CN103505653A

CN103505653A - Traditional Chinese medicine preparation for treating acute and chronic nephritis

Info

Publication number: CN103505653A
Application number: CN201310442363.6A
Authority: CN
Inventors: 雷光文; 衡爱萍
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-09-25
Filing date: 2013-09-25
Publication date: 2014-01-15

Abstract

The invention provides a traditional Chinese medicine preparation for treating acute and chronic nephritis. The traditional Chinese medicine preparation is prepared by the following traditional Chinese medicine raw materials in parts by weight: 13-17 parts of semen plantaginis, 18-22 parts of dianthus superbus, 18-22 parts of polygonum aviculare, 11-15 parts of akebia quinata, 13-17 parts of talc, 18-22 parts of salvia miltiorrhiza, 18-22 parts of Chinese yam, 8-10 parts of pseudo-ginseng, 8-10 parts of lignum dalbergiae odoriferae, 40-60 parts of leonurus and 25-35 parts of lalang grass rhizome. The traditional Chinese medicine preparation can change the internal environment of human bodies, can remove poisonous substances in the blood, can eliminate the material bases of various kidney diseases, can effectively promote the recovery of kidney tissue pathologic change, and has an excellent auxiliary treatment effect on the acute and chronic nephritis.

Description

The Chinese medicine preparation for the treatment of acute and chronic nephritis

Technical field

The invention belongs to human drugs technical field, particularly treat the Chinese medicine preparation of acute and chronic nephritis.

Background technology

Acute and chronic nephritis is mainly by occur-serial symptom of the pathological changes of urinary system.Its main manifestations has: (1) edema; (2) hypertension; (3) pain over renal region and renal colic; (4) urinary irritation symptoms (being urgent micturition, dysurea, frequent micturition); (5) paruria (comprises hypourocrinia, albuminuria, hematuria, cylinderuria, leukocyturia, pyuria and bacteriuria, the kidney function test positive etc.Nephritis is a kind of autoimmune disease, conventionally application hormone therapy, its therapeutic outcome is mainly effective to minute lesion type nephritis, other type curative effect is certainly even not invalid, but thing followed side effect, as edema obesity, acne, secondary infection, sclerotin breakage etc., to patient, brought catastrophic effect; The patient that renal function is badly damaged is more difficult in treatment, commonly uses clinically the therapies such as dialysis and renal transplantation.

Summary of the invention

The object of the invention is to provide a kind of Chinese medicine preparation for the treatment of acute and chronic nephritis, coordinates Western medicine to strengthen therapeutic effect to acute and chronic nephritis.

Chinese medicine thinks that the classical symptom that acute and chronic nephritis occurs is edema, be mainly because of being invaded by exogenous pathogen, overstrain internal injury or drinking and eating irregularly, make gas unfavorable, the defeated cloth of body fluid is not normal, cause water retention, overflowing and cause with women's head-ornaments, eyelid, extremity, abdomen and carry on the back even anasarca etc. in skin, return it to arrive internal organs, is mainly that lung, spleen, kidney three are dirty, at " Jing Yue's complete work, swelling " cloud: " card such as all edema; be lung, spleen, the dirty relevant disease of kidney three, lid water is Zhiyin, the fundamental cause of water disease being in the kidney; Aquation is in gas, therefore it is marked on lung; Water is only feared soil, therefore it is built in spleen.The modern deficiency of the lung is vital QI failing to transform into essence and change water, insufficiency of the spleen the spleen failing to restrict the kidney and anti-gram, suffer from a deficiency of the kidney water without main and absurd row." more brilliantly instructed out spleen, lung, kidney three is dirty and the relation of edema syndrome, if kidney qi is more empty, pathogenic water is more contained; contrary, lung is subject to heresy and while importing kidney into, also can causes equifinality; meanwhile, can not controlling the water circulation if insufficiency of the spleen between spleen kidney, water is wet to be stopped up very; must damage its sun; therefore insufficiency of the spleen further developing must cause kidney yang also to decline, if decline of kidney-YANG; can not replenishing vital QI with drugs of warm nature spleen soil, can make edema more very.Therefore lung, spleen, kidney three is dirty and the morbidity of edema, take kidney as this, take lung as mark, and take dirty that spleen is controlling the water circulation, real is the key point of edema pathogenesis, in addition, the pathogenesis of edema and the heart, liver two are dirty also closely related.

