CN109010656A - A kind of Chinese medicine for treating decompensated liver cirrhosis - Google Patents

A kind of Chinese medicine for treating decompensated liver cirrhosis Download PDF

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Publication number
CN109010656A
CN109010656A CN201811325862.6A CN201811325862A CN109010656A CN 109010656 A CN109010656 A CN 109010656A CN 201811325862 A CN201811325862 A CN 201811325862A CN 109010656 A CN109010656 A CN 109010656A
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spleen
liver
stagnation
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张泽钧
丁恒亚
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994Coix (Job's tears)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/62Nymphaeaceae (Water-lily family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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  • Alternative & Traditional Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
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Abstract

The invention discloses a kind of Chinese medicines for treating decompensated liver cirrhosis, medicine preparation including following parts by weight forms: the radix bupleuri of 5-15 parts by weight, the rhizoma cyperi of 5-10 parts by weight, the semen coicis of 10-20 parts by weight, the Gorgon fruit of 15-25 parts by weight, the rhizome of chuanxiong of 5-10 parts by weight, the rhizoma corydalis of 5-10 parts by weight, the Radix Glycyrrhizae of 5-10 parts by weight.The present invention is according to traditional Chinese medical theory, and theoretical using diagnosis and treatment carries out Chinese prescription screening, and formula is scientific and reasonable, and configuration is simple, has no toxic side effect, curative effect is short, quick.We are using soothing liver-qi stagnation, invigorating the spleen to clear away damp pathogen, the promoting flow of qi and blood circulation as principle of reatment, for the patient of liver and spleen blood stasis defect type decompensated liver cirrhosis, for its stagnation of liver qi, perverse and unreasonable manner multiplies spleen, the dysfunction of the spleen in transport, water-damp not being transformed, so that the stagnation of the circulation of vital energy, blood stasis hand over the cause of disease and primary symptom of resistance, first based on soothing liver-qi stagnation, supplemented by invigorating the spleen to clear away damp pathogen, the last promoting flow of qi and blood circulation, perfect square have the effect of soothing liver-qi stagnation, invigorating the spleen to clear away damp pathogen, promoting flow of qi and blood circulation.

