CN104623384A - Liver smoothing and qi regulating drug for treating mammary gland hyperplasia and preparation method of liver smoothing and qi regulating drug - Google Patents
Liver smoothing and qi regulating drug for treating mammary gland hyperplasia and preparation method of liver smoothing and qi regulating drug Download PDFInfo
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Abstract
The invention discloses a liver smoothing and qi regulating drug for treating mammary gland hyperplasia and a preparation method of the liver smoothing and qi regulating drug. The liver smoothing and qi regulating drug is prepared from the following main crude drugs in parts by weight: 10-20 parts of trichosanthes kirilowii, 8-15 parts of radix asparagi, 8-15 parts of cuttlebones, 6-9 parts of cortex lycii radicis, 10-20 parts of dogwood, 8-15 parts of tangerine leaves, 6-9 parts of tangerine seeds, 5-10 parts of fructus aurantii, 5-10 parts of curculigo capitulata, 3-6 parts of motherwort fruits, 8-16 parts of concha arcae, 7-14 parts of usnea, 7-15 parts of common fenugreek seeds, 8-12 parts of rhizoma anemarrhenae, 8-16 parts of goosegrass herbs and 8-12 parts of pinellia ternata. The liver smoothing and qi regulating drug is free of side effects, safe, remarkable in curative effect, capable of treating both symptoms and root causes, cheap and available in drug resource, low in treatment cost and convenient to use, and is easily accepted by a patient; and mammary gland hyperplasia does not easily recur.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of cyclomastopathy depressed liver-energy dispersing and QI regulating medicine and preparation method thereof.
Background technology
Cyclomastopathy is the common disease of a kind of gynecological.Be apt to occur in the middle-aged women about 25-39 year, because be women's sexual function the most vigorous period during this period of time.Pathogenic factor: long-term dietary structure is unreasonable, living habit is bad, mental pressure is excessive etc. causes body constitution acidify, the function of human body declines, and then it is slack-off to cause body metabolism to circulate, this electrodeposition substance a large amount of cannot be discharged in vivo, cause QI and blood not smooth, therefore the phenomenons such as endocrine hormone imbalance, menoxenia cause mastopathy and cyclomastopathy.Traditional Chinese Medicine thinks that it is that Chinese medicine is referred to as " nodules of the breast " because depressed rage impairing the liver, worry impairing spleen, qi stagnation blood stasis, expectorant congeal into caused by core.Modern medicine is then thought, its generation, develops and lapses to, and is because the hormonal circadian change in human female caused completely.When the estrogen level of ovarian secretion is too high, corpus luteum progestogen are very few, or both secretion is inharmonious, just can cause the breast ductal epithelial cells in breast and proliferation of fibrous tissue.When under the effect of body in some stressors (as work is too nervous, emotion is too exciting, advanced age is unmarried, not suckling in puerperal and suffer from some chronic disease etc.), the breast hyperplasia tissue just likely causing breast to restore can not get restoring or meromorphosis, in the course of time, just forms cyclomastopathy, show as the newborn leaf and nodular particles that thicken, the three large sings and symptomses such as distending pain of the breast and nipple galactorrhea.The clinical manifestation of cyclomastopathy: 1, mastalgia: be often distending pain or twinge, can involve one or both sides breast, lay particular stress on common with side, pain severe patient can not be touched, and even affects daily life and work.Pain can to ipsilateral axillary or the radiation of shoulder back; Part can show as sore nipples or itch.Mastalgia Chang Yuyue premenstrual a couple of days occurs or increases the weight of, and after passing through, pain obviously alleviates or disappears; Pain also can with emotion changes, fatigue, Changes in weather and fluctuating.This pain relevant with menstrual cycle and emotion changes is the main feature of cyclomastopathy clinical manifestation.2, lump in breast: lump can be sent out in one-sided or bilateral breast, single or multiple, is generally apt to occur in the outside upper quadrant of breast.Showing as lamellar not of uniform size, nodositas, streak etc., is wherein common with lamellar.Border is not obvious, and quality is medium or slightly hard, with surrounding tissue without adhesion, often has tenderness.Major part lump in breast also has the feature changed with menstrual cycle, and the moon, premenstrual lump increased hardening, mass reduction deliquescing after menstrual onset.3, nipple discharge: small number of patients can occur nipple discharge, are spontaneous discharge, mostly are faint yellow or light oyster white, also have few person to overflow discharge as seen through extruding nipple.
Therapeutic Method: because the mechanism that occurs cyclomastopathy and the cause of disease there is no definite understanding, treatment is at present upper is symptomatic treatment substantially.After some patients falls ill, several months to 1 ~ 2 year afterwards often can spontaneous remission, how not to need treatment.Symptom is comparatively obvious, and extent of disease is patient more widely, can hold up breast by medicated bra; Oral Chinese medicine XIAOJIN DAN or Mind-easing Powder, or 5% potassium iodide all can relief of symptoms.Operable drug products is more, and as RUKUAIXIAO, RUPIXIAO, Tabellae Asparagini, PINGXIAO PIAN, the spirit of capsule addiction, tamoxifen etc., therapeutic effect differs.In addition, still have hormonotherapy, someone adopts androgen in treating primary disease, uses suppression estrogen effect, softening tuberosity, mitigation symptoms; But this treatment likely aggravates between human hormone unbalance, unsuitable conventional application.Only at serious symptom, when the normal work of impact and life, just consider to adopt.The traditional Chinese medical science is thought, this sick pathogenic factor many with internal organs dysfunction, qi-blood disharmony relevant, the liver spleen of pathological changes internal organs duty, especially the spleen soil people of weakness or the pungent delicious food savoury of surfeit, damage spleen soil, and it is not normal to cause the native transportation capabilities of spleen, gathering wets as expectorant or innately introverted, emotion is constrained, and good sulky or irascible temperament, dynamic then irritability or because of damaged by excess of seven emotions, be worried excessively, and cause the liver failing to maintain the normal flow of QI, Yu Ercheng expectorant etc., all can cause phlegm-damp to be tied poly-, coagulation of QI-blood and form lump.Therapeutic Principle: 1, depressed liver-energy dispersing and QI regulating, harmonizing the functional activities of vital QI.Nipple breast and Liver Channel follow row part, and woman is congenital with liver, and blood stored in the liver, main catharsis, body are cloudy and with positive, are easy to looking angry strongly fragrant.Nodules of the breast person, often have disposition depressed, be worried and worry too much or vexed being irritable and getting angry easily, belch uncomfortable in chest, and mastalgia and Tumor size change, also many emotion changes are relevant more.Stagnation of QI due to depression of the liver has material impact on nodules of the breast pathogenesis.Seven emotions are not smooth, and liver is lost bar and reaches, and stagnation of QI due to depression of the liver is tied in intestines network then pain caking, therefore depressed liver-energy dispersing and QI regulating, harmonizing the functional activities of vital QI is the main principle for the treatment of nodules of the breast.2, blood circulation promoting and blood stasis dispelling, dredges newborn network.Mastalgia and lump are primary symptom, and the two is the performance of syndrome of blood stasis characteristic.Be worried angry, depressed joyless, must cause irritability smooth, mechanism of qi blocks, for a long time then by gas and in, make hematogenous blockage, channel tunnel is unfavorable, can not fill uterus down, above can not galactorrhea room, newborn network impatency, qi depression to blood stasis, condensation in bulk, stagnation of QI and blood may bring about pain.Appoint blood engorgement through preshoot, breast swell and pain increases the weight of, and after menstruation, QI and blood obtains catharsis, swells and ache and also alleviates thereupon.Visible nodules of the breast person occurs that syndrome of blood stasis is inevitable, must pay attention to blood circulation promoting and blood stasis dispelling in treatment, dredges newborn network effect.3, resolving phlegm and softening hard masses, dispersing swelling and dissipating binds.Worry impairing spleen or stagnation of QI due to depression of the liver, perverse and unreasonable manner spleen soil, all can cause dysfunction of the spleen in transportation, raw in phlegm-damp, deficiency of kidney-QI, and punching times is lost and supported.Can not warm spleen sun, then seminal fluid must not transporting, poly-ly wets into expectorant, and with the passing of time, heat-transformation fire-transformation, bright Tianjin is expectorant to stagnation of liver-QI, and expectorant, gas, the stasis of blood are tied mutually and formed nodules of the breast.Therefore, expectorant coagulates has certain influence on nodules of the breast pathogenesis, resolving phlegm and softening hard masses, dispersing swelling and dissipating binds can impel swell and ache be melt into invisible.
