out from water, is placed under natural light and dries；Dry rear aqueous
Rate is controlled less than or equal to 98%；
Step (4)：Step (3) dried Chinese medicine is placed in grinding machine for Chinese herb medicines and pulverized, crosses 500-800 mesh sieves point
Afterwards, the sterilization processing 12-24 hours under UV light sterilization lamp；
Step (5)：The herb powder that step (4) obtains is fitted into Chinese medicine net bag, that is, in the chronic nephritis that obtains medical treatment
Medicine powder.
The invention also discloses the third preparation method of the Chinese medicine composition of described treatment chronic nephritis, formulation is soup
Agent, comprise the following steps：
Step (1)：According to it is described treatment chronic nephritis Chinese medicine composition parts by weight of raw materials weigh rhizoma atractylodis macrocephalae, damp sunset,
Umbellate pore furgus, rhizoma imperatae, stem pith of the rice-paper plant, pivots storage, akebi, plantain seed, Hedyotidis Diffusae, Radix Angelicae Sinensis, the radix paeoniae rubrathe, the red sage root, motherwort, Radix Notoginseng, amber；
Step (2)：The Chinese medicine material weighed in step (1) is placed in medicine pot, and adds clear water immersion 30min, is removed
Debris in medicinal powder；The addition of clear water is advisable with flooding all Chinese medicine materials, after immersion, after boiling by intense fire, and slow fire heating
30-50 minutes, filter to obtain a decoction；
Step (3)：Add clear water in the dregs of a decoction into step (2) in marmite, the addition of clear water is to flood all dregs of a decoction
It is advisable, carries out second and decoct, first boil by intense fire, then be cooked by slow fire 30 minutes, filters to obtain secondary decoction；
Step (4)：Gained decoction in step (2) and step (3) is merged, pack, ice is placed in after naturally cooling to room temperature
Refrigerated in case, refrigerated storage temperature is controlled at 0-5 DEG C, and the traditional Chinese herbal decoction for the treatment of chronic nephritis is thus made.
Pharmacology is as follows：
Rhizoma atractylodis macrocephalae：It is a kind of qi-restoratives medicine, there is strengthening the spleen and replenishing qi and other effects, be that honey wheat bran is sprinkled into hot pot, wait to smolder
When add bighead atractylodes rhizome piece, fry to coke yellow, effusion burnt odor gas, take out, weed out honey wheat bran.Eliminate dampness and have diuretic effect, hidroschesis are antiabortive.For
Spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.
Damp sunset：Damp sunset refers to raw rhizoma alismatis.It is raw with the person of being used as medicine for the section of active compound decontamination.Main function is to detoxify, nature and flavor：It is sweet,
It is cold.Enter kidney, bladder warp.Effect：Li Shui, excreting dampness, expel the heat-evil.Control difficult urination, oedema turgor, vomiting, rush down dysentery, phlegm and retained fluid, tinea pedis, leaching
Disease, hematuria.
Umbellate pore furgus：It is sweet, light, put down.The thoughts of returning home, spleen, stomach, lung, kidney channel.Clearing damp and promoting diuresis.Control difficult urination, oedema, diarrhea, leaching
It is turbid, under band.
Rhizoma imperatae：Nature and flavor：It is sweet, tremble with fear.Return lung, stomach, bladder warp.Effect：Cooling blood and hemostasis, reducing fever and causing diuresis.Cure mainly：For blood-head
Spit blood, bleeding from five sense organs or subcutaneous tissue, hematuria, pyreticosis polydipsia, cough with lung heat, gastropyretic vomiting, jaundice with damp-heat pathogen, oedema oliguria, puckery pain of heat gonorrhea.
The stem pith of the rice-paper plant：It is sweet；It is light；Cold nature.Enter lung, stomach.Effect and effect：Clear snobbish water；Promoting lactation.The main puckery pain of stranguria；It is small
Just it is unfavorable；Oedema；Jaundice；Damp-warm diseases；Scanty drak urine；Postpartum breast is few；Amenorrhea；Under band.For damp-warm syndrome urine, the puckery pain of gonorrhoea, water
Swollen oliguria, agalactia.
Pivot stores：Cold nature, bitter.Return bladder warp.It is inducing diuresis for treating strangurtia, desinsection, antipruritic.The diuresis classified under category damp-clearing drug
Stranguria-relieving medicinal.With diuresis, decompression, antibacterial action, there is hypostypsis effect.Blood clotting can be accelerated, strengthen uterus tension force.
