CN104703598A - 用于疾病治疗的取代的杂环化合物 - Google Patents

用于疾病治疗的取代的杂环化合物 Download PDF

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CN104703598A
CN104703598A CN201380015582.4A CN201380015582A CN104703598A CN 104703598 A CN104703598 A CN 104703598A CN 201380015582 A CN201380015582 A CN 201380015582A CN 104703598 A CN104703598 A CN 104703598A
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alkyl
hydrogen
carbocyclyl
together form
compound
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弗拉迪米尔·A·库克萨
马克·W·奥姆
洪峰
辽·洼田
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Kubota Vision Inc
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Acucela Inc
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HK1210969A1 (en) 2012-01-20 2016-05-13 奥克塞拉有限公司 Substituted heterocyclic compounds for disease treatment
EP2970099A4 (en) 2013-03-12 2016-12-21 Acucela Inc SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF EYE DISEASES AND DRESSES
WO2016202935A1 (en) 2015-06-19 2016-12-22 Bayer Pharma Aktiengesellschaft Glucose transport inhibitors
AU2020221054A1 (en) * 2019-02-12 2021-09-02 The Texas A&M University System Anti-fibrotic NEU3 inhibitor compounds and methods of use
CN121108187A (zh) 2019-04-03 2025-12-12 阿里戈斯治疗公司 吡咯化合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101889017A (zh) * 2007-10-05 2010-11-17 奥克塞拉有限公司 用于治疗疾病的烷氧基化合物

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB884663A (en) 1958-11-06 1961-12-13 Ciba Ltd New amines and processes for their manufacture
CH396941A (de) 1959-08-10 1965-08-15 Ciba Geigy Verfahren zur Herstellung neuer sekundärer Amine
GB1200886A (en) 1966-09-23 1970-08-05 Allen & Hanburys Ltd Phenylaminoethanol derivatives
US3509153A (en) * 1967-03-24 1970-04-28 Miles Lab 5-phenyl (or 5-phenylalkyl)-2-(omega-(4-phenyl-1-piperazinyl)alkyl)tetrazoles
DE2710997C3 (de) 1977-03-14 1980-08-14 Dr. Karl Thomae Gmbh, 7950 Biberach 4-Alkoxy carbonylamino-phenyläthanolamine, deren Herstellung und deren Verwendung als Arzneimittel
US4569354A (en) 1982-03-22 1986-02-11 Boston University Method and apparatus for measuring natural retinal fluorescence
ZA848004B (en) * 1983-10-19 1985-06-26 Hoffmann La Roche Phenoxypropanolamines
JPH0228112A (ja) 1988-04-21 1990-01-30 Kaken Pharmaceut Co Ltd 点眼用眼圧調整剤
US5135955A (en) 1988-04-25 1992-08-04 Eli Lilly And Company Propanamine derivatives
IT1240427B (it) 1990-03-02 1993-12-15 Ministero Dall Uni E Della Ric Arilpropilammine ad azione antifungina
EP0525360B1 (en) 1991-07-30 1998-03-25 Korea Research Institute Of Chemical Technology Novel phenylacetamide derivatives and processes for the preparation thereof
WO1993015045A1 (en) 1992-01-29 1993-08-05 Smithkline Beecham Corporation N-(3-phenylpropyl)oxamic acid, oxamate, and oxamide derivatives
US5604229A (en) * 1992-10-21 1997-02-18 Yoshitomi Pharmaceutical Industries, Ltd. 2-amino-1,3-propanediol compound and immunosuppressant
US5958973A (en) 1993-09-03 1999-09-28 Gilead Sciences, Inc. Polyhydroxy benzoic acid derivatives and their use as neuraminidase inhibitors
KR970700646A (ko) 1994-01-19 1997-02-12 헤르베르트 루프·울리히 볼프 니트록시기를 포함한 벤질아민 유도체, 및 심장 혈관 질환과 안압 상승의 치료를 위한 이의 용도(nitroxy group-containing benzylamine derivatives and their use for treating cardiovascular diseases, as well as increased intra-ocular pressure)
WO2001009327A2 (en) 1999-07-28 2001-02-08 Genentech, Inc. Method of preventing the injury or death of retinal cells and treating ocular diseases
US5541228A (en) 1994-10-14 1996-07-30 Bristol-Myers Squibb Co. Melatonergic agents
US5693804A (en) * 1994-11-17 1997-12-02 Molecular Geriatrics Corporation Substituted 1-aryl-3-piperazin-1'-yl propanones
JPH0940646A (ja) * 1995-07-27 1997-02-10 Yamanouchi Pharmaceut Co Ltd ベンゼン縮合環誘導体又はその塩
US5641750A (en) 1995-11-29 1997-06-24 Amgen Inc. Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product
