CN104519989B - 制备包含气体微泡的组合物 - Google Patents

制备包含气体微泡的组合物 Download PDF

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Publication number
CN104519989B
CN104519989B CN201380033735.8A CN201380033735A CN104519989B CN 104519989 B CN104519989 B CN 104519989B CN 201380033735 A CN201380033735 A CN 201380033735A CN 104519989 B CN104519989 B CN 104519989B
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CN
China
Prior art keywords
gas
protein solution
inlet
feed
heated
Prior art date
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CN201380033735.8A
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English (en)
Chinese (zh)
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CN104519989A (zh
Inventor
S.克瓦勒
O.J.托克鲁德
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GE Healthcare AS
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GE Healthcare AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/248—Reactors comprising multiple separated flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00076—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements inside the reactor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Accessories For Mixers (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • General Preparation And Processing Of Foods (AREA)
CN201380033735.8A 2012-06-26 2013-06-25 制备包含气体微泡的组合物 Active CN104519989B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12173606 2012-06-26
EP12173606.0 2012-06-26
PCT/EP2013/063218 WO2014001297A2 (en) 2012-06-26 2013-06-25 Preparation of composition comprising gas microbubbles

Publications (2)

Publication Number Publication Date
CN104519989A CN104519989A (zh) 2015-04-15
CN104519989B true CN104519989B (zh) 2016-10-26

Family

ID=48699026

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380033735.8A Active CN104519989B (zh) 2012-06-26 2013-06-25 制备包含气体微泡的组合物

Country Status (14)

Country Link
US (1) US10350314B2 (https=)
EP (1) EP2864033B1 (https=)
JP (1) JP6420761B2 (https=)
KR (1) KR102139393B1 (https=)
CN (1) CN104519989B (https=)
AU (2) AU2013283409B2 (https=)
BR (1) BR112014032254B1 (https=)
CA (1) CA2876950C (https=)
DK (1) DK2864033T3 (https=)
ES (1) ES2571481T3 (https=)
IN (1) IN2014DN10714A (https=)
MX (1) MX354719B (https=)
RU (1) RU2640078C2 (https=)
WO (1) WO2014001297A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014DN10714A (https=) 2012-06-26 2015-09-04 Ge Healthcare As
NL2014178B1 (en) * 2015-01-22 2017-01-05 Tide Microfluidics B V System and method for controlled manufacturing of mono-disperse microbubbles.
US11317888B2 (en) 2016-10-11 2022-05-03 Thomas Jefferson University Non-invasive method for pressure measurement
JP7220567B2 (ja) * 2017-02-10 2023-02-10 キリンホールディングス株式会社 スパージャー及び培養装置
CN112808187B (zh) * 2021-01-19 2023-05-30 浙江省林业科学研究院 一种生产气泡胶囊菌剂的自动化设备及方法
US12345068B2 (en) 2021-11-19 2025-07-01 Sundance Spas, Inc. Self-maintaining hot tub or spa

Family Cites Families (24)

* Cited by examiner, † Cited by third party
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US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
US4957656A (en) 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US20080063603A1 (en) 1990-04-02 2008-03-13 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
HU218018B (hu) 1991-09-17 2000-05-28 Sonus Pharmaceuticals Inc. Gázos ultrahang-kontrasztanyag és eljárás ultrahang kontrasztanyaghoz megfelelő gázok kiválasztására
AU722742B2 (en) * 1993-07-02 2000-08-10 Molecular Biosystems, Inc. Methods for making encapsulated microspheres from heat denatured protein using mechanical cavitation
US5855865A (en) * 1993-07-02 1999-01-05 Molecular Biosystems, Inc. Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
WO1995001187A1 (en) 1993-07-02 1995-01-12 Molecular Biosystems, Inc. Protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents
JPH0747251A (ja) 1993-08-06 1995-02-21 Toho Asechiren Kk 混合ガス発生方法
US5370955A (en) 1993-09-27 1994-12-06 Xerox Corporation Electrophotographic elements with arylamine polycondensation polymers
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
PL319600A1 (en) 1994-09-29 1997-08-18 Andaris Ltd Spray-dried microparticles as therapeutic carriers
ATE238072T1 (de) 1996-02-19 2003-05-15 Amersham Health As Verbesserungen an (oder im bezug auf) kontrastmittel
US5976501A (en) 1996-06-07 1999-11-02 Molecular Biosystems, Inc. Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion
TR199901544T2 (xx) * 1996-10-21 1999-09-21 Nycomed Imaging As Kontrast ajanlar�ndaki veya kontrast ajanlar�yla ilgili geli�meler.
JP3693276B2 (ja) 1998-09-17 2005-09-07 東京瓦斯株式会社 温度差を有する気液を配管上で混合するための装置
AR035779A1 (es) 2001-02-06 2004-07-14 Genetics Inst Llc Polipeptidos de fusion derivados de glicoproteina ib alfa de plaqueta y metodos de uso de los mismos
JP4350058B2 (ja) * 2004-11-09 2009-10-21 株式会社デンソー 冷媒用二重管
DE102005052973B4 (de) * 2004-11-09 2014-11-20 Denso Corporation Doppelwandiges Rohr und Herstellungsverfahren dafür
DE102005020727A1 (de) 2005-05-04 2006-11-09 Dr.Ing.H.C. F. Porsche Ag Stranggepresstes Mehrkammerrohr, insbesondere für einen Wärmeübertrager
CN101130094A (zh) * 2007-09-06 2008-02-27 上海新兴医药股份有限公司 一种超声造影剂及其制备方法
CN101507908B (zh) 2009-04-09 2010-12-01 北京化工大学 微通道套管式装置及其应用
IN2014DN10714A (https=) 2012-06-26 2015-09-04 Ge Healthcare As

Also Published As

Publication number Publication date
CA2876950C (en) 2020-09-22
DK2864033T3 (en) 2016-05-17
KR102139393B1 (ko) 2020-07-29
US10350314B2 (en) 2019-07-16
AU2013283409B2 (en) 2017-06-08
BR112014032254A2 (pt) 2017-06-27
CA2876950A1 (en) 2014-01-03
BR112014032254B1 (pt) 2022-11-01
RU2014150473A (ru) 2016-08-20
JP6420761B2 (ja) 2018-11-07
WO2014001297A2 (en) 2014-01-03
EP2864033B1 (en) 2016-04-06
JP2015524792A (ja) 2015-08-27
US20150250904A1 (en) 2015-09-10
EP2864033A2 (en) 2015-04-29
WO2014001297A3 (en) 2014-10-02
RU2640078C2 (ru) 2017-12-26
ES2571481T3 (es) 2016-05-25
KR20150024420A (ko) 2015-03-06
AU2017216553A1 (en) 2017-09-07
CN104519989A (zh) 2015-04-15
HK1209381A1 (en) 2016-04-01
AU2017216553B2 (en) 2019-06-27
AU2013283409A1 (en) 2015-01-22
MX354719B (es) 2018-03-16
MX2014015717A (es) 2015-08-05
IN2014DN10714A (https=) 2015-09-04

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