Description

A kind of Chinese medicine for treating decompensated liver cirrhosis
Technical field
The present invention relates to a kind of Chinese medicines for treating decompensated liver cirrhosis, lose generation more particularly to a kind of liver and spleen blood stasis defect type for the treatment of Repay the Chinese medicine of cirrhosis.
Background technique
Cirrhosis is clinical common chronic progressive hepatopathy, by one or more causes of disease are long-term or repeated action formed Diffusivity hepatic lesion.Cirrhosis is divided into " accumulation " and " bulging " by Chinese medicine, and accumulation refers to Decompensated cirrhosis, and bulging, which refers to, loses generation Repay cirrhosis, bulging is that the state of an illness is further aggravated on the basis of accumulation.
There are many card types for decompensated liver cirrhosis, and wherein liver and spleen blood stasis defect type decompensated liver cirrhosis belongs to wherein more special Different one kind, liver and spleen blood stasis defect type have embodiment in cirrhosis compensatory phase and cirrhosis patients in decompensation, but no due to its primary symptom etc. With factor, the principle of reatment of the two but it is different.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of with strong points, at low cost, and quick, cure rate is high, nontoxic The Chinese medicine of the special treatment liver and spleen blood stasis defect type decompensated liver cirrhosis of side effect.
The technical scheme is that being achieved: a kind of Chinese medicine for treating decompensated liver cirrhosis, including following weight The medicine preparation of number forms: the radix bupleuri of 5-15 parts by weight, the rhizoma cyperi of 5-10 parts by weight, the coix lacryma-jobi of 10-20 parts by weight Benevolence, the Gorgon fruit of 15-25 parts by weight, the rhizome of chuanxiong of 5-10 parts by weight, the rhizoma corydalis of 5-10 parts by weight, 5-10 parts by weight Radix Glycyrrhizae.
Technical solution of the present invention can be achieved in that
A kind of Chinese medicine for treating decompensated liver cirrhosis, the medicine preparation including following parts by weight form: 10 parts by weight Radix bupleuri, the rhizoma cyperi of 8 parts by weight, the semen coicis of 15 parts by weight, the Gorgon fruit of 20 parts by weight, the rhizome of chuanxiong of 8 parts by weight, 8 weights Measure the rhizoma corydalis of number, the Radix Glycyrrhizae of 7 parts by weight.
Chinese medicine of the invention the preparation method is as follows:
Step 1: semen coicis, Gorgon fruit are cleaned, spare;
Step 2: radix bupleuri, rhizome of chuanxiong, rhizoma corydalis, Radix Glycyrrhizae being cleaned, is cleaned, is pulled out after being soaked in water, moisturize slice, dry, standby With;
Step 3: removing feeler and impurity for rhizoma cyperi, pulverizes or shave, spare;
Step 4: adding suitable quantity of water to set in casserole step 2 stock of drugs and be fried boiling, and is added after truce standby in step 1 and step 3 It with drug, is decocted 10-20 minutes with small fire, pulling the dregs of a decoction out after cooling is patent medicine.
Application method: daily one pair of medicine, every pair of medicine can be decocted three times, be taken in three times, and early, middle and late once a dose before meals.It needs It takes 8-24 months.
The pharmacology of specific each drug ingedient is as follows:
Radix bupleuri: it is bitter, it is slightly cold;Inducing diaphoresis is brought down a fever, soothing liver-qi stagnation, lifting disease.
Rhizoma cyperi: pungent, slight bitter, micro- sweet and neutral;Promoting qi circulation and removing obstruction in the collateral, menstruction regulating and pain relieving.
Semen coicis: it is sweet, light, it is cool;Invigorating the spleen excreting dampness, remove numbness antidiarrheal, heat-clearing row are dense.
Gorgon fruit: it is sweet, puckery, it puts down;Supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, tonifying spleen and stopping diarrhea.
Rhizome of chuanxiong: acrid in flavour and warm in nature;Blood-activating and qi-promoting, wind-expelling pain-stopping.
Rhizoma corydalis: pungent, bitter, temperature;Promoting blood circulation, sharp gas, analgesic.
Radix Glycyrrhizae: sweet and neutral;It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
Function of the invention and the major functions: radix bupleuri embodies we's mainly controlling using soothing liver-qi stagnation as main direction in the present invention It then, is monarch drug in a prescription;The effect of rhizoma cyperi auxiliary radix bupleuri reinforces its soothing liver-qi stagnation, semen coicis invigorating the spleen excreting dampness are ministerial drug;Gorgon fruit reinforces ministerial drug The effect of semen coicis invigorating the spleen excreting dampness, rhizome of chuanxiong, the rhizoma corydalis Papillary promoting flow of qi and blood circulation are adjutant;Radix Glycyrrhizae not only coordinating the drug actions of a prescription, to make Medicine, the effect of prescription invigorating the spleen can also be reinforced.
The effect of playing soothing liver-qi stagnation, invigorating the spleen to clear away damp pathogen, the promoting flow of qi and blood circulation altogether after all medicine collaborations.Though each drug of we plays thin jointly Liver relieve stagnation, invigorating the spleen to clear away damp pathogen, the promoting flow of qi and blood circulation effect, but emphasize particularly on different fields again, above-mentioned effect can be just played after all medicines share.Such as exist In we, radix bupleuri itself has multiple efficacies, also not identical as the effect of rising after different compatibility of drugs, as radix bupleuri can play Clearing liver gallbladder-heat dredges the effect of regulating the qi flowing in the channels machine, can also play liter effect for lifting clear sun, and as monarch drug in a prescription and its other medicine in this prescription Object plays the role of soothing liver-qi stagnation after sharing, without the clearing liver gallbladder-heat that recurs, the effect dredged regulating the qi flowing in the channels machine or rise the clear sun of act.
