CN104540839B - 磷铂化合物的合成和提纯方法及其用途 - Google Patents

磷铂化合物的合成和提纯方法及其用途 Download PDF

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Publication number
CN104540839B
CN104540839B CN201380026289.8A CN201380026289A CN104540839B CN 104540839 B CN104540839 B CN 104540839B CN 201380026289 A CN201380026289 A CN 201380026289A CN 104540839 B CN104540839 B CN 104540839B
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Prior art keywords
platinum
reactant mixture
dach
pyrophosphate
complex
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Chinese (zh)
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CN104540839A (zh
Inventor
韦恩·D·卢克
斯蒂芬·约斯特
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Cape Medical Co
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Phosplatin Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201380026289.8A 2012-05-24 2013-03-15 磷铂化合物的合成和提纯方法及其用途 Active CN104540839B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710071127.6A CN106967124B (zh) 2012-05-24 2013-03-15 磷铂化合物的合成和提纯方法及其用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261651200P 2012-05-24 2012-05-24
US61/651,200 2012-05-24
PCT/US2013/031885 WO2013176764A1 (en) 2012-05-24 2013-03-15 Synthetic and purification methods for phosphaplatin compounds and uses thereof

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CN201710071127.6A Division CN106967124B (zh) 2012-05-24 2013-03-15 磷铂化合物的合成和提纯方法及其用途

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CN104540839A CN104540839A (zh) 2015-04-22
CN104540839B true CN104540839B (zh) 2017-02-22

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CN201710071127.6A Active CN106967124B (zh) 2012-05-24 2013-03-15 磷铂化合物的合成和提纯方法及其用途

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Country Status (18)

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US (2) US8846964B2 (https=)
EP (2) EP2855496B1 (https=)
JP (1) JP5833795B2 (https=)
CN (2) CN104540839B (https=)
CY (2) CY1118746T1 (https=)
DK (2) DK2855496T3 (https=)
ES (2) ES2751668T3 (https=)
HR (2) HRP20170416T1 (https=)
HU (2) HUE046327T2 (https=)
IN (1) IN2014KN02722A (https=)
LT (2) LT2855496T (https=)
PL (2) PL2855496T3 (https=)
PT (2) PT3202769T (https=)
RS (2) RS59725B1 (https=)
SI (2) SI2855496T1 (https=)
SM (2) SMT201900617T1 (https=)
TW (2) TWI653237B (https=)
WO (1) WO2013176764A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2855496T (lt) * 2012-05-24 2017-04-10 Phosplatin Therapeutics Llc Fosfaplatinos junginių sintezės ir gryninimo būdai ir jų panaudojimas
CA3020166A1 (en) * 2016-04-06 2017-10-12 Phosplatin Therapeutics Llc Phosphaplatin liquid formulations
TWI791008B (zh) 2017-01-06 2023-02-01 美商弗斯普萊汀治療股份有限公司 作為供骨癌或血癌治療用之治療劑的磷酸鉑(phosphaplatin)化合物
JP7381083B2 (ja) * 2017-09-08 2023-11-15 フォスプラティン テラピューティクス インコーポレイテッド 免疫調節剤としてのホスファプラチン化合物およびその治療的使用
CN113861036B (zh) * 2021-11-08 2024-04-02 合肥工业大学 一种乙二胺高氯酸铜配合物的制备及用途
US11673904B1 (en) 2021-12-09 2023-06-13 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Low pressure process for synthesis of Pt(PF3)4 involving a soluble intermediate and storage of obtained Pt(PF3)4
CN119822568B (zh) * 2025-02-19 2025-08-19 扬州宏鑫环保科技有限公司 一种高效纯化水制备装置及制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234500A (en) * 1979-03-07 1980-11-18 Engelhard Minerals & Chemicals Corporation Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes
CN101389637A (zh) * 2006-01-30 2009-03-18 普拉托技术（私有）公司 铂(ⅱ)配合物的制备
CN101801369A (zh) * 2007-08-06 2010-08-11 俄亥俄大学 磷铂及其在治疗顺铂和卡铂耐药性癌中的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1644388A2 (en) 2003-06-27 2006-04-12 ODANI, Akira Bisphosphonate complexes
JP5489988B2 (ja) * 2007-05-18 2014-05-14 Ｔｔｉ・エルビュー株式会社 有効成分の生体界面への改善された放出を確保する経皮送達装置
CN108210516A (zh) * 2010-06-04 2018-06-29 俄亥俄大学 磷铂及其在治疗癌症中的用途
JP6027619B2 (ja) * 2011-10-05 2016-11-16 ラシンドラ・エヌ・ボーズ ホスファプラチン系抗腫瘍剤の大規模調製のための効率的プロセス
LT2855496T (lt) * 2012-05-24 2017-04-10 Phosplatin Therapeutics Llc Fosfaplatinos junginių sintezės ir gryninimo būdai ir jų panaudojimas