Application publication number CN103816522A(application number 201410104103.2) Chinese patent literature disclose a kind of Chinese medicine for the treatment of cyclomastopathy, it is characterized in that being made up of the crude drug of following weight portion, 4 ~ 8 parts, Poria, Rhizoma Curcumae 9 ~ 12 parts, Semen Sinapis Albae 5 ~ 9 parts, Semen Vaccariae 9 ~ 12 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Radix Polygalae 20 ~ 22 parts, Herba Violae japonicae 2 ~ 4 parts, Rhizoma Polygoni Cuspidati 9 ~ 11 parts, the Radix Angelicae Dahuricae 9 ~ 11 parts, Cornu Cervi Degelatinatum 9 ~ 11 parts, Radix Curcumae 9 ~ 11 parts, Radix Saposhnikoviae 9 ~ 11 parts, Rhizoma Zingiberis 9 ~ 11 parts, Herba Scutellariae Barbatae 14 ~ 18 parts, be soaked in water after above-mentioned 14 crude drug are mixed, to remove slag after decocting to obtain filtrate.Application publication number CN102671141A(application number 201210175977.8) Chinese patent literature disclose a kind of Chinese medicine for the treatment of cyclomastopathy, it is by the medicament made with the following medium-height grass raw material of parts by weight: soft Radix Bupleuri, Rhizoma Bolbostematis, Fructus Toosendan, Rhizoma Corydalis, the summer millet straw, each 9-21 part of Herba Taraxaci 6 taste Chinese medicine, Radix Angelicae Sinensis, Fructus Aurantii (parched), the Rhizoma Atractylodis Macrocephalae, each 8-18 part of Squama Manis 4 taste Chinese medicine, Radix Paeoniae Alba 15-26 part, radix linderae and each 9-18 part of Radix Curcumae, each 5-10 part of Rhizoma Sparganii, Rhizoma Curcumae and Radix Glycyrrhizae.Application publication number CN101954046A(application number 201010291265.3) Chinese patent literature disclose a kind of medicine for the treatment of cyclomastopathy, be crude drug by the Chinese medicine of following parts by weight: Carapax et Plastrum Testudinis 8 ~ 15, Carapax Trionycis 8 ~ 15, Squama Manis 8 ~ 15, Lignum Aquilariae Resinatum 8 ~ 15, the Radix Aucklandiae 8 ~ 15, Pericarpium Citri Reticulatae Viride 8 ~ 15, Rhizoma Sparganii 8 ~ 15, Rhizoma Curcumae 8 ~ 15, Radix Puerariae 8 ~ 15, Rhizoma Cyperi 8 ~ 15, Cortex Cinnamomi 8 ~ 15, Rhizoma Alismatis 8 ~ 15, Radix Curcumae 8 ~ 15, Stalactitum 3 ~ 6, Semen Vaccariae 8 ~ 15, be ground into fine powder and make powder.Above-mentioned be used for preparing in the medicine for the treatment of cyclomastopathy have individual drugs price costly, and medicine source is not easy to obtain.
Cyclomastopathy is one of commonly encountered diseases of women, and the medicine for the treatment of cyclomastopathy has Western medicine and Chinese medicine.Western medicine tamoxifen and derivatives for treatment cyclomastopathy thereof have obtained clinical confirmation, but it also has some obvious side effect simultaneously.Treatment by Chinese herbs cyclomastopathy is safer, but Different therapeutical effect is larger.Take estrogen and also can occur the side effect such as Nausea and vomiting, headache, some conditions of patients instead can increase the weight of, but this treatment likely aggravates between human hormone unbalance, and operative treatment is also one of method of common treatment cyclomastopathy, but easily recur because of it, operative treatment has mainly excised the lactiferous ducts of local proliferation body of gland and expansion, endocrine disturbance in body is not but corrected, therefore easily recur, be secondly leave cicatrix on breast, can not be accepted by young women.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of cyclomastopathy depressed liver-energy dispersing and QI regulating medicine and preparation method thereof.The present invention has no side effect, safety, evident in efficacy, treating both the principal and secondary aspects of a disease, and medicine source is cheap and easy to get, and treatment cost is low, easy to use, not easily recurs, easy to patients.
Technical scheme of the present invention is:
Cyclomastopathy depressed liver-energy dispersing and QI regulating medicine, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Trichosanthis 10-20, Radix Asparagi 8-15, Endoconcha Sepiae 8-15, Cortex Lycii 6-9, Fructus Corni 10-20, Folium Citri tangerinae 8-15, Semen Citri Reticulatae 6-9, Fructus Aurantii 5-10, great Ye Rhizoma Curculiginis 5-10, Fructus Leonuri 3-6, Concha Arcae 8-16, Usnea 7-14, Semen Trigonellae 7-15, Rhizoma Anemarrhenae 8-12, Herba Eleusines Indicae 8-16, Rhizoma Pinelliae 8-12.
Cyclomastopathy depressed liver-energy dispersing and QI regulating medicine, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Trichosanthis 13-16, Radix Asparagi 9-12, Endoconcha Sepiae 10-13, Cortex Lycii 7-8.5, Fructus Corni 12-16, Folium Citri tangerinae 10-13, Semen Citri Reticulatae 7-8.5, Fructus Aurantii 7-9, great Ye Rhizoma Curculiginis 6-8, Fructus Leonuri 4-5.5, Concha Arcae 11-14, Usnea 9-12, Semen Trigonellae 9-13, Rhizoma Anemarrhenae 9-11, Herba Eleusines Indicae 11-14, Rhizoma Pinelliae 9-11.