US6090624A (en) 1996-04-19 2000-07-18 Brown University Research Foundation Immortalized retinal cell lines and their applications
FR2747690B1 (fr) 1996-04-19 1998-06-12 Neurotech Sa Lignees immortalisees de cellules retiniennes et leurs applications au traitement de differents troubles primaires ou secondaires ophtalmologiques ou neurologiques
US6878544B2 (en) 1996-04-19 2005-04-12 Neurotech Sa Retinal cell lines with extended life-span and their applications
AUPO235996A0 (en) 1996-09-16 1996-10-10 Garvan Institute Of Medical Research Method of cell culture
CA2216439A1 (en) 1996-09-25 1998-03-25 Derek Van Der Kooy Pharmaceuticals containing retinal stem cells
DE19643592A1 (de) 1996-10-22 1998-04-23 Bayer Ag Verfahren zur Herstellung von alpha-Alkoxy-alpha-trifluormethyl-arylessigsäureestern und -arylessigsäuren
US6713300B1 (en) 1997-02-27 2004-03-30 University Of Utah Research Foundation Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
TW593331B (en) 1997-07-25 2004-06-21 Inspire Pharmaceuticals Inc Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
US6051605A (en) 1997-08-08 2000-04-18 Warner-Lambert Company Method of treating psychosis and schizophrenia
US6171837B1 (en) 1997-09-29 2001-01-09 The Trustees Of Columbia University In The City Of New York Mouse and human 9-cis-retinol dehydrogenase
AU1996599A (en) 1997-12-05 1999-06-28 Board Of Trustees Of The Leland Stanford Junior University Long-term survival and regeneration of central nervous system neurons
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
IL143382A0 (en) 1999-01-05 2002-04-21 Aventis Pharma Sa Human adult astrocytes, their preparation and uses thereof
EP1107003A1 (en) 1999-12-09 2001-06-13 Trophos Methods for screening compounds active on neurons
US6406840B1 (en) 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
CA2393466C (en) 1999-12-21 2010-01-19 Gpi Nil Holdings, Inc. Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same
CA2397194C (en) * 2000-01-20 2011-05-17 Mark E. Duggan Alpha v integrin receptor antagonists
WO2001083714A2 (en) 2000-05-02 2001-11-08 Central Institute For The Deaf Composition and methods for treating photoreceptor degeneration
US20020009713A1 (en) 2000-05-11 2002-01-24 Miller Freda D. Methods for identifying modulators of neuronal growth
WO2002006268A1 (en) * 2000-07-13 2002-01-24 Sankyo Company, Limited Amino alcohol derivatives
JP2002167382A (ja) * 2000-07-13 2002-06-11 Sankyo Co Ltd アミノアルコ−ル誘導体
JP2002053575A (ja) * 2000-08-09 2002-02-19 Sankyo Co Ltd アミノアルコ−ル類
US20030032078A1 (en) 2001-01-23 2003-02-13 Board Of Regents, The University Of Texas System Methods and compositions for the treatment of macular and retinal degenerations
DE10141018A1 (de) 2001-08-22 2003-03-13 Eth Zuerich Eidgenoessische Te Verwendung von negativ geladenen Phospholipiden, sowie Zusammensetzungen umfassend Phospholipide zur Behandlung des Auges
BR0306811A (pt) * 2002-01-11 2004-10-26 Sankyo Co Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero
JP4771511B2 (ja) * 2003-07-08 2011-09-14 第一三共株式会社 アミノアルコ−ル誘導体又はホスホン酸誘導体を含有する医薬組成物
JP2006506970A (ja) 2002-07-12 2006-03-02 ユニバーシティ オブ ワシントン 神経細胞の延長されたインビトロ培養のための方法および系
DE10235312A1 (de) 2002-08-01 2004-02-12 Basf Ag Verfahren zur Herstellung von Aminoalkoxybenzylaminen und Aminoalkoxybenzonitrilen als Zwischenprodukte
US20060089343A1 (en) 2002-12-06 2006-04-27 Alcon, Inc. Superoxide dismutase mimics for the treatment of ocular disorders and diseases
NZ541828A (en) * 2003-03-04 2008-06-30 Pfizer Prod Inc Use of EP2 selective receptor agonists in medical treatment
US20040242704A1 (en) 2003-03-14 2004-12-02 University Of Washington, Techtransfer - Invention Licensing Stabilized mutant opsin proteins
EP1649009A2 (en) 2003-07-30 2006-04-26 Acucela, Inc. Extended primary retinal cell culture and stress models, and methods of use
EP1661881B1 (en) 2003-08-29 2014-12-17 Ono Pharmaceutical Co., Ltd. Compound capable of binding s1p receptor and pharmaceutical use thereof