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234500A (en) * 1979-03-07 1980-11-18 Engelhard Minerals & Chemicals Corporation Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes
CN101389637A (zh) * 2006-01-30 2009-03-18 普拉托技术（私有）公司 铂(ⅱ)配合物的制备
CN101801369A (zh) * 2007-08-06 2010-08-11 俄亥俄大学 磷铂及其在治疗顺铂和卡铂耐药性癌中的用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Synthetic Strategies to Improve the Cytotoxicity of Platinum-Based Cancer Therapeutics;Caroline Thalia Saouma;《Undergraduate Thesis, MIT》;20051231;第62页第1-2段，第67页第2段，第72页第1-2段 *

Also Published As

Publication number Publication date
TW201347765A (zh) 2013-12-01
US8859796B1 (en) 2014-10-14
CY1122316T1 (el) 2021-01-27
HUE032197T2 (en) 2017-09-28
SI2855496T1 (sl) 2017-04-26
LT3202769T (lt) 2019-12-10
EP2855496A1 (en) 2015-04-08
ES2751668T3 (es) 2020-04-01
WO2013176764A1 (en) 2013-11-28
LT2855496T (lt) 2017-04-10
CN106967124A (zh) 2017-07-21
JP5833795B2 (ja) 2015-12-16
PT2855496T (pt) 2017-03-23
TW201741326A (zh) 2017-12-01
US8846964B2 (en) 2014-09-30
PL2855496T3 (pl) 2017-09-29
TWI599361B (zh) 2017-09-21
EP3202769A1 (en) 2017-08-09
PT3202769T (pt) 2019-10-31
ES2619412T3 (es) 2017-06-26
JP2015523335A (ja) 2015-08-13
PL3202769T3 (pl) 2020-03-31
CY1118746T1 (el) 2018-03-07
SMT201700168T1 (it) 2017-05-08
RS55806B1 (sr) 2017-08-31
US20140024848A1 (en) 2014-01-23
EP2855496B1 (en) 2016-12-14
IN2014KN02722A (https=) 2015-05-08
TWI653237B (zh) 2019-03-11
HRP20170416T1 (hr) 2017-05-19
US20140288321A1 (en) 2014-09-25
HK1203202A1 (en) 2015-10-23
CN104540839A (zh) 2015-04-22
CN106967124B (zh) 2020-03-06
RS59725B1 (sr) 2020-01-31
HUE046327T2 (hu) 2020-03-30
SMT201900617T1 (it) 2020-01-14
DK3202769T3 (da) 2019-10-28
EP3202769B1 (en) 2019-10-02
SI3202769T1 (sl) 2020-02-28
HRP20191904T1 (hr) 2020-01-24
EP2855496A4 (en) 2015-04-08
DK2855496T3 (en) 2017-03-27

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Patentee before: PHOSPLATIN THERAPEUTICS LLC

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Address after: New York, United States

Patentee after: Cape Medical Co.

Address before: New York, United States

Patentee before: Fosplatin treatment Ltd.

CP01 Change in the name or title of a patent holder