Cyclomastopathy depressed liver-energy dispersing and QI regulating medicine, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Trichosanthis 14, Radix Asparagi 11, Endoconcha Sepiae 11, Cortex Lycii 8, Fructus Corni 14, Folium Citri tangerinae 11, Semen Citri Reticulatae 7.5, Fructus Aurantii 8, great Ye Rhizoma Curculiginis 7, Fructus Leonuri 5, Concha Arcae 12, Usnea 11, Semen Trigonellae 10, the Rhizoma Anemarrhenae 10, Herba Eleusines Indicae 12, the Rhizoma Pinelliae 9.5.
Present invention also offers the preparation method aforementioned cyclomastopathy depressed liver-energy dispersing and QI regulating medicine being made pharmaceutically acceptable pill, capsule, granule and tablet.
The preparation method of described pill is:
(1) Radix Asparagi is ground into coarse powder, cross No. three sieves, put in appropriate vessel, add water, amount of water is 6-9 times (preferred amount of water is 7 times of Radix Asparagi weight) of Radix Asparagi weight, airtight, at room temperature flood 24-36 hour (preferably at room temperature flooding 32 hours), filter, firmly press residue, merging filtrate, leave standstill 24 hours, filter, be condensed into the paste medicine (being preferably condensed into the paste medicine that relative density is 1.34) that relative density is 1.32-1.35, dry 8-14 hour (preferably at the temperature of 65 DEG C dry 10 hours) at the temperature of 65 DEG C, be ground into fine powder, cross No. six sieves,
(2) all the other except Radix Asparagi 15 taste crude drug is ground into fine powder respectively, crosses No. six sieves;
(3) by step (1) and step (2) gained fine powder mix homogeneously, add refined honey, the weight of refined honey is 1.2-1.8 times (weight of preferred refined honey is 1.5 times of step (1) and step (2) gained fine powder gross weight) of step (1) and step (2) gained fine powder gross weight, stir, with 70% ethanol pill, make the pill of the heavy 0.25g of every ball, gained pill is dry at the temperature of 60 DEG C, make water content control 8%, be taken out to and cool completely, to obtain final product.
The preparation method of described capsule is:
(1) Radix Asparagi is ground into coarse powder, cross No. three sieves, put in appropriate vessel, add water, amount of water is 6-9 times (preferred amount of water is 7 times of Radix Asparagi weight) of Radix Asparagi weight, airtight, at room temperature flood 24-36 hour (preferably at room temperature flooding 32 hours), filter, firmly press residue, merging filtrate, leave standstill 24 hours, filter, be condensed into the paste medicine (being preferably condensed into the paste medicine that relative density is 1.34) that relative density is 1.32-1.35, dry 8-14 hour (preferably at the temperature of 65 DEG C dry 10 hours) at the temperature of 65 DEG C, be ground into fine powder, cross No. six sieves,
(2) all the other except Radix Asparagi 15 taste crude drug is ground into fine powder respectively, crosses No. six sieves;
(3) by step (1) and step (2) gained fine powder mix homogeneously; add mannitol; the weight of mannitol is the weight of the preferred mannitol of 1/12-1/8(of step (1) and step (2) gained fine powder gross weight is 1/11 of step (1) and step (2) gained fine powder gross weight), stir, be pressed into thin slice with the dry granulator that squeezes; be ground into granule again; load zero capsule, every capsules is equipped with medicated powder 0.35g, by the capsule polishing in buffing machine installed; pressing plate, to obtain final product.
The preparation method of described granule is:
(1) Radix Asparagi is ground into coarse powder, cross No. three sieves, put in appropriate vessel, add water, amount of water is 6-9 times (preferred amount of water is 7 times of Radix Asparagi weight) of Radix Asparagi weight, airtight, at room temperature flood 24-36 hour (preferably at room temperature flooding 32 hours), filter, firmly press residue, merging filtrate, leave standstill 24 hours, filter, be condensed into the paste medicine (being preferably condensed into the paste medicine that relative density is 1.34) that relative density is 1.32-1.35, dry 8-14 hour (preferably at the temperature of 65 DEG C dry 10 hours) at the temperature of 65 DEG C, be ground into fine powder, cross No. six sieves,
(2) all the other except Radix Asparagi 15 taste crude drug is ground into fine powder respectively, crosses No. six sieves;
(3) by step (1) and step (2) gained fine powder mix homogeneously; add mannitol; the weight of mannitol is the weight of the preferred mannitol of 1/12-1/8(of step (1) and step (2) gained fine powder gross weight is 1/11 of step (1) and step (2) gained fine powder gross weight); stir; thin slice is pressed into the dry granulator that squeezes; be ground into granule again, obtain final product.
The preparation method of described tablet is:
(1) Radix Asparagi is ground into coarse powder, cross No. three sieves, put in appropriate vessel, add water, amount of water is 6-9 times (preferred amount of water is 7 times of Radix Asparagi weight) of Radix Asparagi weight, airtight, at room temperature flood 24-36 hour (preferably at room temperature flooding 32 hours), filter, firmly press residue, merging filtrate, leave standstill 24 hours, filter, be condensed into the paste medicine (being preferably condensed into the paste medicine that relative density is 1.34) that relative density is 1.32-1.35, dry 8-14 hour (preferably at the temperature of 65 DEG C dry 10 hours) at the temperature of 65 DEG C, be ground into fine powder, cross No. six sieves,
(2) all the other except Radix Asparagi 15 taste crude drug is ground into fine powder respectively, crosses No. six sieves;
(3) by step (1) and step (2) gained fine powder mix homogeneously; add mannitol; the weight of mannitol is the weight of the preferred mannitol of 1/12-1/8(of step (1) and step (2) gained fine powder gross weight is 1/11 of step (1) and step (2) gained fine powder gross weight); stir; be pressed into thin slice with the dry granulator that squeezes, then be ground into granule, tabletting; the heavy 0.35g of every sheet, to obtain final product.
Treatment cyclomastopathy depressed liver-energy dispersing and QI regulating medicine provided by the invention is easy to use, and scientific formula is reasonable.In addition, excellent results of the present invention also shows:
1, the preparation method of various dosage form is simple, is easy to carry;
2, have no side effect, safety, evident in efficacy;
3, medicine source is cheap and easy to get, and treatment cost is low, not easily recurs, easy to patients;
4, there is depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, resolving phlegm and softening hard masses, dispersing swelling and dissipating binds, nourishing YIN to lower pathogenic fire, moisturize laxation, effect of liver and kidney tonifying, treating both the principal and secondary aspects of a disease can be carried out to cyclomastopathy, thus reach the object for the treatment of cyclomastopathy.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1cyclomastopathy depressed liver-energy dispersing and QI regulating medicine, the primary raw material medicine getting following weight parts is prepared from (every part is 150g): Fructus Trichosanthis 10 parts, Radix Asparagi 8 parts, Endoconcha Sepiae 8 parts, Cortex Lycii 6 parts, Fructus Corni 10 parts, Folium Citri tangerinae 8 parts, Semen Citri Reticulatae 6 parts, Fructus Aurantii 5 parts, great Ye Rhizoma Curculiginis 5 parts, Fructus Leonuri 3 parts, Concha Arcae 8 parts, Usnea 7 parts, Semen Trigonellae 7 parts, the Rhizoma Anemarrhenae 8 parts, Herba Eleusines Indicae 8 parts, the Rhizoma Pinelliae 8 parts.
