CN104582709A - 作为a2a激动剂的n-烷基2-(双取代的)炔基腺苷-5’-糖醛酰胺 - Google Patents

作为a2a激动剂的n-烷基2-(双取代的)炔基腺苷-5’-糖醛酰胺 Download PDF

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Publication number
CN104582709A
CN104582709A CN201380043401.9A CN201380043401A CN104582709A CN 104582709 A CN104582709 A CN 104582709A CN 201380043401 A CN201380043401 A CN 201380043401A CN 104582709 A CN104582709 A CN 104582709A
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alkyl
independently selected
cyclopropyl
ring
compound
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Chinese (zh)
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罗伯特·汤普森
安东尼·博勒霍尔
国权·王
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Lewis and Clark Pharmaceuticals Inc
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Lewis and Clark Pharmaceuticals Inc
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Diabetes (AREA)
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  • Pulmonology (AREA)
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CN201380043401.9A 2012-08-01 2013-07-31 作为a2a激动剂的n-烷基2-(双取代的)炔基腺苷-5’-糖醛酰胺 Pending CN104582709A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261678605P 2012-08-01 2012-08-01
US61/678,605 2012-08-01
US201361787188P 2013-03-15 2013-03-15
US61/787,188 2013-03-15
PCT/US2013/053053 WO2014022577A1 (en) 2012-08-01 2013-07-31 N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as a2a agonists

Publications (1)

Publication Number Publication Date
CN104582709A true CN104582709A (zh) 2015-04-29

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CN201380043401.9A Pending CN104582709A (zh) 2012-08-01 2013-07-31 作为a2a激动剂的n-烷基2-(双取代的)炔基腺苷-5’-糖醛酰胺

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US (1) US9067963B2 (enExample)
EP (1) EP2879683B1 (enExample)
JP (1) JP6545618B2 (enExample)
KR (1) KR20150036767A (enExample)
CN (1) CN104582709A (enExample)
AU (1) AU2013296420B2 (enExample)
BR (1) BR112015002249A2 (enExample)
CA (1) CA2880040A1 (enExample)
EA (1) EA027174B1 (enExample)
IL (1) IL236986A (enExample)
IN (1) IN2015DN00538A (enExample)
MX (1) MX367879B (enExample)
NZ (1) NZ703992A (enExample)
WO (1) WO2014022577A1 (enExample)
ZA (1) ZA201501350B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114025763A (zh) * 2019-06-21 2022-02-08 中国人民解放军军事科学院军事医学研究院 腺苷类化合物、其可药用盐或其立体异构体及用途

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7973025B2 (en) 2005-05-26 2011-07-05 Neuron Systems, Inc. Compositions and methods of treating retinal disease
CA2782015C (en) 2009-12-11 2020-08-25 Neuron Systems, Inc. Topical ophthalmic compositions and methods for the treatment of macular degeneration
US9822141B2 (en) * 2012-08-01 2017-11-21 Lewis And Clark Pharmaceuticals, Inc. N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists
HK1217439A1 (zh) 2013-01-23 2017-01-13 Aldeyra Therapeutics, Inc. 与毒性醛相关的疾病和治疗
MX2018002155A (es) 2015-08-21 2018-06-08 Aldeyra Therapeutics Inc Compuestos deuterados y usos de los mismos.
CA3022665A1 (en) 2016-05-09 2017-11-16 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
ES2968462T3 (es) 2017-03-16 2024-05-09 Aldeyra Therapeutics Inc Sal polimórfica de 6-cloro-3-amino-2(2-hidroxiprolil) quinolina y usos de la misma
JP7311162B2 (ja) 2017-10-10 2023-07-19 アルデイラ セラピューティクス， インコーポレイテッド 炎症性障害の処置
WO2020033344A1 (en) 2018-08-06 2020-02-13 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
US12098132B2 (en) 2019-05-02 2024-09-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
WO2020223685A1 (en) 2019-05-02 2020-11-05 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
WO2021231792A1 (en) 2020-05-13 2021-11-18 Aldeyra Therapeutics, Inc. Pharmaceutical formulations and uses thereof
WO2024258897A1 (en) 2023-06-13 2024-12-19 Dem Biopharma, Inc. Alkoxypyridinyl and related compounds and their use in therapy
WO2025194014A1 (en) 2024-03-15 2025-09-18 Dem Biopharma, Inc. Hetero aryl modulators of apmap and uses thereof
WO2025194015A1 (en) 2024-03-15 2025-09-18 Dem Biopharma, Inc. Heteroaryl modulators of gpr84 and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1315862A (zh) * 1998-09-01 2001-10-03 雅玛山酱油株式会社 治疗眼病的药用组合物
US6322771B1 (en) * 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
US20080009460A1 (en) * 2006-02-10 2008-01-10 Linden Joel M Method to treat sickle cell disease
US20080312160A1 (en) * 2007-04-09 2008-12-18 Guerrant Richard L Method of treating enteritis, intestinal damage, and diarrhea from c. difficile with an a2a adenosine receptor agonist

