CN104812733A - 一种用于制备3-氨基-n-环丙基-2-羟基-己酰胺的方法 - Google Patents

一种用于制备3-氨基-n-环丙基-2-羟基-己酰胺的方法 Download PDF

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Publication number
CN104812733A
CN104812733A CN201380031068.XA CN201380031068A CN104812733A CN 104812733 A CN104812733 A CN 104812733A CN 201380031068 A CN201380031068 A CN 201380031068A CN 104812733 A CN104812733 A CN 104812733A
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CN
China
Prior art keywords
amino
acid
alkyl ester
methyl
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380031068.XA
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English (en)
Chinese (zh)
Inventor
林邦平
王忠美
郭斌
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN2012101939234A external-priority patent/CN102702016A/zh
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Priority to CN201380031068.XA priority Critical patent/CN104812733A/zh
Publication of CN104812733A publication Critical patent/CN104812733A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN201380031068.XA 2012-06-13 2013-06-12 一种用于制备3-氨基-n-环丙基-2-羟基-己酰胺的方法 Pending CN104812733A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201380031068.XA CN104812733A (zh) 2012-06-13 2013-06-12 一种用于制备3-氨基-n-环丙基-2-羟基-己酰胺的方法

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN2012101939234A CN102702016A (zh) 2012-06-13 2012-06-13 一种3-氨基-n-环丙基-2-羟基己酰胺的制备方法
CN2012101939234 2012-06-13
CN2012082591 2012-10-08
CNPCT/CN2012/082591 2012-10-08
CN201380031068.XA CN104812733A (zh) 2012-06-13 2013-06-12 一种用于制备3-氨基-n-环丙基-2-羟基-己酰胺的方法
PCT/EP2013/062121 WO2013186248A1 (en) 2012-06-13 2013-06-12 A method for the preparation of 3-amino-n-cyclopropyl-2-hydroxyl-hexanamide

Publications (1)

Publication Number Publication Date
CN104812733A true CN104812733A (zh) 2015-07-29

Family

ID=48579124

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380031068.XA Pending CN104812733A (zh) 2012-06-13 2013-06-12 一种用于制备3-氨基-n-环丙基-2-羟基-己酰胺的方法

Country Status (5)

Country Link
EP (1) EP2861557A1 (enExample)
CN (1) CN104812733A (enExample)
BR (1) BR112014030870A2 (enExample)
IN (1) IN2014MN02533A (enExample)
WO (1) WO2013186248A1 (enExample)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080108632A1 (en) * 2006-11-02 2008-05-08 Taigen Biotechnology Co., Ltd. Hcv protease inhibitors
CN101186587A (zh) * 2006-11-16 2008-05-28 凯莱英医药化学（天津）有限公司 一种β-氨基酸的衍生物合成方法及其中间产物
EP2039689A1 (en) * 2006-05-26 2009-03-25 Kaneka Corporation Process for production of optically active 3-amino-2 -hydroxypropionic cyclopropylamide derivatives and salts thereof
CN101691338A (zh) * 2009-08-26 2010-04-07 凯莱英生命科学技术(天津)有限公司 一种手性环氧化合物的合成方法及其中间产物与最终产物
WO2010126881A1 (en) * 2009-04-27 2010-11-04 Vertex Pharmaceuticals Incorporated Processes and intermediates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1742913A1 (en) 2003-12-11 2007-01-17 Schering Corporation Inhibitors of hepatitis c virus ns3/ns4a serine protease
NZ571281A (en) 2006-03-16 2011-11-25 Vertex Pharma Processes and intermediates for preparing steric compounds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2039689A1 (en) * 2006-05-26 2009-03-25 Kaneka Corporation Process for production of optically active 3-amino-2 -hydroxypropionic cyclopropylamide derivatives and salts thereof
US20080108632A1 (en) * 2006-11-02 2008-05-08 Taigen Biotechnology Co., Ltd. Hcv protease inhibitors
WO2008057995A2 (en) * 2006-11-02 2008-05-15 Taigen Biotechnology Co., Ltd. Hcv protease inhibitors
CN101186587A (zh) * 2006-11-16 2008-05-28 凯莱英医药化学（天津）有限公司 一种β-氨基酸的衍生物合成方法及其中间产物
WO2010126881A1 (en) * 2009-04-27 2010-11-04 Vertex Pharmaceuticals Incorporated Processes and intermediates
CN101691338A (zh) * 2009-08-26 2010-04-07 凯莱英生命科学技术(天津)有限公司 一种手性环氧化合物的合成方法及其中间产物与最终产物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
孙兴 等: "特拉匹韦", 《中国药物化学杂志》 *

Also Published As

Publication number Publication date
EP2861557A1 (en) 2015-04-22
IN2014MN02533A (enExample) 2015-07-24
BR112014030870A2 (pt) 2017-06-27
WO2013186248A1 (en) 2013-12-19

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Application publication date: 20150729