The preparation method of above-mentioned cyclomastopathy depressed liver-energy dispersing and QI regulating drug particles agent is:
(1) Radix Asparagi is ground into coarse powder, crosses No. three sieves, put in appropriate vessel, add water, amount of water is 6 times of Radix Asparagi weight, airtight, at room temperature flood 24 hours, filter, firmly press residue, merging filtrate, leaves standstill 24 hours, filters, be condensed into the paste medicine that relative density is 1.32, at the temperature of 65 DEG C, drying 8 hours, is ground into fine powder, crosses No. six sieves;
(2) all the other except Radix Asparagi 15 taste crude drug is ground into fine powder respectively, crosses No. six sieves;
(3) by step (1) and step (2) gained fine powder mix homogeneously, add mannitol, the weight of mannitol is 1/12 of step (1) and step (2) gained fine powder gross weight, stirs, and is pressed into thin slice, then is ground into granule, to obtain final product with the dry granulator that squeezes.
The using method of gained cyclomastopathy depressed liver-energy dispersing and QI regulating drug particles of the present invention agent: three times on the one, a 12g, boiled water is taken after mixing it with water.
embodiment 2cyclomastopathy depressed liver-energy dispersing and QI regulating medicine, the primary raw material medicine getting following weight parts is prepared from (every part is 150g): Fructus Trichosanthis 20 parts, Radix Asparagi 15 parts, Endoconcha Sepiae 15 parts, Cortex Lycii 9 parts, Fructus Corni 20 parts, Folium Citri tangerinae 15 parts, Semen Citri Reticulatae 9 parts, Fructus Aurantii 10 parts, great Ye Rhizoma Curculiginis 10 parts, Fructus Leonuri 6 parts, Concha Arcae 16 parts, Usnea 14 parts, Semen Trigonellae 15 parts, the Rhizoma Anemarrhenae 12 parts, Herba Eleusines Indicae 16 parts, the Rhizoma Pinelliae 12 parts.
The preparation method of above-mentioned cyclomastopathy depressed liver-energy dispersing and QI regulating medicine pill is:
(1) Radix Asparagi is ground into coarse powder, crosses No. three sieves, put in appropriate vessel, add water, amount of water is 7 times of Radix Asparagi weight, airtight, at room temperature flood 32 hours, filter, firmly press residue, merging filtrate, leaves standstill 24 hours, filters, be condensed into the paste medicine that relative density is 1.34, at the temperature of 65 DEG C, drying 10 hours, is ground into fine powder, crosses No. six sieves;
(2) all the other except Radix Asparagi 15 taste crude drug is ground into fine powder respectively, crosses No. six sieves;
(3) by step (1) and step (2) gained fine powder mix homogeneously, add refined honey, the weight of refined honey is 1.5 times of step (1) and step (2) gained fine powder gross weight, stir, with 70% ethanol pill, make the pill of the heavy 0.25g of every ball, gained pill is dry at the temperature of 60 DEG C, make water content control 8%, be taken out to and cool completely, to obtain final product.
model case one:week XX, female, 43 years old.Main suit: cyclomastopathy 4 years, bilateral lump in breast pain.Before 4 years there is bilateral breast swell and pain in patient, goes to a doctor, be diagnosed as cyclomastopathy, give the Drug therapy such as TAMOXIFEN PIAN, RUKUAIXIAO, DeGrain, come to go to a doctor to local hospital.Examine and see that patient's bilateral breast touches circle and oval lump, mastalgia, pale tongue with indented margin, white and thin fur, deep and stringy pulse.Be diagnosed as cyclomastopathy.Take the present embodiment gained cyclomastopathy depressed liver-energy dispersing and QI regulating medicine pill, every day three times, each 6 balls, warm water takes.Take 1 month, lump obviously reduces, pain relief.Continue to take 1 month, lump dissipates, and pain disappears.Follow up a case by regular visits to and do not recur so far.
embodiment 3cyclomastopathy depressed liver-energy dispersing and QI regulating medicine, the primary raw material medicine getting following weight parts is prepared from (every part is 150g): Fructus Trichosanthis 13 parts, Radix Asparagi 9 parts, Endoconcha Sepiae 10 parts, Cortex Lycii 7 parts, Fructus Corni 12 parts, Folium Citri tangerinae 10 parts, Semen Citri Reticulatae 7 parts, Fructus Aurantii 7 parts, great Ye Rhizoma Curculiginis 6 parts, Fructus Leonuri 4 parts, Concha Arcae 11 parts, Usnea 9 parts, Semen Trigonellae 9 parts, the Rhizoma Anemarrhenae 9 parts, Herba Eleusines Indicae 11 parts, the Rhizoma Pinelliae 9 parts.
The preparation method of above-mentioned cyclomastopathy depressed liver-energy dispersing and QI regulating medicament capsule agent is:
(1) Radix Asparagi is ground into coarse powder, crosses No. three sieves, put in appropriate vessel, add water, amount of water is 7 times of Radix Asparagi weight, airtight, at room temperature flood 32 hours, filter, firmly press residue, merging filtrate, leaves standstill 24 hours, filters, be condensed into the paste medicine that relative density is 1.34, at the temperature of 65 DEG C, drying 10 hours, is ground into fine powder, crosses No. six sieves;
(2) all the other except Radix Asparagi 15 taste crude drug is ground into fine powder respectively, crosses No. six sieves;
(3) by step (1) and step (2) gained fine powder mix homogeneously; add mannitol; the weight of mannitol is 1/11 of step (1) and step (2) gained fine powder gross weight, stirs, and is pressed into thin slice with the dry granulator that squeezes; be ground into granule again; load zero capsule, every capsules is equipped with medicated powder 0.35g, by the capsule polishing in buffing machine installed; pressing plate, to obtain final product.
model case two:poplar XX, female, 35 years old.Main suit: cyclomastopathy more than 2 years, based on distending pain of the breast.Before 2 years there is bilateral distending pain of the breast symptom in patient, and right side overweights left side, and the row moon is premenstrual to be increased the weight of, and after passing through, pain obviously alleviates, and goes to see a doctor, and is diagnosed as cyclomastopathy, once takes Chinese and western medical treatment, have no improvement, come to go to a doctor.Examine and see patient's red tongue, yellow and thin fur, stringy and rolling pulse, introverted, the bodily form is fat, and happiness is sighed, bitter taste, receive can, two just adjust.Be diagnosed as cyclomastopathy.Take the agent of the present embodiment gained cyclomastopathy depressed liver-energy dispersing and QI regulating medicament capsule, every day three times, each 2, warm water takes.Take two weeks, patient is conscious, and distending pain of the breast symptom alleviates.Continue to take two months, distending pain of the breast transference cure, recovery from illness.Follow up a case by regular visits to and have no recurrence.
embodiment 4cyclomastopathy depressed liver-energy dispersing and QI regulating medicine, the primary raw material medicine getting following weight parts is prepared from (every part is 150g): Fructus Trichosanthis 16 parts, Radix Asparagi 12 parts, Endoconcha Sepiae 13 parts, Cortex Lycii 8.5 parts, Fructus Corni 16 parts, Folium Citri tangerinae 13 parts, Semen Citri Reticulatae 8.5 parts, Fructus Aurantii 9 parts, great Ye Rhizoma Curculiginis 8 parts, Fructus Leonuri 5.5 parts, Concha Arcae 14 parts, Usnea 12 parts, Semen Trigonellae 13 parts, the Rhizoma Anemarrhenae 11 parts, Herba Eleusines Indicae 14 parts, the Rhizoma Pinelliae 11 parts.
