CN104812889B - 通过在低ph下发酵产生有机酸 - Google Patents

通过在低ph下发酵产生有机酸 Download PDF

Info

Publication number
CN104812889B
CN104812889B CN201380058737.2A CN201380058737A CN104812889B CN 104812889 B CN104812889 B CN 104812889B CN 201380058737 A CN201380058737 A CN 201380058737A CN 104812889 B CN104812889 B CN 104812889B
Authority
CN
China
Prior art keywords
gene
genetic modification
yeast cells
acid
yeast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380058737.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN104812889A (zh
Inventor
R·R·约卡姆
S·多勒
J·G·佩罗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PTT Global Chemical PCL
Original Assignee
Myriant Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myriant Corp filed Critical Myriant Corp
Publication of CN104812889A publication Critical patent/CN104812889A/zh
Application granted granted Critical
Publication of CN104812889B publication Critical patent/CN104812889B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56—Lactic acid

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201380058737.2A 2012-09-14 2013-09-13 通过在低ph下发酵产生有机酸 Active CN104812889B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261701293P 2012-09-14 2012-09-14
US61/701,293 2012-09-14
PCT/US2013/059828 WO2014043591A1 (en) 2012-09-14 2013-09-13 Production of organic acids by fermentation at low ph

Publications (2)

Publication Number Publication Date
CN104812889A CN104812889A (zh) 2015-07-29
CN104812889B true CN104812889B (zh) 2018-08-28

Family

ID=50278737

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380058737.2A Active CN104812889B (zh) 2012-09-14 2013-09-13 通过在低ph下发酵产生有机酸

Country Status (9)

Country Link
US (1) US11072807B2 (https=)
EP (1) EP2895593B1 (https=)
JP (3) JP2015528312A (https=)
KR (1) KR102253532B1 (https=)
CN (1) CN104812889B (https=)
BR (1) BR112015005416A2 (https=)
CA (1) CA2884266C (https=)
MY (1) MY182946A (https=)
WO (1) WO2014043591A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2687602A1 (en) 2007-11-20 2014-01-22 DSM IP Assets B.V. Succinic acid production in a eukaryotic cell
KR102311681B1 (ko) * 2015-07-28 2021-10-12 삼성전자주식회사 내산성을 갖는 효모 세포, 그를 이용하여 유기산을 생산하는 방법 및 상기 내산성 효모 세포를 생산하는 방법
KR20190003939A (ko) * 2016-03-02 2019-01-10 피티티지씨 이노베이션 아메리카 코포레이션 유전자 조작된 미생물로부터 개선된 뮤콘산 생산
EP3267345A1 (en) * 2016-07-06 2018-01-10 European Molecular Biology Laboratory Methods for adaptive laboratory evolution
CA3068443A1 (en) 2017-06-30 2019-01-03 Ptt Global Chemical Public Company Limited Genetically modified yeast with increased succinic acid production
EP3645725A1 (en) 2017-06-30 2020-05-06 PTT Global Chemical Public Company Limited Microorganism with stabilized copy number of functional dna sequence and associated methods
WO2019159011A2 (en) 2018-02-16 2019-08-22 Ptt Global Chemical Public Company Limited Microorganisms and processes for lactic acid production
CN108676736B (zh) * 2018-04-20 2020-05-19 华中农业大学 一株可降解柠檬酸的毕赤酵母菌及其应用
US12209236B2 (en) * 2018-05-25 2025-01-28 Danisco Us Inc. Overexpression of fumarate reductase results in an increased fermentation rate in yeast
EP4017515B1 (en) * 2019-08-19 2025-06-25 PTT Global Chemical Public Company Limited Yeast having improvement of lactic acid tolerance and use thereof
CN117467551A (zh) * 2022-07-29 2024-01-30 中国科学院天津工业生物技术研究所 一种高产l-苹果酸的耐酸酵母菌株及其构建方法和应用
CN119875861A (zh) * 2023-10-24 2025-04-25 中国石油化工股份有限公司 一株耐酸马克斯克鲁维酵母菌株及其在生产丁二酸中的应用
CN119162073A (zh) * 2024-11-01 2024-12-20 湖南省微生物研究院 一株柠檬酸杆菌基因工程菌株及其构建方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101365782A (zh) * 2005-11-21 2009-02-11 泰特&莱尔组分美国公司 重组酵母中的苹果酸生产
CN101896606A (zh) * 2007-11-20 2010-11-24 帝斯曼知识产权资产管理有限公司 在重组酵母中生产二羧酸
US20120022546A1 (en) * 2010-06-18 2012-01-26 Vantage Surgical Systems, Inc. Surgical Procedures Using Instrument to Boundary Spacing Information Extracted from Real-Time Diagnostic Scan Data
EP2495304A1 (en) * 2010-12-03 2012-09-05 DSM IP Assets B.V. Dicarboxylic acid production in a yeast cell