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
JPS6299395A (ja) 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd ２−アルキニルアデノシンおよび抗高血圧剤
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
JPH02104783A (ja) * 1988-10-11 1990-04-17 Kanai Hiroyuki スチールコードおよびタイヤ
DE68916036T2 (de) 1988-11-15 1994-09-29 Toa Eiyo Ltd Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen.
US5283327A (en) 1989-06-20 1994-02-01 Yamasa Shoyu Kabushiki Kaisha Tri-O-acetyl-2-alkynyladenosines
US5189027A (en) 1990-11-30 1993-02-23 Yamasa Shoyu Kabushiki Kaisha 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases
JP3025557B2 (ja) * 1991-06-28 2000-03-27 ヤマサ醤油株式会社 ２‐アルキニルアデノシン誘導体
IT1254915B (it) 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
WO2001070700A1 (en) 2000-03-23 2001-09-27 Solvay Pharmaceuticals B.V. 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
WO2003029264A2 (en) 2001-10-01 2003-04-10 University Of Virginia Patent Foundation 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof
AU2003268526A1 (en) 2002-09-09 2004-03-29 Cv Therapeutics, Inc. Adenosine a3 receptor agonists
CN101068825B (zh) 2004-08-02 2013-05-08 弗吉尼亚大学专利基金会 具有a2a激动剂活性的具有修饰的5＇-核糖基团的2-丙炔基腺苷类似物
WO2006091896A2 (en) * 2005-02-25 2006-08-31 Adenosine Therapeutics, Llc Pyridyl substituted xanthines
ES2361886T3 (es) * 2006-06-27 2011-06-24 Cbt Development Limited Profármacos adenosina acetil 2',3'-metilideno novedosos para uso como profármacos para agonistas del receptor adenosina.
MX2009012369A (es) 2007-05-17 2009-12-01 Cv Therapeutics Inc Proceso para preparar un agonista del receptor de adenosina-a2a y sus polimorfos.
US8293720B2 (en) 2007-12-20 2012-10-23 Dogwood Pharmaceuticals, Inc. Substituted 4-{3-[6-amino-9-(3, 4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
US8058259B2 (en) 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
WO2011002917A1 (en) * 2009-06-30 2011-01-06 Pgxhealth, Llc Alkoxy-carbonyl-amino-alkynyl-adenosine compounds and derivatives thereof as a2a r agonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1315862A (zh) * 1998-09-01 2001-10-03 雅玛山酱油株式会社 治疗眼病的药用组合物
US6322771B1 (en) * 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
US20080009460A1 (en) * 2006-02-10 2008-01-10 Linden Joel M Method to treat sickle cell disease
US20080312160A1 (en) * 2007-04-09 2008-12-18 Guerrant Richard L Method of treating enteritis, intestinal damage, and diarrhea from c. difficile with an a2a adenosine receptor agonist

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114025763A (zh) * 2019-06-21 2022-02-08 中国人民解放军军事科学院军事医学研究院 腺苷类化合物、其可药用盐或其立体异构体及用途
CN114025763B (zh) * 2019-06-21 2023-09-12 中国人民解放军军事科学院军事医学研究院 腺苷类化合物、其可药用盐或其立体异构体及用途

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BR112015002249A2 (pt) 2017-07-04
EA027174B1 (ru) 2017-06-30
US9067963B2 (en) 2015-06-30
NZ703992A (en) 2018-04-27
CA2880040A1 (en) 2014-02-06
ZA201501350B (en) 2016-12-21
JP2015524440A (ja) 2015-08-24
EP2879683A1 (en) 2015-06-10
EA201590205A1 (ru) 2015-06-30
MX2015001370A (es) 2016-04-26
EP2879683B1 (en) 2020-01-22
IN2015DN00538A (enExample) 2015-06-26
JP6545618B2 (ja) 2019-07-17
AU2013296420A1 (en) 2015-02-12
AU2013296420B2 (en) 2017-12-07
EP2879683A4 (en) 2016-04-20
WO2014022577A1 (en) 2014-02-06
US20140037538A1 (en) 2014-02-06
IL236986A (en) 2017-06-29
KR20150036767A (ko) 2015-04-07
MX367879B (es) 2019-09-10

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