The preparation method of above-mentioned cyclomastopathy depressed liver-energy dispersing and QI regulating medicine tablet is:
(1) Radix Asparagi is ground into coarse powder, crosses No. three sieves, put in appropriate vessel, add water, amount of water is 7 times of Radix Asparagi weight, airtight, at room temperature flood 32 hours, filter, firmly press residue, merging filtrate, leaves standstill 24 hours, filters, be condensed into the paste medicine that relative density is 1.34, at the temperature of 65 DEG C, drying 10 hours, is ground into fine powder, crosses No. six sieves;
(2) all the other except Radix Asparagi 15 taste crude drug is ground into fine powder respectively, crosses No. six sieves;
(3) by step (1) and step (2) gained fine powder mix homogeneously, add mannitol, the weight of mannitol is 1/11 of step (1) and step (2) gained fine powder gross weight; stir, be pressed into thin slice with the dry granulator that squeezes, then be ground into granule; tabletting, the heavy 0.35g of every sheet, to obtain final product.
model case three:king XX, female, 42 years old.Main suit: breast lumps 3 years, increases the weight of half a year.Before 3 years, Finding case left breast has a caking, Semen Juglandis size, and often in the moon premenstrual distending pain, and caking hardens, then deliquescing after menstruation, pain relief, irregular menstrual period, goes to see a doctor, be diagnosed as cyclomastopathy, give Drug therapy, symptom slightly takes a turn for the better.Nearly aggravation over the past half year, pain is not alleviated all the time, invalid through medication treatment, comes to go to a doctor.Examine and see that patient becomes thin, in left breast, the caking of one piece of about 4 × 5cm, smooth, removable, and pain is radiated to ipsilateral axillary, usually introverted, often sulky, light red tongue, stringy and thready pulse.Be diagnosed as cyclomastopathy.Take the present embodiment gained cyclomastopathy depressed liver-energy dispersing and QI regulating medicine tablet, every day three times, each 4, warm water takes.Take two weeks, above-mentioned symptom alleviates, caking deliquescing.Continue to take 2 months, above-mentioned symptom all disappears, and recovery from illness, follows up a case by regular visits to and do not recur.
embodiment 5cyclomastopathy depressed liver-energy dispersing and QI regulating medicine, the primary raw material medicine getting following weight parts is prepared from (every part is 150g): Fructus Trichosanthis 14 parts, Radix Asparagi 11 parts, Endoconcha Sepiae 11 parts, Cortex Lycii 8 parts, Fructus Corni 14 parts, Folium Citri tangerinae 11 parts, Semen Citri Reticulatae 7.5 parts, Fructus Aurantii 8 parts, great Ye Rhizoma Curculiginis 7 parts, Fructus Leonuri 5 parts, Concha Arcae 12 parts, Usnea 11 parts, Semen Trigonellae 10 parts, the Rhizoma Anemarrhenae 10 parts, Herba Eleusines Indicae 12 parts, the Rhizoma Pinelliae 9.5 parts.
The preparation method of above-mentioned cyclomastopathy depressed liver-energy dispersing and QI regulating drug particles agent is:
(1) Radix Asparagi is ground into coarse powder, crosses No. three sieves, put in appropriate vessel, add water, amount of water is 7 times of Radix Asparagi weight, airtight, at room temperature flood 32 hours, filter, firmly press residue, merging filtrate, leaves standstill 24 hours, filters, be condensed into the paste medicine that relative density is 1.34, at the temperature of 65 DEG C, drying 10 hours, is ground into fine powder, crosses No. six sieves;
(2) all the other except Radix Asparagi 15 taste crude drug is ground into fine powder respectively, crosses No. six sieves;
(3) by step (1) and step (2) gained fine powder mix homogeneously, add mannitol, the weight of mannitol is 1/11 of step (1) and step (2) gained fine powder gross weight, stirs, and is pressed into thin slice, then is ground into granule, to obtain final product with the dry granulator that squeezes.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Trichosanthis: another name Fructus Trichosanthis, Gua Lou, medicine melon is the fruit of Cucurbitaceae Trichosanthes Fructus Trichosanthis and trichosanthes rosthornii Harms.The property of medicine: sweet, micro-hardship, cold.Return lung, stomach, large intestine channel.Function cures mainly: removing heat-phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens moisturizes laxation.Cure mainly cough due to lung-heat, the thoracic obstruction, blocked-up chest, quench one's thirst, constipation, carbuncle sore tumefacting virus.
Radix Asparagi: base is former: be the tuber of liliaceous plant Radix Asparagi.The property of medicine: sweet in the mouth; Bitter; Cold in nature.Return lung, kidney channel.Function cures mainly: nourshing Yin and drynsessmoistening prescription, lung heat clearing pathogenic fire reducing.Main cough caused by dryness-heat, deficiency of YIN chronic cough, consumption of YIN caused by febrile disease, interior-heat is quenched one's thirst, dryness of the intestine constipation, laryngopharynx swelling and pain.
Endoconcha Sepiae: another name: black Quarry bone, sepia bone, Os Sepiae, cuttlebone, cuttlefish lid is the inner shell of the multiple sepiellae seu sepiaes such as Sepiidae animal sepiella maindroni de Rochebrune, prosperous sepiellae seu sepiae, Sepia andreana, white macula sepiellae seu sepiae, brave class sepiellae seu sepiae, plan order sepiellae seu sepiae.The property of medicine: salty, puckery, temperature.Return liver, kidney channel.Function cures mainly: astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.Main haematemesis, hematemesis, metrorrhagia, has blood in stool, epistaxis, wound hemorrhage, emission due to deficiency of the kidney spermatorrhea, and leucorrhea with red and white discharge is had a stomachache noisy, belch pantothenic acid, eczema ulcer.
Cortex Lycii: base is former: be the root bark of eggplant kind of plant Fructus Lycii etc.Chemical composition: root bark is containing cinnamic acid and volume aldehydes matter, betanin.Also have report, betanin is only contained in the leaf and fruit of Fructus Lycii, is not present in root bark.Still containing the material suppressing thiamine activity in root, this inhibitory action can be removed by cysteine and vitamin C.Cupreol, linoleic acid, linolenic acid, 1 acid etc. are still separated to obtain in Cortex Lycii.The property of medicine: sweet, cold.Return lung, liver, kidney channel.Function cures mainly: heat clearing away, removing heat from blood.Control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.
