CN104736539B - 墨蝶呤和四氢乳酰蝶呤的制造法 - Google Patents
墨蝶呤和四氢乳酰蝶呤的制造法 Download PDFInfo
- Publication number
- CN104736539B CN104736539B CN201380022709.5A CN201380022709A CN104736539B CN 104736539 B CN104736539 B CN 104736539B CN 201380022709 A CN201380022709 A CN 201380022709A CN 104736539 B CN104736539 B CN 104736539B
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012-105758 | 2012-05-07 | ||
| JP2012105758 | 2012-05-07 | ||
| JP2012247255 | 2012-11-09 | ||
| JP2012-247255 | 2012-11-09 | ||
| PCT/JP2013/062817 WO2013168693A1 (ja) | 2012-05-07 | 2013-05-07 | セピアプテリン及びテトラヒドロラクトイルプテリンの製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104736539A CN104736539A (zh) | 2015-06-24 |
| CN104736539B true CN104736539B (zh) | 2017-09-01 |
Family
ID=49550728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380022709.5A Active CN104736539B (zh) | 2012-05-07 | 2013-05-07 | 墨蝶呤和四氢乳酰蝶呤的制造法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9181254B2 (https=) |
| EP (1) | EP2848619B1 (https=) |
| JP (1) | JP6084967B2 (https=) |
| CN (1) | CN104736539B (https=) |
| ES (1) | ES2681345T3 (https=) |
| FR (1) | FR25C1044I1 (https=) |
| IN (1) | IN2014DN09053A (https=) |
| WO (1) | WO2013168693A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2715992C (en) * | 2008-02-21 | 2016-11-08 | Teikoku Seiyaku Co., Ltd. | Apparatus and method for simulatively measuring the environment of a wound dressing on skin |
| EP2562176B1 (en) | 2010-04-22 | 2018-08-15 | Nihon University | Medicinal agent and beverage/food for preventing cerebral dysfunction and improving same |
| JP6809781B2 (ja) * | 2015-11-18 | 2021-01-06 | 白鳥製薬株式会社 | プテリン誘導体又はその塩 |
| MA46973A (fr) * | 2016-11-29 | 2019-10-09 | Censa Pharmaceuticals Inc | Polymorphes de sépiaptérine et leurs sels |
| MA46972A (fr) * | 2016-11-29 | 2019-10-09 | Censa Pharmaceuticals Inc | Forme polymorphe de sépiaptérine |
| JP7811085B2 (ja) | 2017-09-01 | 2026-02-04 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンを含む医薬組成物及びその使用 |
| FI3801536T3 (fi) | 2018-05-30 | 2024-08-29 | Ptc Therapeutics Mp Inc | Sepiapteriinin antaminen ilman ruokaa käytettäväksi menetelmässä sepiapteriinin plasma-altistuksen lisäämiseksi |
| EP3801534B1 (en) | 2018-05-30 | 2026-02-18 | PTC Therapeutics MP, Inc. | Treatment of phenylketonuria with sepiapterin |
| AU2019277372B2 (en) | 2018-05-30 | 2024-12-19 | Ptc Therapeutics Mp, Inc. | Pharmaceutically acceptable salts of sepiapterin |
| CN117088883B (zh) * | 2022-12-05 | 2025-10-21 | 哈尔滨工业大学（深圳） | 一种以Pd/Al2O3为催化剂连续加氢制备四氢叶酸的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713454A (en) | 1985-01-28 | 1987-12-15 | Shiratori Pharmaceutical Co., Ltd. | Preparation process of (6R)-tetrahydro-L-biopterin |
| JPS61172877A (ja) | 1985-01-28 | 1986-08-04 | Shiratori Seiyaku Kk | （６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造方法 |
| JP5184783B2 (ja) | 2003-11-17 | 2013-04-17 | バイオマリン ファーマシューティカル インコーポレイテッド | テトラヒドロビオプテリン、及びテトラヒドロビオプテリン類似体の製造方法 |
| JP2011011976A (ja) | 2007-10-10 | 2011-01-20 | Shiratori Pharmaceutical Co Ltd | プテリジン化合物及びｌ−ビオプテリンの製造方法 |
| EP2562176B1 (en) | 2010-04-22 | 2018-08-15 | Nihon University | Medicinal agent and beverage/food for preventing cerebral dysfunction and improving same |
-
2013
- 2013-05-07 CN CN201380022709.5A patent/CN104736539B/zh active Active
- 2013-05-07 US US14/398,884 patent/US9181254B2/en active Active
- 2013-05-07 IN IN9053DEN2014 patent/IN2014DN09053A/en unknown
- 2013-05-07 ES ES13787263.6T patent/ES2681345T3/es active Active
- 2013-05-07 EP EP13787263.6A patent/EP2848619B1/en active Active
- 2013-05-07 WO PCT/JP2013/062817 patent/WO2013168693A1/ja not_active Ceased
- 2013-05-07 JP JP2014514717A patent/JP6084967B2/ja active Active
-
2025
- 2025-11-18 FR FR25C1044C patent/FR25C1044I1/fr active Active
Non-Patent Citations (1)
| Title |
|---|
| Herstellung von (6R,S) -5,6,7,8-Tetrahydro-L-biopterin, 7,8-Dihydro-L-biopterin, L-Sepiapterin, Deoxysepiapterin, (6R,S)-5,6-Dihydrodeoxysepiapterin und 2’-Deoxybiopterin;Bernhard Schircks et al;《Helvetica Chimica Acta》;19781231;第61卷;2731-2738 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2681345T3 (es) | 2018-09-12 |
| IN2014DN09053A (https=) | 2015-05-22 |
| EP2848619A1 (en) | 2015-03-18 |
| JPWO2013168693A1 (ja) | 2016-01-07 |
| JP6084967B2 (ja) | 2017-02-22 |
| FR25C1044I1 (fr) | 2026-01-02 |
| EP2848619A4 (en) | 2015-11-04 |
| EP2848619B1 (en) | 2018-07-11 |
| WO2013168693A1 (ja) | 2013-11-14 |
| CN104736539A (zh) | 2015-06-24 |
| US9181254B2 (en) | 2015-11-10 |
| US20150119574A1 (en) | 2015-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |