CN104837982B - 用于体外组织和器官的再生功能单元的微流体系统 - Google Patents

用于体外组织和器官的再生功能单元的微流体系统 Download PDF

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CN104837982B
CN104837982B CN201380056928.5A CN201380056928A CN104837982B CN 104837982 B CN104837982 B CN 104837982B CN 201380056928 A CN201380056928 A CN 201380056928A CN 104837982 B CN104837982 B CN 104837982B
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matrix
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cells
lumen
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CN104837982A (zh
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T·诺伊曼
A·A·图鲁乌斯卡咿亚
M·E·福弗
G·克莱默
E·阿斯普
H·曼恩
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NORTIS Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/128—Chemically defined matrices for immobilising, holding or storing living parts, e.g. alginate gels; Chemically altering living parts, e.g. by cross-linking
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A01N1/143—Apparatus for organ perfusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
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    • C12M23/20—Material Coatings
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    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
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    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
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    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5085—Supracellular entities, e.g. tissue, organisms of invertebrates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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CN201380056928.5A 2012-09-29 2013-09-27 用于体外组织和器官的再生功能单元的微流体系统 Active CN104837982B (zh)

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US201261707907P 2012-09-29 2012-09-29
US61/707,907 2012-09-29
US201261721002P 2012-10-31 2012-10-31
US61/721,002 2012-10-31
PCT/US2013/062307 WO2014052835A1 (en) 2012-09-29 2013-09-27 Microfluidic system for reproducing functional units of tissues and organs in vitro

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CN104837982A CN104837982A (zh) 2015-08-12
CN104837982B true CN104837982B (zh) 2017-11-21

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US (3) US20150240194A1 (https=)
EP (1) EP2900801A4 (https=)
JP (1) JP6396909B2 (https=)
CN (1) CN104837982B (https=)
AU (1) AU2013323222A1 (https=)
CA (1) CA2886247C (https=)
HK (1) HK1213287A1 (https=)
IN (1) IN2015DN02696A (https=)
WO (1) WO2014052835A1 (https=)

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CN110108622B (zh) * 2019-06-17 2024-02-02 辽宁中医药大学 一种离体微血管内皮屏障功能检测方法与设备
CN110295111A (zh) * 2019-07-15 2019-10-01 清华大学深圳研究生院 一种仿生血管网络肿瘤细胞外渗迁移的装置
CN114410466A (zh) * 2020-04-01 2022-04-29 沈西凌 用于个性化癌症治疗的精确药物筛选
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EP2900801A4 (en) 2016-06-22
WO2014052835A1 (en) 2014-04-03
HK1213287A1 (zh) 2016-06-30
US20250066703A1 (en) 2025-02-27
EP2900801A1 (en) 2015-08-05
JP2015533083A (ja) 2015-11-19
CA2886247A1 (en) 2014-04-03
AU2013323222A1 (en) 2015-04-09
IN2015DN02696A (https=) 2015-09-04
US20150240194A1 (en) 2015-08-27
CA2886247C (en) 2023-01-03
CN104837982A (zh) 2015-08-12
US20190062684A1 (en) 2019-02-28
JP6396909B2 (ja) 2018-09-26

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