CN104606147B - 一种琥珀酸美托洛尔药物组合物及其制备方法 - Google Patents
一种琥珀酸美托洛尔药物组合物及其制备方法 Download PDFInfo
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- CN104606147B CN104606147B CN201510089957.2A CN201510089957A CN104606147B CN 104606147 B CN104606147 B CN 104606147B CN 201510089957 A CN201510089957 A CN 201510089957A CN 104606147 B CN104606147 B CN 104606147B
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- metroprolol succinate
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- ZBOQQGAVXCUYJM-UHFFFAOYSA-N butanedioic acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol Chemical compound OC(=O)CCC(O)=O.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 ZBOQQGAVXCUYJM-UHFFFAOYSA-N 0.000 title claims abstract 29
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- OKJADYKTJJGKDX-UHFFFAOYSA-N Butyl pentanoate Chemical compound CCCCOC(=O)CCCC OKJADYKTJJGKDX-UHFFFAOYSA-N 0.000 claims 1
- WQPDQJCBHQPNCZ-UHFFFAOYSA-N cyclohexa-2,4-dien-1-one Chemical group O=C1CC=CC=C1 WQPDQJCBHQPNCZ-UHFFFAOYSA-N 0.000 claims 1
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- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 22
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- 231100000111 LD50 Toxicity 0.000 description 5
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 5
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- WUBVEMGCQRSBBT-UHFFFAOYSA-N tert-butyl 4-(trifluoromethylsulfonyloxy)-3,6-dihydro-2h-pyridine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(OS(=O)(=O)C(F)(F)F)=CC1 WUBVEMGCQRSBBT-UHFFFAOYSA-N 0.000 description 4
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- FBSAITBEAPNWJG-UHFFFAOYSA-N dimethyl phthalate Natural products CC(=O)OC1=CC=CC=C1OC(C)=O FBSAITBEAPNWJG-UHFFFAOYSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
仪器设备 | 型号 | 厂家 |
流化床 | FBD—2BGS | 昆山元成机械有限公司 |
自动溶出实验仪 | SOTAX AT 7smart | 力扬企业有限公司 |
智能溶出实验仪 | ZRS-8G | 天津大学无线电制造厂 |
电子天平 | XS1505 | METTLER TOLEDO |
pH计 | Sevevn Easy | METTLER TOLEDO |
Claims (10)
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CN201510089957.2A CN104606147B (zh) | 2015-02-27 | 2015-02-27 | 一种琥珀酸美托洛尔药物组合物及其制备方法 |
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CN201510089957.2A CN104606147B (zh) | 2015-02-27 | 2015-02-27 | 一种琥珀酸美托洛尔药物组合物及其制备方法 |
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CN104606147A CN104606147A (zh) | 2015-05-13 |
CN104606147B true CN104606147B (zh) | 2018-07-06 |
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Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101190180B (zh) * | 2006-11-20 | 2011-03-30 | 北京利龄恒泰药业有限公司 | 一种美托洛尔的缓释药物组合物及其制备方法 |
CN102274205B (zh) * | 2011-07-21 | 2013-03-13 | 佛山市隆信医药科技有限公司 | 琥珀酸美托洛尔的缓释胶囊及制备方法 |
CN103655480B (zh) * | 2012-09-14 | 2016-12-21 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种美托洛尔的缓释药物及其制备方法 |
CN102973515B (zh) * | 2012-11-28 | 2016-12-21 | 康普药业股份有限公司 | 一种治疗高血压、心绞痛的缓释制剂 |
-
2015
- 2015-02-27 CN CN201510089957.2A patent/CN104606147B/zh active Active
Non-Patent Citations (3)
Title |
---|
"酒石酸美托洛尔缓释微丸的研究";黄健;《中国优秀博硕士学位论文全文数据库(硕士) 医药卫生科技辑》;20061215(第12期);E079-72:第9-11,21,25-27,34页 * |
流化床底喷包衣技术研究;李祥璐;《辽宁中医药大学学报》;20140531;第16卷(第5期);第228-231页 * |
流化床技术在制药工业的应用;郑国珍 等;《机电信息》;20091231(第8期);第31-35页 * |
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Inventor after: Ma Maoying Inventor after: Geng Xiaoci Inventor after: Chen Jing Inventor after: Wang Xinghui Inventor after: Qiu Yueqin Inventor after: Dong Yunfang Inventor after: Liu Baozhen Inventor after: Wang Tao Inventor after: Wu Miao Inventor after: Zhuo Jiahe Inventor after: Li Fangquan Inventor after: Zhang Tian Inventor after: Liu Jia Inventor after: Liu Xiangwei Inventor after: Zhang Li Inventor after: Wang Qingping Inventor after: Shen Fang Inventor after: Gao Liufang Inventor after: Guan Yuqing Inventor before: Ma Maoying Inventor before: Geng Xiaoci Inventor before: Chen Jing Inventor before: Wang Xinghui Inventor before: Qiu Yueqin Inventor before: Dong Yunfang Inventor before: Liu Baozhen Inventor before: Wu Miao Inventor before: Zhuo Jiahe Inventor before: Li Fangquan Inventor before: Zhang Tian Inventor before: Liu Jia Inventor before: Liu Xiangwei Inventor before: Zhang Li Inventor before: Wang Qingping Inventor before: Shen Fang Inventor before: Gao Liufang Inventor before: Guan Yuqing |
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Free format text: CORRECT: INVENTOR; FROM: MA MAOYING ZHANG TIAN LIU JIA LIU XIANGWEI ZHANG LI WANG QINGPING SHEN FANG GAO LIUFANG GUAN YUQING GENG XIAOCI CHEN JING WANG XINGHUI QIU YUEQIN DONG YUNFANG LIU BAOZHEN WU MIAO ZHUO JIAHE LI FANGQUAN TO: MA MAOYING ZHANG TIAN LIU JIA LIU XIANGWEI ZHANG LI WANG QINGPING SHEN FANG GAO LIUFANG GUAN YUQING GENG XIAOCI CHEN JING WANG XINGHUI QIU YUEQIN DONG YUNFANG LIU BAOZHEN WANG TAO WU MIAO ZHUO JIAHE LI FANGQUAN |
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Address after: 215331 191 Jinyang West Road, Lu Jia town, Kunshan, Suzhou, Jiangsu. Applicant after: YUNG SHIN PHARM.IND.(KUNSHAN) CO.,LTD. Address before: 215331 191 Jinyang West Road, Lu Jia town, Suzhou, Jiangsu. Applicant before: YUNG SHIN PHARMACEUTICAL INDUSTRY (KUNSHAN) CO.,LTD. |
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