CN104623281A - Traditional Chinese medicine preparation for treating hyperthyroidism and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation, which is prepared from the following main active ingredients in parts by weight: 8-12 parts of rhizoma pinelliae preparata, 9-15 parts of caulis perillae, 9-15 parts of fructus aurantii, 6-12 parts of f the bulb of fritillary, 5-10 parts of sargassum, 5-10 parts of raw oyster shells, 10-15 parts of radix angelica esinensis, 15-30 parts of Chinese yam, 15-30 parts of pericarpium citri reticulatae, 9-16 parts of herba cistanches, 8-12 parts of fructus gardeniae, 10-15 parts of fingered citron, 12-25 parts of radix polygonati officinalis, 6-9 parts of herbaviolae, 3-6 parts of gypsum fibrosum, 5-9 parts of flos caryophylli, 9-16 parts of red flower, 10-15 parts of radix codonopsis, 8-12 parts of air potato, 6-9 parts of radix scrophulariae and 8-16 parts of spicaprunellae. The traditional Chinese medicine preparation is significant in effect on treating hyperthyroidism, and the preparation is simple, raw materials are easily available, the traditional Chinese medicine preparation is suitable for popular use, and has good application prospects.

Description

A kind of Chinese medicine preparation and preparation method for the treatment of hyperthyroidism

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine preparation and preparation method for the treatment of hyperthyroidism.

Background technology

The full name of hyperthyroidism is hyperthyroidism, is due to the too much thyroxin of thyroid synthesis release, causes the hyperfunction and sympathetic activation of organism metabolism, causes cardiopalmus, perspiration, feed and the just secondary disease increasing and lose weight.Most of patients also usually has the symptoms such as expophthalmos, blepharoedema, visual deterioration simultaneously.

Hyperthyroidism disease is because comprising diffuse toxic goiter (also claiming Graves disease), and inflammatory hyperthyroidism (subacute thyroiditis, silent thyroiditis, postpartum thyroiditis and Hashitoxicosis), medicine cause hyperthyroidism (levothyroxine sodium and iodine cause hyperthyroidism), hCG dependency hyperthyroidism (the temporary hyperthyroidism of vomiting during pregnancy) and the hyperthyroidism of TSH of pituitary tumor.More than 80% hyperthyroidism is that Graves disease causes clinically, and Graves disease is Autoimmune Thyroid Diseases, and the lymphocyte of patient creates thyrotrophic stimulating immunoglobulin-TSI, and the TSI that we measure clinically is serum thyrotropin receptor antibody: TRAb.The cause of disease of G7raves disease is current and unclear, may with generate heat, do not have enough sleep, stress is large etc., and factor is relevant, but most patient can not find the cause of disease of morbidity clinically.Graves disease usually merges other autoimmune diseases, as vitiligo, alopecia, type 1 diabetes etc.Hyperthyroid patient main manifestations is clinically: nervous, tachycardia, To Be Protected from Heat, hyperhidrosis, bulimia, become thin, weight loss, fatigue and weak and emotion are emotional, irascible temperament, insomnia, absent-minded, exophthalmos, hands tremor of the tongue are trembled, goiter or enlargement, women can have menoxenia even amenorrhea, male can have sexual impotence or breast development etc.Thyromegaly is property symmetrically, and the patient also had is asymmetry enlargement, and goiter or enlargement can move up and down along with swallowing, and also some hyperthyroid patient has thyroid nodule.The eye that causes during hyperthyroidism changes, and a class is benign exophthalmos, patient's exophthalmos, eye gaze or present terrified expression in the eyes; Another kind is malignant exophthalmos, can be changed by benign exophthalmos and form, malignant exophthalmos patient Chang You keeps in dark place, shed tears, diplopia, visual deterioration, eye swell and ache, twinge, have foreign body sensation etc., because eyeball height is given prominence to, eyes can not be closed, conjunctiva, cornea expose and cause hyperemia, edema, corneal ulceration etc., even blind.Also the hyperthyroid patient had do not have eye symptom or symptom not obvious.Above-mentioned is all clinical manifestations of typical hyperthyroidism, but not every hyperthyroidism is suffered from all clinical symptoms and had, and dissimilar hyperthyroidism, clinical manifestation is also different.

Hyperthyroid patient does not obtain appropriate therapeutic for a long time, can cause and become thin and hyperthyroid heart disease.Patient becomes thin and usually easily suffers from acute infectious disease and infect and to disable or dead.Hyperthyroid heart disease causes cardiac dilatation, arrhythmia, atrial fibrillation and heart failure, patient disability, even dead.

The method of existing Chinese traditional treatment hyperthyroidism is more, publication number CN 102988737A (application number 201210513951.X) patent document discloses a kind of pill for the treatment of hyperthyroidism, and the pill of described treatment hyperthyroidism is made up of according to parts by weight following component: Radix Rehmanniae 5-8 part, Spica Prunellae 6-12 part, Radix Salviae Miltiorrhizae 3-9 part, Arillus Longan 2-8 part, black rattan 3-8 part, Poria 2-4 part, Fructus Schisandrae Chinensis 7-12 part, Concha Ostreae 6-15 part, Radix Ophiopogonis 4-7 part, Radix Paeoniae Rubra 3-12 part.Publication number CN 103272184 A (application number 201310236036.5) patent document discloses a kind of medicament for the treatment of hyperthyroidism, and it comprises the material of following weight proportioning: Spica Prunellae 10-20 part, Squama Manis 5-20 part, Concha Meretricis seu Cyclinae 10-30 part, Sargassum 5-20 part, Thallus Laminariae (Thallus Eckloniae) 5-20 part, Radix Platycodonis 10-20 part, Radix Scrophulariae 10-30 part, Lignum Aquilariae Resinatum 5-20 part, Radix Rehmanniae 10-30 part, Concha Ostreae 10-30 part, Concha Haliotidis 10-20 part, Rhizoma Sparganii 5-20 part, Rhizoma Curcumae 5-20 part, Caulis Polygoni Multiflori 10-20 part, Radix Astragali 10-20 part, Radix Semiaquilegiae 5-20 part, Radix Bupleuri 10-20 part and Rhizoma Dioscoreae Bulbiferae 10-20 part.Publication number CN 104107242 A(application number 201410348144.6) patent document discloses a kind of Chinese medicine composition for the treatment of hyperthyroidism and its production and use, it is prepared from by the Chinese crude drug comprising following weight portion: Radix Morindae Officinalis 10-20 part, Herba Scutellariae Barbatae 12-18 part, Semen Cassiae 6-10 part, Radix Cynanchi Paniculati 10-15 part, Rhizoma Chuanxiong 10-20 part, Flos Chrysanthemi Indici 12-16 part, Radix Salviae Miltiorrhizae 6-9 part, Fructus Momordicae 20-30 part, Radix Astragali 20-30 part, Radix Bupleuri 10-16 part, Poria 12-18 part, Radix Scutellariae 15-25 part, Fructus Atriplicis Sibiricae 10-20 part, Radix Paeoniae Alba 6-12 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Radix Glycyrrhizae 10-15 part.