Fructus Corni: base is former: be the sarcocarp of Cornaceae plant Fructus Corni.The property of medicine: sour, puckery, tepor.Return liver, kidney channel.Function cures mainly: liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed, and interior-heat is quenched one's thirst.
Folium Citri tangerinae: base is former: be the leaf of the multiple Fructus Citri tangerinae class such as leaf or Zhu's Fructus Citri tangerinae of rutaceae orange.The property of medicine: bitter, flat.Return Liver Channel.Function cures mainly: soothing the liver, and circulation of qi promoting is reduced phlegm, detumescence poison.Control hypochondriac pain, acute mastitis, lung abscess, cough, chest and diaphragm feeling of fullness, hernia.
Semen Citri Reticulatae: base is former: be the seed of rutaceae orange and variety thereof.The property of medicine: bitter, flat.Return liver, kidney, urinary bladder channel.Function cures mainly: regulate the flow of vital energy, eliminating stagnation, pain relieving.Main hernia, painful and swollen testis, acute mastitis, lumbago.
Fructus Aurantii: base is former: be the mellow fruit nearly such as rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Citrus aurantium Linn., fragrant circle or Citrus aurantium L. var. amara Engl..The property of medicine: bitter, sour, is slightly cold.Return lung, spleen, liver, stomach, large intestine channel.Function cures mainly: dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.
Great Ye Rhizoma Curculiginis: base is former: Hypoxidaceae Curculigo great Ye Rhizoma Curculiginis, is used as medicine with root and root stock.The property of medicine: bitter, puckery, flat.Function cures mainly: moistening the lung and resolving phlegm, relieving cough and asthma, calm spleen invigorating, tonifying the kidney to consolidate the essence.For dyspnea and cough due to deficiency of the kidney, soreness of waist and knee joint, leucorrhea, seminal emission.
Fructus Leonuri: base is former: be the fruit of Labiatae mother wort plant Herba Leonuri and Herba Leonuri Sibirici.Composition: leonuri,fructus contains allene class fatty acid containing alkaloid, herb containing phenolic glycoside class, Herba Leonuri Sibirici fruit kind oil.Pharmacology: have hypotensive effect, has the effect of stimulon palace excitement.The property of medicine: sweet, pungent, is slightly cold, mild toxicity.Return Liver Channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, liver heat removing and eyesight improving.For menoxenia, amenorrhea, dysmenorrhea, cataract, dizzy distending pain.
Concha Arcae: base is former: be the shell of Carnis Arca inflata section animal Scapharca broughtonii, Tegillarca granosa or Scapharca subcrenata.The property of medicine: sweet, salty, flat.Return liver, spleen channel.Function cures mainly: reduce phlegm, softening the hard mass, dissipating blood stasis, removing food stagnancy.Control accumulation of phlegm, stomachache, noisy, acid regurgitation, lump in the abdomen, scrofula, ulcerative gingivitis.
Usnea: base is former: be the thallus of the flat plant Usnea Longissima of Usnea, ring crack Usnea.The property of medicine: sweet, bitter, flat.GUIXIN, kidney, lung meridian.Function cures mainly: expelling phlegm for arresting cough, heat-clearing and toxic substances removing, eliminating dampness and dredging channels, blood-arresting catamenia-regulating, anthelmintic.Main expectorant hot temperature malaria, cough with asthma, pulmonary tuberculosis, headache, conjunctival congestion nebula, carbuncle sore tumefacting virus, scrofula, acute mastitis, burn and scald, venom, pathogenic wind-warm arthralgia pain, traumatic injury, fracture, traumatic hemorrhage, spits blood, has blood in stool, metrorrhagia, menoxenia, leucorrhea, ascariasis, schistosomicide.
Semen Trigonellae: base is former: be the dry mature seed of leguminous plant Semen Trigonellae.The property of medicine: bitter, temperature.Return kidney channel.Function cures mainly: the kidney warming, cold relieving, pain relieving.For kidney cold caused by deficiency, cold and pain in the lower abdomen, inguinal hernia, the disturbance of lower legs due to pathogenic cold and dampness.
The Rhizoma Anemarrhenae: base is former: be the rhizome of the liliaceous plant Rhizoma Anemarrhenae.Chemical composition: main containing Saponin.Rhizome is containing Total saponin about 6%, therefrom detect 6 kinds of Saponins, be called zhimusaponin A-I, A-II, A-III, A-IV, B-I and B-II, wherein zhimusaponin A-III is the disaccharidase glycoside that Sa Ersa ruscogenin and timobiose are combined into, and zhimusaponin A-I is Sa Ersa ruscogenin β-D-galactopyranosyl glucoside.Ruscogenin in Asphodeloides Bge Rhizome is Sa Ersa ruscogenin mainly, the content in dry root about 0.5%, also has markogenin, new gitogenin in addition.The Saponin separated from Asphodeloides Bge Rhizome in the past was once called Chinonin, inferred that is that right that examines the mixture of Saponin, zhimusaponin A-III, A-IV, B etc.Rhizome is still containing reducing sugar and phlegmatic temperament, tannic acid, the fatty wet goods of volume, and every gram contains nicotinic acid 188 microgram again.Niacin amide 12 microgram.Another containing Mengiferin 0.5%.Aerial parts is containing Mengiferin and isomangiferin.Leaf is containing Mengiferin about 0.7%.Flower, containing Saponin, obtains the glycoside unit C that fusing point is 246 ~ 248 DEG C after hydrolysis
27h
42o
4.The property of medicine: bitter, cold.Return lung, stomach, kidney channel.Function cures mainly: nourishing YIN to lower pathogenic fire, moisturizes laxation.Control dysphoria with smothery sensation to quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.
Herba Eleusines Indicae: base is former: be root or the herb of grass Herba Eleusines Indicae.The property of medicine: sweet; Light; Cool.Function cures mainly: clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Main Sunstroke heating, infantile convulsion, encephalitis b, epidemic encephalitis, jaundice, stranguria, dysuria, dysentery, has blood in stool, and skin infection swells and ache, traumatic injury.
The Rhizoma Pinelliae: base is former: be the tuber of the Araeceae Rhizoma Pinelliae.The property of medicine: pungent, temperature.Poisonous.Return spleen, stomach, lung meridian.Function cures mainly: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For cough due to damp-phlegm, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus, gall subcutaneous nodule, swollen ulcer drug.
test example 1the clinical practice of gained cyclomastopathy depressed liver-energy dispersing and QI regulating medicine (embodiment 5) of the present invention: in October ,-2010 in June, 2008, screens 260 routine cyclomastopathy female patients in 4 hospitals, age 24-60 year, the course of disease 5 months-9 years.Be divided into two groups at random, experimental group and matched group.Two groups of case physical data no significant difference, have comparability (P > 0.05).
