CN104520331B - 磷脂酰肌醇蛋白聚糖3的高亲和力单克隆抗体及其用途 - Google Patents

磷脂酰肌醇蛋白聚糖3的高亲和力单克隆抗体及其用途 Download PDF

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CN104520331B
CN104520331B CN201380039993.7A CN201380039993A CN104520331B CN 104520331 B CN104520331 B CN 104520331B CN 201380039993 A CN201380039993 A CN 201380039993A CN 104520331 B CN104520331 B CN 104520331B
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seq
antibody
gpc3
amino acid
cancer
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CN104520331A (zh
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何苗壮
Y·T·冯
高威
张帆
张一帆
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US Department of Health and Human Services
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CN201380039993.7A 2012-06-01 2013-05-31 磷脂酰肌醇蛋白聚糖3的高亲和力单克隆抗体及其用途 Active CN104520331B (zh)

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US201261654232P 2012-06-01 2012-06-01
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PCT/US2013/043633 WO2013181543A1 (en) 2012-06-01 2013-05-31 High-affinity monoclonal antibodies to glypican-3 and use thereof

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CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
RS67768B1 (sr) 2010-11-30 2026-03-31 Chugai Pharmaceutical Co Ltd Terapijski agens koji indukuje citotoksičnost
EP2934532B1 (en) 2012-12-20 2019-10-23 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
TWI693073B (zh) 2012-12-21 2020-05-11 日商中外製藥股份有限公司 對ｇｐｃ３標的治療劑療法為有效之患者投與的ｇｐｃ３標的治療劑
JP6534615B2 (ja) 2013-09-27 2019-06-26 中外製薬株式会社 ポリペプチド異種多量体の製造方法
EP3088890B1 (en) * 2013-12-24 2020-09-23 Chugai Seiyaku Kabushiki Kaisha Method for measuring soluble gpc3 protein
CN113933504A (zh) 2014-05-08 2022-01-14 中外制药株式会社 对gpc3靶向治疗剂疗法有效的患者施用的gpc3靶向治疗剂
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