Beneficial effects of the present invention: for the present invention according to traditional Chinese medical theory, theoretical using diagnosis and treatment carries out Chinese prescription Screening, formula is scientific and reasonable, and configuration is simple, has no toxic side effect, curative effect is short, quick.We with soothing liver-qi stagnation, invigorating the spleen to clear away damp pathogen, The promoting flow of qi and blood circulation is principle of reatment, and for the patient of liver and spleen blood stasis defect type decompensated liver cirrhosis, for its stagnation of liver qi, perverse and unreasonable manner multiplies Spleen, the dysfunction of the spleen in transport, water-damp not being transformed, so that the stagnation of the circulation of vital energy, blood stasis hand over the cause of disease and primary symptom of resistance, first based on soothing liver-qi stagnation, with invigorating the spleen Supplemented by clearing damp, the last promoting flow of qi and blood circulation, perfect square has the effect of soothing liver-qi stagnation, invigorating the spleen to clear away damp pathogen, promoting flow of qi and blood circulation.
Specific embodiment
The present invention is described in further details with reference to embodiments:
Embodiment 1: a kind of Chinese medicine for treating liver and spleen blood stasis defect type decompensated liver cirrhosis, by the medicine preparation of following weight grams At 5 grams of radix bupleuri, 5 grams of rhizoma cyperi, 10 grams of semen coicis, 15 grams of Gorgon fruit, 5 grams of rhizome of chuanxiong, 5 grams of rhizoma corydalis, 5 grams sweet Grass.
Treat the Chinese medicine of liver and spleen blood stasis defect type decompensated liver cirrhosis the preparation method is as follows:
Step 1: semen coicis, Gorgon fruit are cleaned, spare;
Step 2: radix bupleuri, rhizome of chuanxiong, rhizoma corydalis, Radix Glycyrrhizae being cleaned, is cleaned, is pulled out after being soaked in water, moisturize slice, dry, standby With;
Step 3: removing feeler and impurity for rhizoma cyperi, pulverizes or shave, spare;
Step 4: adding suitable quantity of water to set in casserole step 2 stock of drugs and be fried boiling, and is added after truce standby in step 1 and step 3 It with drug, is decocted 10-20 minutes with small fire, pulling the dregs of a decoction out after cooling is patent medicine.
Application method: daily one pair of medicine, every pair of medicine can be decocted three times, be taken in three times, and early, middle and late once a dose before meals.It needs It takes 8-24 months.
Embodiment 2: a kind of Chinese medicine for treating liver and spleen blood stasis defect type decompensated liver cirrhosis, by the drug system of following weight grams It is standby to form: 15 grams of radix bupleuri, 10 grams of rhizoma cyperi, 20 grams of semen coicis, 25 grams of Gorgon fruit, 10 grams of rhizome of chuanxiong, 10 grams of rhizoma corydalis, 10 grams of Radix Glycyrrhizae.
Treat the Chinese medicine of liver and spleen blood stasis defect type decompensated liver cirrhosis the preparation method is as follows:
Step 1: semen coicis, Gorgon fruit are cleaned, spare;
Step 2: radix bupleuri, rhizome of chuanxiong, rhizoma corydalis, Radix Glycyrrhizae being cleaned, is cleaned, is pulled out after being soaked in water, moisturize slice, dry, standby With;
Step 3: removing feeler and impurity for rhizoma cyperi, pulverizes or shave, spare;
Step 4: adding suitable quantity of water to set in casserole step 2 stock of drugs and be fried boiling, and is added after truce standby in step 1 and step 3 It with drug, is decocted 10-20 minutes with small fire, pulling the dregs of a decoction out after cooling is patent medicine.
Application method: daily one pair of medicine, every pair of medicine can be decocted three times, be taken in three times, and early, middle and late once a dose before meals.It needs It takes 8-24 months.
Embodiment 3: a kind of Chinese medicine for treating liver and spleen blood stasis defect type decompensated liver cirrhosis, by the drug system of following weight grams It is standby to form: 10 grams of radix bupleuri, 8 grams of rhizoma cyperi, 15 grams of semen coicis, 20 grams of Gorgon fruit, 8 grams of rhizome of chuanxiong, 8 grams of rhizoma corydalis, 7 grams Radix Glycyrrhizae.
Treat the Chinese medicine of liver and spleen blood stasis defect type decompensated liver cirrhosis the preparation method is as follows:
Step 1: semen coicis, Gorgon fruit are cleaned, spare;
Step 2: radix bupleuri, rhizome of chuanxiong, rhizoma corydalis, Radix Glycyrrhizae being cleaned, is cleaned, is pulled out after being soaked in water, moisturize slice, dry, standby With;
Step 3: removing feeler and impurity for rhizoma cyperi, pulverizes or shave, spare;
Step 4: adding suitable quantity of water to set in casserole step 2 stock of drugs and be fried boiling, and is added after truce standby in step 1 and step 3 It with drug, is decocted 10-20 minutes with small fire, pulling the dregs of a decoction out after cooling is patent medicine.
Application method: daily one pair of medicine, every pair of medicine can be decocted three times, be taken in three times, and early, middle and late once a dose before meals.It needs It takes 8-24 months.
Embodiment 4: a kind of Chinese medicine for treating liver and spleen blood stasis defect type decompensated liver cirrhosis, by the drug system of following weight grams It is standby to form: 9 grams of radix bupleuri, 6 grams of rhizoma cyperi, 12 grams of semen coicis, 18 grams of Gorgon fruit, 6 grams of rhizome of chuanxiong, 6 grams of rhizoma corydalis, 6 grams Radix Glycyrrhizae.
Treat the Chinese medicine of liver and spleen blood stasis defect type decompensated liver cirrhosis the preparation method is as follows:
Step 1: semen coicis, Gorgon fruit are cleaned, spare;
Step 2: radix bupleuri, rhizome of chuanxiong, rhizoma corydalis, Radix Glycyrrhizae being cleaned, is cleaned, is pulled out after being soaked in water, moisturize slice, dry, standby With;
Step 3: removing feeler and impurity for rhizoma cyperi, pulverizes or shave, spare;
Step 4: adding suitable quantity of water to set in casserole step 2 stock of drugs and be fried boiling, and is added after truce standby in step 1 and step 3 It with drug, is decocted 10-20 minutes with small fire, pulling the dregs of a decoction out after cooling is patent medicine.
Application method: daily one pair of medicine, every pair of medicine can be decocted three times, be taken in three times, and early, middle and late once a dose before meals.It needs It takes 8-24 months.
The result of clinical observation of the present invention is as follows:
Effective cure rate of Chinese medicine of the invention counts, and criterion of therapeutical effect is as follows:
Cure: symptom, sign disappear;
Effective: symptom, sign disappearance make moderate progress;
Invalid: symptom, sign are without change.
The present invention treats patient totally 4 of the liver and spleen blood stasis defect type decompensated liver cirrhosis for participating in statistics, in which: recovery from illness 1, Effective 2, invalid 1, total effective rate reaches 75%.
Typical case:
Rather so-and-so, male, 55 years old, is unable to leave the bed, and figure is thin, and abdominal distention, skin has ecchymosis, treats by here, and 14 It fully recovers after month.