Diagnostic criteria: with reference to " Chinese medical disease Standardization of diagnosis and curative effect ", breast has distending pain in various degree, twinge, dull pain, can be radiated to oxter, the shoulder back of the body, can be relevant with menstrual cycle or emotion, continues 3 months or be interrupted pain not alleviate for 3 ~ 6 months.Have a medical check-up: one or both sides breast is single or multiple as seen to differ in size, the lump of form of diverse, lump dispersibles in whole breast, unclear with surrounding tissue boundary, with skin or deep tissues without adhesion, push away movable, can tenderness be had, can with the change of emotion and menstrual cycle and growth and decline, some patients can have nipple discharge or pruritus.Doppler's color ultrasound examination: Ipsilateral breast increases, internal structure is disorderly, echo skewness is thick luminous point, hot spot or latticed performance, be also shown in circular oval or rectangular rope shape enclosed mass not of uniform size, during if any cystic dilatation, can see multiple opaque dark area of fluid differed in size, back wall echo is high.
Therapeutic Method: experimental group uses gained cyclomastopathy depressed liver-energy dispersing and QI regulating medicine of the present invention, using method: three times on the one, a 15g, and boiled water is taken after mixing it with water, and 14 days is a course for the treatment of.Matched group use conventional therapy cyclomastopathy medicine (as TAMOXIFEN PIAN, little gold plaque, nodules of the breast ball, Xiaojie'an capsule etc.), within 14 days, be a course for the treatment of.After two groups of patients all treat six courses for the treatment of, carry out Comparison of therapeutic.
Efficacy assessment standard: draft with reference to State Administration of Traditional Chinese Medicine's " disease of tcm Standardization of diagnosis and curative effect ".Cure: lump in breast and pain disappear, and follow up a case by regular visits to and do not recur for 6 months; Take a turn for the better: lump in breast obviously reduces, and pain obviously alleviates or disappears; Invalid: lump in breast and pain unchanged.Total effectively comprising cures and takes a turn for the better.Result is as shown in table 1.
Table 1: take gained cyclomastopathy depressed liver-energy dispersing and QI regulating medicine cyclomastopathy patient outcomes of the present invention
Prove through clinical trial, after two groups of cases treat six courses for the treatment of, experimental group cures 85 examples, and take a turn for the better 42 examples, invalid 3 examples, total effective rate 97.69%; Matched group cures 48 examples, and take a turn for the better 54 examples, invalid 28 examples, total effective rate 78.46%.The clinical efficacy of experimental group is obviously better than matched group.
The present invention, through scientific compatibility, selects Fructus Trichosanthis, Radix Asparagi, Endoconcha Sepiae and Cortex Lycii etc. to be primary raw material, makes cyclomastopathy depressed liver-energy dispersing and QI regulating medicine.Fructus Trichosanthis removing heat-phlegm in side, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizes laxation.Radix Asparagi is nourshing Yin and drynsessmoistening prescription, lung heat clearing pathogenic fire reducing.Endoconcha Sepiae astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.Cortex Lycii heat clearing away, removing heat from blood.Fructus Corni liver and kidney tonifying, essence astringing and desertion stemming.Folium Citri tangerinae is soothing the liver, circulation of qi promoting, reduces phlegm, detumescence poison.Semen Citri Reticulatae is regulated the flow of vital energy, eliminating stagnation, pain relieving.Fructus Aurantii dispelling the stagnated QI, row expectorant, removing food stagnancy.Great Ye Rhizoma Curculiginis moistening the lung and resolving phlegm, relieving cough and asthma, calm spleen invigorating, tonifying the kidney to consolidate the essence.Fructus Leonuri blood circulation promoting and blood stasis dispelling, liver heat removing and eyesight improving.Concha Arcae reduces phlegm, softening the hard mass, dissipating blood stasis, removing food stagnancy.The clear expelling phlegm for arresting cough of Usnea, heat-clearing and toxic substances removing, eliminating dampness and dredging channels, blood-arresting catamenia-regulating, anthelmintic.Semen Trigonellae the kidney warming, cold relieving, pain relieving.Rhizoma Anemarrhenae nourishing YIN to lower pathogenic fire, moisturizes laxation.Herba Eleusines Indicae clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Rhizoma Pinelliae drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.All medicines share, altogether long memorial liver and qi, blood circulation promoting and blood stasis dispelling, resolving phlegm and softening hard masses, dispersing swelling and dissipating binds, and nourishing YIN to lower pathogenic fire, moisturizes laxation, effect of liver and kidney tonifying, can carry out treating both the principal and secondary aspects of a disease to cyclomastopathy, thus reach the object for the treatment of cyclomastopathy.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. cyclomastopathy depressed liver-energy dispersing and QI regulating medicine, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Trichosanthis 10-20, Radix Asparagi 8-15, Endoconcha Sepiae 8-15, Cortex Lycii 6-9, Fructus Corni 10-20, Folium Citri tangerinae 8-15, Semen Citri Reticulatae 6-9, Fructus Aurantii 5-10, great Ye Rhizoma Curculiginis 5-10, Fructus Leonuri 3-6, Concha Arcae 8-16, Usnea 7-14, Semen Trigonellae 7-15, Rhizoma Anemarrhenae 8-12, Herba Eleusines Indicae 8-16, Rhizoma Pinelliae 8-12.
2. cyclomastopathy depressed liver-energy dispersing and QI regulating medicine as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Fructus Trichosanthis 13-16, Radix Asparagi 9-12, Endoconcha Sepiae 10-13, Cortex Lycii 7-8.5, Fructus Corni 12-16, Folium Citri tangerinae 10-13, Semen Citri Reticulatae 7-8.5, Fructus Aurantii 7-9, great Ye Rhizoma Curculiginis 6-8, Fructus Leonuri 4-5.5, Concha Arcae 11-14, Usnea 9-12, Semen Trigonellae 9-13, Rhizoma Anemarrhenae 9-11, Herba Eleusines Indicae 11-14, Rhizoma Pinelliae 9-11.
3. cyclomastopathy depressed liver-energy dispersing and QI regulating medicine as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Fructus Trichosanthis 14, Radix Asparagi 11, Endoconcha Sepiae 11, Cortex Lycii 8, Fructus Corni 14, Folium Citri tangerinae 11, Semen Citri Reticulatae 7.5, Fructus Aurantii 8, great Ye Rhizoma Curculiginis 7, Fructus Leonuri 5, Concha Arcae 12, Usnea 11, Semen Trigonellae 10, the Rhizoma Anemarrhenae 10, Herba Eleusines Indicae 12, the Rhizoma Pinelliae 9.5.
4. the cyclomastopathy depressed liver-energy dispersing and QI regulating medicine as described in as arbitrary in claims 1 to 3, it is characterized in that, this cyclomastopathy depressed liver-energy dispersing and QI regulating medicine is made pharmaceutically acceptable pill, and the preparation method of described pill is:
(1) Radix Asparagi is ground into coarse powder, cross No. three sieves, put in appropriate vessel, add water, amount of water is 6-9 times (preferred amount of water is 7 times of Radix Asparagi weight) of Radix Asparagi weight, airtight, at room temperature flood 24-36 hour (preferably at room temperature flooding 32 hours), filter, firmly press residue, merging filtrate, leave standstill 24 hours, filter, be condensed into the paste medicine (being preferably condensed into the paste medicine that relative density is 1.34) that relative density is 1.32-1.35, dry 8-14 hour (preferably at the temperature of 65 DEG C dry 10 hours) at the temperature of 65 DEG C, be ground into fine powder, cross No. six sieves,
(2) all the other except Radix Asparagi 15 taste crude drug is ground into fine powder respectively, crosses No. six sieves;
(3) by step (1) and step (2) gained fine powder mix homogeneously, add refined honey, the weight of refined honey is 1.2-1.8 times (weight of preferred refined honey is 1.5 times of step (1) and step (2) gained fine powder gross weight) of step (1) and step (2) gained fine powder gross weight, stir, with 70% ethanol pill, make the pill of the heavy 0.25g of every ball, gained pill is dry at the temperature of 60 DEG C, make water content control 8%, be taken out to and cool completely, to obtain final product.