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1294728B1 (it) 1997-09-12 1999-04-12 Biopolo S C A R L Ceppi di lievito per la riproduzione di acido lattico
US20070031950A1 (en) 1998-09-11 2007-02-08 Winkler Aaron A Production of D-lactic acid with yeast
US6485947B1 (en) 1999-05-21 2002-11-26 Cargill Dow Polymers, Llc Production of lactate using crabtree negative organisms in varying culture conditions
US7141410B2 (en) 2000-11-22 2006-11-28 Natureworks Llc Methods and materials for the production of organic products in cells of Candida species
RU2182689C1 (ru) 2001-06-14 2002-05-20 Юрий Эдуардович Зевацкий Способ и устройство для охлаждения рабочего тела и способ генерации микроволнового излучения
EP1513939B1 (en) * 2002-05-30 2014-12-31 Cargill Inc. Fermentation process using specific oxygen uptake rates as a process control
BRPI0610951A2 (pt) 2005-06-02 2010-08-03 Cargill Inc levedura geneticamente modificada da espécie issatchenkia orientalis e espécies estreitamente relacionadas e processos de fermentação utilizando as mesmas
JP2009507493A (ja) * 2005-09-09 2009-02-26 ジェノマティカ・インコーポレイテッド 増殖連動型のコハク酸塩生成のための方法と生物
WO2007038130A2 (en) 2005-09-22 2007-04-05 Tate & Lyle Ingredients Americas, Inc. Improved strains for the production of organic acids
ES2527980T3 (es) 2005-10-14 2015-02-02 Toray Industries, Inc. Levadura y procedimiento de producción de ácido L-láctico
US8137953B2 (en) 2005-11-23 2012-03-20 Cargill Inc. Lactic acid-producing yeast cells having nonfunctional L- or D-lactate:ferricytochrome C oxidoreductase cells
DE102007019184A1 (de) * 2007-04-20 2008-10-23 Organo Balance Gmbh Mikroorganismus zur Herstellung von Bernsteinsäure
EP2158323A4 (en) 2007-05-18 2011-06-22 Microbia Prec Engineering Inc PRODUCTION OF ORGANIC ACID BY PILZ CELLS
US20100248233A1 (en) 2007-07-23 2010-09-30 Dsm Ip Assets B.V. Acetyl-coa producing enzymes in yeast
EP2687602A1 (en) 2007-11-20 2014-01-22 DSM IP Assets B.V. Succinic acid production in a eukaryotic cell
EP2222854A1 (en) 2007-11-20 2010-09-01 DSM IP Assets B.V. Dicarboxylic acid production in a filamentous fungus
US20110104771A1 (en) 2008-02-15 2011-05-05 Rene Verwall Process for the production of a dicarboxylic acid
ES2623932T3 (es) 2008-07-08 2017-07-12 Dsm Ip Assets B.V. Producción de ácido succínico por fermentación a bajo pH
DE102008051727A1 (de) 2008-10-17 2010-04-22 Organo Balance Gmbh Mikroorganismus zur Herstellung von Bernsteinsäure
US20100104771A1 (en) 2008-10-24 2010-04-29 Applied Materials, Inc. Electrode and power coupling scheme for uniform process in a large-area pecvd chamber
RU2422526C2 (ru) 2009-01-30 2011-06-27 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов (ФГУП ГосНИИгенетика) СПОСОБ ПОЛУЧЕНИЯ ЯНТАРНОЙ КИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ ДРОЖЖЕЙ, ПРИНАДЛЕЖАЩИХ К РОДУ Yarrowia
AU2010232533A1 (en) * 2009-04-02 2011-10-13 University Of Florida Research Foundation, Inc. Engineering the pathway for succinate production
WO2010118932A1 (en) 2009-04-15 2010-10-21 Dsm Ip Assets B.V. Dicarboxylic acid production process
CN102575235B (zh) * 2009-07-30 2015-05-20 代谢探索者公司 用于通过发酵生产生物化学品的突变甲基乙二醛合酶(mgs)
US9783834B2 (en) 2009-08-27 2017-10-10 Dsm Ip Assets B.V. Dicarboxylic acid fermentation process
WO2011063157A2 (en) 2009-11-18 2011-05-26 Myriant Technologies Llc Organic acid production in microorganisms by combined reductive and oxidative tricarboxylic acid cycle pathways
CA2811539A1 (en) 2010-09-24 2012-03-29 Dsm Ip Assets B.V. Dicarboxylic acid production process
WO2012103263A2 (en) 2011-01-25 2012-08-02 Finley Kenneth R Compositions and methods for malate and fumarate production
EP2668281A4 (en) 2011-01-25 2015-08-26 Cargill Inc COMPOSITIONS AND METHODS OF SUCCINATE MANUFACTURE