Akebi：Bitter, it is cold in nature.The thoughts of returning home, small intestine, bladder warp.Function：There is inducing diuresis for treating strangurtia, relieving restlessness that clears away heart-fire, stimulate the menstrual flow lower newborn work(
Effect.Cure mainly：For stranguria, oedema, red, the aphthae of vexed urine, Amenorrhea breast is few, damp and hot numbness pain.
Plantain seed：Nature and flavor：It is sweet, tremble with fear.Enter kidney, bladder warp.Major function：Li Shui, heat-clearing, improving eyesight, eliminating the phlegm.Control urine not
Logical, stranguria with turbid discharge, under band, hematuria, summer-heat and damp rush down dysentery, cough ant phlegm, arthritis with fixed pain caused by dampness, hot eyes hides from view.
Hedyotidis Diffusae：Meridian distribution of property and flavor：Bitter sweet；It is cold；It is nontoxic.The thoughts of returning home；Liver；Spleen；Large intestine channel.Major function：Bitter-cold herbs expelling heat solution
Poison, sweet cold eliminating dampness and heat, there is stronger removing toxicity for eliminating carbuncles effect to carbuncle swells, pharyngalgia, snakebite etc..It is generally used for treating sore, throat
Swelling and pain, abdominalgia with intestinal abscess, venomous snake bite, it is also used for puckery pain of heat gonorrhea, difficult urination.
Radix Angelicae Sinensis：Nature and flavor：Sweet, acrid, warm.Channel tropism：Return liver, the heart, the spleen channel.Major function：Replenishing and activating blood, menstruction regulating and pain relieving, ease constipation
Defaecation.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, fall and flutter
Damage, ulcer sores.
The radix paeoniae rubrathe：Meridian distribution of property and flavor：Bitter, cold nature.Return liver warp.Effect：Clearing heat and cooling blood, blood stasis removing analgesic.For thermal man's ying blood,
Febrile virulent maculae, hematemesis and epistaxis, red eye, swell pain, liver-depressed hypochondrium pain, closed dysmenorrhea, addiction lump in the abdomen stomachache, injury from falling down, carbuncle swells sore.
The red sage root：Bitter, it is slightly cold.The thoughts of returning home, Liver Channel.Effect：Promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire, cool blood to disappear carbuncle.It is main
Control：Swollen for chest impediment and cardialgia, gastral cavity abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea Amenorrhea, sore
Bitterly.
Motherwort：Meridian distribution of property and flavor：It is bitter, pungent, it is slightly cold.Return liver warp, pericardium channel.Major function：Promoting blood circulation, dissolving stasis, menstruation regulating, disappears
Water.Irregular menstruation is controlled, threatened abortion difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle swells sore
Ulcer.
Radix Notoginseng：Also known as pseudo-ginseng, pseudo-ginseng, radix notoginseng, Radix Notoginseng, Yunnan seven.Pseudo-ginseng, warm-natured, sweet, slight bitter, hemostasis stasis,
Detumescence ding-tong.Clinically it is used for haematemesis, bleeding from five sense organs or subcutaneous tissue, traumatism and bleeding tumbling and swelling, postpartum anemic fainting, abdominal pain due to blood stasis and the coronary heart disease heart twist
Pain etc..
Amber：Nature and flavor：It is sweet, put down.Enter the heart, liver, small intestinl channel.Tranquillizing the mind by relieving convulsion, dissipate stasis of blood hemostasis, promoting diuresis for stranguria.Infantile convulsion epilepsy is controlled,
Insomnia of palpitating with fear, blood strangury blood urine, urinary obstruction, women's amenorrhoea, postpartum stop stasis of blood stomachache, skin sore, traumatic injuries.
In terms of Chinese medical discrimination, chronic kidney disease, its disease and evil be unable to do without damp and hot and wet turbid, the too busy to get away spleen in sick position and kidney, on the one hand
It is damp and hot hustle and bustle, the involvement of spleen kidney, gas is cloudy all empty, have impact on biochemistry and the transpiration of kidney yang of ying blood；On the other hand it is spleen nephrasthenia,
Damp and hot puzzlement, it is pure and impure to deceive people, it is entire out-of-sequence with opening to cause the well-behaved unrest of negative and positive.Chronic kidney disease protracted course of disease, normal induced renal damage work(
Can, cause renal failure.
