SG11201407972RA - High-affinity monoclonal antibodies to glypican-3 and use thereof - Google Patents

High-affinity monoclonal antibodies to glypican-3 and use thereof

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Publication number
SG11201407972RA
SG11201407972RA SG11201407972RA SG11201407972RA SG11201407972RA SG 11201407972R A SG11201407972R A SG 11201407972RA SG 11201407972R A SG11201407972R A SG 11201407972RA SG 11201407972R A SG11201407972R A SG 11201407972RA SG 11201407972R A SG11201407972R A SG 11201407972RA
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SG
Singapore
Prior art keywords
lllll
gpc3
international
rule
llll
Prior art date
Application number
SG11201407972RA
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English (en)
Inventor
Mitchell Ho
Yen T Phung
Wei Gao
Yifan Zhang
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Us Health
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Publication date
Application filed by Us Health filed Critical Us Health
Publication of SG11201407972RA publication Critical patent/SG11201407972RA/en

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    • A—HUMAN NECESSITIES
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
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SG11201407972RA 2012-06-01 2013-05-31 High-affinity monoclonal antibodies to glypican-3 and use thereof SG11201407972RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261654232P 2012-06-01 2012-06-01
PCT/US2013/043633 WO2013181543A1 (en) 2012-06-01 2013-05-31 High-affinity monoclonal antibodies to glypican-3 and use thereof

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SG11201407972RA true SG11201407972RA (en) 2015-01-29

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US (1) US9409994B2 (https=)
JP (2) JP6494507B2 (https=)
KR (1) KR102159773B1 (https=)
CN (1) CN104520331B (https=)
SG (1) SG11201407972RA (https=)
WO (1) WO2013181543A1 (https=)

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CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
RS67768B1 (sr) 2010-11-30 2026-03-31 Chugai Pharmaceutical Co Ltd Terapijski agens koji indukuje citotoksičnost
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TWI693073B (zh) 2012-12-21 2020-05-11 日商中外製藥股份有限公司 對ｇｐｃ３標的治療劑療法為有效之患者投與的ｇｐｃ３標的治療劑
JP6534615B2 (ja) 2013-09-27 2019-06-26 中外製薬株式会社 ポリペプチド異種多量体の製造方法
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CN107847593B (zh) * 2015-04-20 2021-12-14 美侬米克国际有限公司 治疗抗体及其用途
US11376326B2 (en) 2015-07-01 2022-07-05 Chugai Seiyaku Kabushiki Kaisha GPC3-targeting therapeutic agent which is administered to patient for whom the GPC3-targeting therapeutic agent is effective
KR101796688B1 (ko) 2015-10-29 2017-12-01 재단법인 목암생명과학연구소 신규 항-글리피칸 3 항체 및 이를 포함하는 약학적 조성물
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