CN104761522B - 光学纯的苄基‑4‑氯苯基的c‑糖苷衍生物 - Google Patents

光学纯的苄基‑4‑氯苯基的c‑糖苷衍生物 Download PDF

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Publication number
CN104761522B
CN104761522B CN201410004395.2A CN201410004395A CN104761522B CN 104761522 B CN104761522 B CN 104761522B CN 201410004395 A CN201410004395 A CN 201410004395A CN 104761522 B CN104761522 B CN 104761522B
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formula
compound
preparation
benzyl
diabetes
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CN104761522A (zh
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吴永谦
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Jilin Huisheng Biopharmaceutical Co ltd
Beijing Huizhiheng Biological Technology Co Ltd
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Xuanzhu Pharma Co Ltd
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Priority to CN201610635305.9A priority Critical patent/CN106349201B/zh
Priority to CN201410004395.2A priority patent/CN104761522B/zh
Priority to JP2014043695A priority patent/JP6008892B2/ja
Priority to KR1020140037632A priority patent/KR101837488B1/ko
Publication of CN104761522A publication Critical patent/CN104761522A/zh
Priority to HK15108213.7A priority patent/HK1207626B/xx
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201410004395.2A 2014-01-03 2014-01-03 光学纯的苄基‑4‑氯苯基的c‑糖苷衍生物 Active CN104761522B (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN201610635305.9A CN106349201B (zh) 2014-01-03 2014-01-03 光学纯的苄基-4-氯苯基的c-糖苷衍生物
CN201410004395.2A CN104761522B (zh) 2014-01-03 2014-01-03 光学纯的苄基‑4‑氯苯基的c‑糖苷衍生物
JP2014043695A JP6008892B2 (ja) 2014-01-03 2014-03-06 光学的に純粋なベンジル‐４−クロロフェニル‐ｃ‐グルコシド誘導体
KR1020140037632A KR101837488B1 (ko) 2014-01-03 2014-03-31 광학적으로 순수한 벤질-4-클로로페닐-c-글루코사이드 유도체
HK15108213.7A HK1207626B (en) 2015-08-25 Optically pure benzyl-4-chlorophenyl c-glucoside derivative

Applications Claiming Priority (1)

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CN201410004395.2A CN104761522B (zh) 2014-01-03 2014-01-03 光学纯的苄基‑4‑氯苯基的c‑糖苷衍生物

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CN104761522B true CN104761522B (zh) 2017-02-15

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105153137A (zh) * 2015-09-17 2015-12-16 上海应用技术学院 一种艾格列净的制备方法
PT3404033T (pt) * 2016-01-04 2020-10-30 Jeil Pharmaceutical Co Ltd Derivado de c-glucósido que contém um anel de fenilo fundido ou um sal farmaceuticamente aceitável do mesmo, processo para preparação do mesmo e composição farmacêutica que compreende o mesmo
JP6785523B2 (ja) * 2016-05-28 2020-11-18 ジ・リン・フイ・シェン・バイオ−ファーマシューティカル・カンパニー・リミテッドＪｉ Ｌｉｎ Ｈｕｉ Ｓｈｅｎｇ Ｂｉｏ−Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． ナトリウム−グルコース共輸送体２阻害剤の結晶形
CN108285439B (zh) * 2017-01-09 2023-05-02 江苏天士力帝益药业有限公司 一种碳糖苷类钠葡萄糖转运蛋白体2抑制剂
WO2019185026A1 (zh) * 2018-03-30 2019-10-03 南京明德新药研发有限公司 作为SGLTs抑制剂的葡糖苷类衍生物及其应用
CN110551088B (zh) * 2018-06-01 2022-10-21 北京惠之衡生物科技有限公司 氘修饰的苄基-4-氯苯基的c-糖苷衍生物
CN112047915B (zh) * 2019-06-05 2023-02-17 北京惠之衡生物科技有限公司 C-糖苷类衍生物新的制备工艺
CN110683998A (zh) * 2019-11-20 2020-01-14 杭州华东医药集团浙江华义制药有限公司 一种恩格列净中间体的制备方法
CN113045525B (zh) * 2021-05-31 2021-09-17 北京惠之衡生物科技有限公司 一种c-糖苷类衍生物的制备方法及其制剂
CN113248464B (zh) * 2021-05-31 2021-10-26 北京惠之衡生物科技有限公司 一种c-糖苷类衍生物的合成方法
CN113336733B (zh) * 2021-05-31 2022-02-18 北京惠之衡生物科技有限公司 一种sglt-2抑制剂的l-脯氨酸共结晶体的制备方法
CN113248554A (zh) * 2021-06-25 2021-08-13 北京惠之衡生物科技有限公司 一种c-糖苷类衍生物的杂质的合成方法
CN113372315B (zh) * 2021-08-12 2021-10-29 北京惠之衡生物科技有限公司 一种c-糖苷类衍生物的杂质的合成方法
CN115073271A (zh) * 2022-06-08 2022-09-20 苏州敬业医药化工有限公司 一种4’-(5-溴-2-氯苄基)苯酚的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1653075A (zh) * 2002-05-20 2005-08-10 百时美施贵宝公司 C－芳基葡糖苷sglt2抑制剂和方法
WO2013000275A1 (zh) * 2011-06-25 2013-01-03 山东轩竹医药科技有限公司 C-糖苷衍生物
CN103030617A (zh) * 2004-03-16 2013-04-10 贝林格尔.英格海姆国际有限公司 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006516257A (ja) * 2003-01-03 2006-06-29 ブリストル−マイヤーズ　スクイブ　カンパニー Ｃ−アリールグルコシドｓｇｌｔ２阻害剤の製造法
US7772191B2 (en) * 2005-05-10 2010-08-10 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
LT2548871T (lt) * 2010-03-18 2017-09-25 Daiichi Sankyo Company, Limited Cikloalkilpakeistieji imidazolo dariniai
WO2012025857A1 (en) * 2010-08-23 2012-03-01 Hetero Research Foundation Cycloalkyl methoxybenzyl phenyl pyran derivatives as sodium dependent glucose co transporter (sglt2) inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1653075A (zh) * 2002-05-20 2005-08-10 百时美施贵宝公司 C－芳基葡糖苷sglt2抑制剂和方法
CN103030617A (zh) * 2004-03-16 2013-04-10 贝林格尔.英格海姆国际有限公司 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
WO2013000275A1 (zh) * 2011-06-25 2013-01-03 山东轩竹医药科技有限公司 C-糖苷衍生物

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Publication number Publication date
JP6008892B2 (ja) 2016-10-19
CN104761522A (zh) 2015-07-08
CN106349201A (zh) 2017-01-25
CN106349201B (zh) 2018-09-18
JP2015129106A (ja) 2015-07-16
KR101837488B1 (ko) 2018-03-12
HK1207626A1 (zh) 2016-02-05
KR20150081220A (ko) 2015-07-13

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