The present invention is using the rhizoma atractylodis macrocephalae of strengthening the spleen and replenishing qi as monarch drug in a prescription, using the damp sunset and umbellate pore furgus of clearing damp and promoting diuresis as ministerial drug, with heat-clearing profit
Rhizoma imperatae, stem pith of the rice-paper plant, pivots storage, akebi, plantain seed and the Hedyotidis Diffusae of clearing heat and detoxicating eliminating dampness and heat of urine, relax bowel work as
Return, the red sage root of the radix paeoniae rubrathe of clearing heat and cooling blood, promoting blood circulation and motherwort, the Radix Notoginseng of hemostasis stasis are adjutant, with tranquillizing the mind by relieving convulsion, dissipate
Stasis of blood hemostasis, the amber of promoting diuresis for stranguria is make medicine, and compatibility is reasonable, has no toxic side effect, strengthening the spleen and replenishing qi, clearing damp and promoting diuresis, clearing heat and detoxicating profit
Urine, can fundamentally dispel it is damp and hot discharge it is wet turbid, treat chronic kidney disease, it is quick, good effect, treat both principal and secondary aspect of disease, do not recur.
The Chinese medicine composition can be prepared into the diversified forms such as Chinese medicinal tablet, particle, traditional Chinese medicine pill, be not limited to decoction and
Capsule, suitable for a variety of therapeutic modalities, application method.
Embodiment
The present invention is further described with reference to embodiment.
Embodiment 1
A kind of Chinese medicine composition for treating chronic nephritis, in parts by weight, the Chinese medicine composition by following parts by weight original
Material composition：15 parts of rhizoma atractylodis macrocephalae, 40 parts of damp sunset, 10 parts of umbellate pore furgus, 30 parts of rhizoma imperatae, 25 parts of the Fen, pivots of the stem pith of the rice-paper plant 10 storage, 10 parts of akebi, car
First sub 30 parts, 15 parts of Hedyotidis Diffusae, 20 parts of Radix Angelicae Sinensis, 10 parts of the radix paeoniae rubrathe, 40 parts of the red sage root, 10 parts of motherwort, 20 parts of Radix Notoginseng, amber 10
Part.
Embodiment 2
A kind of Chinese medicine composition for treating chronic nephritis, in parts by weight, the Chinese medicine composition by following parts by weight original
Material composition：20 parts of rhizoma atractylodis macrocephalae, 20 parts of damp sunset, 20 parts of umbellate pore furgus, 20 parts of rhizoma imperatae, 15 parts of the Fen, pivots of the stem pith of the rice-paper plant 15 storage, 15 parts of akebi, car
First sub 10 parts, 30 parts of Hedyotidis Diffusae, 15 parts of Radix Angelicae Sinensis, 20 parts of the radix paeoniae rubrathe, 20 parts of the red sage root, 15 parts of motherwort, 10 parts of Radix Notoginseng, amber 15
Part.
Embodiment 3
A kind of Chinese medicine composition for treating chronic nephritis, in parts by weight, the Chinese medicine composition by following parts by weight original
Material composition：15 parts of rhizoma atractylodis macrocephalae, 30 parts of damp sunset, 10 parts of umbellate pore furgus, 30 parts of rhizoma imperatae, 25 parts of the Fen, pivots of the stem pith of the rice-paper plant 10 storage, 10 parts of akebi, car
First sub 20 parts, 15 parts of Hedyotidis Diffusae, 20 parts of Radix Angelicae Sinensis, 10 parts of the radix paeoniae rubrathe, 30 parts of the red sage root, 10 parts of motherwort, 20 parts of Radix Notoginseng, amber 10
Part.
Embodiment 4
A kind of Chinese medicine composition for treating chronic nephritis, in parts by weight, the Chinese medicine composition by following parts by weight original
Material composition：20 parts of rhizoma atractylodis macrocephalae, 20 parts of damp sunset, 20 parts of umbellate pore furgus, 20 parts of rhizoma imperatae, 20 parts of the Fen, pivots of the stem pith of the rice-paper plant 15 storage, 15 parts of akebi, car
First sub 10 parts, 30 parts of Hedyotidis Diffusae, 15 parts of Radix Angelicae Sinensis, 20 parts of the radix paeoniae rubrathe, 20 parts of the red sage root, 15 parts of motherwort, 10 parts of Radix Notoginseng, amber 15
Part.
Embodiment 5
A kind of Chinese medicine composition for treating chronic nephritis, in parts by weight, the Chinese medicine composition by following parts by weight original
Material composition：7 parts of rhizoma atractylodis macrocephalae, 25 parts of damp sunset, 15 parts of umbellate pore furgus, 25 parts of rhizoma imperatae, 20 parts of the Fen, pivots of the stem pith of the rice-paper plant 13 storage, 15 parts of akebi, Chinese herbaceous peony
15 parts of son, 20 parts of Hedyotidis Diffusae, 18 parts of Radix Angelicae Sinensis, 15 parts of the radix paeoniae rubrathe, 25 parts of the red sage root, 13 parts of motherwort, 15 parts of Radix Notoginseng, amber 15
Part.
