CN104755169A - 操纵固体载体的方法及操纵固体载体的设备 - Google Patents

操纵固体载体的方法及操纵固体载体的设备 Download PDF

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Publication number
CN104755169A
CN104755169A CN201380055844.XA CN201380055844A CN104755169A CN 104755169 A CN104755169 A CN 104755169A CN 201380055844 A CN201380055844 A CN 201380055844A CN 104755169 A CN104755169 A CN 104755169A
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CN
China
Prior art keywords
plug
tube
container
solid carrier
magnetic force
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380055844.XA
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English (en)
Chinese (zh)
Inventor
村山寿郎
齐藤祐司
高城富美男
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seiko Epson Corp
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Seiko Epson Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seiko Epson Corp filed Critical Seiko Epson Corp
Publication of CN104755169A publication Critical patent/CN104755169A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/1013—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Coating Apparatus (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201380055844.XA 2012-11-12 2013-11-12 操纵固体载体的方法及操纵固体载体的设备 Pending CN104755169A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012-248320 2012-11-12
JP2012248320A JP2014093988A (ja) 2012-11-12 2012-11-12 固相担体の操作方法及び固相担体の操作装置
PCT/JP2013/006657 WO2014073218A1 (en) 2012-11-12 2013-11-12 A method of manipulating solid carriers and an apparatus of manipulating solid carriers

Publications (1)

Publication Number Publication Date
CN104755169A true CN104755169A (zh) 2015-07-01

Family

ID=50069267

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380055844.XA Pending CN104755169A (zh) 2012-11-12 2013-11-12 操纵固体载体的方法及操纵固体载体的设备

Country Status (8)

Country Link
US (1) US20150284710A1 (enExample)
EP (1) EP2916952A1 (enExample)
JP (1) JP2014093988A (enExample)
CN (1) CN104755169A (enExample)
BR (1) BR112015010616A2 (enExample)
IN (1) IN2015DN01303A (enExample)
RU (1) RU2015122685A (enExample)
WO (1) WO2014073218A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015159733A (ja) * 2014-02-26 2015-09-07 セイコーエプソン株式会社 物質結合用固相担体の凍結乾燥体、物質含有液中の物質を物質結合用固相担体と結合させるための容器、および、物質結合用固相担体を含む凍結乾燥体の製造方法
JP2015177770A (ja) * 2014-03-19 2015-10-08 セイコーエプソン株式会社 標的物質の精製装置、核酸精製装置、標的物質の生成方法、及び核酸増幅方法
JP7110900B2 (ja) * 2018-10-15 2022-08-02 株式会社島津製作所 磁性体粒子操作用装置
WO2021086442A1 (en) * 2019-10-29 2021-05-06 Hewlett-Packard Development Company, L.P. Vertically layered fluid columns
WO2025012429A2 (en) * 2023-07-13 2025-01-16 Curetis Gmbh Device and methods for enriching as well as isolating nucleic acid molecules
WO2025038294A1 (en) * 2023-08-15 2025-02-20 Restek Corporation Capillary ampules and capillary ampule systems

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6033574A (en) * 1995-02-21 2000-03-07 Siddiqi; Iqbal W. Method for mixing and separation employing magnetic particles
US6579453B1 (en) * 1997-09-29 2003-06-17 Roche Diagnostics Corporation Apparatus for separating magnetic particles
EP1621890A1 (en) * 2004-07-26 2006-02-01 bioMerieux B.V. Device and method for separating, mixing and concentrating magnetic particles with a fluid and use thereof in purification methods
WO2007041619A2 (en) * 2005-09-30 2007-04-12 Caliper Life Sciences, Inc. Microfluidic device for purifying a biological component using magnetic beads
WO2009014737A1 (en) * 2007-07-25 2009-01-29 Abbott Laboratories Magnetic mixer
CN102138075A (zh) * 2008-10-01 2011-07-27 三星电子株式会社 离心式微流体设备、制造微流体设备的方法以及使用微流体设备测试样品的方法
WO2012086243A1 (ja) * 2010-12-21 2012-06-28 株式会社 島津製作所 管内で対象成分を操作するためのデバイス及び方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985649A (en) * 1974-11-25 1976-10-12 Eddelman Roy T Ferromagnetic separation process and material
CA2379773C (en) * 1999-07-19 2009-01-20 Organon Teknika B.V. Device and method for mixing magnetic particles with a fluid
WO2006136996A2 (en) * 2005-06-23 2006-12-28 Koninklijke Philips Electronics N.V. Apparatus for moving magnetic particles
JP4844263B2 (ja) 2006-07-07 2011-12-28 株式会社島津製作所 微量化学反応方法及び装置
WO2009111316A2 (en) * 2008-02-29 2009-09-11 Northwestern University Barriers for facilitating biological reactions
JP2009207459A (ja) 2008-03-06 2009-09-17 Sony Corp 核酸抽出装置、及び核酸抽出方法
GB0910291D0 (en) * 2009-06-16 2009-07-29 Biochip Devises Pte Ltd Method for conducting multiple reactions in a single reaction tube
JP2012152734A (ja) * 2012-02-14 2012-08-16 Tamagawa Seiki Co Ltd 液体中の磁性粒子の集合／分散装置
JP2012152213A (ja) * 2012-02-14 2012-08-16 Tamagawa Seiki Co Ltd 液体中の磁性粒子の集合／分散装置

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6033574A (en) * 1995-02-21 2000-03-07 Siddiqi; Iqbal W. Method for mixing and separation employing magnetic particles
US6579453B1 (en) * 1997-09-29 2003-06-17 Roche Diagnostics Corporation Apparatus for separating magnetic particles
EP1621890A1 (en) * 2004-07-26 2006-02-01 bioMerieux B.V. Device and method for separating, mixing and concentrating magnetic particles with a fluid and use thereof in purification methods
WO2007041619A2 (en) * 2005-09-30 2007-04-12 Caliper Life Sciences, Inc. Microfluidic device for purifying a biological component using magnetic beads
WO2009014737A1 (en) * 2007-07-25 2009-01-29 Abbott Laboratories Magnetic mixer
CN102138075A (zh) * 2008-10-01 2011-07-27 三星电子株式会社 离心式微流体设备、制造微流体设备的方法以及使用微流体设备测试样品的方法
WO2012086243A1 (ja) * 2010-12-21 2012-06-28 株式会社 島津製作所 管内で対象成分を操作するためのデバイス及び方法

Also Published As

Publication number Publication date
US20150284710A1 (en) 2015-10-08
BR112015010616A2 (pt) 2017-07-11
WO2014073218A1 (en) 2014-05-15
EP2916952A1 (en) 2015-09-16
RU2015122685A (ru) 2017-01-10
JP2014093988A (ja) 2014-05-22
IN2015DN01303A (enExample) 2015-07-03

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Application publication date: 20150701