CN104788354A - 一种5-联苯基-4-氨基-2-甲基戊酸中间体的合成方法 - Google Patents
一种5-联苯基-4-氨基-2-甲基戊酸中间体的合成方法 Download PDFInfo
- Publication number
- CN104788354A CN104788354A CN201510223684.6A CN201510223684A CN104788354A CN 104788354 A CN104788354 A CN 104788354A CN 201510223684 A CN201510223684 A CN 201510223684A CN 104788354 A CN104788354 A CN 104788354A
- Authority
- CN
- China
- Prior art keywords
- compound
- methyl
- group
- phenyl ring
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 **1C=CC(S(OCC(CC2)N(*)C2=O)(=O)=O)=CC=C1 Chemical compound **1C=CC(S(OCC(CC2)N(*)C2=O)(=O)=O)=CC=C1 0.000 description 7
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510223684.6A CN104788354B (zh) | 2015-05-05 | 2015-05-05 | 一种5-联苯基-4-氨基-2-甲基戊酸中间体的合成方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510223684.6A CN104788354B (zh) | 2015-05-05 | 2015-05-05 | 一种5-联苯基-4-氨基-2-甲基戊酸中间体的合成方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104788354A true CN104788354A (zh) | 2015-07-22 |
CN104788354B CN104788354B (zh) | 2018-09-18 |
Family
ID=53553596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510223684.6A Active CN104788354B (zh) | 2015-05-05 | 2015-05-05 | 一种5-联苯基-4-氨基-2-甲基戊酸中间体的合成方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104788354B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105566194A (zh) * | 2016-02-01 | 2016-05-11 | 张伯引 | 一种Sacubitril中间体的制备方法 |
CN106496055A (zh) * | 2016-10-09 | 2017-03-15 | 杭州科巢生物科技有限公司 | 一种抗心衰新药的关键组分沙库比曲的新合成方法 |
CN107304179A (zh) * | 2016-04-19 | 2017-10-31 | 南京欧信医药技术有限公司 | 一种lcz696中间体的合成方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104230865A (zh) * | 2013-06-13 | 2014-12-24 | 上海翰森生物医药科技有限公司 | 联芳基取代的4-氨基丁酸衍生物及其制备方法和用途 |
-
2015
- 2015-05-05 CN CN201510223684.6A patent/CN104788354B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104230865A (zh) * | 2013-06-13 | 2014-12-24 | 上海翰森生物医药科技有限公司 | 联芳基取代的4-氨基丁酸衍生物及其制备方法和用途 |
Non-Patent Citations (1)
Title |
---|
NICHOLAS M. LEONARD: "Formation of Medium-Sized Nitrogen Heterocycles from γ-Silyloxy-γ-Lactams", 《J.ORG.CHEM》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105566194A (zh) * | 2016-02-01 | 2016-05-11 | 张伯引 | 一种Sacubitril中间体的制备方法 |
CN107304179A (zh) * | 2016-04-19 | 2017-10-31 | 南京欧信医药技术有限公司 | 一种lcz696中间体的合成方法 |
CN107304179B (zh) * | 2016-04-19 | 2020-11-10 | 南京欧信医药技术有限公司 | 一种lcz696中间体的合成方法 |
CN106496055A (zh) * | 2016-10-09 | 2017-03-15 | 杭州科巢生物科技有限公司 | 一种抗心衰新药的关键组分沙库比曲的新合成方法 |
Also Published As
Publication number | Publication date |
---|---|
CN104788354B (zh) | 2018-09-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2642598C (en) | Selective androgen receptor modulators | |
Yoshioka et al. | Insertion of arynes into the carbon–oxygen double bond of amides and its application into the sequential reactions | |
CN104788354A (zh) | 一种5-联苯基-4-氨基-2-甲基戊酸中间体的合成方法 | |
KR20090010075A (ko) | (s)-(+)-3-(아미노메틸)-5-메틸 헥산산의 합성 | |
CN102617434B (zh) | 一锅法制备维达列汀 | |
CN105566194A (zh) | 一种Sacubitril中间体的制备方法 | |
PE20070488A1 (es) | Proceso para la preparacion de compuestos derivados del ester del acido amino-acetico | |
JP5647790B2 (ja) | N−カルバモイル−tert−ロイシンの製造法 | |
CN105820064A (zh) | 一种联苯基丙氨醇衍生物的合成方法及中间体 | |
US6683214B2 (en) | Process for producing α-aminoketones | |
JP5260114B2 (ja) | N−アルコキシカルボニル−tert−ロイシンの製造法 | |
CN104086475B (zh) | 一种n-苄氧羰基-l-脯氨酰胺的制备方法 | |
CN104059075B (zh) | 8,9-单,双取代的咪唑[1,2-c]-喹唑啉-3(2H)-酮稠杂环化合物及其制备方法 | |
CN102442947B (zh) | 孟鲁司特钠中间体的制备方法 | |
TWI476183B (zh) | Pyrimidinyl acetonitrile derivatives and their synthesis intermediates | |
CN105189467A (zh) | 制备哒嗪酮化合物的方法 | |
CN104744331B (zh) | 一种依泽替米贝中间体的合成工艺 | |
CN104478791A (zh) | (s)-5-r-5-氮杂螺[2,4]庚烷-6-羧酸的制备方法 | |
CN105384673B (zh) | 3‑氟代‑氮杂环丁烷衍生物的合成方法 | |
JP4326471B2 (ja) | 有機化合物の製造方法 | |
CN108690010A (zh) | 利伐沙班的制备工艺 | |
JP2009126784A (ja) | 2−ヨード−3,4−ジメトキシベンゾニトリルの製造方法。 | |
CN104628547B (zh) | 一种医药中间体二氟甲氧基化合物的合成方法 | |
ES2848200T3 (es) | Procedimiento para la preparación de 2-vinilfenilsulfonatos 3-sustituidos | |
JP2007063267A (ja) | 光学活性なジフェニルアラニン化合物の製造方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
EXSB | Decision made by sipo to initiate substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20170123 Address after: Suzhou City, Jiangsu Province, Suzhou Industrial Park is 215000 Xinghu Street bio Nano Technology Park building 218 A6 -404 unit Applicant after: Suzhou Su Wangsen Biological Medicine Technology Co Ltd Address before: 215000 Dongping street, Suzhou Industrial Park, Jiangsu, China, No. 286, No. Applicant before: Suzhou Qi Liyuan Pharmaceutical Technology Co., Ltd |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20190819 Address after: 215000 9th Floor, Building A, 108 Yuxin Road, Suzhou Industrial Park, Jiangsu Province Patentee after: Suzhou New Medicine Basket Biomedical Technology Co., Ltd. Address before: Suzhou City, Jiangsu Province, Suzhou Industrial Park is 215000 Xinghu Street bio Nano Technology Park building 218 A6 -404 unit Patentee before: Suzhou Su Wangsen Biological Medicine Technology Co Ltd |
|
TR01 | Transfer of patent right | ||
CP01 | Change in the name or title of a patent holder |
Address after: 9 / F, building a, 108 Yuxin Road, Suzhou Industrial Park, 215000 Jiangsu Province Patentee after: Suzhou Zhongke new drug basket Biomedical Technology Co.,Ltd. Address before: 9 / F, building a, 108 Yuxin Road, Suzhou Industrial Park, 215000 Jiangsu Province Patentee before: Suzhou New Medicine Basket Biomedical Technology Co.,Ltd. |
|
CP01 | Change in the name or title of a patent holder |