The prior art comprising above-mentioned patent documentation achieves certain achievement in treatment hyperthyroidism, and the method for current clinical treatment hyperthyroidism disease mainly contains Drug therapy, radiotherapy and operative treatment.Though Drug therapy can alleviate disease to a certain extent, cure the symptoms, not the disease, radiotherapy has carcinogenesis, and operative treatment easily causes sequela.Chinese medicine also exists the difficult problems such as the course of disease is long, refractory more, easily recurs, uncertain therapeutic efficacy is cut.

Summary of the invention

For the deficiency of prior art treatment hyperthyroidism, an object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of hyperthyroidism, and select multiple Chinese herbal medicine, dialectical compatibility, has depressed liver-energy dispersing and QI regulating, clearing away liver-fire, the effect of nourishing the liver and kidney.Treat hyperthyroidism determined curative effect, side effect is low, be applicable to Clinical practice.Another object is just to provide the preparation method of the Chinese medicine preparation of above-mentioned treatment hyperthyroidism.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

Treat a Chinese medicine preparation for hyperthyroidism, take off the primary raw material stating weight proportion and be prepared from: Rhizoma Pinelliae 8-12 part; Caulis Perillae 9-15 part; Fructus Aurantii 9-15 part; Bulbus Fritillariae Thunbergii 6-12 part; Sargassum 5-10 part; Concha Ostreae 5-10 part; Radix Angelicae Sinensis 10-15 part; Rhizoma Dioscoreae 15-30 part; Pericarpium Citri Reticulatae 15-30 part; Herba Cistanches 9-16 part; Fructus Gardeniae 8-12 part; Fructus Citri Sarcodactylis 10-15 part; Rhizoma Polygonati Odorati 12-25 part; Herba Violae 6-9 part; Gypsum Fibrosum 3-6 part; Flos Caryophylli 5-9 part; Flos Carthami 9-16 part; Radix Codonopsis 10-15 part; Rhizoma Dioscoreae Bulbiferae 8-12 part; Radix Scrophulariae 6-9 part; Spica Prunellae 8-16 part.

Treat a Chinese medicine preparation for hyperthyroidism, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Pinelliae 9-11 part; Caulis Perillae 11-13 part; Fructus Aurantii 11-13 part; Bulbus Fritillariae Thunbergii 8-10 part; Sargassum 6-9 part; Concha Ostreae 6-9 part; Radix Angelicae Sinensis 11-14 part; Rhizoma Dioscoreae 20-25 part; Pericarpium Citri Reticulatae 20-25 part; Herba Cistanches 11-14 part; Fructus Gardeniae 9-11 part; Fructus Citri Sarcodactylis 11-14 part; Rhizoma Polygonati Odorati 17-20 part; Herba Violae 7-8 part; Gypsum Fibrosum 4-5 part; Flos Caryophylli 6-8 part; Flos Carthami 11-14 part; Radix Codonopsis 11-14 part; Rhizoma Dioscoreae Bulbiferae 9-11 part; Radix Scrophulariae 7-8 part; Spica Prunellae 11-13 part.

Treat a Chinese medicine preparation for hyperthyroidism, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Pinelliae 10 parts; Caulis Perillae 12 parts; Fructus Aurantii 12 parts; Bulbus Fritillariae Thunbergii 9 parts; Sargassum 7 parts; Concha Ostreae 7 parts; Radix Angelicae Sinensis 13 parts; Rhizoma Dioscoreae 22 parts; Pericarpium Citri Reticulatae 22 parts; Herba Cistanches 12 parts; Fructus Gardeniae 10 parts; Fructus Citri Sarcodactylis 12 parts; Rhizoma Polygonati Odorati 18 parts; Herba Violae 7.5 parts; 4.5 parts, Gypsum Fibrosum; Flos Caryophylli 7 parts; 12 parts, Flos Carthami; Radix Codonopsis 12 parts; Rhizoma Dioscoreae Bulbiferae 10 parts; Radix Scrophulariae 7.5 parts; Spica Prunellae 11 parts.

Present invention also offers the preparation method Chinese medicine preparation of above-mentioned treatment hyperthyroidism being made pharmaceutically acceptable decoction, tablet, capsule and pill.

The preparation method of the Chinese medicine preparation decoction of described treatment hyperthyroidism, step is as follows:

(1) fresh Rhizoma Dioscoreae blender is stirred 5-15 minute (preferred 8-12 minute is more preferably 10 minutes), stir into the thick liquid that viscosity is large, cross 160-200 object drainage screen, filtrate is for subsequent use;

(2) Bulbus Fritillariae Thunbergii, Concha Ostreae and Gypsum Fibrosum are smashed, be placed in refractory container, intense fire heats, and is calcined to crisp, takes out, cools;

(3) Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Flos Caryophylli Flos Carthami are put into glass container, add hot water (the preferably hot water of 75 DEG C-85 DEG C of 70 DEG C-90 DEG C, be more preferably the hot water of 80 DEG C), soak and (preferably soak 25-35 minute in 20-40 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use, filtering residue can be soaked 2-3 time again, merges all filtrate;

(4) be placed in parch container by Caulis Perillae, Radix Angelicae Sinensis, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and Radix Scrophulariae, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), cools, stand-by;

(5) step (2) gains and step (4) gains are placed in marmite, add step (3) gained filtrate, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Pinelliae, Fructus Aurantii, Sargassum, Herba Cistanches, Fructus Gardeniae, Fructus Citri Sarcodactylis, Herba Violae and Spica Prunellae, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges;

(6) step (1) gained filtrate is joined in step (5) gained filtrate, mixing, filter, sterile packaged.

According to preparation method recited above, preferred scheme is: step (1) is 170-190 object drainage screen preferably, is more preferably 180 object drainage screens.

Instructions of taking: each 200-300ml, every day 3 times, 15 days courses for the treatment of.

