CN104522051A - Bactericidal composition - Google Patents
Bactericidal composition Download PDFInfo
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- CN104522051A CN104522051A CN201410727168.2A CN201410727168A CN104522051A CN 104522051 A CN104522051 A CN 104522051A CN 201410727168 A CN201410727168 A CN 201410727168A CN 104522051 A CN104522051 A CN 104522051A
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- China
- Prior art keywords
- acid amides
- ether acid
- chlorobenzene ether
- bactericidal composition
- kocide
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticides and relates to a bactericidal composition which is characterized in that active ingredients of the bactericidal composition contain chlorophenylether amide and copper hydroxide. The composition can be made into a water dispersible granule, has remarkable synergism, can be used to prolong persistent period and is environmentally friendly.
Description
Technical field
The invention belongs to technical field of pesticide, contain the bactericidal composition with synergistic effect of chlorobenzene ether acid amides and Kocide SD specifically.
Background technology
Chlorobenzene ether acid amides is Central China Normal University's pyrazol acid amide compounds newly developed, has good control efficiency, have good preventive effect simultaneously to the banded sclerotial blight of paddy rice and wheat to the disease such as epidemic disease, downy mildew, tikka of the plants such as cucumber, tomato, potato.Field trial shows do not have cross resistance with existing bactericide.Structural formula is as follows:
The copper ion of Kocide SD dependence itself, can reach the effect of sterilization.Copper ion is absorbed by the spore sprouted, and when reaching finite concentration, just can kill spore cell, for preventing and treating the epidemic disease, leaf spot etc. of Vegetables, fruit tree.
Potato late blight is caused by phytophthora infestans, causes the crushing oomycetes disease of one that potato haulm is dead and stem tuber is rotten.During morbidity, stem or petiole are caught an illness existing brown streak.Serious blade of falling ill wither vertical, crispatura, cause the black corruption of complete stool eventually, full field a slice is dried-up, gives out corrupt smell.Stem tuber is caught an illness nascent brown or puce bulk scab, slightly caves in, and the subcutaneous potato meat in sick portion, also in brown, slowly expands to surrounding or rots, causing suffering heavy losses.
Summary of the invention
The object of this invention is to provide and a kind ofly there is synergistic effect and the bactericidal composition of safety and environmental protection, for preventing and treating potato late blight, compared with existing pesticide control, realizing compound synergic, reduce consumption, thus reach the object reduced costs.Be specifically related to the bactericidal composition of chlorobenzene ether acid amides and Kocide SD.
Utilizing above-mentioned bactericidal composition, be equipped with the known auxiliary agent of those skilled in that art, make formulation of the present invention with the known method of those skilled in that art, is water dispersible granules.
In above-mentioned bactericidal composition, the weight ratio of chlorobenzene ether acid amides and Kocide SD is 1:60-60:1.
Above-mentioned bactericidal composition has following characteristics: 1, two kinds of active ingredients composite after, there is good synergistic effect; 2, active ingredient is little to environmental influence, and toxicity is very low; 3, formulation environmental protection; 4, quick-acting is good, and the lasting period is long.
Embodiment
For determining chlorobenzene ether acid amides and the composite synergistic effect of Kocide SD two kinds of active ingredients, first applicant uses these two kinds of compositions to carry out indoor biometrics test, the raw object surveyed is decided to be the phytophthora infestans (Phytophthora infestans de Bary) that can cause potato late blight, this Pseudomonas Mastigomycotina fungi by us.
The test method of indoor biometrics: reference standard NY/T1156.7-2006, adopts growth rate method to measure medicament to the inhibitory action of potato late blight pathogen mycelial growth.On the basis of preliminary experiment, from each medicament, design 5 concentration within the scope of 10%-90% are reached to germ mycelial growth inhibition rate, first by the former medicinal acetone solution of 95% chlorobenzene ether acid amides, the liquid that the former powder of 97% Kocide SD is mixed with series concentration with trace salt acid dissolve is for subsequent use, then liquid is joined in 1% ratio in the PDA medium melting also cool to room temperature, after fully shaking up, pour in the culture dish (Φ 90mm) of sterilizing and make band medicine flat board, often process and repeat, to add the process of sterile water for blank for four times; With card punch (Φ 5mm) the picking phytophthora infestans bacterium cake of sterilizing, mycelia faces down aseptic inoculation in the central authorities of band medicine flat board, be inverted in the interior cultivation of constant incubator of 25 DEG C, adopt right-angled intersection method to measure colony diameter after cultivating 6d, calculate the EC of each medicament to pathogen
50, and calculate toxicity index according to the following equation, compare virulence and the bacteriostasis of different agents.Former medicine used is tested in above-mentioned raw test and reagent is all bought from other producers.
The co-toxicity coefficient method representation that the co-toxicity of mixture preparation adopts Sun Yun abundant:
The theoretical toxicity index TTI=∑ of mixture preparation (percentage of this pharmaceutically active ingredient of the toxicity index ATI of certain medicine × in mixture).
Be synergistic effect when CTC is greater than 120, being antagonism when being less than 80, is addition time between 80-120.
Indoor biometrics test data sees the following form:
Table 1 chlorobenzene ether acid amides, Kocide SD and different ratio thereof are to the measurement result of potato late blight pathogen co-toxicity coefficient
Analyze above-mentioned data can obviously find out, when chlorobenzene ether acid amides and Kocide SD are composite in varing proportions, the co-toxicity coefficient (CTC) of formula is all greater than 120, the prevention and control capability of potato late blight is had to the synergistic effect of different proportion.Visible, chlorobenzene ether acid amides and the composite of Kocide SD become the favourable agents preventing and treating potato late blight.