According to above understanding, the Chinese medicine preparation for the treatment of acute and chronic nephritis provided by the invention, it is to be made by following weight portion raw material of Chinese medicine: Semen Plantaginis 13-17, Herba Dianthi 18-22, Herba Polygoni Avicularis 18-22, Caulis Akebiae 11-15, Talcum 13-17, Radix Salviae Miltiorrhizae 18-22, Rhizoma Dioscoreae 18-22, Radix Notoginseng 8-10, Lignum Dalbergiae Odoriferae 8-10, Herba Leonuri 40-60, Rhizoma Imperatae 25-35.

Preferential proportioning of recommending is: Semen Plantaginis 15, Herba Dianthi 20, Herba Polygoni Avicularis 20, Caulis Akebiae 13, Talcum 15, Radix Salviae Miltiorrhizae 20, Rhizoma Dioscoreae 20, Radix Notoginseng 9, Lignum Dalbergiae Odoriferae 9, Herba Leonuri 50, Rhizoma Imperatae 30.

Semen Plantaginis, Herba Polygoni Avicularis, Herba Dianthi, Talcum clearing away heat and promoting diuresis, eliminating dampness by diuresis antidiarrheal, liver heat removing and eyesight improving, preventing phlegm from forming and stopping coughing in component of the present invention, promoting blood circulation to restore menstrual flow, damp eliminating sore; With Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, except dryly calming the nerves, repellent antipruritic; Rhizoma Dioscoreae, Herba Leonuri, Radix Notoginseng are for hemostasia and dissipation blood stasis, subduing swelling and relieving pain, supplementing the kidney to control the nocturnal, YIN nourishing and the production of body fluid promoting; With Rhizoma Imperatae clearing away heat and promoting production of body fluid, clearing away heat and cooling blood, inducing diuresis to remove edema.The present invention can change the internal environment of human body, gets rid of the noxious substance in blood, removes the material base of all kinds of nephropathys, can effectively promote the recovery of nephridial tissue pathological change.For acute and chronic nephritis, there is good adjuvant treatment effect.

The specific embodiment

Embodiment 1: the Chinese medicine preparation for the treatment of acute and chronic nephritis, it is to be made by following raw material of Chinese medicine: Semen Plantaginis 13, Herba Dianthi 22, Herba Polygoni Avicularis 18, Caulis Akebiae 15, Talcum 13, Radix Salviae Miltiorrhizae 22, Rhizoma Dioscoreae 18, Radix Notoginseng 10, Lignum Dalbergiae Odoriferae 8, Herba Leonuri 60, Rhizoma Imperatae 25.Unit is gram.Each component cleans up, and makes water decoction after mixing.

Embodiment 2: Semen Plantaginis 15, Herba Dianthi 20, Herba Polygoni Avicularis 20, Caulis Akebiae 13, Talcum 15, Radix Salviae Miltiorrhizae 20, Rhizoma Dioscoreae 20, Radix Notoginseng 9, Lignum Dalbergiae Odoriferae 9, Herba Leonuri 50, Rhizoma Imperatae 30.Unit is gram.Each component cleans up, and makes watered pill dosage form after mixing.

Embodiment 3: Semen Plantaginis 17, Herba Dianthi 18, Herba Polygoni Avicularis 22, Caulis Akebiae 11, Talcum 17, Radix Salviae Miltiorrhizae 18, Rhizoma Dioscoreae 22, Radix Notoginseng 8, Lignum Dalbergiae Odoriferae 10, Herba Leonuri 40, Rhizoma Imperatae 35.Unit is gram.Each component cleans up, and is crushed to 120 orders and makes honeyed pill after mixing.

It is as follows that the present invention treats the routine clinical report of chronic nephritis 68:

1 clinical data

Choose in October, 2011-2012 year JIUYUE and be in hospital and outpatient service patients with chronic glomerulonephritis 68 examples, be divided at random two groups, treatment group 34 examples, matched group 34 examples, treatment group man 19 examples wherein, female's 15 examples, 24～63 years old age; Matched group 34 examples, male 18 examples, female's 16 examples, 23～62 years old age.The equal not statistically significants of difference (P < 0.05) such as two groups of sexes, age, the course of disease, have comparability.