The preparation method of the Chinese medicine preparation tablet of described treatment hyperthyroidism, step is as follows:

(1) Bulbus Fritillariae Thunbergii, Concha Ostreae and Gypsum Fibrosum are placed in mortar, grind into powder, are placed in glass container, add volume clear water and stir, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2 times, discards impurity, merges suspension, leave standstill, the clear water on upper strata of inclining, gets precipitation and dries;

(2) Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Flos Caryophylli Flos Carthami are put into glass container, add hot water (the preferably hot water of 75 DEG C-85 DEG C of 70 DEG C-90 DEG C, be more preferably the hot water of 80 DEG C), soak and (preferably soak 25-35 minute in 20-40 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use, filtering residue can be soaked 2-3 time again, merges all filtrate;

(3) be placed in parch container by Caulis Perillae, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and Radix Scrophulariae, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), cools, stand-by;

(4) step (1) gains and step (3) gains are placed in marmite, add step (2) gained filtrate, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Pinelliae, Fructus Aurantii, Sargassum, Herba Cistanches, Fructus Gardeniae, Fructus Citri Sarcodactylis, Herba Violae and Spica Prunellae, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges, being condensed into relative density is 1.20-1.40(45 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.25-1.35, be more preferably and be condensed into the thick paste that relative density is 1.30), make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, dry, be pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 3 times, 15 days courses for the treatment of.

The preparation method of the Traditional Chinese medicine preparation capsule of described treatment hyperthyroidism, step is as follows:

(1) Bulbus Fritillariae Thunbergii, Concha Ostreae and Gypsum Fibrosum are placed in mortar, grind into powder, are placed in glass container, add volume clear water and stir, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2 times, discards impurity, merges suspension, leave standstill, the clear water on upper strata of inclining, gets precipitation and dries;

(2) Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Flos Caryophylli Flos Carthami are put into glass container, add hot water (the preferably hot water of 75 DEG C-85 DEG C of 70 DEG C-90 DEG C, be more preferably the hot water of 80 DEG C), soak and (preferably soak 25-35 minute in 20-40 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use, filtering residue can be soaked 2-3 time again, merges all filtrate;

(3) be placed in parch container by Caulis Perillae, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and Radix Scrophulariae, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), cools, stand-by;

(4) step (1) gains and step (3) gains are placed in marmite, add step (2) gained filtrate, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Pinelliae, Fructus Aurantii, Sargassum, Herba Cistanches, Fructus Gardeniae, Fructus Citri Sarcodactylis, Herba Violae and Spica Prunellae, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges, and being condensed into relative density is 1.20-1.40(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(5) step (4) gained medicated powder is measured according to 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain), be processed into capsule according to the preparation for processing of capsule.

According to preparation method recited above, preferred scheme is: step (4) is preferably concentrated into the thick paste of relative density 1.25-1.35, is more preferably the thick paste being concentrated into relative density 1.30.

Instructions of taking: each 2-3 grain, every day 3 times, 15 days courses for the treatment of.

The preparation method of the Chinese medicine preparation taste pill of described treatment hyperthyroidism, step is as follows:

(1) Bulbus Fritillariae Thunbergii, Concha Ostreae and Gypsum Fibrosum are placed in mortar, grind into powder, are placed in glass container, add volume clear water and stir, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2 times, discards impurity, merges suspension, leave standstill, the clear water on upper strata of inclining, gets precipitation and dries;

(2) Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Flos Caryophylli Flos Carthami are put into glass container, add hot water (the preferably hot water of 75 DEG C-85 DEG C of 70 DEG C-90 DEG C, be more preferably the hot water of 80 DEG C), soak and (preferably soak 25-35 minute in 20-40 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use, filtering residue can be soaked 2-3 time again, merges all filtrate;

(3) be placed in parch container by Caulis Perillae, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and Radix Scrophulariae, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), cools, stand-by;

(4) step (1) gains and step (3) gains are placed in marmite, add step (2) gained filtrate, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Pinelliae, Fructus Aurantii, Sargassum, Herba Cistanches, Fructus Gardeniae, Fructus Citri Sarcodactylis, Herba Violae and Spica Prunellae, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges, being condensed into relative density is 1.20-1.40(45 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.25-1.35, be more preferably and be condensed into the thick paste that relative density is 1.30), dry, pulverize, obtain medicated powder,

(5) Mel is placed in pot, slow fire is tempered to thick, add the medicated powder of step (4) gained, fully mix into ointment thoroughly, make the elementary finished product ball of the consistent size of color and luster even (preferred diameter is 3-5mm, and being more preferably diameter is 4mm), be placed in baking oven and slowly dry, take out, In Shadely naturally to dry in the shade, pack by pharmaceutically acceptable carrier.

According to preparation method recited above, preferred scheme is: the quality of the preferred Mel of step (5) is the 10%-20% of medicated powder quality, and the quality being more preferably Mel is 15% of medicated powder quality.

Using method: each 5-8 ball, every day 3 times, 15 days courses for the treatment of.

Beneficial effect of the present invention is mainly reflected in:

1, the present invention is having remarkable result on Treatment of Hyperthyroidism, to human organ particularly to liver avirulence.

2, the present invention selects multiple Chinese herbal medicine, and dialectical compatibility, has depressed liver-energy dispersing and QI regulating, clearing away liver-fire, the effect of nourishing the liver and kidney.

3, drug effect of the present invention is comprehensive, can conditions of patients be made rapidly to take a turn for the better, fundamentally alleviate disease.

4, Chinese medicine composition preparation of the present invention is simple, and raw material is easy to get, and is suitable for popular use, has good application prospect.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

embodiment 1treat a Chinese medicine preparation for hyperthyroidism, take off and state primary raw material and be prepared from (getting 40g for every part): Rhizoma Pinelliae 8 parts; Caulis Perillae 9 parts; Fructus Aurantii 9 parts; Bulbus Fritillariae Thunbergii 6 parts; Sargassum 5 parts; Concha Ostreae 5 parts; Radix Angelicae Sinensis 10 parts; Rhizoma Dioscoreae 15 parts; Pericarpium Citri Reticulatae 15 parts; Herba Cistanches 9 parts; Fructus Gardeniae 8 parts; Fructus Citri Sarcodactylis 10 parts; Rhizoma Polygonati Odorati 12 parts; Herba Violae 6 parts; 3 parts, Gypsum Fibrosum; Flos Caryophylli 5 parts; 9 parts, Flos Carthami; Radix Codonopsis 10 parts; Rhizoma Dioscoreae Bulbiferae 8 parts; Radix Scrophulariae 6 parts; Spica Prunellae 8 parts.