Embodiment 6
A kind of Chinese medicine composition for treating chronic nephritis, in parts by weight, the Chinese medicine composition by following parts by weight original
Material composition：20 parts of the bighead atractylodes rhizome, 30 parts of damp sunset, 18 parts of umbellate pore furgus, 26 parts of rhizoma imperatae, 25 parts of the Fen, pivots of the stem pith of the rice-paper plant 17 storage, 12 parts of akebi, Chinese herbaceous peony
18 parts of son, 25 parts of Hedyotidis Diffusae, 17 parts of Radix Angelicae Sinensis, 16 parts of the radix paeoniae rubrathe, 17 parts of the red sage root, 12 parts of motherwort, 20 parts of Radix Notoginseng, amber 12
Part.
Embodiment 7：Capsule is made
The preparation method of the Chinese medicine composition for the treatment of chronic nephritis described in embodiment 1-6, formulation are capsule, including as follows
Step：
Step (1)：According to it is described treatment chronic nephritis Chinese medicine composition parts by weight of raw materials weigh rhizoma atractylodis macrocephalae, damp sunset,
Umbellate pore furgus, rhizoma imperatae, stem pith of the rice-paper plant, pivots storage, akebi, plantain seed, Hedyotidis Diffusae, Radix Angelicae Sinensis, the radix paeoniae rubrathe, the red sage root, motherwort, Radix Notoginseng, amber；
Step (2)：The Chinese medicine material weighed in step (1) is placed in clear water and soaks 10-15min, is removed miscellaneous in medicinal powder
Thing；
Step (3)：Chinese medicine material obtained by step (2) is pulled out from water, is placed under natural light and dries；Dry rear aqueous
Rate is controlled less than or equal to 98%；
Step (4)：Step (3) dried Chinese medicine is placed in grinding machine for Chinese herb medicines and pulverized, crosses 500-800 mesh sieves point
Afterwards, the sterilization processing 12-24 hours under UV light sterilization lamp；
Step (5)：The herb powder that step (4) obtains is fitted into capsule, that is, the Chinese medicine glue for the chronic nephritis that obtains medical treatment
Capsule.
Pulvis is made in embodiment 8
The preparation method of the Chinese medicine composition for the treatment of chronic nephritis described in embodiment 1-6, formulation are pulvis, including as follows
Step：
Step (1)：According to it is described treatment chronic nephritis Chinese medicine composition parts by weight of raw materials weigh rhizoma atractylodis macrocephalae, damp sunset,
Umbellate pore furgus, rhizoma imperatae, stem pith of the rice-paper plant, pivots storage, akebi, plantain seed, Hedyotidis Diffusae, Radix Angelicae Sinensis, the radix paeoniae rubrathe, the red sage root, motherwort, Radix Notoginseng, amber；
Step (2)：The Chinese medicine material weighed in step (1) is placed in clear water and soaks 10-15min, is removed miscellaneous in medicinal powder
Thing；
Step (3)：Chinese medicine material obtained by step (2) is pulled out from water, is placed under natural light and dries；Dry rear aqueous
Rate is controlled less than or equal to 98%；
Step (4)：Step (3) dried Chinese medicine is placed in grinding machine for Chinese herb medicines and pulverized, crosses 500-800 mesh sieves point
Afterwards, the sterilization processing 12-24 hours under UV light sterilization lamp；
Step (5)：The herb powder that step (4) obtains is fitted into Chinese medicine net bag, that is, in the chronic nephritis that obtains medical treatment
Medicine powder.
Decoction is made in embodiment 9
The preparation method of the Chinese medicine composition for the treatment of chronic nephritis described in embodiment 1-6, formulation are decoction, including as follows
Step：
Step (1)：According to it is described treatment chronic nephritis Chinese medicine composition parts by weight of raw materials weigh rhizoma atractylodis macrocephalae, damp sunset,
Umbellate pore furgus, rhizoma imperatae, stem pith of the rice-paper plant, pivots storage, akebi, plantain seed, Hedyotidis Diffusae, Radix Angelicae Sinensis, the radix paeoniae rubrathe, the red sage root, motherwort, Radix Notoginseng, amber；
Step (2)：The Chinese medicine material weighed in step (1) is placed in medicine pot, and adds clear water immersion 30min, is removed
Debris in medicinal powder；The addition of clear water is advisable with flooding all Chinese medicine materials, after immersion, after boiling by intense fire, and slow fire heating
30-50 minutes, filter to obtain a decoction；
Step (3)：Add clear water in the dregs of a decoction into step (2) in marmite, the addition of clear water is to flood all dregs of a decoction
It is advisable, carries out second and decoct, first boil by intense fire, then be cooked by slow fire 30 minutes, filters to obtain secondary decoction；
Step (4)：Gained decoction in step (2) and step (3) is merged, pack, ice is placed in after naturally cooling to room temperature
Refrigerated in case, refrigerated storage temperature is controlled at 0-5 DEG C, and the traditional Chinese herbal decoction for the treatment of chronic nephritis is thus made.
