AU2013323222A1 - Microfluidic system for reproducing functional units of tissues and organs in vitro - Google Patents
Microfluidic system for reproducing functional units of tissues and organs in vitro Download PDFInfo
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- C12M23/00—Constructional details, e.g. recesses, hinges
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- C12M23/20—Material Coatings
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- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
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- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
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- C—CHEMISTRY; METALLURGY
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- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
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- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
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- C—CHEMISTRY; METALLURGY
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5085—Supracellular entities, e.g. tissue, organisms of invertebrates
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| PCT/US2013/062307 WO2014052835A1 (en) | 2012-09-29 | 2013-09-27 | Microfluidic system for reproducing functional units of tissues and organs in vitro |
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| KR101741815B1 (ko) | 2014-05-23 | 2017-06-16 | 서강대학교산학협력단 | 세포 공동-배양을 위한 하이드로젤 기반 미세유체칩 |
| EP3161052A4 (en) * | 2014-06-26 | 2018-03-21 | Northeastern University | Microfluidic device and method for analysis of tumor cell microenvironments |
| EP3584312A1 (en) * | 2014-06-27 | 2019-12-25 | Angiocrine Bioscience, Inc. | Neural cells expressing adenovirus e4orf1, and methods of making and using the same |
| WO2016064757A1 (en) * | 2014-10-19 | 2016-04-28 | Nortis, Inc. | Modular microfluidic system for perfused cell culture |
| WO2016081751A1 (en) * | 2014-11-19 | 2016-05-26 | Nortis, Inc. | Method for vascularizing in-vitro generated or ex-vivo tissue fragments in a microfluidic device |
| GB2588276B (en) * | 2015-04-24 | 2021-07-14 | Harvard College | Devices for simulating a function of a tissue and methods of use and manufacturing thereof |
| CA2983821A1 (en) * | 2015-04-24 | 2017-01-05 | President And Fellows Of Harvard College | Devices for simulating a function of a tissue and methods of use and manufacturing thereof |
| CN104849439B (zh) * | 2015-04-30 | 2017-01-18 | 四川农业大学 | 一种高效检测纳米颗粒肾毒性的方法 |
| EP3334821A4 (en) * | 2015-08-14 | 2019-07-17 | The General Hospital Corporation | SYSTEMS AND METHOD FOR USING BIOMIMETIC STRUCTURES FOR COMMUNICATION IN LIVING TISSUE |
| GB201613187D0 (en) * | 2016-07-29 | 2016-09-14 | Univ Central Lancashire | Blood brain barrier model |
| WO2018026784A1 (en) * | 2016-08-01 | 2018-02-08 | University Of Georgia Research Foundation, Inc. | In situ cell delivery using reconstituted photopolymerized chondroitin sulfate glycosaminoglycan hydrogel matrices |
| CN110997900B (zh) * | 2017-07-14 | 2024-06-14 | 多伦多大学管理委员会 | 用于快速产生用于化合物筛选的类器官/球状体的微流体平台 |
| US12036550B2 (en) | 2017-08-28 | 2024-07-16 | The Regents Of The University Of California | Microfluidic device for the digestion of tissues into cellular suspensions |
| US11499128B2 (en) | 2017-09-22 | 2022-11-15 | The Regents Of The University Of Colorado | Organ-on-chip microphysiological system |
| WO2019079725A1 (en) | 2017-10-19 | 2019-04-25 | Georgia Tech Research Corporation | MESOFLUIDIC DEVICE FOR CULTIVATION OF CELLULAR AGGREGATES |