The preparation method of the Chinese medicine preparation decoction of above-mentioned treatment hyperthyroidism, step is as follows:

(1) fresh Rhizoma Dioscoreae blender is stirred 10 minutes, stir into the thick liquid that viscosity is large, cross 180 object drainage screens, filtrate is for subsequent use;

(2) Bulbus Fritillariae Thunbergii, Concha Ostreae and Gypsum Fibrosum are smashed, be placed in refractory container, intense fire heats, and is calcined to crisp, takes out, cools;

(3) Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Flos Caryophylli Flos Carthami are put into glass container, add the hot water of 80 DEG C, soak 30 minutes, filter, filtrate is for subsequent use, and filtering residue can soak 2 times again, merges all filtrate;

(4) be placed in parch container by Caulis Perillae, Radix Angelicae Sinensis, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and Radix Scrophulariae, moderate heat fries 25 minutes, cools, stand-by;

(5) step (2) gains and step (4) gains are placed in marmite, add step (3) gained filtrate, decoct with water 40 minutes, add Rhizoma Pinelliae, Fructus Aurantii, Sargassum, Herba Cistanches, Fructus Gardeniae, Fructus Citri Sarcodactylis, Herba Violae and Spica Prunellae, continue decoction twice, boil 30 minutes, twice filtrate merges at every turn;

(6) step (1) gained filtrate is joined in step (5) gained filtrate, mixing, filter, sterile packaged.

Instructions of taking: each 200-300ml, every day 3 times, 15 days courses for the treatment of.

model case one:liu XX, man, 39 years old, Laiwu City people from Laicheng district, Shandong Province.Occurred cardio palmus shape without obvious inducement before 5 years, go to hospital to look into first merit T3, T4 and raise, TSH declines, and T3 7.54pmol/L, T4 159.61pmol/L, TSH0.004mIU/L, examined as hyperthyroidism, and first merit is looked in treatment after half a year normal, so stop treatment.Unexpectedly again occurred cardiopalmus symptom before 2 years, look into FT3, FT4 and raise, TSH declines, take anti-hyperthyroidism medicine ever since, bad during period state of an illness fashion, each has been all almost just be eased a period of time of taking medicine after being ill, but generally can recur again after drug withdrawal a period of time.

After taking 2 courses for the treatment of of Chinese medicine preparation decoction (embodiment 1) of gained of the present invention treatment hyperthyroidism, cardiopalmus is weak, sensation of oppression over the chest with shortness of breath, and the symptoms such as difference of sleeping night are obviously eased, and the mental status is good.After continuing to take 2 courses for the treatment of, have a medical check-up: the malaise symptoms such as cardiopalmus disappear, and reach clinical cure, patient is well conscious.Later stage visits and learns that period is without uncomfortable reaction, does not recur yet.

embodiment 2treat a Chinese medicine preparation for hyperthyroidism, take off and state primary raw material and be prepared from (getting 50g for every part): Rhizoma Pinelliae 9 parts; Caulis Perillae 11 parts; Fructus Aurantii 11 parts; Bulbus Fritillariae Thunbergii 8 parts; Sargassum 6 parts; Concha Ostreae 6 parts; Radix Angelicae Sinensis 11 parts; Rhizoma Dioscoreae 20 parts; Pericarpium Citri Reticulatae 20 parts; Herba Cistanches 11 parts; Fructus Gardeniae 9 parts; Fructus Citri Sarcodactylis 11 parts; Rhizoma Polygonati Odorati 17 parts; Herba Violae 7 parts; 4 parts, Gypsum Fibrosum; Flos Caryophylli 6 parts; 11 parts, Flos Carthami; Radix Codonopsis 11 parts; Rhizoma Dioscoreae Bulbiferae 9 parts; Radix Scrophulariae 7 parts; Spica Prunellae 11 parts.

The preparation method of the Chinese medicine preparation tablet of above-mentioned treatment hyperthyroidism, step is as follows:

(1) Bulbus Fritillariae Thunbergii, Concha Ostreae and Gypsum Fibrosum are placed in mortar, grind into powder, are placed in glass container, add volume clear water and stir, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2 times, discards impurity, merges suspension, leave standstill, the clear water on upper strata of inclining, gets precipitation and dries;

(2) Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Flos Caryophylli Flos Carthami are put into glass container, add the hot water of 80 DEG C, soak 30 minutes, filter, filtrate is for subsequent use, and filtering residue can soak 2 times again, merges all filtrate;

(3) be placed in parch container by Caulis Perillae, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and Radix Scrophulariae, moderate heat fries 25 minutes, cools, stand-by;

(4) step (1) gains and step (3) gains are placed in marmite, add step (2) gained filtrate, decoct with water 40 minutes, add Rhizoma Pinelliae, Fructus Aurantii, Sargassum, Herba Cistanches, Fructus Gardeniae, Fructus Citri Sarcodactylis, Herba Violae and Spica Prunellae, continue decoction twice, boil 30 minutes at every turn, twice filtrate merges, being condensed into relative density is 1.30(45 DEG C) thick paste, make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, dry, be pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 3 times, 15 days courses for the treatment of.

model case two:rely XX, female, 43 years old, people from Zanhuang County, From Shijiazhuang City of Hebei Province.Because of polyphagia before about 5 years, become thin, times of defecation increases repeatedly, and palpebral fissure is slightly broadening,, the symptoms such as eyeball is slightly given prominence to, the 2 degree of enlargements of two thyroid, go local hospital inspection: first merit shows: FT3, FT4 raise, TSH reduces, and is diagnosed as hyperthyroidism, after take the treatment of the medicine such as thiamazole always.Period Relapse rate outbreak, fail to cure, and the health of Mrs Lai is more shown in and becomes thin always.

After taking 2 courses for the treatment of of Chinese medicine preparation tablet (embodiment 2) of gained of the present invention treatment hyperthyroidism, various malaise symptoms is eased, and the content of FT3, FT4 also declines to some extent.After continuing to take 2 courses for the treatment of, malaise symptoms disappears completely, and body weight too increases about 3kg, reaches clinical cure on inspection, and without uncomfortable reaction during medication.Chase after visiting of later stage to learn, do not recur in the ensuing time more than a year.

embodiment 3treat a Chinese medicine preparation for hyperthyroidism, take off and state primary raw material and be prepared from (getting 20g for every part): Rhizoma Pinelliae 11 parts; Caulis Perillae 13 parts; Fructus Aurantii 13 parts; Bulbus Fritillariae Thunbergii 10 parts; Sargassum 9 parts; Concha Ostreae 9 parts; Radix Angelicae Sinensis 14 parts; Rhizoma Dioscoreae 25 parts; Pericarpium Citri Reticulatae 25 parts; Herba Cistanches 14 parts; Fructus Gardeniae 11 parts; Fructus Citri Sarcodactylis 14 parts; Rhizoma Polygonati Odorati 20 parts; Herba Violae 8 parts; 5 parts, Gypsum Fibrosum; Flos Caryophylli 8 parts; 14 parts, Flos Carthami; Radix Codonopsis 14 parts; Rhizoma Dioscoreae Bulbiferae 11 parts; Radix Scrophulariae 8 parts; Spica Prunellae 13 parts.