Claims (3)

1. a kind of Chinese medicine for treating decompensated liver cirrhosis, it is characterised in that: the medicine preparation including following parts by weight forms: The radix bupleuri of 5-15 parts by weight, the rhizoma cyperi of 5-10 parts by weight, the semen coicis of 10-20 parts by weight, the Gorgon euryale of 15-25 parts by weight It is real, the rhizome of chuanxiong of 5-10 parts by weight, the rhizoma corydalis of 5-10 parts by weight, the Radix Glycyrrhizae of 5-10 parts by weight.
2. a kind of Chinese medicine for treating decompensated liver cirrhosis according to claim 1, it is characterised in that: including following weight The medicine preparation of number forms: the radix bupleuri of 10 parts by weight, the rhizoma cyperi of 8 parts by weight, the semen coicis of 15 parts by weight, 20 weight The Gorgon fruit of number, the rhizome of chuanxiong of 8 parts by weight, the rhizoma corydalis of 8 parts by weight, the Radix Glycyrrhizae of 7 parts by weight.
3. a kind of preparation method of the Chinese medicine for the treatment of decompensated liver cirrhosis as claimed in claim 1 or 2, preparation method is such as Under:
Step 1: semen coicis, Gorgon fruit are cleaned, spare;
Step 2: radix bupleuri, rhizome of chuanxiong, rhizoma corydalis, Radix Glycyrrhizae being cleaned, is cleaned, is pulled out after being soaked in water, moisturize slice, dry, standby With;
Step 3: removing feeler and impurity for rhizoma cyperi, pulverizes or shave, spare;
Step 4: adding suitable quantity of water to set in casserole step 2 stock of drugs and be fried boiling, and is added after truce standby in step 1 and step 3 It with drug, is decocted 10-20 minutes with small fire, pulling the dregs of a decoction out after cooling is patent medicine.
CN201811325862.6A 2018-11-08 2018-11-08 A kind of Chinese medicine for treating decompensated liver cirrhosis Withdrawn CN109010656A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103083590A (en) * 2013-02-04 2013-05-08 郭丽曼 Medicine used for treating decompensated liver cirrhosis, and preparation method thereof
CN104840883A (en) * 2015-05-15 2015-08-19 朱黎明 Traditional Chinese medicine for treating decompensated liver cirrhosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103083590A (en) * 2013-02-04 2013-05-08 郭丽曼 Medicine used for treating decompensated liver cirrhosis, and preparation method thereof
CN104840883A (en) * 2015-05-15 2015-08-19 朱黎明 Traditional Chinese medicine for treating decompensated liver cirrhosis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
谭元生等: "《新编中医手册》", 31 July 2017 *

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Application publication date: 20181218