5. the cyclomastopathy depressed liver-energy dispersing and QI regulating medicine as described in as arbitrary in claims 1 to 3, it is characterized in that, this cyclomastopathy depressed liver-energy dispersing and QI regulating medicine is made pharmaceutically acceptable capsule, and the preparation method of described capsule is:
(1) Radix Asparagi is ground into coarse powder, cross No. three sieves, put in appropriate vessel, add water, amount of water is 6-9 times (preferred amount of water is 7 times of Radix Asparagi weight) of Radix Asparagi weight, airtight, at room temperature flood 24-36 hour (preferably at room temperature flooding 32 hours), filter, firmly press residue, merging filtrate, leave standstill 24 hours, filter, be condensed into the paste medicine (being preferably condensed into the paste medicine that relative density is 1.34) that relative density is 1.32-1.35, dry 8-14 hour (preferably at the temperature of 65 DEG C dry 10 hours) at the temperature of 65 DEG C, be ground into fine powder, cross No. six sieves,
(2) all the other except Radix Asparagi 15 taste crude drug is ground into fine powder respectively, crosses No. six sieves;
(3) by step (1) and step (2) gained fine powder mix homogeneously; add mannitol; the weight of mannitol is the weight of the preferred mannitol of 1/12-1/8(of step (1) and step (2) gained fine powder gross weight is 1/11 of step (1) and step (2) gained fine powder gross weight), stir, be pressed into thin slice with the dry granulator that squeezes; be ground into granule again; load zero capsule, every capsules is equipped with medicated powder 0.35g, by the capsule polishing in buffing machine installed; pressing plate, to obtain final product.
6. the cyclomastopathy depressed liver-energy dispersing and QI regulating medicine as described in as arbitrary in claims 1 to 3, it is characterized in that, this cyclomastopathy depressed liver-energy dispersing and QI regulating medicine is made pharmaceutically acceptable granule, and the preparation method of described granule is:
(1) Radix Asparagi is ground into coarse powder, cross No. three sieves, put in appropriate vessel, add water, amount of water is 6-9 times (preferred amount of water is 7 times of Radix Asparagi weight) of Radix Asparagi weight, airtight, at room temperature flood 24-36 hour (preferably at room temperature flooding 32 hours), filter, firmly press residue, merging filtrate, leave standstill 24 hours, filter, be condensed into the paste medicine (being preferably condensed into the paste medicine that relative density is 1.34) that relative density is 1.32-1.35, dry 8-14 hour (preferably at the temperature of 65 DEG C dry 10 hours) at the temperature of 65 DEG C, be ground into fine powder, cross No. six sieves,
(2) all the other except Radix Asparagi 15 taste crude drug is ground into fine powder respectively, crosses No. six sieves;
(3) by step (1) and step (2) gained fine powder mix homogeneously; add mannitol; the weight of mannitol is the weight of the preferred mannitol of 1/12-1/8(of step (1) and step (2) gained fine powder gross weight is 1/11 of step (1) and step (2) gained fine powder gross weight); stir; thin slice is pressed into the dry granulator that squeezes; be ground into granule again, obtain final product.
7. the cyclomastopathy depressed liver-energy dispersing and QI regulating medicine as described in as arbitrary in claims 1 to 3, it is characterized in that, this cyclomastopathy depressed liver-energy dispersing and QI regulating medicine is made pharmaceutically acceptable tablet, and the preparation method of described tablet is:
(1) Radix Asparagi is ground into coarse powder, crosses No. three sieves, put in appropriate vessel, add water, amount of water is 6-9 times of Radix Asparagi weight, airtight, at room temperature flood 24-36 hour, filter, firmly press residue, merging filtrate, leaves standstill 24 hours, filters, be condensed into the paste medicine that relative density is 1.32-1.35, at the temperature of 65 DEG C, dry 8-14 hour (preferably at the temperature of 65 DEG C dry 10 hours), is ground into fine powder, crosses No. six sieves;
(2) all the other except Radix Asparagi 15 taste crude drug is ground into fine powder respectively, crosses No. six sieves;
(3) by step (1) and step (2) gained fine powder mix homogeneously; add mannitol; the weight of mannitol is the weight of the preferred mannitol of 1/12-1/8(of step (1) and step (2) gained fine powder gross weight is 1/11 of step (1) and step (2) gained fine powder gross weight); stir; be pressed into thin slice with the dry granulator that squeezes, then be ground into granule, tabletting; the heavy 0.35g of every sheet, to obtain final product.
8. the preparation method of cyclomastopathy depressed liver-energy dispersing and QI regulating medicine tablet as claimed in claim 7, is characterized in that, in step (1), amount of water is 7 times of Radix Asparagi weight.
9. the preparation method of cyclomastopathy depressed liver-energy dispersing and QI regulating medicine tablet as claimed in claim 7, it is characterized in that, step at room temperature floods 32 hours in (1).
10. the preparation method of cyclomastopathy depressed liver-energy dispersing and QI regulating medicine tablet as claimed in claim 7, is characterized in that, be condensed into the paste medicine that relative density is 1.34 in step (1).
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| CN105311496A (en) * | 2015-11-30 | 2016-02-10 | 潘素荣 | Traditional Chinese medicine composition for controlling hyperplasia of mammary glands and preparing method thereof |
| CN105687398A (en) * | 2016-03-11 | 2016-06-22 | 李美霞 | Traditional Chinese medicine for treating qi depression and phlegm stagnation type mammary gland hyperplasia |
| CN109224042A (en) * | 2018-09-03 | 2019-01-18 | 张董晓 | A kind of Chinese medicine composition and its preparation for treating cyclomastopathy |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311574A (en) * | 2015-11-30 | 2016-02-10 | 潘素荣 | Liver-soothing and qi-regulating preparation for treating hyperplasia of mammary glands and preparation method thereof |
| CN105311496A (en) * | 2015-11-30 | 2016-02-10 | 潘素荣 | Traditional Chinese medicine composition for controlling hyperplasia of mammary glands and preparing method thereof |
| CN105687398A (en) * | 2016-03-11 | 2016-06-22 | 李美霞 | Traditional Chinese medicine for treating qi depression and phlegm stagnation type mammary gland hyperplasia |
| CN109224042A (en) * | 2018-09-03 | 2019-01-18 | 张董晓 | A kind of Chinese medicine composition and its preparation for treating cyclomastopathy |
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