The preparation method of the Traditional Chinese medicine preparation capsule of above-mentioned treatment hyperthyroidism, step is as follows:

(1) Bulbus Fritillariae Thunbergii, Concha Ostreae and Gypsum Fibrosum are placed in mortar, grind into powder, are placed in glass container, add volume clear water and stir, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2 times, discards impurity, merges suspension, leave standstill, the clear water on upper strata of inclining, gets precipitation and dries;

(2) Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Flos Caryophylli Flos Carthami are put into glass container, add the hot water of 80 DEG C, soak 30 minutes, filter, filtrate is for subsequent use, and filtering residue can soak 2 times again, merges all filtrate;

(3) be placed in parch container by Caulis Perillae, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and Radix Scrophulariae, moderate heat fries 25 minutes, cools, stand-by;

(4) step (1) gains and step (3) gains are placed in marmite, add step (2) gained filtrate, decoct with water 40 minutes, add Rhizoma Pinelliae, Fructus Aurantii, Sargassum, Herba Cistanches, Fructus Gardeniae, Fructus Citri Sarcodactylis, Herba Violae and Spica Prunellae, continue decoction twice, boil 30 minutes at every turn, twice filtrate merges, and being condensed into relative density is 1.30(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(5) step (4) gained medicated powder is measured according to 0.5g/ grain, be processed into capsule according to the preparation for processing of capsule.

Instructions of taking: each 2-3 grain, every day 3 times, 15 days courses for the treatment of.

model case three: Du XX, man, 49 years old, Hengshui City people from Zaoqiang County, Hebei province.There is insomnia in recent months, cardiopalmus, fidgety, night sweat, the symptoms such as rapid heart beat, electrocardiogram prompting sinus tachycardia, tentative diagnosis autonomic nervous dysfunction, gives oryzanol, vitamin B1, propranolol, ANSHEN BUNAO YE takes. and spend one week and again gone to a doctor, claimed not feel any better, in secondary having a medical check-up, find that patient's sight eyes that glitter are gently convex, suggestion goes to hospital to be T3, and T4 checks, result T3, T4 raises, therefore makes a definite diagnosis hyperthyroidism.

After taking 2 courses for the treatment of of Traditional Chinese medicine preparation capsule (embodiment 3) of gained of the present invention treatment hyperthyroidism, insomnia, cardiopalmus, fidgety, night sweat, the symptoms such as rapid heart beat slow down to some extent.After continuing to take 2 courses for the treatment of, the insomnia before occurred, cardiopalmus, fidgety, night sweat, the symptoms such as rapid heart beat disappear substantially, and during inspection, health presents normal condition.Later stage visits and learns and fully recover, and does not recur.

embodiment 4treat a Chinese medicine preparation for hyperthyroidism, take off and state primary raw material and be prepared from (getting 30g for every part): Rhizoma Pinelliae 10 parts; Caulis Perillae 12 parts; Fructus Aurantii 12 parts; Bulbus Fritillariae Thunbergii 9 parts; Sargassum 7 parts; Concha Ostreae 7 parts; Radix Angelicae Sinensis 13 parts; Rhizoma Dioscoreae 22 parts; Pericarpium Citri Reticulatae 22 parts; Herba Cistanches 12 parts; Fructus Gardeniae 10 parts; Fructus Citri Sarcodactylis 12 parts; Rhizoma Polygonati Odorati 18 parts; Herba Violae 7.5 parts; 4.5 parts, Gypsum Fibrosum; Flos Caryophylli 7 parts; 12 parts, Flos Carthami; Radix Codonopsis 12 parts; Rhizoma Dioscoreae Bulbiferae 10 parts; Radix Scrophulariae 7.5 parts; Spica Prunellae 11 parts.

The preparation method of the Chinese medicine preparation pill of above-mentioned treatment hyperthyroidism, step is as follows:

(1) Bulbus Fritillariae Thunbergii, Concha Ostreae and Gypsum Fibrosum are placed in mortar, grind into powder, are placed in glass container, add volume clear water and stir, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2 times, discards impurity, merges suspension, leave standstill, the clear water on upper strata of inclining, gets precipitation and dries;

(2) Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Flos Caryophylli Flos Carthami are put into glass container, add the hot water of 80 DEG C, soak 30 minutes, filter, filtrate is for subsequent use, and filtering residue can soak 2 times again, merges all filtrate;

(3) be placed in parch container by Caulis Perillae, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and Radix Scrophulariae, moderate heat fries 25 minutes, cools, stand-by;

(4) step (1) gains and step (3) gains are placed in marmite, add step (2) gained filtrate, decoct with water 40 minutes, add Rhizoma Pinelliae, Fructus Aurantii, Sargassum, Herba Cistanches, Fructus Gardeniae, Fructus Citri Sarcodactylis, Herba Violae and Spica Prunellae, continue decoction twice, boil 30 minutes at every turn, twice filtrate merges, and being condensed into relative density is 1.30(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(5) Mel is placed in pot, slow fire is tempered to thick, add the medicated powder of step (4) gained, fully mix into ointment thoroughly, make the elementary finished product ball of the consistent size of color and luster even (preferred diameter is 4mm), be placed in baking oven and slowly dry, take out, In Shadely naturally to dry in the shade, pack by pharmaceutically acceptable carrier.

Instructions of taking: each 5-8 ball, every day 3 times, 15 days courses for the treatment of.

The pharmacological effect of each raw material is respectively:

Rhizoma Pinelliae: acrid in the mouth, warm in nature.Return spleen, stomach warp.For Rhizoma Pinelliae and Alumen boil the Preparation process product of rear drying altogether, and Rhizoma Pinelliae is the dry tuber of the aroid Rhizoma Pinelliae.There is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, effect of dissolving lump and resolving mass.For damp-phlegm cold drink, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, and vomiting regurgitation, thymus painful abdominal mass is vexed, globus hystericus.

Caulis Perillae: acrid in the mouth, warm in nature.Return lung, spleen channel.For the dry stem of labiate Folium Perillae.There is regulating the flow of QI to ease the stomach, pain relieving, antiabortive effect.Vexed for chest and diaphragm painful abdominal mass, gastralgia, belch is vomitted, frequent fetal movement.

Fructus Aurantii: bitter in the mouth, pungent, sour, warm in nature.Return spleen, stomach warp.For the dry immature fruit of rutaceae Citrus aurantium Linn. and variety thereof.There is regulating the flow of QI to ease the stomach, effect of the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention, gastroptosis, proctoptosis, uterine prolapse.