| KR102124420B1 (ko) * | 2017-11-02 | 2020-06-18 | 한국과학기술연구원 | 선 스트레인의 조합 및 물성에 따른 구조체 내 미세섬유 정렬 제어 방법 |
| EP3728552B1 (en) * | 2017-12-22 | 2021-05-26 | TissUse GmbH | Microfluidic devices implementing blood and urine circuit for emulating homeostatic microphysiological system |
| CN111670245B (zh) * | 2017-12-22 | 2024-03-12 | 蒂斯由斯股份有限公司 | 建立将iPSC衍生的细胞分化为器官等效物的新型多器官芯片 |
| US11679546B2 (en) | 2018-02-09 | 2023-06-20 | The Regents Of The University Of Colorado, A Body Corporate | Bioprinter and methods of manufacturing an organomimetic device |
| CN112154201B (zh) * | 2018-05-22 | 2024-12-27 | 形态细胞科技公司 | 灌注生物反应器、灌注器件、人造肝脏系统及相关方法 |
| US11480560B2 (en) | 2018-06-11 | 2022-10-25 | The Regents Of The University Of Colorado, A Body Corporate | Delivery of aerosolized respiratory pathogens |
| GB201901273D0 (en) * | 2019-01-30 | 2019-03-20 | Stemnovate Ltd | Method and apparatus for real time monitoring of cell and tissue culture |
| CN110108622B (zh) * | 2019-06-17 | 2024-02-02 | 辽宁中医药大学 | 一种离体微血管内皮屏障功能检测方法与设备 |
| CN110295111A (zh) * | 2019-07-15 | 2019-10-01 | 清华大学深圳研究生院 | 一种仿生血管网络肿瘤细胞外渗迁移的装置 |
| CN114410466A (zh) * | 2020-04-01 | 2022-04-29 | 沈西凌 | 用于个性化癌症治疗的精确药物筛选 |
| WO2021260735A1 (en) * | 2020-06-26 | 2021-12-30 | Ykrita Lifesciences Private Limited | Bioengineered artificial lateral liver (ball) or bioengineered artificial ectopic liver (bael) |
| US20220062895A1 (en) * | 2020-08-27 | 2022-03-03 | Wisconsin Alumni Research Foundation | Microfluidic Device And Method Of Assaying For Immune Cell Exhaustion Using Same |
| CA3211524A1 (en) * | 2021-02-19 | 2022-08-25 | The Regents Of The University Of California | Microfluidic device for the digestion of tissues into cellular suspensions |
| CN112958172B (zh) * | 2021-02-24 | 2021-12-28 | 北京航空航天大学 | 一种模拟体内微生物-肠-脑轴信号传导过程的仿生微流控芯片 |
| CN114350515A (zh) * | 2022-01-11 | 2022-04-15 | 中国药科大学 | 用于内皮细胞三维培养灌注的器官芯片及其应用 |
| CN219694996U (zh) * | 2022-03-07 | 2023-09-15 | 武汉大学 | 蛋白质提取多肽水解自动化处理设备 |
| CN114790441A (zh) * | 2022-05-07 | 2022-07-26 | 上海大学 | 一种基于中空微纤维的器官芯片的制备方法及器官芯片 |
| CN114854585B (zh) * | 2022-05-11 | 2022-09-30 | 中国中医科学院中药研究所 | 一种用于中药肝毒性评价的基于微流控体系的精密肝切片培养模型 |
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| US6632666B2 (en) * | 2000-01-14 | 2003-10-14 | Biolife Solutions, Inc. | Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media |
| JP4260627B2 (ja) * | 2001-04-25 | 2009-04-30 | コーネル リサーチ ファンデイション インコーポレイテッド | 薬物動態学に基づく細胞培養システムのためのデバイスおよび方法 |
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| US20060147429A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Facilitated cellular reconstitution of organs and tissues |
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| US8343740B2 (en) * | 2007-03-29 | 2013-01-01 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Micro-organ device |
| CN101372662B (zh) * | 2008-03-18 | 2011-06-08 | 北京航空航天大学 | 一种具有培养腔旋转和血管牵张功能的血管组织工程反应器 |
| EP2455447B1 (en) * | 2009-07-14 | 2019-03-06 | Dai Nippon Printing Co., Ltd. | Microorganism culture sheet and manufacturing method therefor |
| US9810685B2 (en) * | 2010-10-05 | 2017-11-07 | The Regents Of The University Of California | High-throughput platform comprising microtissues perfused with living microvessels |
| US20150087004A1 (en) * | 2012-02-02 | 2015-03-26 | The Trustees Of The University Of Pennsylvania | Microfabricated 3D Cell Culture System |
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