CN104662002A - 取代脲类化合物的合成方法 - Google Patents

取代脲类化合物的合成方法 Download PDF

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Publication number
CN104662002A
CN104662002A CN201380050477.4A CN201380050477A CN104662002A CN 104662002 A CN104662002 A CN 104662002A CN 201380050477 A CN201380050477 A CN 201380050477A CN 104662002 A CN104662002 A CN 104662002A
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CN
China
Prior art keywords
alkyl
substituted
heterocyclyl
aryl
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380050477.4A
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English (en)
Chinese (zh)
Inventor
多梅尼克·鲁索
若热·布鲁诺·赖斯·瓦农
威廉·马东
蒂博尔·埃塞尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bial Portela and Cia SA
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Bial Portela and Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bial Portela and Cia SA filed Critical Bial Portela and Cia SA
Publication of CN104662002A publication Critical patent/CN104662002A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
CN201380050477.4A 2012-07-27 2013-07-26 取代脲类化合物的合成方法 Pending CN104662002A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261676554P 2012-07-27 2012-07-27
US61/676,554 2012-07-27
PCT/PT2013/000050 WO2014017938A2 (en) 2012-07-27 2013-07-26 Process for the synthesis of substituted urea compounds

Publications (1)

Publication Number Publication Date
CN104662002A true CN104662002A (zh) 2015-05-27

Family

ID=49003969

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380050477.4A Pending CN104662002A (zh) 2012-07-27 2013-07-26 取代脲类化合物的合成方法

Country Status (8)

Country Link
US (1) US20150197503A1 (enExample)
EP (1) EP2882712A2 (enExample)
JP (1) JP2015528013A (enExample)
CN (1) CN104662002A (enExample)
BR (1) BR112015001769A2 (enExample)
CA (1) CA2880299A1 (enExample)
RU (1) RU2015104103A (enExample)
WO (1) WO2014017938A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201401198D0 (en) 2014-01-24 2014-03-12 Bial Portela & Ca Sa Process for the syntheis of substituted urea compounds
US10774064B2 (en) 2016-06-02 2020-09-15 Cadent Therapeutics, Inc. Potassium channel modulators
BR112019014814B1 (pt) 2017-01-23 2024-03-12 Novartis Ag Compostos, composições farmacêuticas dos mesmos e seus usos no tratamento de doenças associadas à disfunção de canais iônicos de potássio
BR122023024273A2 (pt) 2018-02-27 2024-02-20 Incyte Corporation Compostos imidazopirimidinas e triazolopirimidinas, seus usos, método para inibir uma atividade de um receptor de adenosina e composição farmacêutica dos mesmos
EP3810610A1 (en) 2018-05-18 2021-04-28 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
AU2019297361B2 (en) 2018-07-05 2024-06-27 Incyte Corporation Fused pyrazine derivatives as A2A / A2B inhibitors
AU2019366312B2 (en) 2018-10-22 2025-04-24 Novartis Ag Crystalline forms of potassium channel modulators
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86104173A (zh) * 1985-07-01 1987-01-28 詹森药业有限公司 新型5-咪唑羧酸衍生物的制备方法和它们的使用
US4973588A (en) * 1988-02-10 1990-11-27 Mitsui Petrochemical Industries, Ltd. Imidazole derivatives having anti-hypoxia properties
CN1800198A (zh) * 2006-01-18 2006-07-12 中国药科大学 一种制备大环内酯类半合成抗生素泰利霉素的方法
CN1914180A (zh) * 2004-02-02 2007-02-14 塞诺菲-安万特德国有限公司 作为激素敏感性脂肪酶抑制剂的吲唑衍生物
CN102333568A (zh) * 2008-12-24 2012-01-25 比亚尔-珀特拉和Ca股份公司 药物化合物

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GB1238971A (enExample) * 1968-03-02 1971-07-14
DE2458965C3 (de) * 1974-12-13 1979-10-11 Bayer Ag, 5090 Leverkusen 3-Amino-indazol-N-carbonsäure-Derivate, Verfahren zu ihrer Herstellung sowie sie enthaltende Arzneimittel
EP0014810A3 (en) * 1979-01-18 1980-11-26 Fbc Limited Pesticidal pyrazoles, their production, compositions and uses, as well as intermediates and their preparation
JPH01203368A (ja) * 1988-02-10 1989-08-16 Mitsui Petrochem Ind Ltd チオイミダゾール誘導体
FR2674855B1 (fr) * 1991-04-03 1994-01-14 Synthelabo Derives de piperidine, leur preparation et leur application en therapeutique.
WO1994010158A1 (fr) * 1992-10-28 1994-05-11 Toyama Chemical Co., Ltd. Nouveaux derives de 1,2-benzisoxazole ou sel dudit derive, et agent de protection cerebrale contenant ce derive
US20030203862A1 (en) * 1998-03-26 2003-10-30 Miraglia Loren J. Antisense modulation of MDM2 expression
JP2004512810A (ja) * 1999-08-31 2004-04-30 サーナ・セラピューティクス・インコーポレイテッド 核酸に基づく遺伝子発現の調節剤
CN100540538C (zh) * 2001-04-16 2009-09-16 田边三菱制药株式会社 高传导率钙-活化k通道开启剂
US7329662B2 (en) * 2003-10-03 2008-02-12 Hoffmann-La Roche Inc. Pyrazolo-pyridine
CN103140478A (zh) * 2010-07-29 2013-06-05 比亚尔-珀特拉和Ca股份公司 取代的脲化合物的合成方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86104173A (zh) * 1985-07-01 1987-01-28 詹森药业有限公司 新型5-咪唑羧酸衍生物的制备方法和它们的使用
US4973588A (en) * 1988-02-10 1990-11-27 Mitsui Petrochemical Industries, Ltd. Imidazole derivatives having anti-hypoxia properties
CN1914180A (zh) * 2004-02-02 2007-02-14 塞诺菲-安万特德国有限公司 作为激素敏感性脂肪酶抑制剂的吲唑衍生物
CN1800198A (zh) * 2006-01-18 2006-07-12 中国药科大学 一种制备大环内酯类半合成抗生素泰利霉素的方法
CN102333568A (zh) * 2008-12-24 2012-01-25 比亚尔-珀特拉和Ca股份公司 药物化合物

Non-Patent Citations (4)

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C. ROBIN GANELLIN, ET AL.: "Design of Potent Non-Thiourea H3-Receptor Histamine Antagonists", 《JOURNAL OF MEDICINAL CHEMISTRY》 *
CONOR O"BRIEN: "THE REARRAYGEMEKT OF KETOXIME O-SULFONATES TO AMINO KETONES", 《CHEMICAL REVIEWS》 *
RAINER M. LUOND，ET AL.: "Assessment of the Active-Site Requirements of 5-Aminolaevulinic Acid Dehydratase: Evaluation of Substrate and Product Analogues as Competitive Inhibitors", 《J. ORG. CHEM.》 *
REGISTRY: "RN 1233855-18-9", 《STN COLUMBUS》 *

Also Published As

Publication number Publication date
CA2880299A1 (en) 2014-01-30
BR112015001769A2 (pt) 2017-08-22
EP2882712A2 (en) 2015-06-17
US20150197503A1 (en) 2015-07-16
WO2014017938A2 (en) 2014-01-30
RU2015104103A (ru) 2016-09-20
JP2015528013A (ja) 2015-09-24
WO2014017938A3 (en) 2014-03-20

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Effective date of abandoning: 20190531

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