Bulbus Fritillariae Thunbergii: bitter in the mouth, cold in nature.Return lung, heart channel.Another name: Bulbus Fritillariae Thunbergii, resemble shellfish, Bulbus Fritillariae Thunbergii, Bulbus Fritillariae Thunbergii.For the bulb of liliaceous plant Bulbus Fritillariae Thunbergii.Containing peimine, peiminine, peimine glycosides, different peimine, Bulbus Fritillariae Uninbracteatae Buddhist nun fourth alkali, different Bulbus Fritillariae Uninbracteatae Buddhist nun fourth alkali, Bulbus Fritillariae Uninbracteatae sterin, choline etc.There is removing heat-phlegm, sending down the abnormal ascending QI cough-relieving, effect of mass dissipating and swelling eliminating.For wind heat or phlegm-heat cough, lung abscess vomiting pus, scrofula goiter, sore and toxic.

Sargassum: bitter in the mouth, salty, cold in nature.Return liver, stomach, kidney channel.For the dry frond of Sargassaceae plant Sargassum or Sargassum fusiforme (Harv.) Setch.There is hard masses softening and resolving, expectorant, diuretic, effect of anticoagulant and hemostasis.For goiter, scrofula, painful and swollen testis, phlegm retention edema.

Concha Ostreae: salty in the mouth, cold nature.Return liver, gallbladder, kidney channel.For the shell of the long Concha Ostreae of Ostreidae animal, Dalian Bay Concha Ostreae or Crassostrea rivularis.There is tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, restrain astringent or styptic treatment for spontaneous sweating effect.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule ， mass in the abdomen mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.

Radix Angelicae Sinensis: sweet in the mouth, pungent, micro-hardship, warm in nature.Return liver, the heart, spleen channel.For the dry root of umbelliferae angelica.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Rhizoma Dioscoreae: sweet in the mouth, property is put down.Return spleen, lung, kidney channel.For the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Have spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, effect of the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst, anorexia and loose stool, and asthenia is breathed with cough, and quenches one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating, for insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.

Pericarpium Citri Reticulatae: bitter in the mouth, pungent, warm in nature.Return lung, spleen channel.Another name Pericarpium Citri tangerinae, expensive old, Folium Styracis Suberifoliae etc.For the dry mature skin of rutaceae orange and variety thereof.There is regulating qi-flowing for strengthening spleen, effect of drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

Herba Cistanches: sweet in the mouth, salty, warm in nature.Return kidney, large intestine channel.The fleshy stem of the dry zone scale leaf of Rong is sent out for orobanchaceae plant cistanche or pipe fat and red meat.There is kidney-replenishing, benefiting essence-blood, effect of loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.

Fructus Gardeniae: bitter in the mouth, cold in nature.GUIXIN, lung, tri-jiao channel.Another name SHANZHIZI etc.For the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae.There is pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, effect of removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, yellow cellulitis dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.

Fructus Citri Sarcodactylis: acrid in the mouth, hardship, acid, warm in nature.Return liver, spleen, lung meridian.For the dry fruit of rutaceae Fructus Citri Sarcodactylis.There is liver-smoothing, qi-regulating, and effect of stomach and alleviating pain.For stagnation of liver-QI and stomach-QI. distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.

Rhizoma Polygonati Odorati: sweet in the mouth, cold nature.Attach to the lung and stomach meridians.For the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati.There is nourishing YIN to relieve dryness, effect of promoting the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, swallow in thirsty, interior-heat is quenched one's thirst.

Herba Violae: bitter in the mouth, pungent, cold in nature.GUIXIN, Liver Channel.For the dry herb of Violaceae Chinese violet.There is heat-clearing and toxic substances removing, effect of removing heat from blood detumescence.For furuncle swelling toxin, cellulitis carbuncle on the back, erysipelas, venom.

Gypsum Fibrosum: sweet in the mouth, pungent, property Great Cold.Attach to the lung and stomach meridians.Another name Mirabilitum crystallina is Sulfates mineral anhydrite race Gypsum Fibrosum, main containing hydrous calcium sulfate (CaSO ₄2H ₂o) after excavating, removing silt and assorted stone.There is clearing away heat-fire, effect that relieving restlessness is quenched the thirst.For fever caused by exogenous pathogenic factors, high hot excessive thirst, dyspnea and cough due to lung-heat, the high Sheng of stomach-fire, headache, toothache.

Flos Caryophylli: property is pungent, taste temperature.Return lung, spleen, stomach, kidney four warp.For alabastrum and the fruit of Myrtaceae aiphyllium plant.Alabastrum is containing volatile oil and Oleum Caryophylli, main containing eugenol, acetyleugenol, B-caryophyllene in oil, and methyl-n-amyl ketone, methyl salicylate, Humuleno, benzaldehyde, benzylalcohol, 3-Methoxybenzaldehyde, benzyl acetate, chavicol, a-ylangene etc.Triterpenoid is also contained as oleanolic acid, flavone and chromone class rhamnetin, kaempferol, eugenin, eugenitin, isoeugenitin and demethylation compound isoeugenitol thereof in spending.There is effect of warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.For singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, ringworm.

Flos Carthami: acrid in the mouth, warm in nature.GUIXIN, Liver Channel.For the dried floral of feverfew Flos Carthami.There is promoting blood circulation to restore menstrual flow, the function of eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia ， mass in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.Anemia of pregnant woman but to be avoided to use, otherwise can miscarriage be caused.

Radix Codonopsis: sweet in the mouth, property is put down.Return spleen, lung meridian.For Campanulaceae Radix Codonopsis, the plain dry root spending Radix Codonopsis or radix codonpsis tangshen.There is invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

Rhizoma Dioscoreae Bulbiferae: bitter in the mouth, pungent, cool in nature.Return few cloudy, the meridian of Foot-JUE YIN of hands.For the tuber of Dioscoreaceae plant Dioscorea bulbifera L..Rhizoma Dioscoreae Bulbiferae element E acetas is shown containing Rhizoma Dioscoreae Bulbiferae element A-H, 8-.Diosgenin, D-Sorbitol, 2,4,6,7-tetrahydroxy-9-10-dihydro is luxuriant and rich with fragrance, and 2,4,5,6-tetrahydroxy is luxuriant and rich with fragrance, dihydro dioscorine, sucrose, reducing sugar, starch, Saponin, tannin etc.There is removing toxic substances and promoting subsidence of swelling, dissipating phlegm and resolving masses, effect of cooling blood for hemostasis.For thyromegaly, tuberculous lymphadenitis, laryngopharynx swelling and pain, spits blood, spitting of blood, pertussis, cancerous protuberance; Furuncle is controlled in external.

Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature.Return lung, stomach, kidney channel.For the dry root of goatweed Radix Scrophulariae.There is removing heat from blood YIN nourishing, effect of eliminating fire and detoxication.For consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, and scrofula is sick, diphtheria, carbuncle sore tumefacting virus.