Toxicity test
The suitable Adult mouse 40 of body weight is chosen, is divided into control group and administration group, rearing conditions are consistent, and control group is not
Medicine feed, the daily medicine feed of administration group 1 time, records the health of each small white mouse, ingests, drinks water, body weight daily, test duration six
Individual month, compared with control group, administration group small white mouse health, ingest, drink water, body weight increase it is normal, and have no small white mouse
It is sick or dead.Prompt the medicine security good, have no toxic side effect.
The present invention has carried out clinical efficacy tracking with the data given by embodiment 5, and curative effect is summarized as follows：
1. choosing chronic nephritis case load 450, average age 45 years old, patient is randomly divided into four groups, treatment group 150
There was no significant difference for the data such as example, control group 300, two groups of ages, has comparativity.
2. treatment method, the oral Chinese medicine composition made from optimization formula embodiment 5 of the present invention for the treatment of group, per bu sooner or later
Decoction, course for the treatment of 3-5 weeks are taken twice.
3. diagnostic criteria
Reference《Modern Chinese medicine clinical diagnostics》In diagnosis basis carry out clinical diagnosis：
Cure：That is the basic illness such as oedema, pain in the back, blood urine disappears, and urine protein examination continues negative or 24h quantity of proteinuria
＜ 0.2g, under the observation of high power lens, it can be found that urine erythrocyte disappears, arena counts normal, normal renal function；
It is effective：The cardinal symptoms such as the oedema of patient, pain in the back, blood urine disappear, and urine protein examination persistently reduces more than 50%, high
Urine erythrocyte, which counts, under times mirror is no more than 3, and arena counts normal, but stable renal function is not recovered significantly；
Take a turn for the better：The symptoms such as the oedema of patient have been clearly better, and urine protein examination is persistently reduced to 1, or 24h Urine proteins
Quantitative continuous reduces more than 25%, and urine erythrocyte is counted less than 5 under high power lens, and renal function has certain recovery；
It is invalid：The symptom of patient, sign, laboratory examination do not reach effective standard.
Total effective rate=(cure+effective+take a turn for the better)/n × 100%.
4. clinical observation experiment result：
Case load 450, wherein treatment group 150；Control group 300, control group stochastic averagina are divided into three groups, every group 100
Example.
Treatment group：The preparation method that the prescription used provides for the prescription of embodiment 5, embodiment 9,
Control group 1：Using scarce monarch drug in a prescription (rhizoma atractylodis macrocephalae)：A kind of Chinese medicine composition for treating chronic nephritis, with parts by weight
Meter, the Chinese medicine composition are made up of the raw material of following parts by weight：Damp 25 parts of sunset, 15 parts of umbellate pore furgus, 25 parts of rhizoma imperatae, 13 parts of the stem pith of the rice-paper plant,
20 parts of pivot storage, 15 parts of akebi, 15 parts of plantain seed, 20 parts of Hedyotidis Diffusae, 18 parts of Radix Angelicae Sinensis, 15 parts of the radix paeoniae rubrathe, 25 parts of the red sage root, motherwort 13
Part, 15 parts of Radix Notoginseng, 15 parts of amber.
Control group 2：Using scarce ministerial drug (damp sunset)：A kind of Chinese medicine composition for treating chronic nephritis, in parts by weight,
The Chinese medicine composition is made up of the raw material of following parts by weight：7 parts of rhizoma atractylodis macrocephalae, 15 parts of umbellate pore furgus, 25 parts of rhizoma imperatae, the Fen, pivots of the stem pith of the rice-paper plant 13
20 parts of storage, 15 parts of akebi, 15 parts of plantain seed, 20 parts of Hedyotidis Diffusae, 18 parts of Radix Angelicae Sinensis, 15 parts of the radix paeoniae rubrathe, 25 parts of the red sage root, motherwort 13
Part, 15 parts of Radix Notoginseng, 15 parts of amber.