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101365782A (zh) * 2005-11-21 2009-02-11 泰特&莱尔组分美国公司 重组酵母中的苹果酸生产
CN101896606A (zh) * 2007-11-20 2010-11-24 帝斯曼知识产权资产管理有限公司 在重组酵母中生产二羧酸
US20120022546A1 (en) * 2010-06-18 2012-01-26 Vantage Surgical Systems, Inc. Surgical Procedures Using Instrument to Boundary Spacing Information Extracted from Real-Time Diagnostic Scan Data
EP2495304A1 (en) * 2010-12-03 2012-09-05 DSM IP Assets B.V. Dicarboxylic acid production in a yeast cell

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
发酵法生产琥珀酸的研究进展;王金主等;《食品与药品》;20100131;第12卷(第01期);55-59页 *

Also Published As

Publication number Publication date
JP6879976B2 (ja) 2021-06-02
EP2895593B1 (en) 2019-12-11
JP2020127417A (ja) 2020-08-27
CN104812889A (zh) 2015-07-29
CA2884266C (en) 2022-05-24
BR112015005416A2 (pt) 2017-08-08
MY182946A (en) 2021-02-05
KR102253532B1 (ko) 2021-05-18
US20150240270A1 (en) 2015-08-27
EP2895593A1 (en) 2015-07-22
US11072807B2 (en) 2021-07-27
EP2895593A4 (en) 2016-06-22
JP2018134108A (ja) 2018-08-30
KR20150055006A (ko) 2015-05-20
JP2015528312A (ja) 2015-09-28
WO2014043591A1 (en) 2014-03-20
CA2884266A1 (en) 2014-03-20

Similar Documents

Publication Publication Date Title
CN104812889B (zh) 通过在低ph下发酵产生有机酸
CN101978063B (zh) 在真核细胞中生产琥珀酸
EP2121915B1 (en) Materials and methods for efficient succinate and malate production
CN101720357B (zh) 用于生产琥珀酸的微生物
Tran et al. Metabolic engineering of Escherichia coli to enhance hydrogen production from glycerol
US8778656B2 (en) Organic acid production in microorganisms by combined reductive and oxidative tricaboxylic acid cylce pathways
US20100184173A1 (en) Microorganisms for the production of methyl ethyl ketone and 2-butanol
US10597684B2 (en) Methods and organisms with increased carbon flux efficiencies
EP2807262A2 (en) Methods for succinate production
US11034982B2 (en) Genetically modified yeast with increased succinic acid production
Skorokhodova et al. Construction of a synthetic bypass for improvement of aerobic synthesis of succinic acid through the oxidative branch of the tricarboxylic acid cycle by recombinant Escherichia coli strains
Jantama Metabolic engineering of Escherichia coli to efficiently produce succinate in mineral salts media
WO2024155699A1 (en) Anaerobic bioproduction of compounds
Skorokhodova et al. Anaerobic biosynthesis of intermediates of reductive branch of tricarboxylic acids cycle by Escherichia coli strains with inactivated frdAB and sdhAB genes
Wood Kien Trung Tran, Toshinari Maeda &
HK1137485B (en) Materials and methods for efficient succinate and malate production

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CB02 Change of applicant information

Address after: Massachusetts, USA

Applicant after: PTTGC innovating American company

Address before: Massachusetts, USA

Applicant before: Myriant Corp.

CB02 Change of applicant information
TR01 Transfer of patent right

Effective date of registration: 20200119

Address after: Bangkok Thailand

Patentee after: PTT Global Chemistry Public Limited

Address before: Massachusetts, USA

Patentee before: PTTGC innovating American company

TR01 Transfer of patent right