Spica Prunellae: acrid in the mouth, hardship, cold in nature.Return liver, gallbladder meridian.For the dry fruit ear of labiate Spica Prunellae.Have and relieve inflammation or internal heat, improving eyesight, eliminating stagnation, effect of detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.

test example:in order to verify the curative effect of the Chinese medicine preparation (embodiment 4) of gained of the present invention treatment hyperthyroidism, we have done contrast test in March ,-2011 in June, 2008.

General data: screen 200 routine hyperthyroid patients in Duo Suo hospital, man 107 example, female 93 example; Minimal ages 25 years old, max age 68 years old, 49.4 years old mean age; 25-40 year 69 people, 40-55 year 94 people, 56-68 year 37 people.Be divided into experimental group and matched group Liang Ge group (wherein, experimental group 150 people, matched group 50 people) at random.Two groups are compared there was no significant difference (P > 0.05), have comparability in sex, age, the course of disease, state of an illness scoring etc.

Diagnostic criteria: 1. weak, the cardiopalmus of being irritable and irascible, To Be Protected from Heat hyperhidrosis, limbs, receive high easy famine, extremity tremble, ophthalmic bloated, times of defecation are many, menoxenia etc., have wherein more than 6; 2. exophthalmos, widening of palpebral fissure, thyromegaly, trembling of limbs, lose weight, tachycardia, systolic pressure increase, pulse pressure difference increase etc., have wherein more than 4; 3. lab testing: serum T 3, T4 exceed normal value (total T3:1.34-2.73 nmol/L, total T4:78.4-157.4 nmol/L; FT3:3.67-10.43 Pmol/L, FT:4 7.5-21.1 Pmol/L), thyrotropin is lower than normal value (TSH: 0.34-5.60 mIU/L), and iodine uptake rate increases, peak reach person.

Usage and dosage: two groups of patients unify dietary standards.Experimental group takes the Chinese medicine preparation pill of gained of the present invention treatment hyperthyroidism, each 6 balls, every day 3 times, 15 days courses for the treatment of.Matched group: adopt other treatment mode (as thiamazole:, methylthiouracil etc.), wherein thiamazole: adult's starting dose is generally 30mg(6 sheet on the one), several oral, decrement gradually after Morbidity control, every day, maintenance dose needed between 5-15mg(1-3 sheet by the state of an illness); When children's starts dosage be every day by body weight 0.4mg/kg, several oral.Methylthiouracil: adult's starting dose is generally 300mg(3 sheet every day), depending on state of an illness weight between 150-400mg(1 sheet half-4), several oral, decrement gradually after Morbidity control, maintenance dose 50-150mg(every day half-1 slice half); Children's's starting dose presses body weight 4mg/kg every day, and several oral, maintenance dose is cut down according to the circumstance.

Criterion of therapeutical effect: recovery from illness: clinical symptom disappearance, sign disappears substantially, and lab testing recovers normal; Effective: sings and symptoms takes a turn for the better or major part takes a turn for the better, thyroid function decline more than 50% or T3, T4 have a decline; Invalid: after treatment, sings and symptoms is without improvement, check serum T 3, T4 value are without significant change.

4 courses for the treatment of of medication treatment, observe latter 6 months for the treatment of.Adopt the matched group of other treatment mode and take the Comparison of therapeutic that gained of the present invention treats the experimental group of the Chinese medicine preparation of hyperthyroidism, result is as shown in table 1:

Table 1

efficacy analysis:as can be seen from Table 1, take the effective percentage of the Chinese medicine preparation of gained of the present invention treatment hyperthyroidism up to 96%, and adopt other treatment mode only reach 76%, and take the cure rate of the Chinese medicine preparation of gained of the present invention treatment hyperthyroidism up to 68%, and adopt the cure rate of other treatment mode only to reach 40%.Show that the curative effect of the Chinese medicine preparation of gained of the present invention treatment hyperthyroidism is more remarkable.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. treat a Chinese medicine preparation for hyperthyroidism, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Rhizoma Pinelliae 8-12 part; Caulis Perillae 9-15 part; Fructus Aurantii 9-15 part; Bulbus Fritillariae Thunbergii 6-12 part; Sargassum 5-10 part; Concha Ostreae 5-10 part; Radix Angelicae Sinensis 10-15 part; Rhizoma Dioscoreae 15-30 part; Pericarpium Citri Reticulatae 15-30 part; Herba Cistanches 9-16 part; Fructus Gardeniae 8-12 part; Fructus Citri Sarcodactylis 10-15 part; Rhizoma Polygonati Odorati 12-25 part; Herba Violae 6-9 part; Gypsum Fibrosum 3-6 part; Flos Caryophylli 5-9 part; Flos Carthami 9-16 part; Radix Codonopsis 10-15 part; Rhizoma Dioscoreae Bulbiferae 8-12 part; Radix Scrophulariae 6-9 part; Spica Prunellae 8-16 part.

2. the Chinese medicine preparation for the treatment of hyperthyroidism according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Pinelliae 9-11 part; Caulis Perillae 11-13 part; Fructus Aurantii 11-13 part; Bulbus Fritillariae Thunbergii 8-10 part; Sargassum 6-9 part; Concha Ostreae 6-9 part; Radix Angelicae Sinensis 11-14 part; Rhizoma Dioscoreae 20-25 part; Pericarpium Citri Reticulatae 20-25 part; Herba Cistanches 11-14 part; Fructus Gardeniae 9-11 part; Fructus Citri Sarcodactylis 11-14 part; Rhizoma Polygonati Odorati 17-20 part; Herba Violae 7-8 part; Gypsum Fibrosum 4-5 part; Flos Caryophylli 6-8 part; Flos Carthami 11-14 part; Radix Codonopsis 11-14 part; Rhizoma Dioscoreae Bulbiferae 9-11 part; Radix Scrophulariae 7-8 part; Spica Prunellae 11-13 part.

3. the Chinese medicine preparation for the treatment of hyperthyroidism according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from :rhizoma Pinelliae 10 parts; Caulis Perillae 12 parts; Fructus Aurantii 12 parts; Bulbus Fritillariae Thunbergii 9 parts; Sargassum 7 parts; Concha Ostreae 7 parts; Radix Angelicae Sinensis 13 parts; Rhizoma Dioscoreae 22 parts; Pericarpium Citri Reticulatae 22 parts; Herba Cistanches 12 parts; Fructus Gardeniae 10 parts; Fructus Citri Sarcodactylis 12 parts; Rhizoma Polygonati Odorati 18 parts; Herba Violae 7.5 parts; 4.5 parts, Gypsum Fibrosum; Flos Caryophylli 7 parts; 12 parts, Flos Carthami; Radix Codonopsis 12 parts; Rhizoma Dioscoreae Bulbiferae 10 parts; Radix Scrophulariae 7.5 parts; Spica Prunellae 11 parts.