Control group 3：Using scarce ministerial drug (umbellate pore furgus)：A kind of Chinese medicine composition for treating chronic nephritis, in parts by weight,
The Chinese medicine composition is made up of the raw material of following parts by weight：7 parts of rhizoma atractylodis macrocephalae, 25 parts of damp sunset, 25 parts of rhizoma imperatae, the Fen, pivots of the stem pith of the rice-paper plant 13
20 parts of storage, 15 parts of akebi, 15 parts of plantain seed, 20 parts of Hedyotidis Diffusae, 18 parts of Radix Angelicae Sinensis, 15 parts of the radix paeoniae rubrathe, 25 parts of the red sage root, motherwort 13
Part, 15 parts of Radix Notoginseng, 15 parts of amber.
Treatment group, male 75, women 75, age 20-70 year, -2 years March of disease time.Treatment cycle is 3-5
The course for the treatment of, cure rate 66%, obvious effective rate 75%, effective percentage 85%.
Control group 1, male 50, women 50, age 20-70 year, -2 years March of disease time.Treatment cycle is 3-5
The course for the treatment of, cure rate 6%, obvious effective rate 25%, effective percentage are 30%.
Control group 2, male 50, women 50, age 20-70 year, -2 years March of disease time.Treatment cycle is 3-5
The course for the treatment of, cure rate 8%, obvious effective rate 15%, effective percentage are 35%.
Control group 3, male 50, women 50, age 20-70 year, -2 years March of disease time.Treatment cycle is 3-5
The course for the treatment of, cure rate 10%, obvious effective rate 20%, effective percentage are 35%.
5. model case
5.1 weeks certain, man, 45 years old.It is nose heave, chronic kidney disease is diagnosed as by doctor trained in Western medicine, is controlled using Western medicine, is not felt any better,
Big in view of Western medicine toxic side effect, patient is treated to the traditional chinese medical science clinic where inventor then, edema of lower extremity, four limbs burnout without
Power, malt sugar of defecating, clear length is urinated, thick greasy fur, actually wet turbid disease, gives Chinese medicine provided by the invention, edema of lower extremity after one week
Disappearing, stool malt sugar and the clear long symptom of urine also disappear, and there is no the disease of four limbs lassitude after two weeks, mental restoration is normal,
For after treatment, and medication one week.Visited after half a year：Without recurrence.
5.2 Feng so-and-so, female, 37 years old.The edema of the face, Low Back Pain, night, which sleeps, feels unwell, and oliguria color is red, and thin lingual fur is yellow, and matter is partially red, arteries and veins
As moistening number, urine examination albumen increases, and the existing moderate decline of kidney function test, actually wet turbid disease, gives Chinese medicine provided by the invention,
One week rear face edema, Low Back Pain symptom disappear, and night, which sleeps, after two weeks feels unwell and the red symptom of oliguria color disappears, and is after treatment, again
Medication one week, kidney function test, has recovered normal, patient's recovery from illness.Visited after half a year：Without recurrence.
5.3 Mr. Wangs, female, age：45 years old, CGN 1 year, doctor trained in Western medicine regular treatment hormone, treat maximum agent
Amount is：Prednisone, is during which repeatedly reduced to 4 by prednisone 12/daily, and the state of an illness occurs repeatedly after decrement, originally routine urinalysis
Normal to be changed into abnormal, Urine proteins (++) red blood cell (+++), normal renal function, haemocyanin is normal.Patient when medical
All right, stomach receives normal, no abdominal distension, and lower limb are without edema, and urine amount is normal, slightly muddy, and stool is normal.Using this implementation
Check after the prescription treatment of example 5：Treatment is checked for 1 month, Urine proteins (++) red blood cell (++)；Treatment is checked for 2 months, Urine proteins
(+) red blood cell (++)；Treatment is checked for 3 months, Urine proteins (+) red blood cell (+)；Treatment is checked for 4 months, Urine proteins (+) red blood cell
(+)；Treatment is checked for 8 months, Urine proteins (-) red blood cell (+)；After treatment is checked after 3 months again, Urine proteins (-) red blood cell
(—)；After treatment is completed to be that 11 months graft functions are normal.
5.4 Liu, female, 56 years old, edema of lower extremity 2 months, soreness and weakness of waist and knees, severe albuminuria；Blood pressure 150/95mmHg, it is clinical
It is diagnosed as chronic nephritis.Remission but fail to effect a radical cure after western medical treatment 2 months, afterwards using Chinese traditional treatment, use the present invention
2 courses for the treatment of of medicine after, patient clinical symptom disappears more than half, rear to continue 2 courses for the treatment of of after treatment, patient's recovery from illness, and follow-up 1 year is not
Recurrence.