2, diagnostic criteria

Diagnostic criteria with reference to the 2nd national academic conference revision of Nanjing China nephropathy association in 1985.

(1) onset is slow, protracted inflammation, time heavy when light, renal function is faded, can there is anemia in the later stage, electrolyte disturbance, the situations such as blood urea nitrogen, serum creatinine rising.

(2) there are the performances such as albuminuria, hematuria, edema and hypertension in various degree.

(3) in the state of an illness, can bring out acute attack because of reasons such as respiratory tract infection, occur the performance of similar acute nephritis, also have some cases can have the automatic catabasis.

3 Therapeutic Method

Matched group adopts the conventional orally taken for curing of suiting the medicine to the illness of doctor trained in Western medicine.Treatment group adds preparation of the present invention simultaneously, and every twice-daily 7 days is a course for the treatment of, observe the curative effect after 3 courses for the treatment of.

4, criterion of therapeutical effect is treated 3 courses for the treatment of, according to Western medicine diagnose foundation, carries out Clinical efficacy comparison:

(1) cure: clinical symptom disappearance, laboratory checking index normal;

(2) effective: clinical symptoms is clearly better, laboratory checking index is clearly better;

(3) take a turn for the better: clinical symptoms takes a turn for the better, laboratory checking index takes a turn for the better;

(4) invalid: clinical symptoms, lab index are all without improving.

5, two groups of Clinical efficacy comparisons see the following form.

Clinical efficacy statistical table

Group	Number of cases	Cure	Effective	Take a turn for the better	Invalid	Effective percentage
							Treatment group	34	6	19	7	2	94.1％
Matched group	34	0	12	13	9	73.5％

Two groups of effective percentage have significant difference, (P < 0.05)

By table, shown, the curative effect for the treatment of group is better than matched group.In clinical practice, find, take medicine patient clinical symptom of the present invention and improve obviously, mental status is obviously better than matched group patient.

6, conclusion: the present invention can change the internal environment of human body, gets rid of the noxious substance in blood, removes the material base of all kinds of nephropathys.Radix Salviae Miltiorrhizae GUIXIN in prescription, Liver Channel, can stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and relieving restlessness clears away heart-fire.Effective ingredient contained in Radix Salviae Miltiorrhizae has the microcirculation of improvement, anticoagulant, promotion fibrinolytic, and anticoagulant, suppresses thrombotic effect.Clinical pharmacology shows that its contained TANSHINONES has anticoagulant, removes fibre, thrombolytic and effect for reducing fat, can effectively promote the recovery of nephridial tissue pathological change.Component has no side effect, economical convenient: this method to improving patient's symptom, maintain its life and play a part certain.At we's auxiliary lower patient suitably decrement hormone and the number of times of dialysing, add the relatively cheap and taking convenience of consumption cost, greatly alleviated the burden of patient on economy, body and mind.

Claims

1. the Chinese medicine preparation for the treatment of acute and chronic nephritis, is characterized in that being made by following weight portion raw material of Chinese medicine: Semen Plantaginis 13-17, Herba Dianthi 18-22, Herba Polygoni Avicularis 18-22, Caulis Akebiae 11-15, Talcum 13-17, Radix Salviae Miltiorrhizae 18-22, Rhizoma Dioscoreae 18-22, Radix Notoginseng 8-10, Lignum Dalbergiae Odoriferae 8-10, Herba Leonuri 40-60, Rhizoma Imperatae 25-35.

2. the Chinese medicine preparation for the treatment of acute and chronic nephritis according to claim 1, is characterized in that being made by following weight portion raw material of Chinese medicine: Semen Plantaginis 15, Herba Dianthi 20, Herba Polygoni Avicularis 20, Caulis Akebiae 13, Talcum 15, Radix Salviae Miltiorrhizae 20, Rhizoma Dioscoreae 20, Radix Notoginseng 9, Lignum Dalbergiae Odoriferae 9, Herba Leonuri 50, Rhizoma Imperatae 30.