4., according to the Chinese medicine preparation of the arbitrary described treatment hyperthyroidism of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:

(1) fresh Rhizoma Dioscoreae blender is stirred 5-15 minute (preferred 8-12 minute is more preferably 10 minutes), stir into the thick liquid that viscosity is large, cross 160-200 object drainage screen, filtrate is for subsequent use;

(2) Bulbus Fritillariae Thunbergii, Concha Ostreae and Gypsum Fibrosum are smashed, be placed in refractory container, intense fire heats, and is calcined to crisp, takes out, cools;

(3) Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Flos Caryophylli Flos Carthami are put into glass container, add hot water (the preferably hot water of 75 DEG C-85 DEG C of 70 DEG C-90 DEG C, be more preferably the hot water of 80 DEG C), soak and (preferably soak 25-35 minute in 20-40 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use, filtering residue can be soaked 2-3 time again, merges all filtrate;

(4) be placed in parch container by Caulis Perillae, Radix Angelicae Sinensis, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and Radix Scrophulariae, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), cools, stand-by;

(5) step (2) gains and step (4) gains are placed in marmite, add step (3) gained filtrate, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Pinelliae, Fructus Aurantii, Sargassum, Herba Cistanches, Fructus Gardeniae, Fructus Citri Sarcodactylis, Herba Violae and Spica Prunellae, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges;

(6) step (1) gained filtrate is joined in step (5) gained filtrate, mixing, filter, sterile packaged.

5. the preparation method of the Chinese medicine preparation decoction for the treatment of hyperthyroidism according to claim 4, is characterized in that: step (1) is 170-190 object drainage screen preferably, is more preferably 180 object drainage screens.

6., according to the Chinese medicine preparation of the arbitrary described treatment hyperthyroidism of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:

(1) Bulbus Fritillariae Thunbergii, Concha Ostreae and Gypsum Fibrosum are placed in mortar, grind into powder, are placed in glass container, add volume clear water and stir, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2 times, discards impurity, merges suspension, leave standstill, the clear water on upper strata of inclining, gets precipitation and dries;

(2) Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Flos Caryophylli Flos Carthami are put into glass container, add hot water (the preferably hot water of 75 DEG C-85 DEG C of 70 DEG C-90 DEG C, be more preferably the hot water of 80 DEG C), soak and (preferably soak 25-35 minute in 20-40 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use, filtering residue can be soaked 2-3 time again, merges all filtrate;

(3) be placed in parch container by Caulis Perillae, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and Radix Scrophulariae, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), cools, stand-by;

(4) step (1) gains and step (3) gains are placed in marmite, add step (2) gained filtrate, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Pinelliae, Fructus Aurantii, Sargassum, Herba Cistanches, Fructus Gardeniae, Fructus Citri Sarcodactylis, Herba Violae and Spica Prunellae, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges, being condensed into relative density is 1.20-1.40(45 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.25-1.35, be more preferably and be condensed into the thick paste that relative density is 1.30), make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, dry, be pressed into lamellar, sugar coating.

7., according to the Chinese medicine preparation of the arbitrary described treatment hyperthyroidism of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is as follows:

(1) Bulbus Fritillariae Thunbergii, Concha Ostreae and Gypsum Fibrosum are placed in mortar, grind into powder, are placed in glass container, add volume clear water and stir, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2 times, discards impurity, merges suspension, leave standstill, the clear water on upper strata of inclining, gets precipitation and dries;

(2) Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Flos Caryophylli Flos Carthami are put into glass container, add hot water (the preferably hot water of 75 DEG C-85 DEG C of 70 DEG C-90 DEG C, be more preferably the hot water of 80 DEG C), soak and (preferably soak 25-35 minute in 20-40 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use, filtering residue can be soaked 2-3 time again, merges all filtrate;

(3) be placed in parch container by Caulis Perillae, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and Radix Scrophulariae, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), cools, stand-by;

(4) step (1) gains and step (3) gains are placed in marmite, add step (2) gained filtrate, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Pinelliae, Fructus Aurantii, Sargassum, Herba Cistanches, Fructus Gardeniae, Fructus Citri Sarcodactylis, Herba Violae and Spica Prunellae, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges, and being condensed into relative density is 1.20-1.40(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(5) step (4) gained medicated powder is measured according to 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain), be processed into capsule according to the preparation for processing of capsule.

8. the preparation method of the Traditional Chinese medicine preparation capsule for the treatment of hyperthyroidism according to claim 7, is characterized in that: step (4) is preferably concentrated into the thick paste of relative density 1.25-1.35, is more preferably the thick paste being concentrated into relative density 1.30.

9., according to the Chinese medicine preparation of the arbitrary described treatment hyperthyroidism of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:

(1) Bulbus Fritillariae Thunbergii, Concha Ostreae and Gypsum Fibrosum are placed in mortar, grind into powder, are placed in glass container, add volume clear water and stir, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2 times, discards impurity, merges suspension, leave standstill, the clear water on upper strata of inclining, gets precipitation and dries;

(2) Pericarpium Citri Reticulatae, Rhizoma Polygonati Odorati, Flos Caryophylli Flos Carthami are put into glass container, add hot water (the preferably hot water of 75 DEG C-85 DEG C of 70 DEG C-90 DEG C, be more preferably the hot water of 80 DEG C), soak and (preferably soak 25-35 minute in 20-40 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use, filtering residue can be soaked 2-3 time again, merges all filtrate;

(3) be placed in parch container by Caulis Perillae, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Radix Codonopsis, Rhizoma Dioscoreae Bulbiferae and Radix Scrophulariae, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), cools, stand-by;

(4) step (1) gains and step (3) gains are placed in marmite, add step (2) gained filtrate, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add Rhizoma Pinelliae, Fructus Aurantii, Sargassum, Herba Cistanches, Fructus Gardeniae, Fructus Citri Sarcodactylis, Herba Violae and Spica Prunellae, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges, being condensed into relative density is 1.20-1.40(45 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.25-1.35, be more preferably and be condensed into the thick paste that relative density is 1.30), dry, pulverize, obtain medicated powder,

(5) Mel is placed in pot, slow fire is tempered to thick, add the medicated powder of step (4) gained, fully mix into ointment thoroughly, make the elementary finished product ball of the consistent size of color and luster even (preferred diameter is 3-5mm, and being more preferably diameter is 4mm), be placed in baking oven and slowly dry, take out, In Shadely naturally to dry in the shade, pack by pharmaceutically acceptable carrier.

10. the preparation method of the Chinese medicine preparation pill for the treatment of hyperthyroidism according to claim 9, is characterized in that: the quality of the preferred Mel of step (5) is the 10%-20% of medicated powder quality, and the quality being more preferably Mel is 15% of medicated powder quality.