US7706863B2 (en) 2004-01-21 2010-04-27 University Of Washington Methods for assessing a physiological state of a mammalian retina
US7566808B2 (en) 2004-02-17 2009-07-28 President And Fellows Of Harvard College Management of ophthalmologic disorders, including macular degeneration
BR122020017756B1 (pt) * 2004-08-26 2022-02-15 Pfizer Inc Uso de compostos de aminoeteroarila enantiomericamente puros na preparação de um medicamento para o tratamento de crescimento celular anormal em um mamífero
TWI359810B (en) 2004-11-04 2012-03-11 Mitsubishi Tanabe Pharma Corp Carboxylic acid derivative containing thiazole rin
US20060252107A1 (en) 2005-02-22 2006-11-09 Acucela, Inc. Compositions and methods for diagnosing and treating retinal diseases
WO2006101102A1 (ja) * 2005-03-22 2006-09-28 Kyowa Hakko Kogyo Co., Ltd. 固形腫瘍治療剤
US8098907B2 (en) 2005-07-01 2012-01-17 Siemens Corporation Method and system for local adaptive detection of microaneurysms in digital fundus images
TW200744567A (en) 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
NZ567858A (en) 2005-11-01 2011-08-26 Array Biopharma Inc Pyridine compounds useful as Glucokinase activators
UA96283C2 (uk) * 2005-12-23 2011-10-25 Зіланд Фарма А/С Модифіковані міметики лізину
WO2007079593A1 (en) 2006-01-13 2007-07-19 Mcgill University Novel melatonin ligands having antidepressant activity as well as sleep inducing properties
WO2007120528A2 (en) 2006-03-31 2007-10-25 La Jolla Pharmaceutical Company Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases
KR101495611B1 (ko) * 2006-04-07 2015-02-25 메틸진 인코포레이티드 히스톤 데아세틸라아제의 억제제
CN101443348A (zh) * 2006-05-23 2009-05-27 Irm责任有限公司 作为通道活化蛋白酶抑制剂的化合物和组合物
US8642612B2 (en) * 2006-07-18 2014-02-04 Potomac Pharmaceuticals, Inc. Nicotinic desensitizers and methods of selecting, testing, and using them
EP2059507B1 (en) * 2006-07-28 2013-03-20 Pfizer Products Inc. Ep2 agonist
BRPI0810063A2 (pt) 2007-04-20 2014-10-14 Acucela Inc Composto, composição farmacêutica, e, métodos para modular fluxo de cromóforo em um ciclo retinóide, para tratar uma doença ou distúrbio oftálmico em um indivíduo, para inibir adaptação ao escuro em uma célula fotorreceptora de bastão da retina, para inibir regeneração de rodopsina em uma célula fotoreceptora de bastão da retina, para reduzir isquemia em um olho de um indivíduo, para inibir neovascularização na retina de um olho de um indivíduo, e para inibir degeneração de uma célula da retina em uma retina
TW200906389A (en) * 2007-05-25 2009-02-16 Daiichi Sankyo Co Ltd Pharmaceutical composition comprising of therapeutic or prophylactic agents for hepatitis
NZ601866A (en) 2007-06-29 2013-12-20 Acucela Inc Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders
US7973079B2 (en) * 2007-09-27 2011-07-05 Revision Therapeutics, Inc. Methods and compounds for treating retinol-related diseases
CA2701286A1 (en) * 2007-10-25 2009-04-30 Achaogen, Inc. Carbacephem .beta.-lactam antibiotics
KR101270122B1 (ko) 2007-11-01 2013-05-31 어큐셀라 인코포레이티드 안과 질환 및 장애를 치료하기 위한 아민 유도체 화합물
WO2009113637A1 (ja) * 2008-03-12 2009-09-17 東ソー株式会社 新規なチアゾール誘導体、チアゾール誘導体固定化マトリックス、及びそれらの製造方法
MX2011002448A (es) 2008-09-05 2011-05-25 Acucela Inc Compuestos enlazados con azufre para el tratamiento de enfermedades y trastornos oftalmicos.
JP5773877B2 (ja) 2008-10-22 2015-09-02 アキュセラ インコーポレイテッド 眼の疾患及び障害を治療する化合物
EP4000610A1 (en) 2009-07-02 2022-05-25 Acucela Inc. Pharmacology of visual cycle modulators
GB2474120B (en) * 2009-10-01 2011-12-21 Amira Pharmaceuticals Inc Compounds as Lysophosphatidic acid receptor antagonists
HK1210969A1 (en) 2012-01-20 2016-05-13 奥克塞拉有限公司 Substituted heterocyclic compounds for disease treatment
TW201406707A (zh) 2012-05-04 2014-02-16 Acucela Inc 用以治療糖尿病性視網膜病變及其他眼部疾病之方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101889017A (zh) * 2007-10-05 2010-11-17 奥克塞拉有限公司 用于治疗疾病的烷氧基化合物

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