CN104529775B - α‑细辛醇酯及其制备方法与应用 - Google Patents

α‑细辛醇酯及其制备方法与应用 Download PDF

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Publication number
CN104529775B
CN104529775B CN201410699506.6A CN201410699506A CN104529775B CN 104529775 B CN104529775 B CN 104529775B CN 201410699506 A CN201410699506 A CN 201410699506A CN 104529775 B CN104529775 B CN 104529775B
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China
Prior art keywords
compound
asarone
preparation
acid
ethyl acetate
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CN201410699506.6A
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Chinese (zh)
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CN104529775A (zh
Inventor
郑晓晖
秦方刚
白亚军
王世祥
张毅
何希瑞
刘佩
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XI'AN PUYANG SCIENCE AND TECHNOLOGY DEVELOPMENT Co Ltd
Northwest University
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XI'AN PUYANG SCIENCE AND TECHNOLOGY DEVELOPMENT Co Ltd
Northwest University
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Application filed by XI'AN PUYANG SCIENCE AND TECHNOLOGY DEVELOPMENT Co Ltd, Northwest University filed Critical XI'AN PUYANG SCIENCE AND TECHNOLOGY DEVELOPMENT Co Ltd
Priority to CN201410699506.6A priority Critical patent/CN104529775B/zh
Publication of CN104529775A publication Critical patent/CN104529775A/zh
Priority to SI201531204T priority patent/SI3225616T1/sl
Priority to CA2968652A priority patent/CA2968652C/en
Priority to HUE15863145A priority patent/HUE049249T2/hu
Priority to NZ732395A priority patent/NZ732395A/en
Priority to DK15863145.7T priority patent/DK3225616T3/da
Priority to KR1020177017335A priority patent/KR102029898B1/ko
Priority to PCT/CN2015/095686 priority patent/WO2016082780A1/zh
Priority to SG11201704239PA priority patent/SG11201704239PA/en
Priority to PL15863145T priority patent/PL3225616T3/pl
Priority to EP15863145.7A priority patent/EP3225616B1/en
Priority to HK18103381.1A priority patent/HK1243995B/en
Priority to RU2017121591A priority patent/RU2673887C1/ru
Priority to US15/529,283 priority patent/US10131619B2/en
Priority to JP2017527866A priority patent/JP6506841B2/ja
Priority to MYPI2017701893A priority patent/MY175619A/en
Priority to AU2015353112A priority patent/AU2015353112B2/en
Priority to IL252461A priority patent/IL252461B/en
Application granted granted Critical
Publication of CN104529775B publication Critical patent/CN104529775B/zh
Priority to CY20201100376T priority patent/CY1123193T1/el
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    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
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    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
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    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/24—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with monohydroxylic compounds
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    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
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CN201410699506.6A 2014-11-26 2014-11-26 α‑细辛醇酯及其制备方法与应用 Active CN104529775B (zh)

Priority Applications (19)

Application Number Priority Date Filing Date Title
CN201410699506.6A CN104529775B (zh) 2014-11-26 2014-11-26 α‑细辛醇酯及其制备方法与应用
EP15863145.7A EP3225616B1 (en) 2014-11-26 2015-11-26 Alpha-asary-laldehyde ester, preparation method therefor, and application thereof
RU2017121591A RU2673887C1 (ru) 2014-11-26 2015-11-26 СЛОЖНЫЙ α-АЗАРИ-ЛАЛДЕГИДНЫЙ ЭФИР, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ЕГО ПРИМЕНЕНИЯ
HUE15863145A HUE049249T2 (hu) 2014-11-26 2015-11-26 Alfa-azaril-aldehid észter, elõállítási eljárása és alkalmazása
NZ732395A NZ732395A (en) 2014-11-26 2015-11-26 Α-asary-laldehyde ester, preparation method therefor, and application thereof
DK15863145.7T DK3225616T3 (da) 2014-11-26 2015-11-26 Alpha-asary-laldehydester, fremgangsmåde til fremstilling deraf og anvendelse deraf
KR1020177017335A KR102029898B1 (ko) 2014-11-26 2015-11-26 α-아사릴알데히드 에스테르, 이의 제조 방법, 및 이의 응용
PCT/CN2015/095686 WO2016082780A1 (zh) 2014-11-26 2015-11-26 α-细辛醇酯及其制备方法与应用
SG11201704239PA SG11201704239PA (en) 2014-11-26 2015-11-26 α-ASARY-LALDEHYDE ESTER, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
PL15863145T PL3225616T3 (pl) 2014-11-26 2015-11-26 Ester aldehydu alfa-asarylowego, jego sposób wytwarzania i jego zastosowanie
SI201531204T SI3225616T1 (sl) 2014-11-26 2015-11-26 Alfa-asaril-aldehidni ester, postopek njegove priprave in njegova uporaba
HK18103381.1A HK1243995B (en) 2014-11-26 2015-11-26 Alpha-asary-laldehyde ester, preparation method therefor, and application thereof
CA2968652A CA2968652C (en) 2014-11-26 2015-11-26 Esters of .alpha.-asaronol, methods of preparation and uses thereof
US15/529,283 US10131619B2 (en) 2014-11-26 2015-11-26 α-Asary-laldehyde ester, preparation method therefor, and application thereof
JP2017527866A JP6506841B2 (ja) 2014-11-26 2015-11-26 α−アサリルアルデヒドエステル、その調製方法及びその用途
MYPI2017701893A MY175619A (en) 2014-11-26 2015-11-26 A-asary-laldehyde ester, preparation method therefor, and application thereof
AU2015353112A AU2015353112B2 (en) 2014-11-26 2015-11-26 Alpha-asary-laldehyde ester, preparation method therefor, and application thereof
IL252461A IL252461B (en) 2014-11-26 2017-05-23 Alpha-asrylaldehyde ester, a method for its preparation and application
CY20201100376T CY1123193T1 (el) 2014-11-26 2020-04-27 Εστερας α-ασαρυλ-αλδεϋδης, μεθοδος παρασκευης αυτου και εφαρμογη αυτης

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CN104529775B true CN104529775B (zh) 2017-07-14

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EP (1) EP3225616B1 (enExample)
JP (1) JP6506841B2 (enExample)
KR (1) KR102029898B1 (enExample)
CN (1) CN104529775B (enExample)
AU (1) AU2015353112B2 (enExample)
CA (1) CA2968652C (enExample)
CY (1) CY1123193T1 (enExample)
DK (1) DK3225616T3 (enExample)
HU (1) HUE049249T2 (enExample)
IL (1) IL252461B (enExample)
MY (1) MY175619A (enExample)
NZ (1) NZ732395A (enExample)
PL (1) PL3225616T3 (enExample)
RU (1) RU2673887C1 (enExample)
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CN104529775B (zh) * 2014-11-26 2017-07-14 西北大学 α‑细辛醇酯及其制备方法与应用
MX2019001455A (es) 2016-08-04 2019-06-20 Takasago Perfumery Co Ltd Compuestos de sensacion de calor.
CN113248380B (zh) * 2020-11-23 2023-01-10 西北大学 一种乙酸α-细辛醇酯与α-细辛醇的合成方法
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