CN104788492A - 氧化的脂质化合物和其用途 - Google Patents
氧化的脂质化合物和其用途 Download PDFInfo
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- CN104788492A CN104788492A CN201510099273.0A CN201510099273A CN104788492A CN 104788492 A CN104788492 A CN 104788492A CN 201510099273 A CN201510099273 A CN 201510099273A CN 104788492 A CN104788492 A CN 104788492A
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- Prior art keywords
- carboxyl
- glyceryl
- illness
- butyl
- hexadecyl
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- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C07F9/106—Adducts, complexes, salts of phosphatides
-
- C—CHEMISTRY; METALLURGY
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4411—Amides of acyclic unsaturated acids
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Families Citing this family (19)
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| US6838452B2 (en) | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
| US7807847B2 (en) | 2004-07-09 | 2010-10-05 | Vascular Biogenics Ltd. | Process for the preparation of oxidized phospholipids |
| US9006217B2 (en) | 2007-01-09 | 2015-04-14 | Vascular Biogenics Ltd. | High-purity phospholipids |
| US8569529B2 (en) | 2007-01-09 | 2013-10-29 | Vascular Biogenics Ltd. | High-purity phospholipids |
| US8999960B2 (en) | 2008-10-08 | 2015-04-07 | Vascular Biogenics Ltd. | Oxidized thiophospholipid compounds and uses thereof |
| KR20110095288A (ko) * | 2008-11-06 | 2011-08-24 | 바스큘라 바이오제닉스 리미티드 | 산화된 지질 화합물 및 이의 용도 |
| WO2012119781A2 (en) * | 2011-03-10 | 2012-09-13 | University Of Geneva | Novel lipids, phospholipids, phospholipid and lipid compositions and their use |
| SG11201400208PA (en) | 2011-09-01 | 2014-03-28 | Vascular Biogenics Ltd | Formulations and dosage forms of oxidized phospholipids |
| EP2791101B1 (en) * | 2011-12-12 | 2019-09-18 | Vascular Biogenics Ltd. | Treatment of non-alcoholic steatohepatitis |
| CN106999506A (zh) | 2014-11-26 | 2017-08-01 | 脉管生物生长有限公司 | 氧化脂质以及纤维化的治疗或预防 |
| US9771385B2 (en) * | 2014-11-26 | 2017-09-26 | Vascular Biogenics Ltd. | Oxidized lipids |
| EP3735977A1 (en) * | 2015-07-31 | 2020-11-11 | Vascular Biogenics Ltd. | Motile sperm domain containing protein 2 and cancer |
| ES2963268T3 (es) * | 2015-07-31 | 2024-03-26 | Immunewalk Therapeutics Inc | Proteína 2 que contiene el dominio de esperma móvil e inflamación |
| JP6755530B2 (ja) * | 2016-09-02 | 2020-09-16 | 国立大学法人岩手大学 | 皮膚炎の予防又は治療用医薬組成物 |
| WO2021199003A1 (en) * | 2020-04-02 | 2021-10-07 | Vascular Biogenics Ltd. | Oxidized lipids and treatment or prevention of inflammation or infectious disease caused by coronavirus infection |
| JP7559223B2 (ja) | 2020-08-24 | 2024-10-01 | ギリアード サイエンシーズ， インコーポレイテッド | リン脂質化合物及びその使用 |
| IL301202A (en) | 2020-09-10 | 2023-05-01 | Vascular Biogenics Ltd | Antibodies against MOTILE SPERM DOMAIN CONTAINING PROTEIN 2 and methods of using them |
| TWI925033B (zh) | 2020-10-16 | 2026-05-11 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
| AU2023242443A1 (en) * | 2022-03-28 | 2024-08-29 | F. Hoffmann-La Roche Ag | Synthesis of isomerically pure polyol-based phosphoramidites |
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| SG11201400208PA (en) | 2011-09-01 | 2014-03-28 | Vascular Biogenics Ltd | Formulations and dosage forms of oxidized phospholipids |
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| ZA201102872B (en) | 2013-01-30 |
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| CN102271517A (zh) | 2011-12-07 |
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| EP2826370A3 (en) | 2015-04-08 |
| KR20110095288A (ko) | 2011-08-24 |
| US20130203707A1 (en) | 2013-08-08 |
| HK1206198A1 (en) | 2016-01-08 |
| EP2826369A2 (en) | 2015-01-21 |
| EP2348866A4 (en) | 2012-04-11 |
| NZ592357A (en) | 2013-09-27 |
| WO2010052718A9 (en) | 2011-06-16 |
| JP5752599B2 (ja) | 2015-07-22 |
| AU2009312355A2 (en) | 2011-05-12 |
| AU2009312355A1 (en) | 2010-05-14 |
| HK1206199A1 (en) | 2016-01-08 |
| JP2015129157A (ja) | 2015-07-16 |
| CN102271517B (zh) | 2015-04-08 |
| US9206206B2 (en) | 2015-12-08 |
| AU2009312355C1 (en) | 2016-02-18 |
| ES2534044T3 (es) | 2015-04-16 |
| RU2011122729A (ru) | 2012-12-20 |
| WO2010052718A1 (en) | 2010-05-14 |
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Application publication date: 20150722 |