5.5 Lins, man 35 years old, face and edema of lower extremity, weak pain in the back, 24 hours quantification of 3g of Urine proteins, begin in urine
There are red blood cell+1~+3 eventually, be diagnosed as chronic nephritis.After 2 courses for the treatment of of drug therapy using the present invention, patient symptom disappears big
Half, patient fully recovers after continuing to strengthen 2 courses for the treatment of of treatment, and follow-up 1 year is without recurrence.
The foregoing description of the disclosed embodiments, professional and technical personnel in the field are enable to realize or using the present invention.
A variety of modifications to these embodiments will be apparent for those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, it is of the invention
The embodiments shown herein is not intended to be limited to, but more to be met and principles disclosed herein and features of novelty phase
Consistent most wide scope.
Claims (8)
1. a kind of Chinese medicine composition for treating chronic nephritis, it is characterised in that in parts by weight, the Chinese medicine composition is by following heavy
Measure the raw material composition of part：15~20 parts of rhizoma atractylodis macrocephalae, 20~40 parts of damp sunset, 10~20 parts of umbellate pore furgus, 20~30 parts of rhizoma imperatae, the stem pith of the rice-paper plant 10
15~25 parts of~15 Fen, pivots storage, 10~15 parts of akebi, 10~30 parts of plantain seed, 15~30 parts of Hedyotidis Diffusae, Radix Angelicae Sinensis 15~20
Part, 10~20 parts of the radix paeoniae rubrathe, 20~40 parts of the red sage root, 10~15 parts of motherwort, 10~20 parts of Radix Notoginseng, 10~15 parts of amber.
2. it is according to claim 1 treatment chronic nephritis Chinese medicine composition, it is characterised in that the Chinese medicine composition by with
The raw material composition of lower parts by weight：It is 15~20 parts of rhizoma atractylodis macrocephalae, 20~30 parts of damp sunset, 10~20 parts of umbellate pore furgus, 20~30 parts of rhizoma imperatae, logical
Careless 20~25 parts of 10~15 Fen, pivots storage, 10~15 parts of akebi, 10~20 parts of plantain seed, 15~30 parts of Hedyotidis Diffusae, Radix Angelicae Sinensis 15~
20 parts, 10~20 parts of the radix paeoniae rubrathe, 20~30 parts of the red sage root, 10~15 parts of motherwort, 10~20 parts of Radix Notoginseng, 10~15 parts of amber.
3. it is according to claim 2 treatment chronic nephritis Chinese medicine composition, it is characterised in that the Chinese medicine composition by with
The raw material composition of lower parts by weight：17 parts of rhizoma atractylodis macrocephalae, 25 parts of damp sunset, 15 parts of umbellate pore furgus, 25 parts of rhizoma imperatae, the Fen, pivots of the stem pith of the rice-paper plant 13 store 20 parts,
15 parts of akebi, 15 parts of plantain seed, 20 parts of Hedyotidis Diffusae, 18 parts of Radix Angelicae Sinensis, 15 parts of the radix paeoniae rubrathe, 25 parts of the red sage root, 13 parts of motherwort, Radix Notoginseng
15 parts, 15 parts of amber.
4. it is according to claim 2 treatment chronic nephritis Chinese medicine composition, it is characterised in that the Chinese medicine composition by with
The raw material composition of lower parts by weight：20 parts of rhizoma atractylodis macrocephalae, 30 parts of damp sunset, 18 parts of umbellate pore furgus, 26 parts of rhizoma imperatae, the Fen, pivots of the stem pith of the rice-paper plant 17 store 25 parts,
12 parts of akebi, 18 parts of plantain seed, 25 parts of Hedyotidis Diffusae, 17 parts of Radix Angelicae Sinensis, 16 parts of the radix paeoniae rubrathe, 17 parts of the red sage root, 12 parts of motherwort, Radix Notoginseng
20 parts, 12 parts of amber.
5. according to the Chinese medicine composition of any described treatment chronic nephritis of claim 1-4, it is characterised in that the Chinese traditional medicine composition
Any one in pulvis, capsule and decoction can be made in thing.
6. according to the preparation method of the Chinese medicine composition of any described treatment chronic nephritis of claim 1-4, formulation is capsule,
It is characterised in that it includes following steps：
Step (1)：According to it is described treatment chronic nephritis Chinese medicine composition parts by weight of raw materials weigh rhizoma atractylodis macrocephalae, damp sunset, umbellate pore furgus,
Rhizoma imperatae, stem pith of the rice-paper plant, pivots storage, akebi, plantain seed, Hedyotidis Diffusae, Radix Angelicae Sinensis, the radix paeoniae rubrathe, the red sage root, motherwort, Radix Notoginseng, amber；
Step (2)：The Chinese medicine material weighed in step (1) is placed in clear water and soaks 10-15min, removes debris in medicinal powder；
Step (3)：Chinese medicine material obtained by step (2) is pulled out from water, is placed under natural light and dries；Dry rear moisture content control
System is less than or equal to 98%；
Step (4)：Step (3) dried Chinese medicine is placed in grinding machine for Chinese herb medicines and pulverized, after crossing 500-800 mesh sieves point,
The sterilization processing 12-24 hours under UV light sterilization lamp；
Step (5)：The herb powder that step (4) obtains is filled in capsule, that is, the Chinese medicinal capsule for the chronic nephritis that obtains medical treatment.