Tested by indoor biometrics, checking chlorobenzene ether acid amides and Kocide SD two kinds of active ingredients composite after, have good synergistic effect, below by way of instantiation in order to further describe the present invention, but the present invention is absolutely not only only limitted to these embodiments following.In formula, percentage is all weight percentage, and the former medicine used and auxiliary agent are other producers and buy.
Formulation examples is as follows:
Example one, 30.5% chlorobenzene ether acid amides copper hydroxide water dispersible granule
Example two, 26% chlorobenzene ether acid amides copper hydroxide water dispersible granule
Example three, 22% chlorobenzene ether acid amides copper hydroxide water dispersible granule
Example four, 18% chlorobenzene ether acid amides copper hydroxide water dispersible granule
Example five, 16% chlorobenzene ether acid amides copper hydroxide water dispersible granule
Example six, 30% chlorobenzene ether acid amides copper hydroxide water dispersible granule
Example seven, 33% chlorobenzene ether acid amides copper hydroxide water dispersible granule
Example eight, 52% chlorobenzene ether acid amides copper hydroxide water dispersible granule
Example nine, 61% chlorobenzene ether acid amides copper hydroxide water dispersible granule
Select above example to carry out preventing and treating the field trial of potato late blight, determine to fill a prescription and prevent and treat the effect of potato late blight, simultaneously with the Contrast on effect of chlorobenzene ether acid amides and Kocide SD single dose, the control efficiency of the checking embodiment of the present invention.Concrete test method is with reference to GB/T17980.34-2000.Test site is area, Luliang, Yunnan Province, and test each process four repetition, community randomized arrangement, each plot area is 20m
2adopt back-pack electric compression sprayer, dispenser was sunny calm for the same day, the planting habit of planting habit all with local of all communities is identical, spraying time is on May 12nd, 2014 first, carries out dispenser first and investigate and carry out secondary dispenser after 7 days, carries out last dispenser and carry out second time investigation after 14 days after 7 days, record the synoptic data of the same day of dispenser first and a week thereafter, specific as follows:
Table 2 duration of test meteorological data
Investigation method is: every community gets 5 investigation at random, and look into 2 ~ 3 strains at often, whole blade is investigated in every strain.
The grade scale of disease index:
0 grade: without scab;
1 grade: lesion area accounts for less than 5% of whole leaf area;
3 grades: lesion area accounts for 6% ~ 10% of whole leaf area;
5 grades: lesion area accounts for 11% ~ 25% of whole leaf area;
7 grades: lesion area accounts for 26% ~ 50% of whole leaf area;
9 grades: lesion area accounts for more than 51% of whole leaf area.
Table 316% chlorobenzene ether acid amides copper hydroxide water dispersible granule and different agents are to the preventive effect of potato late blight
As can be seen from above-mentioned data, after medicine first in the investigation of 7 days, the preventive effect of chlorobenzene ether acid amides and Kocide SD complex preparation is all more than 72%, and the preventive effect of 24% chlorobenzene ether amide suspending agents is 40.85%, the preventive effect of 50% copper hydroxide water dispersible granule is 45.33%, compare two kinds of single doses, complex preparation preventive effect is extremely remarkable, has good synergistic effect after two kinds of active ingredients are composite.And after last medicine in the investigation of 14 days, the preventive effect of all complex preparations to potato late blight is improved, and the preventive effect of two kinds of single doses then slightly reduces, visible, the lasting period of composite rear preparation extends, more lasting to the control efficiency of potato late blight.
Claims (2)
1. a bactericidal composition, is characterized in that: active component is made up of chlorobenzene ether acid amides and Kocide SD, and the weight ratio of described chlorobenzene ether acid amides and Kocide SD is 1:60 ~ 60:1.
2. composition according to claim 1, is characterized in that: make water dispersible granules by active component and auxiliary material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410727168.2A CN104522051A (en) | 2014-12-03 | 2014-12-03 | Bactericidal composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410727168.2A CN104522051A (en) | 2014-12-03 | 2014-12-03 | Bactericidal composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104522051A true CN104522051A (en) | 2015-04-22 |
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ID=52837831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410727168.2A Pending CN104522051A (en) | 2014-12-03 | 2014-12-03 | Bactericidal composition |
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| Country | Link |
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| CN (1) | CN104522051A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226244A (en) * | 1996-07-24 | 1999-08-18 | 拜尔公司 | Carbanilides used as pesticides |
| JP2004189738A (en) * | 2002-11-29 | 2004-07-08 | Nippon Nohyaku Co Ltd | Substituted anilide derivative, its intermediate, agricultural horticultural chemical and usage of the same |
| CN101056858A (en) * | 2004-09-06 | 2007-10-17 | 巴斯福股份公司 | (hetero)cyclyl(thio) carboxylic acid anilides for controlling pathogenic fungi |
| CN103391925A (en) * | 2010-11-15 | 2013-11-13 | 拜耳知识产权有限责任公司 | 5-halogenopyrazolecarboxamides |
-
2014
- 2014-12-03 CN CN201410727168.2A patent/CN104522051A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226244A (en) * | 1996-07-24 | 1999-08-18 | 拜尔公司 | Carbanilides used as pesticides |
| JP2004189738A (en) * | 2002-11-29 | 2004-07-08 | Nippon Nohyaku Co Ltd | Substituted anilide derivative, its intermediate, agricultural horticultural chemical and usage of the same |
| CN101056858A (en) * | 2004-09-06 | 2007-10-17 | 巴斯福股份公司 | (hetero)cyclyl(thio) carboxylic acid anilides for controlling pathogenic fungi |
| CN103391925A (en) * | 2010-11-15 | 2013-11-13 | 拜耳知识产权有限责任公司 | 5-halogenopyrazolecarboxamides |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150422 |
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| WD01 | Invention patent application deemed withdrawn after publication |