7. according to the preparation method of the Chinese medicine composition of any described treatment chronic nephritis of claim 1-4, formulation is pulvis,
It is characterised in that it includes following steps：
Step (1)：According to it is described treatment chronic nephritis Chinese medicine composition parts by weight of raw materials weigh rhizoma atractylodis macrocephalae, damp sunset, umbellate pore furgus,
Rhizoma imperatae, stem pith of the rice-paper plant, pivots storage, akebi, plantain seed, Hedyotidis Diffusae, Radix Angelicae Sinensis, the radix paeoniae rubrathe, the red sage root, motherwort, Radix Notoginseng, amber；
Step (2)：The Chinese medicine material weighed in step (1) is placed in clear water and soaks 10-15min, removes debris in medicinal powder；
Step (3)：Chinese medicine material obtained by step (2) is pulled out from water, is placed under natural light and dries；Dry rear moisture content control
System is less than or equal to 98%；
Step (4)：Step (3) dried Chinese medicine is placed in grinding machine for Chinese herb medicines and pulverized, after crossing 500-800 mesh sieves point,
The sterilization processing 12-24 hours under UV light sterilization lamp；
Step (5)：The herb powder that step (4) obtains is fitted into Chinese medicine net bag, that is, the traditional Chinese medicine powder for the chronic nephritis that obtains medical treatment
Agent.
8. according to the preparation method of the Chinese medicine composition of any described treatment chronic nephritis of claim 1-4, formulation is decoction,
It is characterised in that it includes following steps：
Step (1)：According to it is described treatment chronic nephritis Chinese medicine composition parts by weight of raw materials weigh rhizoma atractylodis macrocephalae, damp sunset, umbellate pore furgus,
Rhizoma imperatae, stem pith of the rice-paper plant, pivots storage, akebi, plantain seed, Hedyotidis Diffusae, Radix Angelicae Sinensis, the radix paeoniae rubrathe, the red sage root, motherwort, Radix Notoginseng, amber；
Step (2)：The Chinese medicine material weighed in step (1) is placed in medicine pot, and adds clear water immersion 30min, removes medicinal powder
Middle debris；The addition of clear water is advisable with flooding all Chinese medicine materials, after immersion, after boiling by intense fire, and slow fire heating 30-50
Minute, filter to obtain a decoction；
Step (3)：Clear water is added in the dregs of a decoction into step (2) in marmite, the addition of clear water is advisable with flooding all dregs of a decoction,
Carry out second to decoct, first boil by intense fire, then be cooked by slow fire 30 minutes, filter to obtain secondary decoction；
Step (4)：Gained decoction in step (2) and step (3) is merged, pack, is placed in after naturally cooling to room temperature in refrigerator
Refrigeration, refrigerated storage temperature are controlled at 0-5 DEG C, and the traditional Chinese herbal decoction for the treatment of chronic nephritis is thus made.
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|---|---|---|---|---|
| WO2009097512A1 (en) * | 2008-02-01 | 2009-08-06 | Innovative Drug Discovery Inc. | Herbal pharmaceutical compositions to treat inflammation and inflammation associated conditions and diseases |
| CN103505653A (en) * | 2013-09-25 | 2014-01-15 | 雷光文 | Traditional Chinese medicine preparation for treating acute and chronic nephritis |
| CN104689216A (en) * | 2015-03-30 | 2015-06-10 | 刘军芳 | Medicine for treating chronic nephritis |
-
2017
- 2017-12-08 CN CN201711296439.3A patent/CN107823484A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009097512A1 (en) * | 2008-02-01 | 2009-08-06 | Innovative Drug Discovery Inc. | Herbal pharmaceutical compositions to treat inflammation and inflammation associated conditions and diseases |
| CN103505653A (en) * | 2013-09-25 | 2014-01-15 | 雷光文 | Traditional Chinese medicine preparation for treating acute and chronic nephritis |
| CN104689216A (en) * | 2015-03-30 | 2015-06-10 | 刘军芳 | Medicine for treating chronic nephritis |
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